Molecular imaging of a cancer-targeting theragnostics probe using a nucleolin aptamer- and microRNA-221 molecular beacon-conjugated nanoparticle.

abstract：:The conventional biomimetic apatite coating process can be accelerated by immersing substrates into concentrated simulated body fluid (5 x SBF) at 37 degrees C to form an initial coating of apatite precursor spheres, and transform the precursors into plate-like apatite structures. Depending on processing parameters, d...

journal_title：Biomaterials

authors： Chou YF,Huang W,Dunn JC,Miller TA,Wu BM

更新日期：2005-01-01 00:00:00

abstract：:Liver diseases can be caused by viral infection, metabolic disorder, alcohol consumption, carcinoma or injury, chronically progressing to end-stage liver disease or rapidly resulting in acute liver failure. In either situation, liver transplantation is most often sought for life saving, which is, however, significantl...

journal_title：Biomaterials

authors： Zhang J,Zhao X,Liang L,Li J,Demirci U,Wang S

更新日期：2018-03-01 00:00:00

abstract：:We investigated the feasibility and efficacy of target thrombolysis with recombinant tissue plasminogen activator (rtPA) covalently bound to magnetic nanoparticle (MNP) and retained to the target site in vivo by an external magnet. Polyacrylic acid-coated magnetite (PAA-MNP, 246 nm) was synthesized and characterized; ...

journal_title：Biomaterials

authors： Ma YH,Wu SY,Wu T,Chang YJ,Hua MY,Chen JP

更新日期：2009-07-01 00:00:00

abstract：:A series of PLA/PEO/PLA triblock copolymers was prepared by ring opening polymerization of rac-lactide in the presence of various di-hydroxyl poly (ethylene glycol)s, using CaH2 as a biocompatible initiator. Hydrogels were prepared by a phase separation method consisting of introducing small amounts of water over solu...

journal_title：Biomaterials

authors： Molina I,Li S,Martinez MB,Vert M

更新日期：2001-02-01 00:00:00

abstract：:Reduced expression of autophagy regulators has been observed in pathological cartilage in humans and mice. The present study aimed to investigate the synergistic therapeutic effect of promotion of chondrocyte autophagy via exposure to sinomenium (SIN) encapsulated by chitosan microspheres (CM-SIN) and photo-crosslinke...

journal_title：Biomaterials

authors： Chen P,Xia C,Mei S,Wang J,Shan Z,Lin X,Fan S

更新日期：2016-03-01 00:00:00

abstract：:The suitability of polymeric biomaterials as surfaces for the attachment and growth of cells has often been investigated in cell culture. In this study the contribution that serum fibronectin (Fn) or vitronectin (Vn) make to the attachment and spreading of cells cultured from explanted human bone (bone-derived cells) ...

journal_title：Biomaterials

authors： Howlett CR,Evans MD,Walsh WR,Johnson G,Steele JG

更新日期：1994-02-01 00:00:00

abstract：:A series of supramolecular pseudo-block polycations (CD-SS-pDM/Ad-pPEGs) were realized by assembling bioreducible β-cyclodextrin-cored star poly (2-dimethyl amino)ethyl methacrylate with different molecular weight and an adamantine-ended linear poly(poly(ethylene glycol)ethyl ether methacrylate) (pPEGEEMA) via the hos...

journal_title：Biomaterials

authors： Hu Y,Yuan W,Zhao NN,Ma J,Yang WT,Xu FJ

更新日期：2013-07-01 00:00:00

abstract：:We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs--bupivacaine, limonene, sodium dodecyl sulfate); this was also se...

journal_title：Biomaterials

authors： Khoo X,Simons EJ,Chiang HH,Hickey JM,Sabharwal V,Pelton SI,Rosowski JJ,Langer R,Kohane DS

更新日期：2013-01-01 00:00:00

abstract：:Gold nanoparticles have been conceived as a radiosensitizer in cancer radiation therapy, but one of the important questions for primary drug screening is what size of gold nanoparticles can optimally enhance radiation effects. Herein, we perform in vitro and in vivo radiosensitization studies of 4.8, 12.1, 27.3, and 4...

journal_title：Biomaterials

authors： Zhang XD,Wu D,Shen X,Chen J,Sun YM,Liu PX,Liang XJ

更新日期：2012-09-01 00:00:00

abstract：:Biologic scaffold materials composed of extracellular matrix (ECM) are typically derived by processes that involve decellularization of tissues or organs. Preservation of the complex composition and three-dimensional ultrastructure of the ECM is highly desirable but it is recognized that all methods of decellularizati...

journal_title：Biomaterials

authors： Crapo PM,Gilbert TW,Badylak SF

更新日期：2011-04-01 00:00:00

abstract：:Breast cancer cells (BCC) and macrophages are known to interact via epidermal growth factor (EGF) produced by macrophages and colony stimulating factor-1 (CSF-1) produced by BCC. Despite contradictory findings, this interaction is perceived as a paracrine loop. Further, the underlying mechanism of interaction remains ...

journal_title：Biomaterials

authors： Onal S,Turker-Burhan M,Bati-Ayaz G,Yanik H,Pesen-Okvur D

更新日期：2021-01-01 00:00:00

abstract：:Compared to soluble cytokines, surface-tethered ligands can deliver biological signalling with precise control of spatial positioning and concentration. A strategy that immobilises ligand molecules on a surface in a uniform orientation using non-cleavable linkages under physiological conditions would enhance the speci...

journal_title：Biomaterials

authors： Lee EJ,Be CL,Vinson AR,Riches AG,Fehr F,Gardiner J,Gengenbach TR,Winkler DA,Haylock D

更新日期：2015-01-01 00:00:00

abstract：:The infection of an implanted prosthetic material can have serious consequences on the tissue integration of the implant and the scarring process in the host, and may even necessitate replacement of the prosthesis. This study was designed to explore the in vitro effects of Staphylococcus aureus (Sa) and Staphylococcus...

journal_title：Biomaterials

authors： Bellón JM,G-Honduvilla N,Jurado F,Carranza A,Buján J

更新日期：2001-07-01 00:00:00

abstract：:The adhesion of osteoblasts to substrates is mediated through proteins that have adsorbed to the substrate, providing integrins on the cell membrane with ligands to connect to. The integrins regulate cell behavior through bi-directional signaling pathways. This critical review has the purpose to consider the research ...

journal_title：Biomaterials

authors： Siebers MC,ter Brugge PJ,Walboomers XF,Jansen JA

更新日期：2005-01-01 00:00:00

abstract：:Podophyllotoxin (PPT) exhibited significant activity against P-glycoprotein mediated multidrug resistant (MDR) tumor cell lines; however, due to its poor solubility and high toxicity, PPT cannot be dosed systemically, preventing its clinical use for MDR cancer. We developed a nanoparticle dosage form of PPT by covalen...

journal_title：Biomaterials

authors： Roy A,Ernsting MJ,Undzys E,Li SD

更新日期：2015-06-01 00:00:00

abstract：:Multiblock, high molecular weight, linear, backbone degradable HPMA copolymer-prostaglandin E1 (PGE1) conjugate has been synthesized by RAFT polymerization mediated by a new bifunctional chain transfer agent (CTA), which contains an enzymatically degradable oligopeptide sequence flanked by two dithiobenzoate groups, f...

journal_title：Biomaterials

authors： Pan H,Sima M,Miller SC,Kopečková P,Yang J,Kopeček J

更新日期：2013-09-01 00:00:00

abstract：:This paper presents for the first time a mathematical model for a mechanism of controlled drug release involving both ion exchange and transient counter diffusion of a drug and counterions. Numerical analysis was conducted to study the effect of different factors on drug release kinetics including environmental condit...

journal_title：Biomaterials

authors： Abdekhodaie MJ,Wu XY

更新日期：2008-04-01 00:00:00

abstract：:Bone defects, such as compressive fractures in the vertebral bodies, are frequently treated with acrylic bone cements (e.g., PMMA). Although these biomaterials have sufficient mechanical properties for fixing the fracture, they are non-degradable and do not remodel or integrate with host tissue. In an alternative appr...

journal_title：Biomaterials

authors： Guelcher SA,Srinivasan A,Dumas JE,Didier JE,McBride S,Hollinger JO

更新日期：2008-04-01 00:00:00

abstract：:To prevent wear debris-induced osteolysis and aseptic loosening, cross-linked ultra-high molecular weight polyethylene's (UHMWPE) with improved wear resistance have been developed. Hip simulator studies have demonstrated very low wear rates with these new materials leading to their widespread clinical use. However, th...

journal_title：Biomaterials

authors： Sethi RK,Neavyn MJ,Rubash HE,Shanbhag AS

更新日期：2003-07-01 00:00:00

abstract：:Previous studies have shown that heterotopic induction of bone formation by calcium phosphate-based macroporous constructs is set into motion by the geometry of the implanted substrata, i.e. a sequence of repetitive concavities assembled within the macroporous spaces. The aim of this study was to construct osteoinduct...

journal_title：Biomaterials

authors： Ripamonti U,Roden LC,Renton LF

更新日期：2012-05-01 00:00:00

abstract：:Hydrophobically derivatized hyperbranched polyglycerol (HPG)-polyethylene glycol (PEG) polymers bearing stearoyl chains (HPG-C18-PEG) were originally developed as human serum albumin substitutes and further as a unimolecular drug delivery system. In view of these in vivo applications and the potential for membrane int...

journal_title：Biomaterials

authors： Liu Z,Janzen J,Brooks DE

更新日期：2010-04-01 00:00:00

abstract：:Three critical aspects of searching for and understanding how to find highly resistant surfaces to protein adhesion are addressed here with specific application to synthetic membrane filtration. They include the (i) discovery of a series of previously unreported monomers from a large library of monomers with high prot...

journal_title：Biomaterials

authors： Gu M,Kilduff JE,Belfort G

更新日期：2012-02-01 00:00:00

abstract：:This work reports the development of new non-thrombogenic polymers based on the linear polymers of polyamidoamines (PAAs), having heparin binding ability, obtained by polyaddition of secondary amines to N,N'-methylene bis-acrylamide. PAAs could not be used directly in the making of blood-contacting materials due to th...

journal_title：Biomaterials

authors： Dey RK,Ray AR

更新日期：2003-08-01 00:00:00

abstract：:The immune system is a powerful resource for the eradication of cancer, but to overcome the low immunogenicity of tumor cells, a sufficiently strong CD8(+) T cell-mediated adaptive immune response is required. Nanoparticulate biomaterials represent a potentially effective delivery system for cancer vaccines, as they c...

journal_title：Biomaterials

authors： Molino NM,Neek M,Tucker JA,Nelson EL,Wang SW

更新日期：2016-04-01 00:00:00

abstract：:Silver nanoparticles (AgNPs) have anti-cancer effect. However, whether and how these particles could inhibit the growth of acute myeloid leukemia (AML) cells is unclear. In the present study, we prepared AgNPs with various sizes and investigated their cytotoxic effect on AML cells. We found that AgNPs could inhibit th...

journal_title：Biomaterials

authors： Guo D,Zhu L,Huang Z,Zhou H,Ge Y,Ma W,Wu J,Zhang X,Zhou X,Zhang Y,Zhao Y,Gu N

更新日期：2013-10-01 00:00:00

abstract：:Collagen in vertebrate animals is often arranged in alternating lamellae or in bundles of aligned fibrils which are designed to withstand in vivo mechanical loads. The formation of these organized structures is thought to result from a complex, large-area integration of individual cell motion and locally-controlled sy...

journal_title：Biomaterials

authors： Saeidi N,Karmelek KP,Paten JA,Zareian R,DiMasi E,Ruberti JW

更新日期：2012-10-01 00:00:00

abstract：:This study designs a pH-sensitive nanoparticle carrier of methotrexate (MTX) and combretastatin A4 (CA4) based on pullulan for the combination therapy against hepatocellular carcinoma (HCC). Briefly, N-urocanyl pullulan (URPA) with the degree of substitution (DS) of 5.2% was synthesized and then conjugated with MTX to...

journal_title：Biomaterials

authors： Wang Y,Chen H,Liu Y,Wu J,Zhou P,Wang Y,Li R,Yang X,Zhang N

更新日期：2013-09-01 00:00:00

abstract：:Tetragonal zirconia polycrystal (TZP) is a new interesting ceramic for the manufacture of medical devices. Its wide use in orthopedic and odontoiatric implants was limited till now by the high chemical and radiochemical impurities of the raw materials. Purification processes now available allow to obtain high purity c...

journal_title：Biomaterials

authors： Covacci V,Bruzzese N,Maccauro G,Andreassi C,Ricci GA,Piconi C,Marmo E,Burger W,Cittadini A

更新日期：1999-02-01 00:00:00

abstract：:In an effort to examine liver injury, immune response, and other physiological effects in mice caused by intragastric administration of nanoparticulate anatase titanium dioxide (5nm), we assessed T lymphocytes, B lymphocyte and NK lymphocyte counts, hematological indices, biochemical parameters of liver functions, and...

journal_title：Biomaterials

authors： Duan Y,Liu J,Ma L,Li N,Liu H,Wang J,Zheng L,Liu C,Wang X,Zhao X,Yan J,Wang S,Wang H,Zhang X,Hong F

更新日期：2010-02-01 00:00:00

abstract：:The aim of the present study was to evaluate the potential of acellular dermal matrix as a carrier for delivery of stem cells to the site of soft tissue defect in a murine skin injury model and to determine the potential of stem cells delivered via such an approach to successfully engraft, survive and differentiate lo...

journal_title：Biomaterials

authors： Altman AM,Matthias N,Yan Y,Song YH,Bai X,Chiu ES,Slakey DP,Alt EU

更新日期：2008-04-01 00:00:00