Biocompatible polymeric nanocomplexes as an intracellular stimuli-sensitive prodrug for type-2 diabetes combination therapy.

abstract：:A biodegradable microvessel scaffold comprised of distinct parenchymal and vascular compartments separated by a permeable membrane interface was conceptualized, fabricated, cellularized, and implanted. The device was designed with perfusable microfluidic channels on the order of 100 μm to mimic small blood vessels, an...

journal_title：Biomaterials

authors： Ye X,Lu L,Kolewe ME,Park H,Larson BL,Kim ES,Freed LE

更新日期：2013-12-01 00:00:00

abstract：:Cationic polymer PEI-CyD is doped with Nd by plasma technology to produce the gene vector: Nd@PEI-CyD. Luciferase expression and EGFP transfection experiments performed in vitro reveal that Nd@PEI-CyD has significantly higher transfection efficiency than lipofectamine 2000 and PEI-CyD and the mechanism is studied and ...

journal_title：Biomaterials

authors： Wang Q,Jin W,Wu G,Zhao Y,Jin X,Hu X,Zhou J,Tang G,Chu PK

更新日期：2014-01-01 00:00:00

abstract：:Site specific targeting remains elusive for gene and stem cell therapies in the cardiovascular field. One promising option involves use of devices that deliver larger and more sustained cell/gene payloads to specific disease sites using the versatility of percutaneous vascular access technology. Smooth muscle cells (S...

journal_title：Biomaterials

authors： Kumar AH,Martin K,Doyle B,Huang CL,Pillai GK,Ali MT,Skelding KA,Wang S,Gleeson BM,Jahangeer S,Ritman EL,Russell SJ,Caplice NM

更新日期：2014-10-01 00:00:00

abstract：:This study was undertaken to evaluate the influence of storage conditions on the shelf-life of porcine bioprosthetic valves. Fifty-five unimplanted porcine bioprostheses have been evaluated. The valves were stored in 0.5% buffered glutaraldehyde solution for different periods of time (7, 23 and 32 months). Twenty-eigh...

journal_title：Biomaterials

authors： Julien M,Létouneau DR,Marois Y,Cardou A,King MW,Guidoin R,Chachra D,Lee JM

更新日期：1997-04-01 00:00:00

abstract：:This highly absorbent, biodegradable dressing derived from seaweed can be successfully applied to cleanse a wide variety of secreting lesions. The high absorption of exudate is achieved via strong hydrophilic gel formation and this serves to control wound secretion levels and to minimize bacterial contamination. Algin...

journal_title：Biomaterials

authors： Gilchrist T,Martin AM

更新日期：1983-10-01 00:00:00

abstract：:Astroglial cell survival and ion channel activity are relevant molecular targets for the mechanistic study of neural cell interactions with biomaterials and/or electronic interfaces. Astrogliosis is the most typical reaction to in vivo brain implants and needs to be avoided by developing biomaterials that preserve ast...

journal_title：Biomaterials

authors： Benfenati V,Toffanin S,Capelli R,Camassa LM,Ferroni S,Kaplan DL,Omenetto FG,Muccini M,Zamboni R

更新日期：2010-11-01 00:00:00

abstract：:Superparamagnetic magnetite nanoparticles (MNP) coated with silica were synthesized and chronically implanted into the middle ear epithelial tissues of a guinea pig model (n=16) for the generation of force by an external magnetic field. In vivo limitations of biocompatibility include particle morphology, size distribu...

journal_title：Biomaterials

authors： Dormer K,Seeney C,Lewelling K,Lian G,Gibson D,Johnson M

更新日期：2005-05-01 00:00:00

abstract：:This animal experiment compared the regenerative processes within defined bony defects of the porcine skull after delivery of routinely utilized bone graft materials: anorganic bone matrix (ABM) and an identical ABM carrying the cell binding peptide P-15. Particulated autogenous bone was used as a control group. The c...

journal_title：Biomaterials

authors： Thorwarth M,Schultze-Mosgau S,Wehrhan F,Kessler P,Srour S,Wiltfang J,Andreas Schlegel K

更新日期：2005-10-01 00:00:00

abstract：:This study was designed to examine the adhesion, proliferation, and morphology of chondrocytes on new scaffolds; and to examine these cells histologically for the ability of the chondrocytes to maintain chondrogenic properties after subcutaneous implantation into nude mice. Both 75:25 poly (L-lactide-co-epsilon-caprol...

journal_title：Biomaterials

authors： Honda M,Morikawa N,Hata K,Yada T,Morita S,Ueda M,Kimata K

更新日期：2003-09-01 00:00:00

abstract：:Type I collagen constitutes a major portion of the extracellular matrix (ECM) in arterial wall and it is the major substrate for cell growth and differentiation. The goal of this study was to evaluate the differentiation and proliferation of placenta-derived multipotent cells (PDMCs) on polymerized type I collagen fib...

journal_title：Biomaterials

authors： Chou MT,Chang SN,Ke C,Chang HI,Sung ML,Kuo HC,Chen CN

更新日期：2010-05-01 00:00:00

abstract：:Targeting delivery system has been widely used in packaging drugs for medical therapies attributed to its high efficiency and efficacy. A Traditional Chinese Medicine (TCM) formula consisting of Herba Epimedii has previously been shown to effectively treat postmenopausal osteoporosis. We have subsequently found that i...

journal_title：Biomaterials

authors： Huang L,Wang X,Cao H,Li L,Chow DH,Tian L,Wu H,Zhang J,Wang N,Zheng L,Yao X,Yang Z,Qin L

更新日期：2018-11-01 00:00:00

abstract：:After surgery, the bone and soft tissues around integrated biomaterials can be adversely affected by implant-related factors acting over a period of years. However, few studies have directly addressed the effects upon the adjacent soft tissue. The present study was designed to test the biological effects of various si...

journal_title：Biomaterials

authors： Sun JS,Tsuang YH,Chang WH,Li J,Liu HC,Lin FH

更新日期：1997-05-01 00:00:00

abstract：:The in vivo properties of a new kind of calcium phosphate cement were investigated in this study. Calcium phosphate cement was implanted as paste into femoral bone and dorsal muscle of dogs for 3 and 6 months, and as prehardened form into thigh muscles of dogs for 1, 2 and 6 months. Histology was performed on thin un-...

journal_title：Biomaterials

authors： Yuan H,Li Y,de Bruijn JD,de Groot K,Zhang X

更新日期：2000-06-01 00:00:00

abstract：:We analysed tissues harvested during 24 retrievals of hip joint prostheses, with one or both articular components made of alumina. We describe the morphology of wear particles, measure their size and analyse their chemical composition. We relate histopathological aspects to the parameters that characterize ceramic wea...

journal_title：Biomaterials

authors： Pizzoferrato A,Stea S,Sudanese A,Toni A,Nigrisoli M,Gualtieri G,Squarzoni S

更新日期：1993-07-01 00:00:00

abstract：:The use of defined in vitro systems to study the developmental and physiological characteristics of a variety of cell types is increasing, due in large part to their ease of integration with tissue engineering, regenerative medicine, and high-throughput screening applications. In this study, myotubes derived from feta...

journal_title：Biomaterials

authors： Das M,Rumsey JW,Bhargava N,Stancescu M,Hickman JJ

更新日期：2009-10-01 00:00:00

abstract：:Prostate cancer (PCa) is a leading cause of death for men worldwide. Most PCa patients die from metastasis and bone is the most common metastatic site. Three dimensional (3D) porous chitosan-alginate (CA) scaffolds were developed for bone tissue engineering and demonstrated for culture of cancer cells and enrichment o...

journal_title：Biomaterials

authors： Xu K,Ganapathy K,Andl T,Wang Z,Copland JA,Chakrabarti R,Florczyk SJ

更新日期：2019-10-01 00:00:00

abstract：:Understanding and controlling cell proliferation on biomaterial surfaces is critical for scaffold/artificial-niche design in tissue engineering. The mechanism by which underlying integrin ligates with functionalized biomaterials to induce cell proliferation is still not completely understood. In this study, poly-l-lac...

journal_title：Biomaterials

authors： Naganuma T,Traversa E

更新日期：2014-05-01 00:00:00

abstract：:Cochlear implant (CI) is a successful device to restore hearing. Despite continuous development, frequency discrimination is poor in CI users due to an anatomical gap between the auditory neurons and CI electrode causing current spread and unspecific neural stimulation. One strategy to close this anatomical gap is gui...

journal_title：Biomaterials

authors： Li H,Edin F,Hayashi H,Gudjonsson O,Danckwardt-Lillieström N,Engqvist H,Rask-Andersen H,Xia W

更新日期：2017-04-01 00:00:00

abstract：:It is estimated that 4 to 5 million people are currently co-infected with Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV). HIV/HCV co-infection is associated with unique health risks including increased hepatotoxicity of antiretrovirals, accelerated progression of HCV and liver diseases. The standard in...

journal_title：Biomaterials

authors： Zhang J,Mulvenon A,Makarov E,Wagoner J,Knibbe J,Kim JO,Osna N,Bronich TK,Poluektova LY

更新日期：2013-05-01 00:00:00

abstract：:Two types of isoelastic endosseous dental implants were produced and their functionality was tested. One type consisted of a porous sintered TiTa30 alloy, the other had a special surface structure consisting of titanium wire loops. Their mechanical properties were optimized by the production parameter (sintering and d...

journal_title：Biomaterials

authors： Breme J,Biehl V,Schulte W,d'Hoedt B,Donath K

更新日期：1993-10-01 00:00:00

abstract：:In the stem-cell niche, the extracellular matrix (ECM) serves as a structural support that additionally provides stem cells with signals that contribute to the regulation of stem-cell function, via reciprocal interactions between cells and components of the ECM. Recently, cell-derived ECMs have emerged as in vitro cel...

journal_title：Biomaterials

authors： Ragelle H,Naba A,Larson BL,Zhou F,Prijić M,Whittaker CA,Del Rosario A,Langer R,Hynes RO,Anderson DG

更新日期：2017-06-01 00:00:00

abstract：:Although an expanded polytetrafluoroethylene patch is a suitable synthetic material to repair large abdominal wall defects, lack of tissue ingrowth into the patch may give rise to herniation at the fascia-patch interface. This study was undertaken to determine whether perforations and/or ethanol pretreatment improved ...

journal_title：Biomaterials

authors： Simmermacher RK,van der Lei B,Schakenraad JM,Bleichrodt RP

更新日期：1991-01-01 00:00:00

abstract：:Lung fibrosis is a poor prognostic factor for pulmonary adenocarcinoma, and the effect of a rigid microenvironment on cancer behavior is unclear. We cultured A549 cells on matrices of 0.2, 2, and 25 kPa to mimic the rigidities of normal lung parenchyma, progressive fibrotic change, and lung fibrosis, respectively. Lun...

journal_title：Biomaterials

authors： Chang CC,Hsieh TL,Tiong TY,Hsiao CH,Ji AT,Hsu WT,Lee OK,Ho JH

更新日期：2015-08-01 00:00:00

abstract：:Very elastic poly(L-lactide-co-epsilon-caprolactone) (PLCL) (50:50) copolymer blended with gelatin was electrospun into microfibers from a hexafluoroisopropanol solution. PLCL fiber sheet exhibited the unique soft and flexible behavior while gelatin fiber was hard and brittle. As the gelatin content of PLCL/gelatin fi...

journal_title：Biomaterials

authors： Lee J,Tae G,Kim YH,Park IS,Kim SH,Kim SH

更新日期：2008-04-01 00:00:00

abstract：:Intravascular catheter-associated infections (CAIs), which are normally induced by microbial adhesion and subsequent biofilm formation, are a major cause of morbidity and mortality. Therefore, strategies to prevent CAIs are in great demand. In this study, a series of diblock copolymers of PEG and cationic polycarbonat...

journal_title：Biomaterials

authors： Ding X,Yang C,Lim TP,Hsu LY,Engler AC,Hedrick JL,Yang YY

更新日期：2012-10-01 00:00:00

abstract：:A cross-linking method for collagen-based biomaterials was developed using the water-soluble carbodiimide 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC). Cross-linking using EDC involves the activation of carboxylic acid groups to give O-acylisourea groups, which form cross-links after reaction wit...

journal_title：Biomaterials

authors： Olde Damink LH,Dijkstra PJ,van Luyn MJ,van Wachem PB,Nieuwenhuis P,Feijen J

更新日期：1996-04-01 00:00:00

abstract：:Each year, hundreds of thousands coronary bypass procedures are performed in the US, yet there currently exists no off-the-shelf alternative to autologous vessel transplant. In the present study, we investigated the use of mouse thrombospondin-2 knockout (TSP2 KO) cells, which secrete a non-thrombogenic and pro-migrat...

journal_title：Biomaterials

authors： Kristofik NJ,Qin L,Calabro NE,Dimitrievska S,Li G,Tellides G,Niklason LE,Kyriakides TR

更新日期：2017-10-01 00:00:00

abstract：:Angiogenesis is a complex multistage process involving multiple factors and numerous cells. The use of the Chorioallantoic Membrane (CAM) assay is well documented as a method to investigate angiogenesis. This technique is ideal for screening samples, but requires an objective analysis technique. The angiogenic respons...

journal_title：Biomaterials

authors： Oates M,Chen R,Duncan M,Hunt JA

更新日期：2007-09-01 00:00:00

abstract：:Mesenchymal stromal/stem cell (MSC)-based therapy is a promising approach for the treatment of heart failure. However, current MSC-delivery methods result in poor donor cell engraftment, limiting the therapeutic efficacy. To address this issue, we introduce here a novel technique, epicardial placement of bi-layered, a...

journal_title：Biomaterials

authors： Kobayashi K,Ichihara Y,Sato N,Umeda N,Fields L,Fukumitsu M,Tago Y,Ito T,Kainuma S,Podaru M,Lewis-McDougall F,Yamahara K,Uppal R,Suzuki K

更新日期：2019-07-01 00:00:00

abstract：:There are many ways to influence cell activities, and biomaterials with functional groups attached is an attractive method that clearly has the ability to modulate cell behavior. The evidence is clear that biomaterials, with or without growth factors and cells, have resulted in numerous products for the regenerative m...

journal_title：Biomaterials

authors： Ratcliffe A

更新日期：2011-06-01 00:00:00