Abstract：
:This study addresses the problem of antibiotic resistance in adhesive, biomaterial-centred infections. It is suggested that this anionic, extracapsular, polysaccharide slime produced by bacteria protects them from antibiotics and sequesters critical ions from the surface of biomaterials. Biofilm-enclosed bacteria on the surface of stainless steel substrata in a test chamber were challenged with incremental levels of tobramycin. In this setting, the minimum inhibitory concentration and minimum bactericidal level of tobramycin for Staphylococcus epidermis were well above normal.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Gristina AG,Hobgood CD,Webb LX,Myrvik QNdoi
10.1016/0142-9612(87)90077-9subject
Has Abstractpub_date
1987-11-01 00:00:00pages
423-6issue
6eissn
0142-9612issn
1878-5905pii
0142-9612(87)90077-9journal_volume
8pub_type
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