Cryogel/hydrogel biomaterials and acupuncture combined to promote diabetic skin wound healing through immunomodulation.

abstract：:Each year, hundreds of thousands coronary bypass procedures are performed in the US, yet there currently exists no off-the-shelf alternative to autologous vessel transplant. In the present study, we investigated the use of mouse thrombospondin-2 knockout (TSP2 KO) cells, which secrete a non-thrombogenic and pro-migrat...

journal_title：Biomaterials

authors： Kristofik NJ,Qin L,Calabro NE,Dimitrievska S,Li G,Tellides G,Niklason LE,Kyriakides TR

更新日期：2017-10-01 00:00:00

abstract：:Brain tumors and brain metastases are among the deadliest malignancies of all human cancers, largely due to the cellular blood-brain and blood-tumor barriers that limit the delivery of imaging and therapeutic agents from the systemic circulation to tumors. Thus, improved strategies for brain tumor visualization and ta...

journal_title：Biomaterials

authors： Wu JB,Shi C,Chu GC,Xu Q,Zhang Y,Li Q,Yu JS,Zhau HE,Chung LW

更新日期：2015-10-01 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is the major cause of lower back pain, while the currently available treatments are symptomatic rather than curative. Tissue engineering is a powerful therapeutic strategy that can restore the normal biomechanical motion of the human spine. The ability of a biphasic elastic scaff...

journal_title：Biomaterials

authors： Wan Y,Feng G,Shen FH,Laurencin CT,Li X

更新日期：2008-02-01 00:00:00

abstract：:Here, scaffolds as cell and tissue carriers are approached from an engineering point of view, emphasizing material superstructuring in the design of supports. Superstructure engineering provides optimal spatial and nutritional conditions for cell maintenance by the arrangement of structural elements (e.g. pores or fib...

journal_title：Biomaterials

authors： Wintermantel E,Mayer J,Blum J,Eckert KL,Lüscher P,Mathey M

更新日期：1996-01-01 00:00:00

abstract：:Nickel-titanium shape-memory alloys (NiTi-SMA) were coated with calcium phosphate by dipping in oversaturated calcium phosphate solution. The layer thickness (typically 5-20 micrometer) can be varied by choice of the immersion time. The porous nature of the layer of microcrystals makes it mechanically stable enough to...

journal_title：Biomaterials

authors： Choi J,Bogdanski D,Köller M,Esenwein SA,Müller D,Muhr G,Epple M

更新日期：2003-09-01 00:00:00

abstract：:The infection of an implanted prosthetic material can have serious consequences on the tissue integration of the implant and the scarring process in the host, and may even necessitate replacement of the prosthesis. This study was designed to explore the in vitro effects of Staphylococcus aureus (Sa) and Staphylococcus...

journal_title：Biomaterials

authors： Bellón JM,G-Honduvilla N,Jurado F,Carranza A,Buján J

更新日期：2001-07-01 00:00:00

abstract：:We studied three different types of scaffolds, encapsulating bone morphogenetic protein-2 (BMP-2) plasmid, in terms of their performances in bone regeneration in nude mice. The plasmid was loaded into fibrous matrices in three different ways: coating of naked DNA (Group A) or DNA/chitosan nanoparticles (Group B) onto ...

journal_title：Biomaterials

authors： Nie H,Ho ML,Wang CK,Wang CH,Fu YC

更新日期：2009-02-01 00:00:00

abstract：:The functionalization of polytetrafluoroethylene (PTFE) for human thrombomodulin (hTM) binding has been achieved by CO2 plasma activation and subsequent vapour phase graft polymerization of acrylic acid (AA). The PTFE surfaces after CO2 plasma treatment, AA grafting and hTM immobilization were characterized by attenua...

journal_title：Biomaterials

authors： Vasilets VN,Hermel G,König U,Werner C,Müller M,Simon F,Grundke K,Ikada Y,Jacobasch HJ

更新日期：1997-09-01 00:00:00

abstract：:The present study deals with the synthesis and characterization of radiopaque polymers which could, when solubilized in an appropriate water-miscible solvent, be useful embolic materials for the treatment of cerebral aneurysms and arteriovenous malformations. For this purpose cellulose (both microcrystalline and powde...

journal_title：Biomaterials

authors： Mottu F,Rüfenacht DA,Laurent A,Doelker E

更新日期：2002-01-01 00:00:00

abstract：:Porous silica gels with high surface areas were prepared from tetraethylothosilicate and polyacrylic acid (PAA) of high molecular weight in acidic media by a sol-gel method. PAA content and ageing temperatures were varied in order to obtain different microstructures. Samples were sintered at temperatures up to 400 deg...

journal_title：Biomaterials

authors： Gallardo J,Galliano PG,Porto López JM

更新日期：2002-11-01 00:00:00

abstract：:Osteomyelitis characterized by an inflammatory response often leads to bone loss and the spread of bacterial infection to surrounding soft tissues. To overcome the side effects induced by the systemic antibiotic treatment for osteomyelitis, recent investigations have explored the use of antibiotic-loaded undegradable ...

journal_title：Biomaterials

authors： Peng KT,Chen CF,Chu IM,Li YM,Hsu WH,Hsu RW,Chang PJ

更新日期：2010-07-01 00:00:00

abstract：:Osteogenic agents, such as bone morphogenetic protein-2 (BMP-2), can stimulate the degradation as well as the formation of bone. Hence, they could impair the osteoconductivity of functionalized implant surfaces. We assessed the effects of BMP-2 and its mode of delivery on the osteoconductivity of dental implants with ...

journal_title：Biomaterials

authors： Liu Y,Enggist L,Kuffer AF,Buser D,Hunziker EB

更新日期：2007-06-01 00:00:00

abstract：:Efficient and site-specific delivery of anticancer drugs to tumors is important in the development of effective cancer chemotherapy. As an undecapeptide of the tachykinin neuropeptide family, the substance P (SP)/neurokinin-1 receptor (NK1R) system has been identified as a promising ligand-receptor pair in tumor-speci...

journal_title：Biomaterials

authors： Wu J,Zhou Y,Li S,Qu D,Zhu WH,Tian H

更新日期：2017-03-01 00:00:00

abstract：:A major role of respiratory mucus is to trap inhaled particles, including pathogens and environmental particulates, to limit body exposure. Despite the tremendous health implications, how particle size and surface chemistry affect mobility in respiratory mucus from humans without lung disease is not known. We prepared...

journal_title：Biomaterials

authors： Schuster BS,Suk JS,Woodworth GF,Hanes J

更新日期：2013-04-01 00:00:00

abstract：:We present a new ultrasonic technique for monitoring the entire setting process of injectable bone cement. The problem with existing standards is their subjectivity. Because of this the results are not comparable between different research groups. A strong advantage with the proposed technique is that it is non-invasi...

journal_title：Biomaterials

authors： Carlson J,Nilsson M,Fernández E,Planell JA

更新日期：2003-01-01 00:00:00

abstract：:Glioma is still hard to be treated due to their complex microenvironment. In this study, a gold nanoparticle-based delivery system was developed. The system, An-PEG-DOX-AuNPs, was loaded with doxorubicin (DOX) through hydrazone, an acid-responsive linker, and was functionalized with angiopep-2, a specific ligand of lo...

journal_title：Biomaterials

authors： Ruan S,Yuan M,Zhang L,Hu G,Chen J,Cun X,Zhang Q,Yang Y,He Q,Gao H

更新日期：2015-01-01 00:00:00

abstract：:Percutaneous implants are commonly associated with several problems, and different failure modes have been described. Infections constitute one serious complication which may lead to the removal of the implant. In contrast to infections around polymer implants, infections around skin-penetrating titanium implants anch...

journal_title：Biomaterials

authors： Holgers KM,Ljungh A

更新日期：1999-07-01 00:00:00

abstract：:The surface and bulk properties of novel methacrylate polymers prepared by gelling poly(ethyl methacrylate) (PEMA) powder with different ratios of tetrahydrofurfuryl methacrylate (THFMA) and hydroxyethyl methacrylate (HEMA) monomers were investigated. The water adsorption and desorption characteristics of these polyme...

journal_title：Biomaterials

authors： Hutcheon GA,Messiou C,Wyre RM,Davies MC,Downes S

更新日期：2001-04-01 00:00:00

abstract：:Peel bond strength and tensile bond strength between three polyvinylsiloxane denture soft liners and a heat-cured acrylic resin denture base were measured using two adhesive systems. The soft lining materials differed only in regard of their filler content and compliance. The values of bond strength and mode of failur...

journal_title：Biomaterials

authors： McCabe JF,Carrick TE,Kamohara H

更新日期：2002-03-01 00:00:00

abstract：:Platelet concentrates (PCs) constitute new biological mediators used in osseous reconstructive surgery. In this study, we assessed (i) the effects of various concentrations of calcium and thrombin on the kinetics of platelet-derived growth factor (PDGF-BB), transforming growth factor-beta1(TGF-beta 1), basic fibroblas...

journal_title：Biomaterials

authors： Martineau I,Lacoste E,Gagnon G

更新日期：2004-08-01 00:00:00

abstract：:The majority of epithelia in our organism perform barrier functions on being exposed to different fluids at the luminal and basal sides. To simulate this natural situation under in vitro conditions for biomaterial testing and tissue engineering the epithelia have to withstand mechanical and fluid stress over a prolong...

journal_title：Biomaterials

authors： Schumacher K,Strehl R,de VU,Minuth WW

更新日期：2002-02-01 00:00:00

abstract：:Recently, engineering the surface of nanotherapeutics with biologics to provide them with superior biocompatibility and targeting towards pathological tissues has gained significant popularity. Although the functionalization of drug delivery vectors with cellular materials has been shown to provide synthetic particles...

journal_title：Biomaterials

authors： Evangelopoulos M,Parodi A,Martinez JO,Yazdi IK,Cevenini A,van de Ven AL,Quattrocchi N,Boada C,Taghipour N,Corbo C,Brown BS,Scaria S,Liu X,Ferrari M,Tasciotti E

更新日期：2016-03-01 00:00:00

abstract：:In order to improve the administration of drugs for all pathology of the oral cavity, we have developed an intraoral controlled release delivering system, permitting to reach high enough local concentrations for desirable therapeutic effect with minimal side effects. We have formulated tablets of 200 mg intended to be...

journal_title：Biomaterials

authors： Diarra M,Pourroy G,Muster D,Zingraff M,Boymond C

更新日期：1998-08-01 00:00:00

abstract：:Although PEGylated liposomes (PEG-LS) have been intensively studied as drug-delivery vehicles, the rigidity and the hydrophilic PEG corona of liposomal membranes often limits cellular uptake, resulting in insufficient drug delivery to target cells. Thus, it is necessary to develop a new type of lipid-based self-assemb...

journal_title：Biomaterials

authors： Saw PE,Yu M,Choi M,Lee E,Jon S,Farokhzad OC

更新日期：2017-04-01 00:00:00

abstract：:The design of bioartificial liver assist device requires an effective attachment of primary hepatocytes on polymeric biomaterials. A better understanding of this cell-surface interaction would aid the optimal choice of biomaterials. In this study, the adhesion contact dynamics of primary hepatocytes on poly(ethylene t...

journal_title：Biomaterials

authors： Tan WJ,Teo GP,Liao K,Leong KW,Mao HQ,Chan V

更新日期：2005-03-01 00:00:00

abstract：:Recent advances in efficient microRNA (miRNA) delivery techniques using brain-targeted nanoparticles offer critical information for understanding the functional role of miRNAs in vivo, and for supporting targeted gene therapy in terms of treating miRNA-associated neurological diseases. Here, we report the rabies virus...

journal_title：Biomaterials

authors： Hwang DW,Son S,Jang J,Youn H,Lee S,Lee D,Lee YS,Jeong JM,Kim WJ,Lee DS

更新日期：2011-07-01 00:00:00

abstract：:The metabolic disposition and elimination process of the anhydride co-polymer poly[1,3-bis(p-carboxy-phenoxypropane):sebacic acid] 20:80 [P(CPP:Sa)20:80] implanted in the rat brain was studied. Two polymers were prepared, one with [14C]SA and unlabelled CPP, and the other co-polymer with [14C]CPP and unlabelled SA. Wi...

journal_title：Biomaterials

authors： Domb AJ,Rock M,Schwartz J,Perkin C,Yipchuk G,Broxup B,Villemure JG

更新日期：1994-07-01 00:00:00

abstract：:Tissue engineering scaffolds with complex geometries can provide an architecture that directs tissue formation. Drug delivery from these scaffolds to promote regeneration is often challenging due to the complex fabrication processes. Surface-mediated DNA delivery from multiple channel bridges was applied to deliver li...

journal_title：Biomaterials

authors： De Laporte L,Yan AL,Shea LD

更新日期：2009-04-01 00:00:00

abstract：:Adipose tissue engineering offers a promising alternative to the current breast reconstruction options. Here we investigated patient-specific breast scaffolds fabricated from poly(d,l)-lactide polymer with pore sizes>1 mm for their potential in long-term sustained regeneration of high volume adipose tissue. An optimis...

journal_title：Biomaterials

authors： Chhaya MP,Melchels FP,Holzapfel BM,Baldwin JG,Hutmacher DW

更新日期：2015-06-01 00:00:00

abstract：:Two commercially available amalgam alloy powders (one lathe-cut, the other spherical) were characterized in terms of density, surface area, particle size distribution and appearance under the scanning electron microscope. A third, experimental alloy powder, prepared by electrodeposition, was subjected to a similar ana...

journal_title：Biomaterials

authors： Davies EH,Kuhn AT

更新日期：1984-11-01 00:00:00