Abstract:
:In vivo tracking of transplanted stem cells has been a central aim of stem cell therapy. Although many tracking systems have been introduced, no method has yet been validated for clinical applications. We developed a novel sophisticated peptide (GV1001) that mimics hTERT (human telomerase reverse transcriptase) and analysed its ability to track and protect stem cells after transplantation. Ferrocenecarboxylic acid-conjugated GV1001 (Fe-GV1001) efficiently penetrated stem cells with no adverse effects. Moreover, Fe-GV1001 improved the viability, proliferation, and migration of stem cells under hypoxia. After Fe-GV1001-labelled stem cells were transplanted into the brains of rats after stroke, the labelled cells were easily tracked by MRI. Our findings indicate that Fe-GV1001 can be used for the in vivo tracking of stem cells after transplantation into the brain and can improve the efficacy of stem cell therapy by sustaining and enhancing stem cell characteristics under disease conditions.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Park HH,Lee KY,Park DW,Choi NY,Lee YJ,Son JW,Kim S,Moon C,Kim HW,Rhyu IJ,Koh SHdoi
10.1016/j.biomaterials.2017.11.009subject
Has Abstractpub_date
2018-02-01 00:00:00pages
80-91eissn
0142-9612issn
1878-5905pii
S0142-9612(17)30740-8journal_volume
155pub_type
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