Tissue-engineered cartilage with inducible and tunable immunomodulatory properties.

abstract：:Glioma is still hard to be treated due to their complex microenvironment. In this study, a gold nanoparticle-based delivery system was developed. The system, An-PEG-DOX-AuNPs, was loaded with doxorubicin (DOX) through hydrazone, an acid-responsive linker, and was functionalized with angiopep-2, a specific ligand of lo...

journal_title：Biomaterials

authors： Ruan S,Yuan M,Zhang L,Hu G,Chen J,Cun X,Zhang Q,Yang Y,He Q,Gao H

更新日期：2015-01-01 00:00:00

abstract：:A series of polymer and copolymer networks with varying hydrophilicity and distribution of the hydrophilic groups was synthesized and biologically tested with monolayer culture of human chondrocytes in vitro. Cell viability (MTT), proliferation (BrdU incorporation) and aggrecan expression (PG ELISA) were quantified at...

journal_title：Biomaterials

authors： Pérez Olmedilla M,Garcia-Giralt N,Pradas MM,Ruiz PB,Gómez Ribelles JL,Palou EC,García JC

更新日期：2006-03-01 00:00:00

abstract：:A computational model based on finite element method (FEM) and computational fluid dynamics (CFD) is developed to analyse the mechanical stimuli in a composite scaffold made of polylactic acid (PLA) matrix with calcium phosphate glass (Glass) particles. Different bioreactor loading conditions were simulated within the...

journal_title：Biomaterials

authors： Milan JL,Planell JA,Lacroix D

更新日期：2009-09-01 00:00:00

abstract：:MicroRNAs (miRNA, miR) have been reported as cancer biomarkers that regulate tumor suppressor genes. Hence, simultaneous detecting and inhibiting of miRNA function will be useful as a cancer theragnostics probe to minimize side effects and invasiveness. In this study, we developed a cancer-targeting therangostics prob...

journal_title：Biomaterials

authors： Kim JK,Choi KJ,Lee M,Jo MH,Kim S

更新日期：2012-01-01 00:00:00

abstract：:The hypothesis that E-selectin on activated endothelial cells could be exploited to selectively target drug delivery systems to tumor vasculature was investigated. HPMA copolymer-doxorubicin (DOX) conjugates displaying the high affinity E-selectin binding peptide (Esbp, primary sequence DITWDQLWDLMK) as targeting liga...

journal_title：Biomaterials

authors： Shamay Y,Paulin D,Ashkenasy G,David A

更新日期：2009-11-01 00:00:00

abstract：:Injectable, biodegradable scaffolds are important biomaterials for tissue engineering and drug delivery. Hydrogels derived from natural polysaccharides are ideal scaffolds as they resemble the extracellular matrices of tissues comprised of various glycosaminoglycans (GAGs). Here, we report a new class of biocompatible...

journal_title：Biomaterials

authors： Tan H,Chu CR,Payne KA,Marra KG

更新日期：2009-05-01 00:00:00

abstract：:This experimental investigation aims at revealing the mechanical behaviour and failure pattern of direct fibre-reinforced resin-bonded dental bridge with various designs. To evaluate the overall effects of some newly developed dental materials, in the experiment, genuine composite dental bridge specimens are prepared ...

journal_title：Biomaterials

authors： Li W,Swain MV,Li Q,Ironside J,Steven GP

更新日期：2004-09-01 00:00:00

abstract：:A facile and efficient method to immobilize bioactive proteins onto polymeric substrate was established. Testis-specific protease 50 (TSP50) was immobilized on ultrafine biodegradable polymer fibers, i.e., (1) to prepare a propargyl-containing polymer P(LA90-co-MPC10) by introducing propargyl group into a cyclic carbo...

journal_title：Biomaterials

authors： Shi Q,Chen X,Lu T,Jing X

更新日期：2008-03-01 00:00:00

abstract：:This study examined the antibacterial activity of prepolymerized resin filler, in which the bactericide quaternary ammonium was immobilized. The experimental filler was prepared by grinding prepolymerized resin blocks of methacrylate monomers, silica particles, and the antibacterial monomer methacryloyloxydodecylpyrid...

journal_title：Biomaterials

authors： Imazato S,Ebi N,Takahashi Y,Kaneko T,Ebisu S,Russell RR

更新日期：2003-09-01 00:00:00

abstract：:Alginate/aminopropyl-silicate/alginate (Alg/AS/Alg) membrane was prepared on Ca-alginate gel beads by a sol-gel process. The membrane has identical to Si-O-Si identical to bonds as well as electrostatic bonds between amino groups of AS and carboxyl groups of alginate. Permeability and stability were investigated for t...

journal_title：Biomaterials

authors： Sakai S,Ono T,Ijima H,Kawakami K

更新日期：2002-11-01 00:00:00

abstract：:The aim of the present study was to evaluate the potential of acellular dermal matrix as a carrier for delivery of stem cells to the site of soft tissue defect in a murine skin injury model and to determine the potential of stem cells delivered via such an approach to successfully engraft, survive and differentiate lo...

journal_title：Biomaterials

authors： Altman AM,Matthias N,Yan Y,Song YH,Bai X,Chiu ES,Slakey DP,Alt EU

更新日期：2008-04-01 00:00:00

abstract：:Helicobacter pylori (H. pylori) infection is highly prevalent, and has a strong association with various gastric diseases, including gastritis, digestive ulcers, and cancer. H. pylori strains with resistance to existing antibiotics have emerged in the past two decades. Currently, treatment of H. pylori infection (invo...

journal_title：Biomaterials

authors： Narayana JL,Huang HN,Wu CJ,Chen JY

更新日期：2015-08-01 00:00:00

abstract：:Photoacoustic tomography (PAT) also referred to as optoacoustic tomography (OAT) is a hybrid imaging modality that employs nonionizing optical radiation and ultrasonic detection. Here, we describe the application of a new class of optical contrast agents based on mesoscopic hollow gold nanospheres (HAuNS) to PAT. HAuN...

journal_title：Biomaterials

authors： Lu W,Huang Q,Ku G,Wen X,Zhou M,Guzatov D,Brecht P,Su R,Oraevsky A,Wang LV,Li C

更新日期：2010-03-01 00:00:00

abstract：:Hybrid drug delivery system containing both organic and inorganic nanocarriers is expected to achieve its complementary advantages for the aim of improving the performance of antineoplastic drugs in tumor therapy. Here we report the use of liposomes and gold nanoparticles to construct a liposome with a hybrid Cluster ...

journal_title：Biomaterials

authors： Zhang N,Chen H,Liu AY,Shen JJ,Shah V,Zhang C,Hong J,Ding Y

更新日期：2016-01-01 00:00:00

abstract：:The urgent needs of functional arterial replacements for curing the vascular system diseases have been proposed for many years. However, an ideal small-diameter vascular scaffold, which is nonthrombogenic, minimizes intimal hyperplasia, matches the mechanical properties of natural vessels, and supports neovascular tis...

journal_title：Biomaterials

authors： Han F,Jia X,Dai D,Yang X,Zhao J,Zhao Y,Fan Y,Yuan X

更新日期：2013-10-01 00:00:00

abstract：:An independent assessment was performed of the results of woven carbon implants of mesh or rods into articular cartilage defects performed by two surgeons in the knees of 96 patients. Eight had symptomatic osteochondritis, 31 had chondromalacia patellae and 57 had early osteoarthritis. They were reviewed up to 5 yr af...

journal_title：Biomaterials

authors： Pongor P,Betts J,Muckle DS,Bentley G

更新日期：1992-01-01 00:00:00

abstract：:The water-soluble, low toxic and less biodegradable chitosan derivative N-succinyl-chitosan (Suc-chitosan) was investigated for body distribution and urinary excretion on a long-time scale (24-72 h after i.v. injection) using a fluorescein-labeling technique. Fluorescein isothiocyanate (FITC)-labeled Suc-chitosan (Suc...

journal_title：Biomaterials

authors： Kato Y,Onishi H,Machida Y

更新日期：2000-08-01 00:00:00

abstract：:An increased demand for soft-tissue substitutes has impelled the development of an in vitro adipose tissue. Ideally, such a tissue should contain a vascular network that can deliver blood throughout the construct following its engraftment. This study describes the in vitro fabrication of a pre-vascularized adipose tis...

journal_title：Biomaterials

authors： Sorrell JM,Baber MA,Traktuev DO,March KL,Caplan AI

更新日期：2011-12-01 00:00:00

abstract：UNLABELLED:Scarcity of donor tissue to treat corneal blindness and the need to deliver stem cells or pharmacologic agents to ensure corneal graft survival are major challenges. Here, new composite collagen-based hydrogels are developed as implants to restore corneal transparency while serving as a possible reservoir fo...

journal_title：Biomaterials

authors： Rafat M,Xeroudaki M,Koulikovska M,Sherrell P,Groth F,Fagerholm P,Lagali N

更新日期：2016-03-01 00:00:00

abstract：:In vivo tracking of transplanted stem cells has been a central aim of stem cell therapy. Although many tracking systems have been introduced, no method has yet been validated for clinical applications. We developed a novel sophisticated peptide (GV1001) that mimics hTERT (human telomerase reverse transcriptase) and an...

journal_title：Biomaterials

authors： Park HH,Lee KY,Park DW,Choi NY,Lee YJ,Son JW,Kim S,Moon C,Kim HW,Rhyu IJ,Koh SH

更新日期：2018-02-01 00:00:00

abstract：:In addition to unidirectional laminates and short fiber reinforcements for compression bone plate developments in the literature, we have proposed using a textile structure, i.e. braid preform, for this purpose. In the present paper, the influence of braiding angles and plate thicknesses on the bending performance of ...

journal_title：Biomaterials

authors： Fujihara K,Huang ZM,Ramakrishna S,Satknanantham K,Hamada H

更新日期：2003-07-01 00:00:00

abstract：:Implantation of a medical implant within the body inevitably triggers a host inflammatory response that negatively impacts its function and longevity. Nevertheless, the degree and severity of this response may be reduced by selecting appropriate materials, implant geometry, surface topography and surface treatment. He...

journal_title：Biomaterials

authors： Li J,Chu MK,Gordijo CR,Abbasi AZ,Chen K,Adissu HA,Löhn M,Giacca A,Plettenburg O,Wu XY

更新日期：2015-04-01 00:00:00

abstract：:Hydroxy-fluorapatites (OH-FAps) occur biologically in teeth and form the basis for application as biomaterials. This work aims to synthesize a series of fluoride substituted calcium hydroxyapatites (OHAps) to determine how fluoride influences the synthesis and the resulting characteristics of solid solutions. OH-FAPs ...

journal_title：Biomaterials

authors： Rodríguez-Lorenzo LM,Hart JN,Gross KA

更新日期：2003-09-01 00:00:00

abstract：:The use of artificial tissues in regenerative medicine is limited due to hypoxia. As a strategy to overcome this drawback, we have shown that photosynthetic biomaterials can produce and provide oxygen independently of blood perfusion by generating chimeric animal-plant tissues during dermal regeneration. In this work,...

journal_title：Biomaterials

authors： Chávez MN,Schenck TL,Hopfner U,Centeno-Cerdas C,Somlai-Schweiger I,Schwarz C,Machens HG,Heikenwalder M,Bono MR,Allende ML,Nickelsen J,Egaña JT

更新日期：2016-01-01 00:00:00

abstract：:Neural stem cells (NSCs) have the capacity to differentiate into neurons, astrocytes, and oligodendrocytes. Accordingly, NSCs hold great promise in drug screening and treatment of several common diseases. However, a major obstacle in applied stem cell research is the limitation of synthetic matrices for culturing stem...

journal_title：Biomaterials

authors： Lewicka M,Hermanson O,Rising AU

更新日期：2012-11-01 00:00:00

abstract：:Understanding how nanovectors transport DNA molecules through cell membranes is of great importance in gene therapy. In this paper, we systematically investigate the mechanism of cellular uptake of cationic polymeric nanovectors containing DNA molecules through dissipative particle dynamics simulations. Our results sh...

journal_title：Biomaterials

authors： Ding HM,Ma YQ

更新日期：2013-11-01 00:00:00

abstract：:An increasing number of studies in cardiac cell therapy have provided encouraging results for cardiac repair. Adult stem cells may overcome ethical and availability concerns, with the additional advantages, in some cases, to allow autologous grafts to be performed. However, the major problems of cell survival, cell fa...

journal_title：Biomaterials

authors： Karam JP,Muscari C,Montero-Menei CN

更新日期：2012-08-01 00:00:00

abstract：:The adsorption of chondroitin-4-sulphate (C4S) and heparin onto titanium has been studied in the absence and presence of bovine serum albumin (BSA). Isotherm data (0.02 M calcium acetate, pH 6.8) have shown that BSA in solution and BSA-coated titanium result in decreased adsorption for both C4S and heparin. For the BS...

journal_title：Biomaterials

authors： Hughes Wassell DT,Embery G

更新日期：1997-08-01 00:00:00

abstract：:Polyphosphazenes have been synthesized with tris(hydroxymethyl)amino methane (THAM) side groups and with co-substituents glycine ethyl ester and alanine ethyl ester. The THAM side group was linked to the polyphosphazene backbone via the amino function. The three pendent hydroxyl functions on each THAM side group were ...

journal_title：Biomaterials

authors： Krogman NR,Weikel AL,Kristhart KA,Nukavarapu SP,Deng M,Nair LS,Laurencin CT,Allcock HR

更新日期：2009-06-01 00:00:00

abstract：:Poly(N-isopropylacrylamide) (PNIPAAm) is known to be thermally responsive material and has a lower critical solution temperature (LCST, 32 degrees C) at which a macromolecular transition from a hydrophilic to a hydrophobic structure occurs. Chitosan is a useful natural polymeric biomaterial due to its biocompatibility...

journal_title：Biomaterials

authors： Cho JH,Kim SH,Park KD,Jung MC,Yang WI,Han SW,Noh JY,Lee JW

更新日期：2004-11-01 00:00:00