Inactivation of encapsulated cells and their therapeutic effects by means of TGL triple-fusion reporter/biosafety gene.

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic/stromal reaction, which contributes to the poor clinical outcome of this disease. Therefore, greater understanding of the stroma development and tumor-stroma interactions is highly required. Pancreatic stellate cells (PSC) are myofibr...

journal_title：Biomaterials

authors： Ware MJ,Keshishian V,Law JJ,Ho JC,Favela CA,Rees P,Smith B,Mohammad S,Hwang RF,Rajapakshe K,Coarfa C,Huang S,Edwards DP,Corr SJ,Godin B,Curley SA

更新日期：2016-11-01 00:00:00

abstract：:In the present study, the effects of a calcium magnesium silicate bioactive ceramic (akermanite) on proliferation and osteoblastic differentiation of human bone marrow stromal cells (hBMSC) have been investigated and compared with the classical ceramic (beta-tricalcium phosphate, beta-TCP). Akermanite and beta-TCP dis...

journal_title：Biomaterials

authors： Sun H,Wu C,Dai K,Chang J,Tang T

更新日期：2006-11-01 00:00:00

abstract：:Interest in the identification and isolation of circulating tumor cells (CTCs) has been growing since the introduction of CTCs as an alternative to the tumor tissue biopsy, which can potentially be important indices for prognosis and cancer treatment. However, the contamination of non-specific binding of normal hemato...

journal_title：Biomaterials

authors： Wu JC,Tseng PY,Tsai WS,Liao MY,Lu SH,Frank CW,Chen JS,Wu HC,Chang YC

更新日期：2013-07-01 00:00:00

abstract：:Understanding and controlling cell proliferation on biomaterial surfaces is critical for scaffold/artificial-niche design in tissue engineering. The mechanism by which underlying integrin ligates with functionalized biomaterials to induce cell proliferation is still not completely understood. In this study, poly-l-lac...

journal_title：Biomaterials

authors： Naganuma T,Traversa E

更新日期：2014-05-01 00:00:00

abstract：:The ageing behaviour of ultra-high molecular weight polyethylene (UHMWPE) has been studied following gamma irradiation (25 or 40 kGy) in air. Accelerated ageing procedures used elevated temperature (70 degrees C) and/or pressurised oxygen (5bar). Shelf-aged UHMWPE was also studied. The variation in surface density and...

journal_title：Biomaterials

authors： Buchanan FJ,Shipway PH

更新日期：2002-01-01 00:00:00

abstract：:To evaluate whether cytokeratin expression in human oral epithelial cells could be influenced by implant materials used in dental surgery, passaged human oral gingival epithelial cells were seeded on commercially pure titanium (CP-Ti) or on Ti6Al4V titanium alloy. Confluence was achieved after about 15 days on both su...

journal_title：Biomaterials

authors： Lagneau C,Farges JC,Exbrayat P,Lissac M

更新日期：1998-06-01 00:00:00

abstract：:The in vivo cellular microenvironment is regulated by a complex interplay of soluble factors and signaling molecules secreted by cells and it plays a critical role in the growth and development of normal and diseased tissues. In vitro systems that can recapitulate the microenvironment at the cellular level are needed ...

journal_title：Biomaterials

authors： Chandrasekaran S,Giang UB,King MR,DeLouise LA

更新日期：2011-10-01 00:00:00

abstract：:The hydrophilic nature of hydrogel matrices makes them disadvantageous to entrap poorly soluble therapeutic agents and greatly restricts their applications as drug-delivery systems. In this study, we demonstrated that sustained delivery of lipophilic drugs in hydrogel-based devices can be readily achieved by enhancing...

journal_title：Biomaterials

authors： Chen MC,Tsai HW,Liu CT,Peng SF,Lai WY,Chen SJ,Chang Y,Sung HW

更新日期：2009-04-01 00:00:00

abstract：:Control of the precise location and extent of cellular attachment and proliferation, and of tissue outgrowth is important in a number of biomedical applications, including biomaterials and tissue engineered medical devices. Here we describe a method to control and direct the location and define boundaries of tissue gr...

journal_title：Biomaterials

authors： Thissen H,Johnson G,Hartley PG,Kingshott P,Griesser HJ

更新日期：2006-01-01 00:00:00

abstract：:Brushite (dicalcium phosphate dihydrate, DCPD, CaHPO4 x 2H2O) was deposited electrolytically from calcium dihydrogen phosphate solution with and without potassium chloride (KCl) as a supporting electrolyte. The kinetics of brushite transformation to hydroxyapatite (HA, Ca5(PO4)3OH) in the presence of calcium and prote...

journal_title：Biomaterials

authors： Kumar M,Xie J,Chittur K,Riley C

更新日期：1999-08-01 00:00:00

abstract：:Calcium phosphate ceramics used for clinical applications vary considerably in their phase composition. A range of hydroxyapatite and tricalcium phosphate powders, some of which are used in plasma-sprayed coatings for metal prostheses, were found to leach substances which change the pH of water and cell culture medium...

journal_title：Biomaterials

authors： Sharpe JR,Sammons RL,Marquis PM

更新日期：1997-03-01 00:00:00

abstract：:This work reports the development of new non-thrombogenic polymers based on the linear polymers of polyamidoamines (PAAs), having heparin binding ability, obtained by polyaddition of secondary amines to N,N'-methylene bis-acrylamide. PAAs could not be used directly in the making of blood-contacting materials due to th...

journal_title：Biomaterials

authors： Dey RK,Ray AR

更新日期：2003-08-01 00:00:00

abstract：:We report the fabrication of a one-pot antigen system that delivers antigen to dendritic cells (DCs) and tracks their in vivo migration after injection. Multifunctional polymer nanoparticles containing ovalbumin protein, magnetic resonance imaging contrast agents (iron oxide nanoparticles), and near-infrared fluoropho...

journal_title：Biomaterials

authors： Noh YW,Jang YS,Ahn KJ,Lim YT,Chung BH

更新日期：2011-09-01 00:00:00

abstract：:A tissue-engineered substitute that facilitates large-volume regeneration of the subcutaneous adipose tissue layer is needed for reconstructive plastic surgery. Towards this goal, we describe the in vitro culture of primary human adipose-derived stem cells (ASC) seeded into placental decellular matrix (PDM) and cross-...

journal_title：Biomaterials

authors： Flynn LE,Prestwich GD,Semple JL,Woodhouse KA

更新日期：2008-04-01 00:00:00

abstract：:A nanohybrid vesicle was developed from cholesteryl succinyl silane(CSS) in combination of sol-gel process and self-assembly technique. The silicalike surface adds CSS vesicles remarkably high stability against destabilization in blood or leakage of drug cargos. It was found that CSS vesicles alone exhibited selective...

journal_title：Biomaterials

authors： Ma Y,Dai Z,Zha Z,Gao Y,Yue X

更新日期：2011-12-01 00:00:00

abstract：:A novel asymmetric chitosan membrane has been prepared by immersion-precipitation phase-inversion method and evaluated as wound covering. This new type of chitosan wound dressing which consists of skin surface on top-layer supported by a macroporous sponge-like sublayer was designed. The thickness of the dense skin su...

journal_title：Biomaterials

authors： Mi FL,Shyu SS,Wu YB,Lee ST,Shyong JY,Huang RN

更新日期：2001-01-01 00:00:00

abstract：:Cancer therapeutics are developed through extensive screening; however, many therapeutics evaluated with 2D in vitro cultures during pre-clinical trials suffer from lower efficacy in patients. Replicating the in vivo tumor microenvironment in vitro with three-dimensional (3D) porous scaffolds offers the possibility of...

journal_title：Biomaterials

authors： Florczyk SJ,Wang K,Jana S,Wood DL,Sytsma SK,Sham J,Kievit FM,Zhang M

更新日期：2013-12-01 00:00:00

abstract：:Although folate exhibits many advantages over other targeting ligands, it has one major defect: poor water solubility. Once it was conjugated to hydrophilic drug carrier such as N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer, the hydrophobic folate may be buried inside the random polymer coil and not exposed to b...

journal_title：Biomaterials

authors： Li L,Yang Q,Zhou Z,Zhong J,Huang Y

更新日期：2014-06-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biomaterials

authors： Kyle S,McPherson MJ,Aggeli A,Ingham E

更新日期：2011-07-01 00:00:00

abstract：:A type III glass-ionomer cement (Vidrion F), currently used as fast-setting lining material and fissure sealant, was implanted into rat dental alveolus immediately after tooth extraction and its biocompatibility was analysed in terms of incorporation into alveolar bone in the wound healing process. Histological and hi...

journal_title：Biomaterials

authors： Brentegani LG,Bombonato KF,Carvalho TL

更新日期：1997-01-01 00:00:00

abstract：:Osteoarthritis (OA) is a major cause of disability and socioeconomic loss worldwide. However, the current pharmacological approaches used to treat OA are largely palliative. Being the hallmark of OA, the cartilage extracellular matrix (ECM) destruction and abnormal homeostasis is gaining more attention as a therapeuti...

journal_title：Biomaterials

authors： Peng Z,Sun H,Bunpetch V,Koh Y,Wen Y,Wu D,Ouyang H

更新日期：2021-01-01 00:00:00

abstract：:In situ gelating dextran-tyramine (Dex-TA) injectable hydrogels have previously shown promising features for cartilage repair. Yet, despite suitable mechanical properties, this system lacks intrinsic biological signals. In contrast, platelet lysate-derived hydrogels are rich in growth factors and anti-inflammatory cyt...

journal_title：Biomaterials

authors： Moreira Teixeira LS,Leijten JC,Wennink JW,Chatterjea AG,Feijen J,van Blitterswijk CA,Dijkstra PJ,Karperien M

更新日期：2012-05-01 00:00:00

abstract：:The blood-brain barrier (BBB) prevents entry of neurotoxic substances but also that of drugs into the brain. Here, the paracellular barrier is formed by tight junctions (TJs) with claudin-5 (Cldn5) being the main sealing constituent. Transient BBB opening by targeting Cldn5 could improve paracellular drug delivery. Th...

journal_title：Biomaterials

authors： Neuhaus W,Piontek A,Protze J,Eichner M,Mahringer A,Subileau EA,Lee IM,Schulzke JD,Krause G,Piontek J

更新日期：2018-04-01 00:00:00

abstract：:Using laser Raman microprobe spectroscopy, we have characterized the degree of hydroxylation and the state of atomic order of several natural and synthetic calcium phosphate phases, including apatite of biological (human bone, heated human bone, mouse bone, human and boar dentin, and human and boar enamel), geological...

journal_title：Biomaterials

authors： Pasteris JD,Wopenka B,Freeman JJ,Rogers K,Valsami-Jones E,van der Houwen JA,Silva MJ

更新日期：2004-01-01 00:00:00

abstract：:The water absorption characteristics of resins, upon which many composite filling materials are based, have been studied. In general, the equilibrium uptake is less than that predicted from the water absorption of composite filling materials, if it is assumed that the polymer alone absorbs the water. Also, whereas the...

journal_title：Biomaterials

authors： Braden M,Davy KW

更新日期：1986-11-01 00:00:00

abstract：:A surface with covalently bonded heparin was tested in an in vivo model. Heparinized and non-heparinized tubings were inserted in the pig aorta. They were left in place for up to 16 wk. After removal they were analysed for their capacity to take up and inhibit thrombin. A comparison was also made with tubings that had...

journal_title：Biomaterials

authors： Arnander C,Bagger-Sjöbäck D,Frebelius S,Larsson R,Swedenborg J

更新日期：1987-11-01 00:00:00

abstract：:Acellular porcine cornea stroma (APCS) prepared using pancreatic phospholipase A(2) was proven to be promising corneal scaffold. However, its dense ultrastructure provides insufficient space that prevents the seeded cells from organizing into a functional tissue. In this report, freezing dry APCS (FD-APCS) biomaterial...

journal_title：Biomaterials

authors： Xiao J,Duan H,Liu Z,Wu Z,Lan Y,Zhang W,Li C,Chen F,Zhou Q,Wang X,Huang J,Wang Z

更新日期：2011-10-01 00:00:00

abstract：:For chronic non-viral gene therapy, biodegradable carriers with low cytotoxicity are essential. To create a series of non-toxic and biodegradable gene carriers, hyperbranched polymers based on 2,2-bis-(methylol)propionic acid (bis-MPA); (Boltorn H) were modified by introducing tertiary amines. The terminal OH groups w...

journal_title：Biomaterials

authors： Reul R,Nguyen J,Kissel T

更新日期：2009-10-01 00:00:00

abstract：:Most part of pH- and temperature-sensitive microspheres used for the controlled delivery of drugs are not biodegradable. Therefore, the aim of this work is to prepare pH- and temperature-sensitive microspheres from biodegradable and biocompatible natural polymers. Pullulan microspheres were prepared by suspension cros...

journal_title：Biomaterials

authors： Fundueanu G,Constantin M,Ascenzi P

更新日期：2008-06-01 00:00:00

abstract：:Nanotherapeutics have been investigated for years, but only modest survival benefits were observed clinic. This is partially attributed to the short and rapid elimination of nanodrug after intravenous administration. In this study, a long circulation single wall carbon nanotube (SWCNT) complex was successfully fabrica...

journal_title：Biomaterials

authors： Xie L,Wang G,Zhou H,Zhang F,Guo Z,Liu C,Zhang X,Zhu L

更新日期：2016-10-01 00:00:00