Lactose mediated liver-targeting effect observed by ex vivo imaging technology.

abstract：:A PCL/hydrogel construct that would mimic the structural organization, biochemistry and anatomy of meniscus was engineered. The compressive (380 ± 40 kPa) and tensile modulus (18.2 ± 0.9 MPa) of the PCL scaffolds were increased significantly when constructs were printed with a shifted design and circumferential strand...

journal_title：Biomaterials

authors： Bahcecioglu G,Bilgen B,Hasirci N,Hasirci V

更新日期：2019-10-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) hold great promise as a cell source for regenerative medicine yet its culture, maintenance of pluripotency and induction of differentiation remain challenging. Conversely, graphene (G) and graphene oxide (GO) have captured tremendous interests in the fields of materials science, ...

journal_title：Biomaterials

authors： Chen GY,Pang DW,Hwang SM,Tuan HY,Hu YC

更新日期：2012-01-01 00:00:00

abstract：:Current approaches for topical vaginal administration of nanoparticles result in poor retention and extensive leakage. To overcome these challenges, we developed a nanoparticle-releasing nanofiber delivery platform and evaluated its ability to improve nanoparticle retention in a murine model. We individually tailored ...

journal_title：Biomaterials

authors： Krogstad EA,Ramanathan R,Nhan C,Kraft JC,Blakney AK,Cao S,Ho RJY,Woodrow KA

更新日期：2017-11-01 00:00:00

abstract：:This article reports a novel preparation method of poly(ethylene glycol) (PEG)-polystyrene (PST) amphiphilic block copolymers with well-defined block lengths by using photopolymerization of an iniferter, benzyl N,N-diethyldithiocarbamate. PEG macroiniferters, which were prepared by end-capping of PEG monomethyl ethers...

journal_title：Biomaterials

authors： Nakayama Y,Miyamura M,Hirano Y,Goto K,Matsuda T

更新日期：1999-05-01 00:00:00

abstract：:Tissue engineering in vitro and in vivo involves the interaction of cells with a material surface. The nature of the surface can directly influence cellular response, ultimately affecting the rate and quality of new tissue formation. Initial events at the surface include the orientated adsorption of molecules from the...

journal_title：Biomaterials

authors： Boyan BD,Hummert TW,Dean DD,Schwartz Z

更新日期：1996-01-01 00:00:00

abstract：:Programmed cell death-ligand 1 (PD-L1)-based immune checkpoint blockade therapy using the anti-PD-L1 antibody is effective for a subset of patients with advanced metastatic melanoma but about half of the patients do not respond to the therapy because of the tumor immunosuppressive microenvironment. Immunogenic cell de...

journal_title：Biomaterials

authors： Qiu N,Liu Y,Liu Q,Chen Y,Shen L,Hu M,Zhou X,Shen Y,Gao J,Huang L

更新日期：2020-12-17 00:00:00

abstract：:A synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro-Lys (GRGDSPK), which includes the cell-adhesive region of fibronectin, Arg-Gly-Asp (RGD), was covalently bound to a dialdehyde starch (DAS) coating on a polymer surface by reductive amination. The GRGDSPK/DAS-coated surface was characterized by atomic force microscopy (AFM)...

journal_title：Biomaterials

authors： Holland J,Hersh L,Bryhan M,Onyiriuka E,Ziegler L

更新日期：1996-11-01 00:00:00

abstract：:In normal tissue repair, macrophages exhibit a pro-inflammatory phenotype (M1) at early stages and a pro-healing phenotype (M2) at later stages. We have previously shown that M1 macrophages initiate angiogenesis while M2 macrophages promote vessel maturation. Therefore, we reasoned that scaffolds that promote sequenti...

journal_title：Biomaterials

authors： Spiller KL,Nassiri S,Witherel CE,Anfang RR,Ng J,Nakazawa KR,Yu T,Vunjak-Novakovic G

更新日期：2015-01-01 00:00:00

abstract：:In order to clarify the role of a primer on the adhesion between dental precious metals and resin, surface-enhanced Raman scattering (SERS) technique has been applied to the structural analysis of the adhesive monomer, 6-(N-(4-vinylbenzyl)propylamino)-1,3,5-triazine-2, 4-dithione (VBATDT) adsorbed on colloidal Au surf...

journal_title：Biomaterials

authors： Suzuki M,Fujishima A,Miyazaki T,Hisamitsu H,Kojima K,Kadoma Y

更新日期：1999-05-01 00:00:00

abstract：:The regeneration of large bone defects remains an unsolved clinical problem, which could benefit from recent findings on the biology of skeletal stem and progenitor cells. The elucidation of conditions to specifically control their dynamic and function will likely enable the development of novel treatment strategies. ...

journal_title：Biomaterials

authors： Papageorgiou P,Vallmajo-Martin Q,Kisielow M,Sancho-Puchades A,Kleiner E,Ehrbar M

更新日期：2019-10-01 00:00:00

abstract：:A quantitative comparison between nuclear DNA release from carriers and their transfection activity would be highly useful for improving the effectiveness of non-viral gene vectors. We previously reported that, for condensed DNA particles, a close relationship exists between the efficiency of DNA release and transfect...

journal_title：Biomaterials

authors： Yamada Y,Nomura T,Harashima H,Yamashita A,Yui N

更新日期：2012-05-01 00:00:00

abstract：:Canonical transient receptor potential channel 6 (TRPC6) can play an important role in governing how cells perceive the surrounding material environment and regulate Ca(2+) signaling. We have designed a TRPC6 reporter based on fluorescence resonance energy transfer (FRET) to visualize the TRPC6-mediated calcium entry ...

journal_title：Biomaterials

authors： Lei L,Lu S,Wang Y,Kim T,Mehta D,Wang Y

更新日期：2014-03-01 00:00:00

abstract：:This study was designed to develop a skin permeable recombinant low-molecular-weight protamine (LMWP) conjugated epidermal growth factor (EGF) (rLMWP-EGF) by linking a highly positive charged LMWP to the N-terminal of EGF through genetic recombination. We evaluated its biological activity, skin permeability, and wound...

journal_title：Biomaterials

authors： Choi JK,Jang JH,Jang WH,Kim J,Bae IH,Bae J,Park YH,Kim BJ,Lim KM,Park JW

更新日期：2012-11-01 00:00:00

abstract：:Monocytes/Macrophages have long been recognized as key players in inflammation and wound healing and are often employed in vitro to gain an understanding of the inflammatory response to biomaterials. Previous work has demonstrated a drastic decrease in primary monocyte adherent density on biomaterial surfaces coupled ...

journal_title：Biomaterials

authors： Waldeck H,Wang X,Joyce E,Kao WJ

更新日期：2012-01-01 00:00:00

abstract：:The currently available surgical options to repair the diaphragm are associated with significant risks of defect recurrence, lack of growth potential and restored functionality. A tissue engineered diaphragm has the potential to improve surgical outcomes for patients with congenital or acquired disorders. Here we show...

journal_title：Biomaterials

authors： Gubareva EA,Sjöqvist S,Gilevich IV,Sotnichenko AS,Kuevda EV,Lim ML,Feliu N,Lemon G,Danilenko KA,Nakokhov RZ,Gumenyuk IS,Grigoriev TE,Krasheninnikov SV,Pokhotko AG,Basov AA,Dzhimak SS,Gustafsson Y,Bautista G,Beltrán Ro

更新日期：2016-01-01 00:00:00

abstract：:Hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) were studied by computer graphics with a personal computer. Crystal models of fluoridated hydroxyapatite and fluorapatite, in which F- ions are substituted into some or all OH- positions, were also drawn. Data on the structural coordinates of the hydroxyapatite a...

journal_title：Biomaterials

authors： Okazaki M,Sato M

更新日期：1990-10-01 00:00:00

abstract：:Loosening of the femoral component in a total hip arthroplasty with concomitant bone loss can pose a problem for revision surgery due to inadequate structure in the remaining femur. While impaction allografting has shown promise, it has also shown serious complications, especially with moderate to severe bone loss. It...

journal_title：Biomaterials

authors： Speirs AD,Oxland TR,Masri BA,Poursartip A,Duncan CP

更新日期：2005-12-01 00:00:00

abstract：:Poly(trimethylene carbonate) (PTMC) with molecular weights greater than 100 kg/mol is known to degrade readily in vivo while PTMC of less than 70 kg/mol is resistant to degradation. The reason for the molecular weight dependent degradation rate of PTMC is unclear, and may be due to differences in macrophage behavior o...

journal_title：Biomaterials

authors： Vyner MC,Li A,Amsden BG

更新日期：2014-11-01 00:00:00

abstract：:The design of peptide-based subunit vaccine formulations for the direct delivery of tumor antigen peptides (Aps) to dendritic cells (DCs) localized within draining lymph nodes (DLNs) is challenging. Mature DCs (mDCs) are abundantly distributed within DLNs but have dramatically reduced endocytic uptake and antigen-proc...

journal_title：Biomaterials

authors： Qian Y,Jin H,Qiao S,Dai Y,Huang C,Lu L,Luo Q,Zhang Z

更新日期：2016-08-01 00:00:00

abstract：:Dextran hydrogels were formed in situ by enzymatic crosslinking of dextran-tyramine conjugates and their mechanical, swelling and degradation properties were evaluated. Two types of dextran-tyramine conjugates (M(n,dextran)=14k, M(w)/M(n)=1.45), i.e. dextran-tyramine linked by a urethane bond (denoted as Dex-TA) or by...

journal_title：Biomaterials

authors： Jin R,Hiemstra C,Zhong Z,Feijen J

更新日期：2007-06-01 00:00:00

abstract：:Drug-loaded implants have attracted considerable attention in cancer treatment due to their precise delivery of drugs into cancer tissues. Contrary to injected drug delivery, the application of drug-loaded implants remains underutilized given the requirement for a surgical operation. Nevertheless, drug-loaded implants...

journal_title：Biomaterials

authors： Yang Y,Qiao X,Huang R,Chen H,Shi X,Wang J,Tan W,Tan Z

更新日期：2020-02-01 00:00:00

abstract：:Multilayered coatings composed of mixtures of HA and P2O5-based bioactive glasses are of potential clinical benefit in orthopaedic and dental surgery. Pre-immersion of these materials has been reported to further enhance their efficacy in vivo, although the precise biological effects of this treatment are not yet know...

journal_title：Biomaterials

authors： Ferraz MP,Knowles JC,Olsen I,Monteiro FJ,Santos JD

更新日期：2000-04-01 00:00:00

abstract：:In arterial replacement there is a clear clinical need for a functional substitute possessing appropriate haemocompatible properties to be implanted as small diameter artery. Endothelial cell seeding constitutes an appreciated method to improve blood compatibility on the condition that cells firmly adhere to the suppo...

journal_title：Biomaterials

authors： Rémy M,Durand M,Menu P,Voegel JC,Ponsot JF,Bérard X,Harmand MF,Bordenave L

更新日期：2013-12-01 00:00:00

abstract：:Neuromuscular circuits (NMCs) are vital for voluntary movement, and effective models of NMCs are needed to understand the pathogenesis of, as well as to identify effective treatments for, multiple diseases, including Duchenne's muscular dystrophy and amyotrophic lateral sclerosis. Microfluidics are ideal for recapitul...

journal_title：Biomaterials

authors： Bellmann J,Goswami RY,Girardo S,Rein N,Hosseinzadeh Z,Hicks MR,Busskamp V,Pyle AD,Werner C,Sterneckert J

更新日期：2019-12-01 00:00:00

abstract：:Hybrid drug delivery system containing both organic and inorganic nanocarriers is expected to achieve its complementary advantages for the aim of improving the performance of antineoplastic drugs in tumor therapy. Here we report the use of liposomes and gold nanoparticles to construct a liposome with a hybrid Cluster ...

journal_title：Biomaterials

authors： Zhang N,Chen H,Liu AY,Shen JJ,Shah V,Zhang C,Hong J,Ding Y

更新日期：2016-01-01 00:00:00

abstract：:Measurements were made of the extremes in temperature which occur at different sites in the oral cavity during fluid intake. The results indicate that temperatures noted at the tooth surface, within the mouth, during fluid intake were less than the temperatures of the fluid imbibed. Variations in temperature were note...

journal_title：Biomaterials

authors： Longman CM,Pearson GJ

更新日期：1987-09-01 00:00:00

abstract：:Certain types of implanted medical devices depend on oxygen supplied from surrounding tissues for their function. However, there is a concern that the tissue associated with the foreign body response to implants may become impermeable to oxygen over the long term and render the implant nonfunctional. We report oxygen ...

journal_title：Biomaterials

authors： Kumosa LS,Routh TL,Lin JT,Lucisano JY,Gough DA

更新日期：2014-09-01 00:00:00

abstract：:Non-linear optical microscopy methods can characterize over time multiple functional properties of engineered tissues during development. Here, we demonstrate how the combined use of third-harmonic generation (THG) and two-photon excited fluorescence (2PEF) imaging can provide direct quantitative biomarkers of adipoge...

journal_title：Biomaterials

authors： Chang T,Zimmerley MS,Quinn KP,Lamarre-Jouenne I,Kaplan DL,Beaurepaire E,Georgakoudi I

更新日期：2013-11-01 00:00:00

abstract：:A graft copolymer having poly(L-lysine) (PLL) as the backbone and monomethoxy poly(ethylene glycol) (MPEG) as pendent chains was synthesized. This polycationic copolymer was used to form microcapsules with sodium alginate, a polyanion. Microcapsules and model surfaces formed with PLL-graft-MPEG demonstrated reduced pr...

journal_title：Biomaterials

authors： Sawhney AS,Hubbell JA

更新日期：1992-01-01 00:00:00

abstract：:Small-diameter vascular grafts made of biomedical polytetrafluoroethylene (PTFE) suffer from the poor long-term patency rate originating from thrombosis and intimal hyperplasia, which can be ascribed to the insufficient endothelialization and chronic inflammation of the materials. Hence, bio-functionalization of PTFE ...

journal_title：Biomaterials

authors： Gao A,Hang R,Li W,Zhang W,Li P,Wang G,Bai L,Yu XF,Wang H,Tong L,Chu PK

更新日期：2017-09-01 00:00:00