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A preliminary report on the biocompatibility of photopolymerizable semi-interpenetrating anhydride networks.

Abstract：

:A new family of poly(anhydrides) (PA) has been developed which can be cured photochemically to produce degradable networks. These degradable anhydride networks may be useful in orthopaedics as bone cements and as matrices for drug delivery. This system, which is a semi-interpenetrating network (semi-IPN), has been evaluated for biocompatibility in subcutaneous tissue in rats and appears to undergo degradation primarily by surface erosion. The inflammatory response to the semi-IPN implants was minimal at both short (3 and 6 weeks) and long (28 weeks) time points and the fibrotic response was largely absent throughout the duration of this study. Furthermore, the OrthoCure implant material integrated well with the surrounding tissue and was invaded with vascularized connective tissue. For reference, linear PA controls were tested and showed a foreign body response culminating in the formation of relatively avascular fibrous capsule several cell layers thick, which became thicker over time, a response similar to what is typically observed in FDA approved implantable polymeric device systems.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Shastri VP,Padera RF,Tarcha P,Langer R

doi

10.1016/s0142-9612(03)00563-5

keywords:

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

715-21

issue

4

eissn

0142-9612

issn

1878-5905

pii

S0142961203005635

journal_volume

25

pub_type

杂志文章

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