Convergence of physical and chemical signaling in the modulation of vascular smooth muscle cell cycle and proliferation by fibrillar collagen-regulated P66Shc.

abstract：:A liposomal system with surface lactoferrin (Lf) was developed for delivering neuron growth factor (NGF) across the blood-brain barrier (BBB) and improving the viability of neuron-like SK-N-MC cells with deposited β-amyloid peptide (Aβ). The Lf-grafted liposomes carrying NGF (Lf/NGF-liposomes) were applied to a monola...

journal_title：Biomaterials

authors： Kuo YC,Wang CT

更新日期：2014-07-01 00:00:00

abstract：:Superparamagnetic magnetite nanoparticles (MNP) coated with silica were synthesized and chronically implanted into the middle ear epithelial tissues of a guinea pig model (n=16) for the generation of force by an external magnetic field. In vivo limitations of biocompatibility include particle morphology, size distribu...

journal_title：Biomaterials

authors： Dormer K,Seeney C,Lewelling K,Lian G,Gibson D,Johnson M

更新日期：2005-05-01 00:00:00

abstract：:Acute kidney injury (AKI) is associated with high mortality and morbidity with no effective treatment available at present, which greatly escalates the risk of chronic kidney disease. Nanotechnology-based drug delivery for targeting renal tubules offers a new strategy for AKI treatment but remains challenging due to t...

journal_title：Biomaterials

authors： Yu H,Lin T,Chen W,Cao W,Zhang C,Wang T,Ding M,Zhao S,Wei H,Guo H,Zhao X

更新日期：2019-10-01 00:00:00

abstract：:Biodegradable polylactide implants allow secure fixation of osteochondral fractures with minimal adverse effects. The goal of this prospective, randomized animal study was to show whether osteoconductive effects can be achieved through the development of poly-L/DL(70/30)lactide composite implants with 10% beta-tricalc...

journal_title：Biomaterials

authors： Prokop A,Jubel A,Hahn U,Dietershagen M,Bleidistel M,Peters C,Höfl A,Rehm KE

更新日期：2005-07-01 00:00:00

abstract：:Esterified hyaluronic acid (HYAFF) is routinely used for clinical tissue engineering applications such as skin and cartilage. In a previous study we developed a technique for in vitro generation of cylindrical constructs from cellularized HYAFF flat sheets. In the present investigation we studied the possibility to im...

journal_title：Biomaterials

authors： Arrigoni C,Camozzi D,Imberti B,Mantero S,Remuzzi A

更新日期：2006-02-01 00:00:00

abstract：:We design a class of imprinted hybrid microgels that can optically monitor glucose levels with high sensitivity and selectivity in complex media at physiological pH, acting like a "glucose-indicator". Such imprinted hybrid microgels were made of Ag nanoparticles (NPs) in situ immobilized in molecularly imprinted gluco...

journal_title：Biomaterials

authors： Wu W,Shen J,Li Y,Zhu H,Banerjee P,Zhou S

更新日期：2012-10-01 00:00:00

abstract：:Particle-associated periprosthetic osteolysis remains a major issue in joint replacement. Ongoing bone loss resulting from wear particle-induced inflammation is accompanied by continued attempts at bone repair. Previously we showed that mesenchymal stem cells (MSCs) are recruited systemically to bone exposed to contin...

journal_title：Biomaterials

authors： Gibon E,Yao Z,Rao AJ,Zwingenberger S,Batke B,Valladares R,Smith RL,Biswal S,Gambhir SS,Goodman SB

更新日期：2012-05-01 00:00:00

abstract：:H2O2-specific peroxalate chemiluminescence is recognized as a potential signal for sensitive in vivo imaging of inflammation but the effect of underlying peroxalate-emitter energetics on its efficiency has rarely been understood. Here we report a simple nanophotonic way of boosting near-infrared chemiluminescence with...

journal_title：Biomaterials

authors： Seo YH,Singh A,Cho HJ,Kim Y,Heo J,Lim CK,Park SY,Jang WD,Kim S

更新日期：2016-04-01 00:00:00

abstract：:Plaque-induced lesions can produce peri-implant bone loss with ultimate implant loss. Although the peri-implant tissues seem to be more resistant than the periodontal ones to plaque and calculus, they can produce a more extensive spread of the infection to the deeper tissues around implants. The case of a 45-year-old ...

journal_title：Biomaterials

authors： Piattelli A,Cosci F,Scarano A,Trisi P

更新日期：1995-08-01 00:00:00

abstract：:Rational design and develop of targeted contrast agents binding to cancer-related proteins will achieve more accurate cancer diagnosis and prognosis by magnetic resonance (MR) imaging. CREKA is a tumor-homing pentapeptide (Cys-Arg-Glu-Lys-Ala) specifically homes to fibrin-fibronectin complexes abundantly expressed in ...

journal_title：Biomaterials

authors： Zhou Z,Wu X,Kresak A,Griswold M,Lu ZR

更新日期：2013-10-01 00:00:00

abstract：:A bilayer artificial skin composed of a silicone sheet and a collagen sponge sheet was developed by us in 1986, modifying Yannas and Burke's technique. It was used in experimental animals and clinically, both with success; but the artificial skin was inconvenient for clinical use in terms of disinfection and preservat...

journal_title：Biomaterials

authors： Matsuda K,Suzuki S,Isshiki N,Ikada Y

更新日期：1993-10-01 00:00:00

abstract：:The micro-environment is an important factor in the differentiation of cultured stem cells for the purpose of site specific transplantation. In an attempt to optimize differentiation conditions, co-culture systems composed of both stem cells and primary cells or cell lines were used in hydrogel with in vitro and in vi...

journal_title：Biomaterials

authors： Park JS,Yang HN,Woo DG,Kim H,Na K,Park KH

更新日期：2010-10-01 00:00:00

abstract：:Pharmacotherapy of head and neck squamous cell carcinoma (HNSCC) often fails due to the development of chemoresistance and severe systemic side effects of current regimens limiting dose escalation. Preclinical models comprising all major elements of treatment resistance are urgently needed for the development of new s...

journal_title：Biomaterials

authors： Gronbach L,Wolff C,Klinghammer K,Stellmacher J,Jurmeister P,Alexiev U,Schäfer-Korting M,Tinhofer I,Keilholz U,Zoschke C

更新日期：2020-11-01 00:00:00

abstract：:Four commercial hydroxyapatites (both natural and synthetic) were tested to assess transformations of the chemical and crystalline structure following variation of temperature from 20 to 1600 degrees C. The thermal behaviour of hydroxyapatite is relevant for biomedical applications such as plasma spraying of metallic ...

journal_title：Biomaterials

authors： Locardi B,Pazzaglia UE,Gabbi C,Profilo B

更新日期：1993-05-01 00:00:00

abstract：:Morphological changes of human polymorphonuclear neutrophils (PMN) adhering to hydrophilic (glass) and hydrophobic (FEP-Teflon, polyethylene, polypropylene) surfaces were studied in a parallel-plate flow chamber at the light and scanning electron microscopical levels. The PMN were exposed to a shear stress of 0.19 Pa ...

journal_title：Biomaterials

authors： Tomczok J,Sliwa-Tomczok W,Klein CL,van Kooten TG,Kirkpatrick CJ

更新日期：1996-07-01 00:00:00

abstract：:The discovery of electric fields in biological tissues has led to efforts in developing technologies utilizing electrical stimulation for therapeutic applications. Native tissues, such as cartilage and bone, exhibit piezoelectric behavior, wherein electrical activity can be generated due to mechanical deformation. Yet...

journal_title：Biomaterials

authors： Damaraju SM,Shen Y,Elele E,Khusid B,Eshghinejad A,Li J,Jaffe M,Arinzeh TL

更新日期：2017-12-01 00:00:00

abstract：:Certain types of implanted medical devices depend on oxygen supplied from surrounding tissues for their function. However, there is a concern that the tissue associated with the foreign body response to implants may become impermeable to oxygen over the long term and render the implant nonfunctional. We report oxygen ...

journal_title：Biomaterials

authors： Kumosa LS,Routh TL,Lin JT,Lucisano JY,Gough DA

更新日期：2014-09-01 00:00:00

abstract：:It is widely accepted that implant surface factors affect the quality of the bone-to-implant interface. Recent additional treatments superimposed on moderately rough cpTitanium surface provide further enhancement of bone-to-implant contact. The aim of this study was to compare osteoinductive and bone-specific gene exp...

journal_title：Biomaterials

authors： Guo J,Padilla RJ,Ambrose W,De Kok IJ,Cooper LF

更新日期：2007-12-01 00:00:00

abstract：:A new family of poly(anhydrides) (PA) has been developed which can be cured photochemically to produce degradable networks. These degradable anhydride networks may be useful in orthopaedics as bone cements and as matrices for drug delivery. This system, which is a semi-interpenetrating network (semi-IPN), has been eva...

journal_title：Biomaterials

authors： Shastri VP,Padera RF,Tarcha P,Langer R

更新日期：2004-02-01 00:00:00

abstract：:Implant surface topography influences osteoblastic proliferation, differentiation and extracellular matrix protein expressions. Studies on preliminary interactions of osteoblast-like cells on implant interface through in vitro systems, can give lucid insights to osseo-integrative efficacies of when in vivo implants. I...

journal_title：Biomaterials

authors： Jayaraman M,Meyer U,Bühner M,Joos U,Wiesmann HP

更新日期：2004-02-01 00:00:00

abstract：:Resurfacing of cartilage defects using cell-seeded, biomaterial grafts is a promising approach for articular cartilage repair and in this study we investigated the ability of human chondrocytes from osteoarthritic joints to generate cartilage tissue under standard conditions in cultured over 21 days on Hyalograft matr...

journal_title：Biomaterials

authors： Katopodi T,Tew SR,Clegg PD,Hardingham TE

更新日期：2009-02-01 00:00:00

abstract：:Covalent immobilization of cell-adhesive proteins such as collagen and fibronectin on to the surface of poly(vinyl alcohol) hydrogel was investigated by using diisocyanates, polyisocyanates, and cyanogen bromide. It was found that 0.5 and 12 micrograms/cm2 of collagen were immobilized on to the surface by using hexame...

journal_title：Biomaterials

authors： Kobayashi H,Ikada Y

更新日期：1991-10-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) play an important role in regulating osteoblastic differentiation and bone formation. But the diffuse of BMPs into muscle tissues around bone injury sites often leads to heterotopic ossification, which has been regarded as one of major side-effects of BMP implementation in bone defec...

journal_title：Biomaterials

authors： Zhang J,Zhao Y,Hou X,Chen B,Xiao Z,Han J,Shi C,Liu J,Miao Q,Dai J

更新日期：2014-11-01 00:00:00

abstract：:Films made of poly (3-hydroxybutyrate) (PHB), poly(3-hydroxybutyrate- co-3-hydroxyhexanoate) (PHBHHx) consisting of 5%, 12% and 20% hydroxyhexanoate (HHx), respectively, were evaluated for biomedical application in comparison with poly (L-Lactide) (PLA). With the increase of HHx content in PHBHHx, the polymer surface ...

journal_title：Biomaterials

authors： Wang YW,Yang F,Wu Q,Cheng YC,Yu PH,Chen J,Chen GQ

更新日期：2005-03-01 00:00:00

abstract：:Glioma is still hard to be treated due to their complex microenvironment. In this study, a gold nanoparticle-based delivery system was developed. The system, An-PEG-DOX-AuNPs, was loaded with doxorubicin (DOX) through hydrazone, an acid-responsive linker, and was functionalized with angiopep-2, a specific ligand of lo...

journal_title：Biomaterials

authors： Ruan S,Yuan M,Zhang L,Hu G,Chen J,Cun X,Zhang Q,Yang Y,He Q,Gao H

更新日期：2015-01-01 00:00:00

abstract：:Geliperm hydrogel provides optimal physiological conditions for wound healing. The material is composed of two interlaced networks, one of polyacrylamide and one of agar, and contains about 96% firmly bound water. It is supplied in smooth, elastic, transparent sheets which are impermeable to bacteria but permeable to ...

journal_title：Biomaterials

authors： Kickhöfen B,Wokalek H,Scheel D,Ruh H

更新日期：1986-01-01 00:00:00

abstract：:The aim of this study was to evaluate the physical-chemical properties, in vivo biocompatibility and antimicrobial activity of bioactive glasses (BG) used as a controlled release device for tetracycline hydrochloride and an inclusion complex formed by tetracycline and beta-cyclodextrin at 1:1 molar ratio. The BG as we...

journal_title：Biomaterials

authors： Domingues ZR,Cortés ME,Gomes TA,Diniz HF,Freitas CS,Gomes JB,Faria AM,Sinisterra RD

更新日期：2004-01-01 00:00:00

abstract：:Specifically inhibiting the proliferation of activated macrophages and clearing the high levels of reactive oxygen species (ROS) secreted by macrophages is crucial for osteoarthritis (OA) treatment. Moreover, if the clearance of these high levels of ROS can be simultaneously used to induce oxidation-responsive release...

journal_title：Biomaterials

authors： Yang G,Fan M,Zhu J,Ling C,Wu L,Zhang X,Zhang M,Li J,Yao Q,Gu Z,Cai X

更新日期：2020-10-01 00:00:00

abstract：:Premature ovarian failure (POF) is the most frequently occurred disease in ovary. Direct inhibition of mammalian target of rapamycin (mTOR) activity can treat woman POF but brings adverse effects to women. Herein, by rational design of a hydrogelator Nap-Phe-Phe-Asp-Arg-Leu-Tyr-OH (Y) and co-assembling Y with an inhib...

journal_title：Biomaterials

authors： Shi Z,Li X,Wei M,Chen P,Zhang T,Ling X,Zhang J,Zhao C,Wang F,Liang G

更新日期：2020-11-16 00:00:00

abstract：:Autophagy has attracted a great deal of research interest in tumor therapy in recent years. An attempt was made in this direction and now we report that iron oxide NPs synthesized by us selectively induce autophagy in cancer cells (A549) and not in normal cells (IMR-90). It was also noteworthy that autophagy correlate...

journal_title：Biomaterials

authors： Khan MI,Mohammad A,Patil G,Naqvi SA,Chauhan LK,Ahmad I

更新日期：2012-02-01 00:00:00