Abstract：
:In this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into rabbit bone defects in order to investigate its in vivo degradation. 1, 2, 3 and 8 weeks after surgery, the bone explants were analyzed by synchrotron X-ray microfluorescence, infrared mapping spectroscopy, scanning electron microscopy, and optical microscopy after histological coloration. The results showed that the labelled polysaccharide-based hydrogel was likely to undergo phagocytosis that seemed to occur from the edge to the center of the implantation site up to at least the 8th week.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Laïb S,Fellah BH,Fatimi A,Quillard S,Vinatier C,Gauthier O,Janvier P,Petit M,Bujoli B,Bohic S,Weiss Pdoi
10.1016/j.biomaterials.2008.11.031subject
Has Abstractpub_date
2009-03-01 00:00:00pages
1568-77issue
8eissn
0142-9612issn
1878-5905pii
S0142-9612(08)00923-Xjournal_volume
30pub_type
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