当前位置： SCI文献检索 > BIOMATERIALS期刊下所有文献 > The effect of cerium valence states at cerium oxide nanoparticle surfaces on cell proliferation.

The effect of cerium valence states at cerium oxide nanoparticle surfaces on cell proliferation.

Abstract：

:Understanding and controlling cell proliferation on biomaterial surfaces is critical for scaffold/artificial-niche design in tissue engineering. The mechanism by which underlying integrin ligates with functionalized biomaterials to induce cell proliferation is still not completely understood. In this study, poly-l-lactide (PL) scaffold surfaces were functionalized using layers of cerium oxide nanoparticles (CNPs), which have recently attracted attention for use in therapeutic application due to their catalytic ability of Ce(4+) and Ce(3+) sites. To isolate the influence of Ce valance states of CNPs on cell proliferation, human mesenchymal stem cells (hMSCs) and osteoblast-like cells (MG63) were cultured on the PL/CNP surfaces with dominant Ce(4+) and Ce(3+) regions. Despite cell type (hMSCs and MG63 cells), different surface features of Ce(4+) and Ce(3+) regions clearly promoted and inhibited cell spreading, migration and adhesion behavior, resulting in rapid and slow cell proliferation, respectively. Cell proliferation results of various modified CNPs with different surface charge and hydrophobicity/hydrophilicity, indicate that Ce valence states closely correlated with the specific cell morphologies and cell-material interactions that trigger cell proliferation. This finding suggests that the cell-material interactions, which influence cell proliferation, may be controlled by introduction of metal elements with different valence states onto the biomaterial surface.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Naganuma T,Traversa E

doi

10.1016/j.biomaterials.2014.01.074

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

4441-53

issue

15

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(14)00118-5

journal_volume

35

pub_type

杂志文章

相关文献

BIOMATERIALS文献大全
  • The role of stiffness of gelatin-hydroxyphenylpropionic acid hydrogels formed by enzyme-mediated crosslinking on the differentiation of human mesenchymal stem cell.

    abstract：:We report the stimulation of neurogenesis and myogenesis of human mesenchymal stem cells (hMSCs) on the surfaces of biodegradable hydrogels with different stiffness. The hydrogels were composed of gelatin-hydroxyphenylpropionic acid (Gtn-HPA) conjugate were formed using the oxidative coupling of phenol moieties cataly...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.07.075

    authors： Wang LS,Boulaire J,Chan PP,Chung JE,Kurisawa M

    更新日期：2010-11-01 00:00:00

  • Integrin beta1 silencing in osteoblasts alters substrate-dependent responses to 1,25-dihydroxy vitamin D3.

    abstract：:Surface microroughness increases osteoblast differentiation and enhances responses of osteoblasts to 1,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3]. The observations that beta1 integrin expression is increased in osteoblasts grown on Ti substrates with rough microarchitecture, and that it is regulated by 1alpha,25(OH)2D3...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2006.02.022

    authors： Wang L,Zhao G,Olivares-Navarrete R,Bell BF,Wieland M,Cochran DL,Schwartz Z,Boyan BD

    更新日期：2006-07-01 00:00:00

  • Implantation of porous acrylic cement in soft tissues: an animal and human biopsy histological study.

    abstract：:Long-term (8 and 24 month) reactions of the (hypo) dermis of the guinea pig to solid and porous (50 vol%) acrylic implants and four human biopsies from porous subcutaneous acrylic implants were studied light microscopically. The solid implants were encapsulated by dense connective tissue. Mobility was evidenced by the...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(90)90105-y

    authors： van Mullem PJ,Vaandrager JM,Nicolai JP,de Wijn JR

    更新日期：1990-07-01 00:00:00

  • Osseointegration of chitosan coated porous titanium alloy implant by reactive oxygen species-mediated activation of the PI3K/AKT pathway under diabetic conditions.

    abstract：:Chitosan coated porous titanium alloy implant (CTI) is demonstrated a promising approach to improve osseointegration capacity of pure porous titanium alloy implant (TI). Since chitosan has been demonstrated to exhibit antioxidant activity, we propose CTI may ameliorate the ROS overproduction, thus reverse the poor oss...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.09.012

    authors： Li X,Ma XY,Feng YF,Ma ZS,Wang J,Ma TC,Qi W,Lei W,Wang L

    更新日期：2015-01-01 00:00:00

  • Nanocarriers with ultrahigh chromophore loading for fluorescence bio-imaging and photodynamic therapy.

    abstract：:We describe the design of original nanocarriers that allows for ultrahigh chromophore loading while maintaining the photo-activity of each individual molecule. They consist in shells of charged biocompatible polymers grafted on gold nanospheres. The self-organization of extended polymer chains results from repulsive c...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.07.032

    authors： Navarro JR,Lerouge F,Cepraga C,Micouin G,Favier A,Chateau D,Charreyre MT,Lanoë PH,Monnereau C,Chaput F,Marotte S,Leverrier Y,Marvel J,Kamada K,Andraud C,Baldeck PL,Parola S

    更新日期：2013-11-01 00:00:00

  • A programmable microenvironment for cellular studies via microfluidics-generated double emulsions.

    abstract：:High throughput cellular studies require small sample volume to reduce costs and enhance sensitivity. Microfluidics-generated water-in-oil (W/O) single emulsion droplet systems, in particular, provide uniform, well defined and discrete microenvironment for cell culture, screening, and sorting. However, these single em...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.03.002

    authors： Zhang Y,Ho YP,Chiu YL,Chan HF,Chlebina B,Schuhmann T,You L,Leong KW

    更新日期：2013-06-01 00:00:00

  • Composite core-and-skirt collagen hydrogels with differential degradation for corneal therapeutic applications.

    abstract：UNLABELLED:Scarcity of donor tissue to treat corneal blindness and the need to deliver stem cells or pharmacologic agents to ensure corneal graft survival are major challenges. Here, new composite collagen-based hydrogels are developed as implants to restore corneal transparency while serving as a possible reservoir fo...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2016.01.004

    authors： Rafat M,Xeroudaki M,Koulikovska M,Sherrell P,Groth F,Fagerholm P,Lagali N

    更新日期：2016-03-01 00:00:00

  • Localized delivery of CRISPR/dCas9 via layer-by-layer self-assembling peptide coating on nanofibers for neural tissue engineering.

    abstract：:The clustered regularly interspaced short palindromic repeat (CRISPR) systems have a wide variety of applications besides precise genome editing. In particular, the CRISPR/dCas9 system can be used to control specific gene expression by CRISPR activation (CRISPRa) or interference (CRISPRi). However, the safety concerns...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2020.120225

    authors： Zhang K,Chooi WH,Liu S,Chin JS,Murray A,Nizetic D,Cheng D,Chew SY

    更新日期：2020-10-01 00:00:00

  • Supramolecular pseudo-block gene carriers based on bioreducible star polycations.

    abstract：:A series of supramolecular pseudo-block polycations (CD-SS-pDM/Ad-pPEGs) were realized by assembling bioreducible β-cyclodextrin-cored star poly (2-dimethyl amino)ethyl methacrylate with different molecular weight and an adamantine-ended linear poly(poly(ethylene glycol)ethyl ether methacrylate) (pPEGEEMA) via the hos...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.03.092

    authors： Hu Y,Yuan W,Zhao NN,Ma J,Yang WT,Xu FJ

    更新日期：2013-07-01 00:00:00

  • Hydroxyapatite-polyethylene composites for bone substitution: effects of ceramic particle size and morphology.

    abstract：:Synthetic hydroxyapatite particles of two median sizes and different morphologies have been used to manufacture hydroxyapatite reinforced high density polyethylene composites (HAPEX) for medical applications. The effects of hydroxyapatite particle size on properties of the resultant composites were investigated using ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(98)00154-9

    authors： Wang M,Joseph R,Bonfield W

    更新日期：1998-12-01 00:00:00

  • Comparison of different tissue-derived stem cell sheets for periodontal regeneration in a canine 1-wall defect model.

    abstract：:Cytotherapeutic approaches have been investigated to overcome the limitations of existing procedures for periodontal regeneration. In this study, cell sheet transplantation was performed using three kinds of mesenchymal tissue (periodontal ligament, alveolar periosteum, and bone marrow)-derived cells to compare the di...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.04.071

    authors： Tsumanuma Y,Iwata T,Washio K,Yoshida T,Yamada A,Takagi R,Ohno T,Lin K,Yamato M,Ishikawa I,Okano T,Izumi Y

    更新日期：2011-09-01 00:00:00

  • Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells.

    abstract：:Given that vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), over-expressed in breast cancer cells and M2-like tumor-associated macrophages (M2-TAMs) within tumor microenvironment (TME), work synergistically and independently in mediating tumor progression and immunosuppression, combinatori...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2018.09.017

    authors： Song Y,Tang C,Yin C

    更新日期：2018-12-01 00:00:00

  • 3D cell entrapment in crosslinked thiolated gelatin-poly(ethylene glycol) diacrylate hydrogels.

    abstract：:The combined use of natural ECM components and synthetic materials offers an attractive alternative to fabricate hydrogel-based tissue engineering scaffolds to study cell-matrix interactions in three-dimensions (3D). A facile method was developed to modify gelatin with cysteine via a bifunctional PEG linker, thus intr...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.09.031

    authors： Fu Y,Xu K,Zheng X,Giacomin AJ,Mix AW,Kao WJ

    更新日期：2012-01-01 00:00:00

  • Stable corneal regeneration four years after implantation of a cell-free recombinant human collagen scaffold.

    abstract：:We developed cell-free implants, comprising carbodiimide crosslinked recombinant human collagen (RHC), to enable corneal regeneration by endogenous cell recruitment, to address the worldwide shortage of donor corneas. Patients were grafted with RHC implants. Over four years, the regenerated neo-corneas were stably int...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.11.079

    authors： Fagerholm P,Lagali NS,Ong JA,Merrett K,Jackson WB,Polarek JW,Suuronen EJ,Liu Y,Brunette I,Griffith M

    更新日期：2014-03-01 00:00:00

  • The in vivo performance of polyvinyl alcohol macro-encapsulated islets.

    abstract：:Islet transplantation is a method for the treatment of type 1 diabetes mellitus (DM) and has been widely performed around the world. The long-term cryopreservation of islets shows many advantages in the field of islet transplantation. Previous studies have described the development of sheet-type polyvinyl alcohol (PVA...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.01.088

    authors： Qi Z,Shen Y,Yanai G,Yang K,Shirouzu Y,Hiura A,Sumi S

    更新日期：2010-05-01 00:00:00

  • Activatable near infrared dye conjugated hyaluronic acid based nanoparticles as a targeted theranostic agent for enhanced fluorescence/CT/photoacoustic imaging guided photothermal therapy.

    abstract：:Targeted theranostic nano-system integrating functions of both diagnosis and therapy shows great potential for improving diagnosis and therapeutic efficacy. Herein, multifunctional nanoparticle based on activatable hyaluronic acid (HA) conjugating two near-infrared (NIR) dyes of Cy5.5 and IR825 was successfully design...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2017.04.006

    authors： Liang X,Fang L,Li X,Zhang X,Wang F

    更新日期：2017-07-01 00:00:00

  • Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing.

    abstract：:The nanotopography and nanoscale geometry of the extra-cellular matrix (ECM) are important regulators of cell adhesion, motility and fate decision. However, unlike the sensing of matrix mechanics and ECM density, the molecular processes regulating the direct sensing of the ECM nanotopography and nanoscale geometry are...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2019.119683

    authors： Di Cio S,Iskratsch T,Connelly JT,Gautrot JE

    更新日期：2020-02-01 00:00:00

  • Physicochemically modified silicon as a substrate for protein microarrays.

    abstract：:Reverse phase protein microarrays (RPMA) enable high throughput screening of posttranslational modifications of important signaling proteins within diseased cells. One limitation of protein-based molecular profiling is the lack of a PCR-like intrinsic amplification system for proteins. Enhancement of protein microarra...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2006.08.051

    authors： Nijdam AJ,Ming-Cheng Cheng M,Geho DH,Fedele R,Herrmann P,Killian K,Espina V,Petricoin EF 3rd,Liotta LA,Ferrari M

    更新日期：2007-01-01 00:00:00

  • An electrochemical glucose biosensor exploiting a polyaniline grafted multiwalled carbon nanotube/perfluorosulfonate ionomer-silica nanocomposite.

    abstract：:A glucose biosensor was fabricated with loading of glucose oxidase (GOx) into a new organic-inorganic hybrid nanocomposite. The preparation involves formation of silica network into a Nafion (perfluorosulfonate ionomer) and subsequent loading of polyaniline grafted multiwalled carbon nanotubes (MWNT-g-PANI) onto Nafio...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.07.047

    authors： Gopalan AI,Lee KP,Ragupathy D,Lee SH,Lee JW

    更新日期：2009-10-01 00:00:00

  • Poly(glycerol-dodecanoate), a biodegradable polyester for medical devices and tissue engineering scaffolds.

    abstract：:In this paper we describe the mechanical and biological features of a thermosetting polyester synthesized from glycerol and dodecanedioic acid named Poly-Glycerol-Dodecanoate (PGD). This polymer shows a glass transition temperature (T(g)) around 32 degrees C, and this accounts for its mechanical properties. At room te...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.08.021

    authors： Migneco F,Huang YC,Birla RK,Hollister SJ

    更新日期：2009-11-01 00:00:00

  • Odontogenic differentiation of human dental pulp stem cells induced by preameloblast-derived factors.

    abstract：:The differentiation of odontoblasts is initiated by the organization of differentiating ameloblasts during tooth formation. However, the exact roles of ameloblast-derived factors in odontoblast differentiation have not yet been characterized. We investigated the effects of preameloblast-conditioned medium (PA-CM) on t...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.09.007

    authors： Lee JH,Lee DS,Choung HW,Shon WJ,Seo BM,Lee EH,Cho JY,Park JC

    更新日期：2011-12-01 00:00:00

  • Optical imaging of intracellular reactive oxygen species for the assessment of the cytotoxicity of nanoparticles.

    abstract：:The generation of intracellular reactive oxygen species (ROS) was optically monitored using ROS-sensitive gold nanoprobes in response to an exposure of nanoparticles (NPs). Fluorescent dye-labeled hyaluronic acid was grafted onto the surface of gold nanoparticles (HF-AuNPs) for imaging intracellular ROS. The ultrasens...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.11.072

    authors： Lee K,Lee H,Lee KW,Park TG

    更新日期：2011-04-01 00:00:00

  • Lactose mediated liver-targeting effect observed by ex vivo imaging technology.

    abstract：:Two kinds of micelles containing Rhodamine B were prepared by a solvent evaporation method. One (Lac-f-micelles: lactose-free micelles) was from a Rhodamine-containing copolymer, poly(ethylene glycol)-b-poly(l-lactide-co-2,2-dihydroxylmethyl-propylene carbonate/Rhodamine) [PEG(5000)-b-P(LA(4000)-co-DHP(600)/Rhodamine)...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.12.019

    authors： Ma P,Liu S,Huang Y,Chen X,Zhang L,Jing X

    更新日期：2010-03-01 00:00:00

  • Electrical conduction in some nucleic acid base complexes with acridine orange dye: study of localized levels.

    abstract：:Semiconduction activation energies of adenine, guanine, thymine and uracil complexes with acridine orange dye at various dye concentrations were measured in both Ohmic and space charge limited (SCL) current regimes. The behaviour of the complexes is non-extrinsic at high dye concentrations but extrinsic at low dye con...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(89)90025-2

    authors： Sarkar D,Misra TN

    更新日期：1989-04-01 00:00:00

  • Lack of OH in nanocrystalline apatite as a function of degree of atomic order: implications for bone and biomaterials.

    abstract：:Using laser Raman microprobe spectroscopy, we have characterized the degree of hydroxylation and the state of atomic order of several natural and synthetic calcium phosphate phases, including apatite of biological (human bone, heated human bone, mouse bone, human and boar dentin, and human and boar enamel), geological...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(03)00487-3

    authors： Pasteris JD,Wopenka B,Freeman JJ,Rogers K,Valsami-Jones E,van der Houwen JA,Silva MJ

    更新日期：2004-01-01 00:00:00

  • Epinecidin-1 antimicrobial activity: In vitro membrane lysis and In vivo efficacy against Helicobacter pylori infection in a mouse model.

    abstract：:Helicobacter pylori (H. pylori) infection is highly prevalent, and has a strong association with various gastric diseases, including gastritis, digestive ulcers, and cancer. H. pylori strains with resistance to existing antibiotics have emerged in the past two decades. Currently, treatment of H. pylori infection (invo...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.05.014

    authors： Narayana JL,Huang HN,Wu CJ,Chen JY

    更新日期：2015-08-01 00:00:00

  • Transplantation of human mesenchymal stem cells loaded on collagen scaffolds for the treatment of traumatic brain injury in rats.

    abstract：:Studies have suggested that mesenchymal stem cells (MSCs) have therapeutic effects following traumatic brain injury (TBI). However, cell distribution and survival rate are two major barriers to their success as therapeutic treatment. The improvement of cell therapy using collagen delivery matrices had been reported. H...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.04.047

    authors： Guan J,Zhu Z,Zhao RC,Xiao Z,Wu C,Han Q,Chen L,Tong W,Zhang J,Han Q,Gao J,Feng M,Bao X,Dai J,Wang R

    更新日期：2013-08-01 00:00:00

  • A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns.

    abstract：:Peritoneal invasion through the mesothelial cell layer is a hallmark of ovarian cancer metastasis. Using tissue engineering technologies, we recreated an ovarian tumor microenvironment replicating this aspect of disease progression. Ovarian cancer cell-laden hydrogels were combined with mesothelial cell-layered melt e...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2018.10.014

    authors： Loessner D,Rockstroh A,Shokoohmand A,Holzapfel BM,Wagner F,Baldwin J,Boxberg M,Schmalfeldt B,Lengyel E,Clements JA,Hutmacher DW

    更新日期：2019-01-01 00:00:00

  • 808 nm-excited upconversion nanoprobes with low heating effect for targeted magnetic resonance imaging and high-efficacy photodynamic therapy in HER2-overexpressed breast cancer.

    abstract：:To avoid the overheating effect of excitation light and improve the efficacy of photodynamic therapy (PDT) of upconversion nanoplatform, a novel nanoprobe based on 808 nm-excited upconversion nanocomposites (T-UCNPs@Ce6@mSiO2) with low heating effect and deep penetration has been successfully constructed for targeted ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2016.06.037

    authors： Zeng L,Pan Y,Zou R,Zhang J,Tian Y,Teng Z,Wang S,Ren W,Xiao X,Zhang J,Zhang L,Li A,Lu G,Wu A

    更新日期：2016-10-01 00:00:00

  • Neoplastic transformation of cells by soluble but not particulate forms of metals used in orthopaedic implants.

    abstract：:Recent developments in cell culture techniques have made it possible to study the cellular mechanisms involved in carcinogenesis and to apply these methods as screening tools in vitro. This study investigated and compared the ability of the metals most commonly used in orthopedic implants to induce toxicity and neopla...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(97)00209-3

    authors： Doran A,Law FC,Allen MJ,Rushton N

    更新日期：1998-04-01 00:00:00