Histological reaction to titanium alloy and hydroxyapatite particles in the rabbit tibia.

abstract：:As synergistic photothermal immunotherapy has developed as one of the most attractive strategies for cancer therapy, it is crucial to design an effective photothermal immunotherapy system to enhance the synergistic anti-tumor effect and reveal the essential role of each treatment. In this study, we designed CpG self-c...

journal_title：Biomaterials

authors： Dong X,Liang J,Yang A,Qian Z,Kong D,Lv F

更新日期：2019-07-01 00:00:00

abstract：:The present study investigated the ectopic osteoinduction and early degradation of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded porous beta-tricalcium phosphate (beta-TCP) in mice. The porous beta-TCP with 50 microg of rhBMP-2 (n = 25) and porous beta-TCP (control group, n = 25) were implanted into ...

journal_title：Biomaterials

authors： Liang G,Yang Y,Oh S,Ong JL,Zheng C,Ran J,Yin G,Zhou D

更新日期：2005-07-01 00:00:00

abstract：:A cross-linking method for collagen-based biomaterials was developed using the water-soluble carbodiimide 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC). Cross-linking using EDC involves the activation of carboxylic acid groups to give O-acylisourea groups, which form cross-links after reaction wit...

journal_title：Biomaterials

authors： Olde Damink LH,Dijkstra PJ,van Luyn MJ,van Wachem PB,Nieuwenhuis P,Feijen J

更新日期：1996-04-01 00:00:00

abstract：:In this paper, we describe interactions between neural cells and the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) toward development of electrically conductive biomaterials intended for direct, functional contact with electrically active tissues such as the nervous system, heart, and skeletal muscle. We...

journal_title：Biomaterials

authors： Richardson-Burns SM,Hendricks JL,Foster B,Povlich LK,Kim DH,Martin DC

更新日期：2007-03-01 00:00:00

abstract：:Highly cross-linked aliphatic polyurethane networks have been prepared by the bulk step reaction of low molecular weight polyols and hexamethylenediisocyanate (HDI). These polyurethane networks are optically transparent, colourless and autoclavable amorphous glassy thermosets, which are suited for use in ophthalmic ap...

journal_title：Biomaterials

authors： Bruin P,Meeuwsen EA,van Andel MV,Worst JG,Pennings AJ

更新日期：1993-11-01 00:00:00

abstract：:Experimental and histological studies on the reaction of surrounding gingiva to permucosal implants of dense calcium hydroxyapatite were carried out in dogs. Epithelial attachment and connection of supra-alveolar collagen fibres to the implant surface seemed to form a biological seal around implants similar to that ar...

journal_title：Biomaterials

authors： Kurashina K,de Lange GL,de Putter C,de Groot K

更新日期：1984-07-01 00:00:00

abstract：:Zwitterionic hydrogels such as those based on polycarboxybetaine (PCB) or polysulfobetaine (PSB) have potential for various biomedical applications, due to their biocompatibility and low biofouling properties. However, the poor mechanical properties of zwitterionic hydrogels developed to date remain a challenge, sever...

journal_title：Biomaterials

authors： Liu Q,Chiu A,Wang L,An D,Li W,Chen EY,Zhang Y,Pardo Y,McDonough SP,Liu L,Liu WF,Chen J,Ma M

更新日期：2020-02-01 00:00:00

abstract：:The engineering of functional skeletal muscle tissue substitutes holds promise for the treatment of various muscular diseases and injuries. However, no tissue fabrication technology currently exists for the generation of a relatively large and thick bioartificial muscle made of densely packed, uniformly aligned, and d...

journal_title：Biomaterials

authors： Bian W,Bursac N

更新日期：2009-03-01 00:00:00

abstract：:Nano- to micro-structured biodegradable poly(L-lactide-co-epsilon-caprolactone) (PLCL) fabrics were prepared by electrospinning. Electrospun microfiber fabrics with different compositions of PLCL (mol% in feed; 70/30, 50/50, and 30/70), poly(L-lactide) (PLL) and poly(epsilon-caprolactone) (PCL) were obtained using met...

journal_title：Biomaterials

authors： Kwon IK,Kidoaki S,Matsuda T

更新日期：2005-06-01 00:00:00

abstract：:Physiologically relevant hepatic cell culture models must be based on three-dimensional (3D) culture of human cells. However, liver cells are generally cultured in two-dimensional (2D) format that deviates from the normal in vivo morphology. We generated 3D culture environment for HepaRG liver progenitor cells using w...

journal_title：Biomaterials

authors： Malinen MM,Kanninen LK,Corlu A,Isoniemi HM,Lou YR,Yliperttula ML,Urtti AO

更新日期：2014-06-01 00:00:00

abstract：:Multi-layered poly(glycerol-sebacate) (PGS) scaffolds with controlled pore microarchitectures were fabricated, combined with heart cells, and cultured with perfusion to engineer contractile cardiac muscle constructs. First, one-layered (1L) scaffolds with accordion-like honeycomb shaped pores and elastomeric mechanica...

journal_title：Biomaterials

authors： Park H,Larson BL,Guillemette MD,Jain SR,Hua C,Engelmayr GC Jr,Freed LE

更新日期：2011-03-01 00:00:00

abstract：:Hydrogel materials that display inherent activity against bacteria can be used to directly treat accessible wounds to prevent or kill existing infection. Hydrogels composed of self-assembling β-hairpin peptides, having a high content of arginine, were found to be extremely effective at killing both gram-positive and g...

journal_title：Biomaterials

authors： Veiga AS,Sinthuvanich C,Gaspar D,Franquelim HG,Castanho MA,Schneider JP

更新日期：2012-12-01 00:00:00

abstract：:Vesicoureteral reflux and urinary incontinence can be treated by endoscopic injection. Injectables such as collagen and hyaluronic acid-dextranomer are commonly used, however are not offering optimal therapeutic effect yet. In the present study a novel application for poly(acrylonitrile)-based hydrogel (Hypan), alread...

journal_title：Biomaterials

authors： Ramseyer P,Meagher-Villemure K,Burki M,Frey P

更新日期：2007-02-01 00:00:00

abstract：:By taking advantage of the excessively upregulated expression of neuropilin (NRP) on the surface of both glioma cells and endothelial cells of angiogenic blood vessels, the ligand of NRP with high affinity - tLyp-1 peptide, which also contains a CendR motif ((R/K)XX(R/K)), was functionalized to the surface of PEG-PLA ...

journal_title：Biomaterials

authors： Hu Q,Gao X,Gu G,Kang T,Tu Y,Liu Z,Song Q,Yao L,Pang Z,Jiang X,Chen H,Chen J

更新日期：2013-07-01 00:00:00

abstract：:Endothelial cells derived from the bovine pulmonary artery (line CPAE, CCL 209, American Tissue Culture Collection, Rockville, MD, USA) were cultured on pristine or fluorine ion-irradiated polystyrene (5 x 10(12) or 5 x 10(14) F ions/cm2, 150 keV). At 24-h post-seeding interval, the number of cells which adhered to th...

journal_title：Biomaterials

authors： Bacáková L,Mares V,Lisá V,Svorcík V

更新日期：2000-06-01 00:00:00

abstract：:Bone tissue is an anisotropic non-homogeneous composite material composed of inorganic, bone mineral fibres (hydroxyapatite) embedded in an organic matrix (type I collagen and non-collagenous proteins). Factors contributing to the overall mechanical behaviour include constituent volume fraction, mechanical properties,...

journal_title：Biomaterials

authors： Walsh WR,Guzelsu N

更新日期：1994-01-01 00:00:00

abstract：:We have developed nanoparticles based on Murine Leukemia Virus virus-like-particles (VLPs) that efficiently deliver therapeutic bioactive proteins in their native state into target cells. Nuclear transcription factors and toxic proteins were incorporated into the VLPs from stable producer cells without transducing vir...

journal_title：Biomaterials

authors： Wu DT,Roth MJ

更新日期：2014-09-01 00:00:00

abstract：:The development of electrospun ultrafine fibres from biodegradable and biocompatible polymers has created exciting opportunities for biomedical applications. Fibre meshes with high surface area, suitable porosity and stiffness have been produced. Despite desirable structural and topographical properties, for most synt...

journal_title：Biomaterials

authors： Duque Sánchez L,Brack N,Postma A,Pigram PJ,Meagher L

更新日期：2016-11-01 00:00:00

abstract：:Patients regularly taking non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin (IND) have a risk of small intestinal injuries. In this study, we have developed an oral nanotherapeutics by using a redox nanoparticle (RNP(O)), which is prepared by self-assembly of an amphiphilic block copolymer that posse...

journal_title：Biomaterials

authors： Sha S,Vong LB,Chonpathompikunlert P,Yoshitomi T,Matsui H,Nagasaki Y

更新日期：2013-11-01 00:00:00

abstract：:The kinetics of thrombin inhibition by antithrombin (AT) and heparin cofactor II (HC II) were analysed as a function of the heparin concentration, from 10(-9) to 10(-4) M. The initial concentrations of inhibitor (l) and thrombin (E) were set at equimolar levels (CI = CE = 10(-8) M). The experimental data indicate that...

journal_title：Biomaterials

authors： Maaroufi RM,Jozefowicz M,Tapon-Bretaudière J,Fischer AM

更新日期：1997-02-01 00:00:00

abstract：:The study was to produce a novel hybrid poly-(lactic-co-glycolic acid) (PLGA)-gelatin/chondroitin/hyaluronate (PLGA-GCH) scaffold and evaluate its potentials in cartilage repair. The porous PLGA-GCH scaffold was developed to mimic the natural extra cellular matrix of cartilage. The differentiated mesenchymal stem cell...

journal_title：Biomaterials

authors： Fan H,Hu Y,Zhang C,Li X,Lv R,Qin L,Zhu R

更新日期：2006-09-01 00:00:00

abstract：:The in vitro labelling of cultured cells with iron oxide nanoparticles (NPs) is a frequent practice in biomedical research. To date, the potential cytotoxicity of these particles remains an issue of debate. In the present study, 4 different NP types (dextran-coated Endorem, carboxydextran-coated Resovist, lipid-coated...

journal_title：Biomaterials

authors： Soenen SJ,Himmelreich U,Nuytten N,De Cuyper M

更新日期：2011-01-01 00:00:00

abstract：:We investigated the hypothesis that immobilizing TGF-β1 within fibrin hydrogels may act in synergy with cyclic mechanical stimulation to enhance the properties of vascular grafts. To this end, we engineered a fusion TGF-β1 protein that can covalently anchor to fibrin during polymerization upon the action of factor XII...

journal_title：Biomaterials

authors： Liang MS,Koobatian M,Lei P,Swartz DD,Andreadis ST

更新日期：2013-10-01 00:00:00

abstract：:Titanium (Ti) osseointegration is critical for the success of dental and orthopedic implants. Previous studies have shown that surface roughness at the micro- and submicro-scales promotes osseointegration by enhancing osteoblast differentiation and local factor production. Only relatively recently have the effects of ...

journal_title：Biomaterials

authors： Gittens RA,McLachlan T,Olivares-Navarrete R,Cai Y,Berner S,Tannenbaum R,Schwartz Z,Sandhage KH,Boyan BD

更新日期：2011-05-01 00:00:00

abstract：:High-molecular-weight polyethylenimine (25 kDa, PEI25k) is one of the most common cationic polymers utilized in non-viral gene therapy. However, its methylene backbone (-CH(2)CH(2)N(x)-) and high charge density can result in poor biodegradability and high toxicity to cells. We hypothesize that optimizing the polymer l...

journal_title：Biomaterials

authors： Xiong MP,Forrest ML,Ton G,Zhao A,Davies NM,Kwon GS

更新日期：2007-11-01 00:00:00

abstract：:This study addresses the problem of antibiotic resistance in adhesive, biomaterial-centred infections. It is suggested that this anionic, extracapsular, polysaccharide slime produced by bacteria protects them from antibiotics and sequesters critical ions from the surface of biomaterials. Biofilm-enclosed bacteria on t...

journal_title：Biomaterials

authors： Gristina AG,Hobgood CD,Webb LX,Myrvik QN

更新日期：1987-11-01 00:00:00

abstract：:Bone defects caused by fractures or cancer-mediated destruction are debilitating. Chitosan is commonly used in scaffold matrices for bone healing, but rarely as a free drug. We demonstrate that free chitosan promotes osteoblast proliferation and osteogenesis in mesenchymal stem cells, increases osteopontin and collage...

journal_title：Biomaterials

authors： Tan ML,Shao P,Friedhuber AM,van Moorst M,Elahy M,Indumathy S,Dunstan DE,Wei Y,Dass CR

更新日期：2014-09-01 00:00:00

abstract：:Injectable hydrogel biomaterials are promising therapies to promote repair and regeneration post-myocardial infarction (MI). However, the timing of delivery and the mechanisms through which biomaterial treatments confer their benefits are translational issues that remain to be addressed. We assessed the efficacy of an...

journal_title：Biomaterials

authors： Blackburn NJ,Sofrenovic T,Kuraitis D,Ahmadi A,McNeill B,Deng C,Rayner KJ,Zhong Z,Ruel M,Suuronen EJ

更新日期：2015-01-01 00:00:00

abstract：:Adipose-derived stem cells (ASCs) hold promise for bone regeneration but possess inferior osteogenesis potential. Allotransplantation of ASCs engineered with the BMP2/VEGF-expressing baculoviruses into rabbits healed critical-size segmental bone defects. To translate the technology to clinical applications, we aimed t...

journal_title：Biomaterials

authors： Lin CY,Wang YH,Li KC,Sung LY,Yeh CL,Lin KJ,Yen TC,Chang YH,Hu YC

更新日期：2015-05-01 00:00:00

abstract：:Most part of pH- and temperature-sensitive microspheres used for the controlled delivery of drugs are not biodegradable. Therefore, the aim of this work is to prepare pH- and temperature-sensitive microspheres from biodegradable and biocompatible natural polymers. Pullulan microspheres were prepared by suspension cros...

journal_title：Biomaterials

authors： Fundueanu G,Constantin M,Ascenzi P

更新日期：2008-06-01 00:00:00