Covalent immobilization of proteins on to the surface of poly(vinyl alcohol) hydrogel.

Abstract:

:Covalent immobilization of cell-adhesive proteins such as collagen and fibronectin on to the surface of poly(vinyl alcohol) hydrogel was investigated by using diisocyanates, polyisocyanates, and cyanogen bromide. It was found that 0.5 and 12 micrograms/cm2 of collagen were immobilized on to the surface by using hexamethylene diisocyanate and cyanogen bromide, respectively. The big difference in the graft amount between the two methods was ascribed to the different reaction media employed for the surface modifications; toluene for the reaction with hexamethylene diisocyanate and water for the reaction with cyanogen bromide.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Kobayashi H,Ikada Y

doi

10.1016/0142-9612(91)90024-5

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

747-51

issue

8

eissn

0142-9612

issn

1878-5905

pii

0142-9612(91)90024-5

journal_volume

12

pub_type

杂志文章
  • Biological surface engineering: a simple system for cell pattern formation.

    abstract::Biological surface engineering using synthetic biological materials has a great potential for advances in our understanding of complex biological phenomena. We developed a simple system to engineer biologically relevant surfaces using a combination of self-assembling oligopeptide monolayers and microcontact printing (...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(99)00014-9

    authors: Zhang S,Yan L,Altman M,Lässle M,Nugent H,Frankel F,Lauffenburger DA,Whitesides GM,Rich A

    更新日期:1999-07-01 00:00:00

  • Riboflavin carrier protein-targeted fluorescent USPIO for the assessment of vascular metabolism in tumors.

    abstract::Riboflavin (Rf) and its metabolic analogs flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are essential for normal cellular growth and function. Their intracellular transport is regulated by the riboflavin carrier protein (RCP), which has been shown to be over-expressed by metabolically active cancer...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2012.08.036

    authors: Jayapaul J,Arns S,Lederle W,Lammers T,Comba P,Gätjens J,Kiessling F

    更新日期:2012-12-01 00:00:00

  • Acidity-triggered charge-convertible nanoparticles that can cause bacterium-specific aggregation in situ to enhance photothermal ablation of focal infection.

    abstract::Focal infections that are caused by antibiotic-resistant bacteria are becoming an ever-growing challenge to human health. To address this challenge, a pH-responsive amphiphilic polymer of polyaniline-conjugated glycol chitosan (PANI-GCS) that can self-assemble into nanoparticles (NPs) in situ is developed. The PANI-GC...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2016.11.045

    authors: Korupalli C,Huang CC,Lin WC,Pan WY,Lin PY,Wan WL,Li MJ,Chang Y,Sung HW

    更新日期:2017-02-01 00:00:00

  • The inhibition of postinfarct ventricle remodeling without polycythaemia following local sustained intramyocardial delivery of erythropoietin within a supramolecular hydrogel.

    abstract::Erythropoietin (EPO) can protect myocardium from ischemic injury, but it also plays an important role in promoting polycythaemia, the potential for thrombo-embolic complications. Local sustained delivery of bioactive agents directly to impaired tissues using biomaterials is an approach to limit systemic toxicity and i...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2009.04.033

    authors: Wang T,Jiang XJ,Lin T,Ren S,Li XY,Zhang XZ,Tang QZ

    更新日期:2009-09-01 00:00:00

  • Reprogramming induced pluripotent stem cells in the absence of c-Myc for differentiation into hepatocyte-like cells.

    abstract::Induced pluripotent stem cells (iPSCs) with four reprogramming factors (Oct-4/Sox2/Klf-4/c-Myc) have been shown to differentiate into hepatic lineages. However, it was unclear whether obviation of the c-Myc oncogene in iPSCs affected hepatic differentiation or inhibited in vivo tumor formation. In this study, we demon...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2011.05.009

    authors: Li HY,Chien Y,Chen YJ,Chen SF,Chang YL,Chiang CH,Jeng SY,Chang CM,Wang ML,Chen LK,Hung SI,Huo TI,Lee SD,Chiou SH

    更新日期:2011-09-01 00:00:00

  • Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery.

    abstract::The release of the anti-inflammatory agent dexamethasone (DEX) from nanoparticles of poly(lactic-co-glycolic acid) (PLGA) embedded in alginate hydrogel (HG) matrices was investigated. DEX-loaded PLGA nanoparticles were prepared using a solvent evaporation technique and were characterized for size, drug loading, and in...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2005.12.021

    authors: Kim DH,Martin DC

    更新日期:2006-05-01 00:00:00

  • Problems of encapsulation of total joint replacements.

    abstract::Particulate wear debris of artificial joints, metallic and plastic, and solutions of metals in body fluids are known to have adverse effects. Encapsulation of the articulating parts would prevent wear debris from entering the surrounding tissue and check tissue ingrowth into the joint. The capsule could contain an art...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(80)90056-3

    authors: Derbyshire B,Skorecki J,Wheble VH

    更新日期:1980-01-01 00:00:00

  • Effect of composition of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) on growth of fibroblast and osteoblast.

    abstract::Films made of poly (3-hydroxybutyrate) (PHB), poly(3-hydroxybutyrate- co-3-hydroxyhexanoate) (PHBHHx) consisting of 5%, 12% and 20% hydroxyhexanoate (HHx), respectively, were evaluated for biomedical application in comparison with poly (L-Lactide) (PLA). With the increase of HHx content in PHBHHx, the polymer surface ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2004.03.023

    authors: Wang YW,Yang F,Wu Q,Cheng YC,Yu PH,Chen J,Chen GQ

    更新日期:2005-03-01 00:00:00

  • Retinal pigment epithelium cell culture on surface modified poly(hydroxybutyrate-co-hydroxyvalerate) thin films.

    abstract::There is currently no effective treatment for the retinal disorders caused by retinal pigment epithelium (RPE) degeneration. Transplantation of allografts is the main strategy towards correction of this malady. Tissue engineering could offer hope and involve the use of biodegradable polymeric templates to replace dise...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(03)00302-8

    authors: Tezcaner A,Bugra K,Hasirci V

    更新日期:2003-11-01 00:00:00

  • Therapeutic effects of neuropeptide substance P coupled with self-assembled peptide nanofibers on the progression of osteoarthritis in a rat model.

    abstract::Osteoarthritis (OA) is a progressively degenerative disease that is accompanied by articular cartilage deterioration, sclerosis of the underlying bone and ultimately joint destruction. Although therapeutic medicine and surgical treatment are done to alleviate the symptoms of OA, it is difficult to restore normal carti...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2015.09.040

    authors: Kim SJ,Kim JE,Kim SH,Kim SJ,Jeon SJ,Kim SH,Jung Y

    更新日期:2016-01-01 00:00:00

  • Heterogeneous iron-containing fluoridated apatites.

    abstract::The iron-containing fluoridated hydroxyapatites Fe-FeFAp and FeF-FeAp were synthesized heterogeneously in the presence of ferrous ions at 80 degrees C and pH 7.4 in two different types of solution, i.e. fluoride-free solution during the initial half of the experimental period and fluoride-containing solution during th...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(96)00094-4

    authors: Okazaki M,Takahashi J

    更新日期:1997-01-01 00:00:00

  • Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy.

    abstract::A comprehensive strategy for the preparation of mulberry-like dual-drug complicated nanocarriers (MLDC NCs) with high drug loading and adjustable dual-drug ratio was developed. First, apogossypolone (ApoG2) amphiphilic starch micelles (AASt MCs) were prepared by self-assembly process, and doxorubicin (DOX) hyaluronic ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2014.10.073

    authors: Li K,Liu H,Gao W,Chen M,Zeng Y,Liu J,Xu L,Wu D

    更新日期:2015-01-01 00:00:00

  • Bone response to degradable thermoplastic composite in rabbits.

    abstract::The aim of this study was to evaluate biologic behavior of a composite of bioactive glass (BAG) (S53P4) and copolymer of poly(epsilon-caprolactone-co-DL-lactide) in experimental bone defects in rabbits. Twenty New Zealand white rabbits were used for the study. Bone defects (4 x 6mm) were prepared in the medial surface...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(02)00546-x

    authors: Närhi TO,Jansen JA,Jaakkola T,de Ruijter A,Rich J,Seppälä J,Yli-Urpo A

    更新日期:2003-05-01 00:00:00

  • Effect of adhesive layer thickness on the bond strength of a zinc polycarboxylate dental cement.

    abstract::This study reports the effect of varying the thickness of a commercial zinc polycarboxylate dental cement on its adhesion in a metal-to-metal single lap joint. The thickness was controlled externally in a specially designed apparatus, rather than by the inclusion of isodimensional glass spheres, as has been done previ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(95)98279-n

    authors: Akinmade AO,Nicholson JW

    更新日期:1995-01-01 00:00:00

  • An cell-assembly derived physiological 3D model of the metabolic syndrome, based on adipose-derived stromal cells and a gelatin/alginate/fibrinogen matrix.

    abstract::One of the major obstacles in drug discovery is the lack of in vitro three-dimensional (3D) models that can capture more complex features of a disease.Here we established a in vitro physiological model of the metabolic syndrome (MS) using cell-assembly technique (CAT), which can assemble cells into designated places t...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2010.01.111

    authors: Xu M,Wang X,Yan Y,Yao R,Ge Y

    更新日期:2010-05-01 00:00:00

  • PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography.

    abstract::We report the synthesis and characterization of dendrimer-entrapped gold nanoparticles (Au DENPs) modified by polyethylene glycol (PEG) with enhanced biocompatibility for computed tomography (CT) imaging applications. In this study, amine-terminated poly(amidoamine) dendrimers of generation 5 (G5.NH(2)) modified by PE...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2011.10.052

    authors: Peng C,Zheng L,Chen Q,Shen M,Guo R,Wang H,Cao X,Zhang G,Shi X

    更新日期:2012-02-01 00:00:00

  • pH-sensitive radiolabeled and superfluorinated ultra-small palladium nanosheet as a high-performance multimodal platform for tumor theranostics.

    abstract::Radiolabeled nanomaterials, especially those with ultra-small structures, have been the research focus in recent years, and thus may open up new prospects for clinical diseases theranostics. Herein, fluorinated Pd nanosheets labeled with Gd or radionuclides are developed as multimodal platforms for tumor theranostics....

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2018.06.040

    authors: Guo Z,Chen M,Peng C,Mo S,Shi C,Fu G,Wen X,Zhuang R,Su X,Liu T,Zheng N,Zhang X

    更新日期:2018-10-01 00:00:00

  • Non-destructive label-free monitoring of collagen gel remodeling using optical coherence tomography.

    abstract::Matrix remodeling plays a fundamental role in physiological and pathological processes, as well as in tissue engineering applications. In this paper, optical coherence tomography (OCT), a non-destructive optical imaging technology, was used to image collagen gel remodeling by smooth muscle cells (SMCs). The optical sc...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2010.06.042

    authors: Levitz D,Hinds MT,Ardeshiri A,Hanson SR,Jacques SL

    更新日期:2010-11-01 00:00:00

  • Adsorption of bovine serum albumin onto acrylamide-maleic acid hydrogels.

    abstract::In this study, acrylamide-maleic acid hydrogels containing different amounts of maleic acid have been prepared by irradiating with gamma radiation. They have been used in experiments on bovine serum albumin (BSA) adsorption. Acrylamide-maleic acid hydrogel containing 60 mg of maleic acid and irradiated at 5.20 kGy has...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(94)90117-1

    authors: Saraydin D,Karadağ E,Oztop HN,Güven O

    更新日期:1994-09-01 00:00:00

  • The role of physiological mechanical cues on mesenchymal stem cell differentiation in an airway tract-like dense collagen-silk fibroin construct.

    abstract::Airway tracts serve as a conduit of transport in the respiratory system. Architecturally, these are composed of cartilage rings that offer flexibility and prevent collapse during normal breathing. To this end, the successful regeneration of an airway tract requires the presence of differentiated chondrocytes and airwa...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2014.04.040

    authors: Ghezzi CE,Marelli B,Donelli I,Alessandrino A,Freddi G,Nazhat SN

    更新日期:2014-08-01 00:00:00

  • Structure-biocompatibility relationship of dendritic polyglycerol derivatives.

    abstract::Nanocarriers possess advanced physicochemical properties that improve bioavailability, enhance cellular dynamics, and control targetability in drug delivery. In particular, dendritic polyglycerol is a promising new biocompatible scaffold for drug delivery. The present explores the structure-biocompatibility relationsh...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2010.02.001

    authors: Khandare J,Mohr A,Calderón M,Welker P,Licha K,Haag R

    更新日期:2010-05-01 00:00:00

  • Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints.

    abstract::Developing repair strategies for osteochondral tissue presents complex challenges due to its interfacial nature and complex zonal structure, consisting of subchondral bone, intermediate calcified cartilage and the superficial cartilage regions. In this study, the long term ability of a multi-layered biomimetic collage...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2016.02.006

    authors: Levingstone TJ,Ramesh A,Brady RT,Brama PAJ,Kearney C,Gleeson JP,O'Brien FJ

    更新日期:2016-05-01 00:00:00

  • Microfabricated microporous membranes reduce the host immune response and prolong the functional lifetime of a closed-loop insulin delivery implant in a type 1 diabetic rat model.

    abstract::Implantation of a medical implant within the body inevitably triggers a host inflammatory response that negatively impacts its function and longevity. Nevertheless, the degree and severity of this response may be reduced by selecting appropriate materials, implant geometry, surface topography and surface treatment. He...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2015.01.005

    authors: Li J,Chu MK,Gordijo CR,Abbasi AZ,Chen K,Adissu HA,Löhn M,Giacca A,Plettenburg O,Wu XY

    更新日期:2015-04-01 00:00:00

  • Nitrous acid pretreatment of tendon xenografts cross-linked with glutaraldehyde and sterilized with gamma irradiation.

    abstract::Collagenous xenografts made from kangaroo tail tendon cross-linked with glutaraldehyde have a potential application in the reconstruction of massive digital tendon deficits. However, a limitation to the clinical use of these xenografts has been the optimization of collagen cross-linking, and subsequent bio-incorporati...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(98)90187-9

    authors: Johnson KA,Rogers GJ,Roe SC,Howlett CR,Clayton MK,Milthorpe BK,Schindhelm K

    更新日期:1999-06-01 00:00:00

  • Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxel.

    abstract::Angiogenesis plays a prominent role in cancer progression. Anti-angiogenic therapy therefore, either alone or in combination with conventional cytotoxic therapy, offers a promising therapeutic approach. Paclitaxel (PTX) is a widely-used potent cytotoxic drug that also exhibits anti-angiogenic effects at low doses. How...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2011.01.073

    authors: Eldar-Boock A,Miller K,Sanchis J,Lupu R,Vicent MJ,Satchi-Fainaro R

    更新日期:2011-05-01 00:00:00

  • Alginate hydrogels as synthetic extracellular matrix materials.

    abstract::Alginate hydrogels are used extensively in cell encapsulation, cell transplantation, and tissue engineering applications. Alginates possess many favorable properties required in biomaterials, but are unable to specifically interact with mammalian cells. We have therefore covalently modified alginate polysaccharides wi...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(98)00107-0

    authors: Rowley JA,Madlambayan G,Mooney DJ

    更新日期:1999-01-01 00:00:00

  • Generating substrate bound functional chemokine gradients in vitro.

    abstract::Microcontact printing (mCP) is employed to generate discontinuous microscale gradients of active fractalkine, a chemokine expressed by endothelial cells near sites of inflammation where it is believed to form concentration gradients descending away from the inflamed area. In vivo, fractalkine is a transmembrane molecu...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2009.06.018

    authors: Hjortø GM,Hansen M,Larsen NB,Kledal TN

    更新日期:2009-10-01 00:00:00

  • Structurally engineered anodic alumina nanotubes as nano-carriers for delivery of anticancer therapeutics.

    abstract::Here, we report a study on the biocompatibility, cell uptake and in vitro delivery of tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) by new nano-carriers called anodic alumina nanotubes (AANTs) for potential cancer therapy. AANTs were electrochemically engineered by a unique pulse anodization pr...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2014.03.059

    authors: Wang Y,Santos A,Kaur G,Evdokiou A,Losic D

    更新日期:2014-07-01 00:00:00

  • Cancer cell aggregate hypoxia visualized in vitro via biocompatible fiber sensors.

    abstract::To fully understand biological behavior in vitro often dictates that oxygen be reported at either a local or a cellular level. Oxygen sensors based on the luminescent quenching of a specific form of electrospun fiber were developed for measurement of both gaseous and dissolved oxygen concentrations. Electrospinning wa...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2015.10.055

    authors: Xue R,Nelson MT,Teixeira SA,Viapiano MS,Lannutti JJ

    更新日期:2016-01-01 00:00:00

  • Neural differentiation of pluripotent cells in 3D alginate-based cultures.

    abstract::Biomaterial-supported culture methods, allowing for directed three-dimensional differentiation of stem cells are an alternative to canonical two-dimensional cell cultures. In this paper, we evaluate the suitability of alginate for three-dimensional cultures to enhance differentiation of mouse embryonic stem cells (mES...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2014.02.039

    authors: Bozza A,Coates EE,Incitti T,Ferlin KM,Messina A,Menna E,Bozzi Y,Fisher JP,Casarosa S

    更新日期:2014-05-01 00:00:00