Abstract:
:Polycaprolactone (PCL) membrane was modified by grafting copolymerization of methacrylic acid (MAA) initiated under UV light. The covalent immobilization of gelatin on PCL-g-PMAA surface was consequently performed by using condensing agent, 1-ethyl-3-(3-dimethylamino propyl) carbodiimide hydrochloride. The occurrence of grafting copolymerization of PMAA and further immobilization of gelatin was confirmed by ATR-FTIR and X-ray photoelectron spectroscopy characterizations. The existence of carboxyl groups grafted on PCL surface was verified quantitatively by absorbance spectroscopy where rhodamine 6G was employed to react with carboxyl groups to generate an absorbance at 512 nm. The endothelial cell culture proved that the PCL membrane slightly modified with suitable amount of PMAA or gelatin had better cytocompatibility than control PCL or PCL membrane heavily modified with PMAA or gelatin.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Zhu Y,Gao C,Shen Jdoi
10.1016/s0142-9612(02)00247-8keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
4889-95issue
24eissn
0142-9612issn
1878-5905pii
S0142961202002478journal_volume
23pub_type
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