Abstract：
:Cytotherapeutic approaches have been investigated to overcome the limitations of existing procedures for periodontal regeneration. In this study, cell sheet transplantation was performed using three kinds of mesenchymal tissue (periodontal ligament, alveolar periosteum, and bone marrow)-derived cells to compare the differences between cell sources in a canine severe defect model (one-wall intrabony defect). Periodontal ligament cells (PDLCs), iliac bone marrow mesenchymal stromal cells (BMMSCs), and alveolar periosteal cells (APCs) were obtained from each dog; a total of four dogs were used. Three-layered cell sheets of each cell source supported with woven polyglycolic acid were autologously transplanted to the denuded root surface. One-wall intrabony defects were filled with a mixture of β-tricalcium phosphate (β-TCP) and collagen. Eight weeks after the transplantation, periodontal regeneration was significantly observed with both newly formed cementum and well-oriented PDL fibers more in the PDLC group than in the other groups. In addition, nerve filament was observed in the regenerated PDL tissue only in the PDLC group. The amount of alveolar bone regeneration was highest in the PDLC group, although it did not reach statistical significance among the groups. These results indicate that PDLC sheets combined with β-TCP/collagen scaffold serve as a promising tool for periodontal regeneration.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Tsumanuma Y,Iwata T,Washio K,Yoshida T,Yamada A,Takagi R,Ohno T,Lin K,Yamato M,Ishikawa I,Okano T,Izumi Ydoi
10.1016/j.biomaterials.2011.04.071subject
Has Abstractpub_date
2011-09-01 00:00:00pages
5819-25issue
25eissn
0142-9612issn
1878-5905pii
S0142-9612(11)00493-5journal_volume
32pub_type
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