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Supramolecular pseudo-block gene carriers based on bioreducible star polycations.

Abstract：

:A series of supramolecular pseudo-block polycations (CD-SS-pDM/Ad-pPEGs) were realized by assembling bioreducible β-cyclodextrin-cored star poly (2-dimethyl amino)ethyl methacrylate with different molecular weight and an adamantine-ended linear poly(poly(ethylene glycol)ethyl ether methacrylate) (pPEGEEMA) via the host-guest interaction. The pseudo-block CD-SS-pDM/Ad-pPEG carriers were investigated in terms of DNA binding capability, cytotoxicity, gene transfection in HepG2 and COS7 cell lines, and in vivo anti-tumor activity. The pseudo-block carriers exhibited undiminished pDNA-condensing abilities compared with the starting star carriers. Meanwhile, the pseudo-block carriers displayed lower cytotoxicity and higher gene transfection efficiencies at various N/P ratios. These results are consistent with the favorable properties of pPEGEEMA as expected. Furthermore, cellular internalization results and in vivo anti-tumor activity analysis demonstrated that assembled pPEGEEMA could enhance the stability of pseudo-block carriers, thus improving their cellular internalization and gene transfection efficiency. The present study demonstrated that supramolecular pseudo-block polycations via the host-guest interaction is an effective means to produce new gene carriers.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Hu Y,Yuan W,Zhao NN,Ma J,Yang WT,Xu FJ

doi

10.1016/j.biomaterials.2013.03.092

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

5411-22

issue

21

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(13)00426-2

journal_volume

34

pub_type

杂志文章

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