A porous tissue engineering scaffold selectively degraded by cell-generated reactive oxygen species.

abstract：:Collagen in vertebrate animals is often arranged in alternating lamellae or in bundles of aligned fibrils which are designed to withstand in vivo mechanical loads. The formation of these organized structures is thought to result from a complex, large-area integration of individual cell motion and locally-controlled sy...

journal_title：Biomaterials

authors： Saeidi N,Karmelek KP,Paten JA,Zareian R,DiMasi E,Ruberti JW

更新日期：2012-10-01 00:00:00

abstract：:Nanovectors hold substantial promise in abating the off-target effects of therapeutics by providing a means to selectively accumulate payloads at the target lesion, resulting in an increase in the therapeutic index. A sophisticated understanding of the factors that govern the degradation and release dynamics of these ...

journal_title：Biomaterials

authors： Martinez JO,Chiappini C,Ziemys A,Faust AM,Kojic M,Liu X,Ferrari M,Tasciotti E

更新日期：2013-11-01 00:00:00

abstract：:Novel biological adhesives made from chitin derivatives were prepared and evaluated for their adhesive properties and biocompatibility. Chitin derivatives with acrylic groups, such as 2-hydroxy-3-methacryloyloxypropylated carboxymethyl chitin (HMA-CM-chitin), were synthesized and cured by the addition of an aqueous hy...

journal_title：Biomaterials

authors： Azuma K,Nishihara M,Shimizu H,Itoh Y,Takashima O,Osaki T,Itoh N,Imagawa T,Murahata Y,Tsuka T,Izawa H,Ifuku S,Minami S,Saimoto H,Okamoto Y,Morimoto M

更新日期：2015-02-01 00:00:00

abstract：:Zwitterionic hydrogels such as those based on polycarboxybetaine (PCB) or polysulfobetaine (PSB) have potential for various biomedical applications, due to their biocompatibility and low biofouling properties. However, the poor mechanical properties of zwitterionic hydrogels developed to date remain a challenge, sever...

journal_title：Biomaterials

authors： Liu Q,Chiu A,Wang L,An D,Li W,Chen EY,Zhang Y,Pardo Y,McDonough SP,Liu L,Liu WF,Chen J,Ma M

更新日期：2020-02-01 00:00:00

abstract：:The polymer poly-N-acetylglucosamine (pGlcNAc) containing fiber material is becoming increasingly important as a topical agent for hemostasis at wound sites. The pGlcNAc polymeric fiber provides hemostasis through redundant mechanisms that include platelet activation for fibrin network formation. The research presente...

journal_title：Biomaterials

authors： Fischer TH,Thatte HS,Nichols TC,Bender-Neal DE,Bellinger AD,Vournakis JN

更新日期：2005-09-01 00:00:00

abstract：:A study on the evolution with age of the mineral composition of bones was performed on samples belonging to human and other common mammalian species (cattle, sheep, dog). The study was carried out on the ashes obtained by calcination of the bone samples (1 h at 900 degrees C). The calcined powders were carefully exami...

journal_title：Biomaterials

authors： Ravaglioli A,Krajewski A,Celotti GC,Piancastelli A,Bacchini B,Montanari L,Zama G,Piombi L

更新日期：1996-03-01 00:00:00

abstract：:Although silicones possess many useful properties as biomaterials, their hydrophobicity can be problematic. To a degree, this issue can be addressed by surface modification with hydrophilic polymers such as poly(ethylene glycol), but the resulting structures are usually not conducive to cell growth. In the present wor...

journal_title：Biomaterials

authors： Alauzun JG,Young S,D'Souza R,Liu L,Brook MA,Sheardown HD

更新日期：2010-05-01 00:00:00

abstract：:Impaction grafting using morsellised allograft bone restores bone stock, but carries the potential for transmission of infection. Synthetic bone graft substitutes can eliminate this risk but may, however, influence outcome. In this study we tested the hypothesis that a 50/50 mix of hydroxyapatite and allograft does no...

journal_title：Biomaterials

authors： Aulakh TS,Jayasekera N,Kuiper JH,Richardson JB

更新日期：2009-03-01 00:00:00

abstract：:The calcination and natural sintering of calcium deficient hydroxyapatite powders Ca(10-x)(PO4)(6-x)(HPO4)x(OH)(2-x) (with 0 < or = x < or = 1) were studied. For temperature below 700 degrees C, particle coalescence occurs without densification. The particle coalescence is associated with a reduction of the specific s...

journal_title：Biomaterials

authors： Raynaud S,Champion E,Bernache-Assollant D

更新日期：2002-02-01 00:00:00

abstract：:Recent advances in materials development and tissue engineering has resulted in a substantial number of bioinspired materials that recapitulate cardinal features of bone extracellular matrix (ECM) such as dynamic inorganic and organic environment(s), hierarchical organization, and topographical features. Bone mimickin...

journal_title：Biomaterials

authors： Shih YV,Varghese S

更新日期：2019-04-01 00:00:00

abstract：:Patient-derived tumor organoids offer potentially useful models of cancer tissue physiology. Yet, conventional organoid cultures utilize generic matrices that are difficult to tailor for various unique tumor microenvironments. Here, we employ synthetic, enzymatically crosslinked hydrogels to define mechanical and bioc...

journal_title：Biomaterials

authors： Ng S,Tan WJ,Pek MMX,Tan MH,Kurisawa M

更新日期：2019-10-01 00:00:00

abstract：:Nanomaterials conjugated with biomacromolecules, including viruses, have great potential for in vivo applications. Therefore, it is important to evaluate the safety of nanoparticle-conjugated macromolecule biomaterials (Nano-mbio). Although a number of studies have assessed the risks of nanoparticles and macromolecule...

journal_title：Biomaterials

authors： Wang M,Zheng Z,Meng J,Wang H,He M,Zhang F,Liu Y,Hu B,He Z,Hu Q,Wang H

更新日期：2015-09-01 00:00:00

abstract：:Polytetrafluoroethylene (PTFE) is a commonly used medical polymer due to its biological stability and other attractive properties such as high hardness and wear resistance. However, the low surface energy and lack of functional groups to interact with the cellular environment have severely limited its applications in ...

journal_title：Biomaterials

authors： Wang H,Kwok DT,Wang W,Wu Z,Tong L,Zhang Y,Chu PK

更新日期：2010-01-01 00:00:00

abstract：:The introduction of metal-on-metal total disc replacements motivated studies to evaluate the effects of cobalt-chromium (CoCr) nanoparticles on cells of the dura mater. Porcine fibroblasts and epithelial cells isolated from the dura mater were cultured with clinically-relevant CoCr nanoparticles and the ions, generate...

journal_title：Biomaterials

authors： Behl B,Papageorgiou I,Brown C,Hall R,Tipper JL,Fisher J,Ingham E

更新日期：2013-05-01 00:00:00

abstract：:Chitosan (CHT)/poly(ɛ-caprolactone) (PCL) blend 3D fiber-mesh scaffolds were studied as possible support structures for articular cartilage tissue (ACT) repair. Micro-fibers were obtained by wet-spinning of three different polymeric solutions: 100:0 (100CHT), 75:25 (75CHT) and 50:50 (50CHT) wt.% CHT/PCL, using a commo...

journal_title：Biomaterials

authors： Neves SC,Moreira Teixeira LS,Moroni L,Reis RL,Van Blitterswijk CA,Alves NM,Karperien M,Mano JF

更新日期：2011-02-01 00:00:00

abstract：:The clinical application of cancer radiotherapy is critically impeded by hypoxia-induced radioresistance, insufficient DNA damage, and multiple DNA repair mechanisms. Herein we demonstrate a dual-hyperthermia strategy to potentiate radiotherapy by relieving tumor hypoxia and preventing irradiation-induced DNA damage r...

journal_title：Biomaterials

authors： Li Q,Hang L,Jiang W,Dou J,Xiao L,Tang X,Yao Y,Wang Y

更新日期：2020-10-01 00:00:00

abstract：:The interactions between alginate and polycations have been studied by using different labelling techniques. Binding of poly-L-lysine (PLL) to alginate in the gel state is mainly governed by the amount of dissociable negative charges on the bead surface. PLL was found to bind more rapidly to gel beads made from algina...

journal_title：Biomaterials

authors： Thu B,Bruheim P,Espevik T,Smidsrød O,Soon-Shiong P,Skjåk-Braek G

更新日期：1996-05-01 00:00:00

abstract：:It has been widely accepted that lymph nodes (LNs) are critical targets of cancer vaccines and particles sized between 10 and 100 nm with a neutral or negative surface charge are preferred for lymphatic transfer after subcutaneous or intradermal injection. However their limited uptake by antigen presenting cells (APCs...

journal_title：Biomaterials

authors： Zeng Q,Li H,Jiang H,Yu J,Wang Y,Ke H,Gong T,Zhang Z,Sun X

更新日期：2017-04-01 00:00:00

abstract：:This paper completes the model of biodegradation for biodegradable polymers that was previously developed by Wang et al. (Wang Y, Pan J, Han X, Sinka, Ding L. A phenomenological model for the degradation of biodegradable polymers. Biomaterials 2008;29:3393-401). Crystallisation during biodegradation was not considered...

journal_title：Biomaterials

authors： Han X,Pan J

更新日期：2009-01-01 00:00:00

abstract：:A novel low-pressure radio-frequency plasma treatment protocol was developed to achieve the effective through-thickness surface modification of large porous poly (D,L-lactide) (PDLLA) polymer scaffolds using air or water: ammonia plasma treatments. Polymer films were modified as controls. Scanning electron micrographs...

journal_title：Biomaterials

authors： Safinia L,Datan N,Höhse M,Mantalaris A,Bismarck A

更新日期：2005-12-01 00:00:00

abstract：:Effects of the granularity of the raw materials on the hydration and hardening process of calcium phosphate cement (CPC) composed of equimolar tetracalcium phosphate (TECP) and dicalcium phosphate anhydrous (DCPA) were investigated systematically. The variation of pH value in CPC slurry indicated that the control step...

journal_title：Biomaterials

authors： Liu C,Shao H,Chen F,Zheng H

更新日期：2003-10-01 00:00:00

abstract：:Bone defects caused by fractures or cancer-mediated destruction are debilitating. Chitosan is commonly used in scaffold matrices for bone healing, but rarely as a free drug. We demonstrate that free chitosan promotes osteoblast proliferation and osteogenesis in mesenchymal stem cells, increases osteopontin and collage...

journal_title：Biomaterials

authors： Tan ML,Shao P,Friedhuber AM,van Moorst M,Elahy M,Indumathy S,Dunstan DE,Wei Y,Dass CR

更新日期：2014-09-01 00:00:00

abstract：:A simple and sensitive method for the quantitative determination of solid-supported primary and/or secondary amino groups using commercially available reagents is described. The solid supports are treated in an aqueous environment with either 2-iminothiolane (ITL) or sulpho-succinimidyl-3-(4-hydroxyphenyl)propionate (...

journal_title：Biomaterials

authors： Kakabakos SE,Tyllianakis PE,Evangelatos GP,Ithakissios DS

更新日期：1994-03-01 00:00:00

abstract：:Fibrous polyurethane (FPU) prostheses with or without fibronectin coating and gelatin impregnation and FPU prostheses with or without fibronectin coating were seeded with 4.8 x 10(5) subcultivated dog endothelial cells per cm2 prosthesis. Expanded polytetrafluoroethylene (ePTFE) prostheses with and without fibronectin...

journal_title：Biomaterials

authors： Hess F,Jerusalem R,Reijnders O,Jerusalem C,Steeghs S,Braun B,Grande P

更新日期：1992-01-01 00:00:00

abstract：:Here, we report a study on the biocompatibility, cell uptake and in vitro delivery of tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) by new nano-carriers called anodic alumina nanotubes (AANTs) for potential cancer therapy. AANTs were electrochemically engineered by a unique pulse anodization pr...

journal_title：Biomaterials

authors： Wang Y,Santos A,Kaur G,Evdokiou A,Losic D

更新日期：2014-07-01 00:00:00

abstract：:The photodynamic activity of a carrier-sensitizer system consisting of heterotopic colloidal nanoparticles (diameter 100-1000 nm) of a cationic amphiphilic cyclodextrin, heptakis(2-omega-amino-O-oligo(ethylene oxide)-6-hexylthio)-beta-CD (SC6CDNH2) encapsulating the anionic 5,10,15,20-tetrakis(4-sulfonatophenyl)-21H,2...

journal_title：Biomaterials

authors： Sortino S,Mazzaglia A,Monsù Scolaro L,Marino Merlo F,Valveri V,Sciortino MT

更新日期：2006-08-01 00:00:00

abstract：:The synthesis of a new potential anti-thrombogenic polymer is described. Limited halogenation of an aryloxy-substituted polyphosphazene, followed by quaternization with triethylamine yielded a polymer capable of forming polyelectrolyte complexes with sodium heparin. The results of preliminary clotting tests with bovin...

journal_title：Biomaterials

authors： Neenan TX,Allcock HR

更新日期：1982-04-01 00:00:00

abstract：:Virus-based nanoparticles have shown promise as vehicles for delivering therapeutic genes. However, the rational design of viral vectors that enable selective tropism towards particular types of cells and tissues remains challenging. Here, we explored structural-functional relationships of the adeno-associated virus 2...

journal_title：Biomaterials

authors： Zhang C,Yao T,Zheng Y,Li Z,Zhang Q,Zhang L,Zhou D

更新日期：2016-02-01 00:00:00

abstract：:Atherosclerosis is the leading cause of many fatal cardiovascular and cerebrovascular diseases. Whereas nanomedicines are promising for targeted therapy of atherosclerosis, great challenges remain in development of effective, safe, and translational nanotherapies for its treatment. Herein we hypothesize that non-proin...

journal_title：Biomaterials

authors： Dou Y,Chen Y,Zhang X,Xu X,Chen Y,Guo J,Zhang D,Wang R,Li X,Zhang J

更新日期：2017-10-01 00:00:00

abstract：:Polycaprolactone (PCL) membrane was modified by grafting copolymerization of methacrylic acid (MAA) initiated under UV light. The covalent immobilization of gelatin on PCL-g-PMAA surface was consequently performed by using condensing agent, 1-ethyl-3-(3-dimethylamino propyl) carbodiimide hydrochloride. The occurrence ...

journal_title：Biomaterials

authors： Zhu Y,Gao C,Shen J

更新日期：2002-12-01 00:00:00