Structurally engineered anodic alumina nanotubes as nano-carriers for delivery of anticancer therapeutics.

Abstract:

:Here, we report a study on the biocompatibility, cell uptake and in vitro delivery of tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) by new nano-carriers called anodic alumina nanotubes (AANTs) for potential cancer therapy. AANTs were electrochemically engineered by a unique pulse anodization process, which enables precise control of the nanotube geometry, and used here as nano-carriers for drug delivery. In vitro cytotoxicity and cell uptake of AANTs was assessed using MDA-MB231-TXSA human breast cancer cells and mouse RAW 264.7 macrophage cells. AANTs exhibited excellent biocompatibility in both cell lines over a time course of five days even at a maximum concentration of AANTs of 100 μgmL(-1). Transmission electron microscopy and fluorescence microscopy confirmed a significant uptake of AANTs by RAW 264.7 cells and breast cancer cells. AANTs loaded with the pro-apoptotic protein Apo2L/TRAIL showed exceptional loading capacity (104 ± 14.4 μgmg(-1) of AANTs) and demonstrated significant decrease in viability of MDA-MB231-TXSA cancer cells due to apoptosis induction. These results demonstrate that AANTs are promising nano-carriers for drug delivery applications.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Wang Y,Santos A,Kaur G,Evdokiou A,Losic D

doi

10.1016/j.biomaterials.2014.03.059

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

5517-26

issue

21

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(14)00319-6

journal_volume

35

pub_type

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