Cartilage regeneration using mesenchymal stem cells and a PLGA-gelatin/chondroitin/hyaluronate hybrid scaffold.

abstract：:Biomimetic materials are often capable of subtly affecting tissue development, regeneration and carcinogenesis due to their high similarity to natural tissues. Despite the benefit of using such materials in tissue engineering, their prospective use in cancer therapy has been neglected, particularly the functions and m...

journal_title：Biomaterials

authors： Li X,Wang Y,Chen Y,Zhou P,Wei K,Wang H,Wang J,Fang H,Zhang S

更新日期：2020-10-01 00:00:00

abstract：:The long-term patency rates of vascular grafts and stents are limited by the lack of surface endothelialisation of the implanted materials. We have previously reported that GRGDS and WQPPRARI peptide micropatterns increase the endothelialisation of prosthetic materials in vitro. To investigate the mechanisms by which ...

journal_title：Biomaterials

authors： Hoesli CA,Garnier A,Juneau PM,Chevallier P,Duchesne C,Laroche G

更新日期：2014-01-01 00:00:00

abstract：:Biologic scaffold materials composed of extracellular matrix (ECM) are typically derived by processes that involve decellularization of tissues or organs. Preservation of the complex composition and three-dimensional ultrastructure of the ECM is highly desirable but it is recognized that all methods of decellularizati...

journal_title：Biomaterials

authors： Crapo PM,Gilbert TW,Badylak SF

更新日期：2011-04-01 00:00:00

abstract：:Retinal degeneration impairs the vision of millions in all age groups worldwide. Increasing evidence suggests that the etiology of many retinal degenerative diseases is associated with impairment in biochemical reactions involved in the visual cycle, a metabolic pathway responsible for regeneration of the visual chrom...

journal_title：Biomaterials

authors： Puntel A,Maeda A,Golczak M,Gao SQ,Yu G,Palczewski K,Lu ZR

更新日期：2015-03-01 00:00:00

abstract：:Glioblastoma (GBM) is the deadliest and most common type of primary brain tumor in adults with a grim prognosis despite multimodal treatments. Dendritic cell (DC)-based immunotherapy has emerged as a promising therapeutic modality for GBM, whose efficacy is nonetheless fundamentally undermined by GBM-induced immunosup...

journal_title：Biomaterials

authors： Li TF,Li K,Zhang Q,Wang C,Yue Y,Chen Z,Yuan SJ,Liu X,Wen Y,Han M,Komatsu N,Xu YH,Zhao L,Chen X

更新日期：2018-10-01 00:00:00

abstract：:The purpose of this study is to analyze the roles of two non-invasive techniques, bone scintigraphy and resonance frequency analysis (RFA), in the osseointegration assessment. Sixty implants with sandblasted/acid-etched (SA) or machined (MA) surface were placed into the distal femur condyles of 30 rabbits. At 1, 2, 4,...

journal_title：Biomaterials

authors： Zhou Y,Jiang T,Qian M,Zhang X,Wang J,Shi B,Xia H,Cheng X,Wang Y

更新日期：2008-02-01 00:00:00

abstract：:Astroglial cell survival and ion channel activity are relevant molecular targets for the mechanistic study of neural cell interactions with biomaterials and/or electronic interfaces. Astrogliosis is the most typical reaction to in vivo brain implants and needs to be avoided by developing biomaterials that preserve ast...

journal_title：Biomaterials

authors： Benfenati V,Toffanin S,Capelli R,Camassa LM,Ferroni S,Kaplan DL,Omenetto FG,Muccini M,Zamboni R

更新日期：2010-11-01 00:00:00

abstract：:Highly fluorescent core-shell silica nanoparticles made by the modified Stöber process (C dots) are promising as tools for sensing and imaging subcellular agents and structures but will only be useful if they can be easily delivered to the cytoplasm of the subject cells. This work shows that C dots can be electrostati...

journal_title：Biomaterials

authors： Fuller JE,Zugates GT,Ferreira LS,Ow HS,Nguyen NN,Wiesner UB,Langer RS

更新日期：2008-04-01 00:00:00

abstract：:A poly(urethane urea) (PUU) synthesized from 2,4-toluene diisocyanate (TDI) and polyethylene glycol (PEG) with ethylenediamine (ED) as the chain extender was rendered radiopaque by attaching 3,4,5-triiodobenzoic acid (TIB) onto the polymer backbone. The radiopaque polyurethane obtained was characterized by infra red (...

journal_title：Biomaterials

authors： James NR,Jayakrishnan A

更新日期：2007-07-01 00:00:00

abstract：:Most urgent health problems are related to a blood vessel formation failure. The use of stem cells from different sources or species for both in vitro and in vivo engineering of endothelium does not necessarily imply their direct commitment towards a vascular phenotype. In the present study, we used human amniotic flu...

journal_title：Biomaterials

authors： Mirabella T,Cilli M,Carlone S,Cancedda R,Gentili C

更新日期：2011-05-01 00:00:00

abstract：:We hypothesized that reduced stem stiffness of orthopaedic implants contributes to a high risk of loosening, since interface stresses and relative motions may exceed a tolerable range. To study this hypothesis, three types of load-bearing implant with different stiffnesses were inserted into the tibia of the goat. His...

journal_title：Biomaterials

authors： Buma P,van Loon PJ,Versleyen H,Weinans H,Slooff TJ,de Groot K,Huiskes R

更新日期：1997-09-01 00:00:00

abstract：:At the present time, three poly(ortho ester) systems have been described. The first one was developed at the Alza Corporation and is prepared by the transesterification reaction between a diol and diethoxytetrahydrofuran. It is currently marketed under the trade name of Alzamer. A second poly(ortho ester) system, deve...

journal_title：Biomaterials

authors： Heller J

更新日期：1990-11-01 00:00:00

abstract：:Random copolymers of trimethylene carbonate and epsilon-caprolactone have been synthesized through ring-opening polymerization using rare earth alkoxides as initiator. The structure of the copolymers has been characterized by 1H and 13C NMR. Their thermal behaviour, their permeability to liquid and their mechanical pr...

journal_title：Biomaterials

authors： Schappacher M,Fabre T,Mingotaud AF,Soum A

更新日期：2001-11-01 00:00:00

abstract：:The present study provides in vivo trials of silicone rubber chambers filled with different concentrations of bilobalide (0, 50, 100, 200, 400 microM) to bridge a 15 mm sciatic nerve defect in rats. Collagen was also filled in the chambers to prevent the bilobalide from leakage. Histological and electrophysiological t...

journal_title：Biomaterials

authors： Chen YS,Liu CJ,Cheng CY,Yao CH

更新日期：2004-02-01 00:00:00

abstract：:The recent introduction of microseparation of the components of ceramic-on-ceramic hip prostheses during hip simulations has produced clinically relevant wear rates, wear patterns and wear particles. This provided an opportunity to determine the response of primary human peripheral blood mononuclear cells to clinicall...

journal_title：Biomaterials

authors： Hatton A,Nevelos JE,Matthews JB,Fisher J,Ingham E

更新日期：2003-03-01 00:00:00

abstract：:Programmed cell death-ligand 1 (PD-L1)-based immune checkpoint blockade therapy using the anti-PD-L1 antibody is effective for a subset of patients with advanced metastatic melanoma but about half of the patients do not respond to the therapy because of the tumor immunosuppressive microenvironment. Immunogenic cell de...

journal_title：Biomaterials

authors： Qiu N,Liu Y,Liu Q,Chen Y,Shen L,Hu M,Zhou X,Shen Y,Gao J,Huang L

更新日期：2020-12-17 00:00:00

abstract：:To achieve an optimum drug delivery such as targeting or controlled release utilizing bioconjugation with polymeric modifier, the conjugate between drugs and polymeric modifiers must be designed to show desirable pharmacokinetic characteristics in vivo. In this study, we assessed the biopharmaceutical properties of va...

journal_title：Biomaterials

authors： Kaneda Y,Tsutsumi Y,Yoshioka Y,Kamada H,Yamamoto Y,Kodaira H,Tsunoda S,Okamoto T,Mukai Y,Shibata H,Nakagawa S,Mayumi T

更新日期：2004-07-01 00:00:00

abstract：:Biomimetic materials that target the immune system and generate an anti-tumor responses hold promise in augmenting cancer immunotherapy. These synthetic materials can be engineered and optimized for their biodegradability, physical parameters such as shape and size, and controlled release of immune-modulators. As thes...

journal_title：Biomaterials

authors： Kosmides AK,Meyer RA,Hickey JW,Aje K,Cheung KN,Green JJ,Schneck JP

更新日期：2017-02-01 00:00:00

abstract：:Titanium and its alloys are widely used in load-bearing implants as a result of their excellent mechanical properties and corrosion resistance. In order to improve their performances with respect to osseointegration, the use of bioactive coatings has been suggested. Polypyrrole (PPy) has been chosen as coating polymer...

journal_title：Biomaterials

authors： De Giglio E,Guascito MR,Sabbatin L,Zambonin G

更新日期：2001-10-01 00:00:00

abstract：:We investigated the hypothesis that immobilizing TGF-β1 within fibrin hydrogels may act in synergy with cyclic mechanical stimulation to enhance the properties of vascular grafts. To this end, we engineered a fusion TGF-β1 protein that can covalently anchor to fibrin during polymerization upon the action of factor XII...

journal_title：Biomaterials

authors： Liang MS,Koobatian M,Lei P,Swartz DD,Andreadis ST

更新日期：2013-10-01 00:00:00

abstract：:The creation of 3D scaffolds that mimic the structure of physiological tissue required for normal cell function is a major bioengineering challenge. For corneal stroma reconstruction this necessitates the creation of a stroma-like scaffold consisting of a stack of orthogonally disposed sheets of aligned collagen fibri...

journal_title：Biomaterials

authors： Torbet J,Malbouyres M,Builles N,Justin V,Roulet M,Damour O,Oldberg A,Ruggiero F,Hulmes DJ

更新日期：2007-10-01 00:00:00

abstract：:The emergence of combinatorial chemistries and the increased discovery of natural compounds have led to the production of expansive libraries of drug candidates and vast numbers of compounds with potentially interesting biological activities. Despite broad interest in high throughput screening (HTS) across varied fiel...

journal_title：Biomaterials

authors： Wu J,Wheeldon I,Guo Y,Lu T,Du Y,Wang B,He J,Hu Y,Khademhosseini A

更新日期：2011-01-01 00:00:00

abstract：:Effects of the granularity of the raw materials on the hydration and hardening process of calcium phosphate cement (CPC) composed of equimolar tetracalcium phosphate (TECP) and dicalcium phosphate anhydrous (DCPA) were investigated systematically. The variation of pH value in CPC slurry indicated that the control step...

journal_title：Biomaterials

authors： Liu C,Shao H,Chen F,Zheng H

更新日期：2003-10-01 00:00:00

abstract：:Despite the promise for stem cell-based tissue engineering for regenerative therapy, slow and insufficient vascularization of large tissue constructs negatively impacts the survival and function of these transplanted cells. A combination of channeled porous silk scaffolds and prevascularization with endothelial cells ...

journal_title：Biomaterials

authors： Zhang W,Wray LS,Rnjak-Kovacina J,Xu L,Zou D,Wang S,Zhang M,Dong J,Li G,Kaplan DL,Jiang X

更新日期：2015-07-01 00:00:00

abstract：:Nano-scale modification of a segmented polyurethane (SPU) with cross-linked 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer was performed to obtain a biocompatible elastomer. To control the domain size and the depth of the modified layer, various compositions of monomers, including MPC, 2-ethylhexyl methacrylat...

journal_title：Biomaterials

authors： Morimoto N,Watanabe A,Iwasaki Y,Akiyoshi K,Ishihara K

更新日期：2004-10-01 00:00:00

abstract：:A number of neurodegenerative disorders may potentially be treated by the delivery of therapeutic genes to neurons. Nonviral gene delivery systems, however, typically provide low transfection efficiency in post-mitotic differentiated neurons. To uncover mechanistic reasons for this observation, we compared gene transf...

journal_title：Biomaterials

authors： Suk JS,Suh J,Choy K,Lai SK,Fu J,Hanes J

更新日期：2006-10-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biomaterials

authors： Kyle S,McPherson MJ,Aggeli A,Ingham E

更新日期：2011-07-01 00:00:00

abstract：:The interactions of two insoluble anticoagulant polystyrene derivatives with human platelets were studied in an in vitro system similar to a chromatography column. Blood was pumped through the column and platelets were counted before and after passage through the column. Interaction of platelets with the beads led to ...

journal_title：Biomaterials

authors： Fougnot C,Lindon J,Kirshner L,Salzman EW,Jozefowicz M

更新日期：1984-05-01 00:00:00

abstract：:Titanium surfaces with micro-nano hybrid topography (nanoscale nodules in microscale pits) have been recently demonstrated to show higher biological capability than those with microtopography alone. On the other hand, UV treatment of titanium surfaces, which is called UV photofunctionalization, has recently been intro...

journal_title：Biomaterials

authors： Tsukimura N,Yamada M,Iwasa F,Minamikawa H,Att W,Ueno T,Saruwatari L,Aita H,Chiou WA,Ogawa T

更新日期：2011-07-01 00:00:00

abstract：:Vaccine efficacy is improved upon specific delivery to professional antigen (Ag) presenting cells, such as dendritic cells (DCs). Antigenicity and adjuvanticity of vaccine components can be enhanced by encapsulation within nanoparticle (NP) vaccine carriers that are targeted to the human DC-specific C-type lectin rece...

journal_title：Biomaterials

authors： Cruz LJ,Tacken PJ,Pots JM,Torensma R,Buschow SI,Figdor CG

更新日期：2012-06-01 00:00:00