Tissue engineering scaffolds using superstructures.


:Here, scaffolds as cell and tissue carriers are approached from an engineering point of view, emphasizing material superstructuring in the design of supports. Superstructure engineering provides optimal spatial and nutritional conditions for cell maintenance by the arrangement of structural elements (e.g. pores or fibres) so as to vary the order of cell to cell contact. This approach is illustrated in the design of several scaffolds: knitted fabrics as three-dimensional superstructures for optimized osteosynthesis implants, a new injectable open porous implant system, an angiopolar non-degradable ceramic cell carrier, and an injectable or microsurgically implantable entangled carrier system. The implications for tissue engineering are discussed.






Wintermantel E,Mayer J,Blum J,Eckert KL,Lüscher P,Mathey M




Has Abstract


1996-01-01 00:00:00














  • Bioabsorbable fixation in orthopaedic surgery and traumatology.

    abstract::Bioabsorbable internal fixation devices were introduced clinically in the treatment of fractures and osteotomies of the extremities at the Department of Orthopaedics and Traumatology, Helsinki University, in 1984. Since November 5, 1984, a total of 3200 patients were managed using bone or ligament fixation devices mad...


    pub_type: 杂志文章,评审


    authors: Rokkanen PU,Böstman O,Hirvensalo E,Mäkelä EA,Partio EK,Pätiälä H,Vainionpää SI,Vihtonen K,Törmälä P

    更新日期:2000-12-01 00:00:00

  • The effect of a fibrin-fibronectin/beta-tricalcium phosphate/recombinant human bone morphogenetic protein-2 system on bone formation in rat calvarial defects.

    abstract::In spite of good prospects for bone morphogenetic proteins (BMP) applications, an ideal carrier system for BMPs has not yet been identified. The purpose of this study was to evaluate the osteogenic effect of a fibrin-fibronectin sealing system (FFSS) combined with beta-tricalcium phosphate (beta-TCP) as a carrier syst...


    pub_type: 杂志文章


    authors: Hong SJ,Kim CS,Han DK,Cho IH,Jung UW,Choi SH,Kim CK,Cho KS

    更新日期:2006-07-01 00:00:00

  • Nuclear localization signal-enhanced RNA interference of EZH2 and Oct4 in the eradication of head and neck squamous cell carcinoma-derived cancer stem cells.

    abstract::Metastasis is the major cause of high mortality in head and neck squamous cell carcinoma (HNSCC), in which HNSCC-derived cancer stem cells (CSCs) may be involved. Several reports have coupled non-viral gene delivery with RNA interference (RNAi) to target specific genes in cancer cells. However, the delivery efficiency...


    pub_type: 杂志文章


    authors: Lo WL,Chien Y,Chiou GY,Tseng LM,Hsu HS,Chang YL,Lu KH,Chien CS,Wang ML,Chen YW,Huang PI,Hu FW,Yu CC,Chu PY,Chiou SH

    更新日期:2012-05-01 00:00:00

  • The use of biotinylated-EGF-modified gelatin nanoparticle carrier to enhance cisplatin accumulation in cancerous lungs via inhalation.

    abstract::To develop a polymer-anticancer drug conjugate, we employed gelatin nanoparticles (GPs) as carriers of cisplatin (CDDP) with anticipated improved therapeutic effect and reduced side effects. The anticancer activities of CDDP-incorporated in GPs (GP-Pt) with biotinylated-EGF (bEGF) modification (GP-Pt-bEGF) were studie...


    pub_type: 杂志文章


    authors: Tseng CL,Su WY,Yen KC,Yang KC,Lin FH

    更新日期:2009-07-01 00:00:00

  • Bioactivation of an anorganic bone matrix by P-15 peptide for the promotion of early bone formation.

    abstract::This animal experiment compared the regenerative processes within defined bony defects of the porcine skull after delivery of routinely utilized bone graft materials: anorganic bone matrix (ABM) and an identical ABM carrying the cell binding peptide P-15. Particulated autogenous bone was used as a control group. The c...


    pub_type: 杂志文章


    authors: Thorwarth M,Schultze-Mosgau S,Wehrhan F,Kessler P,Srour S,Wiltfang J,Andreas Schlegel K

    更新日期:2005-10-01 00:00:00

  • Inactivation of encapsulated cells and their therapeutic effects by means of TGL triple-fusion reporter/biosafety gene.

    abstract::The immobilization of cells within alginate-poly-l-lysine-alginate (APA) microcapsules has been demonstrated to be an effective technology design for long term delivery of therapeutic products. Despite promising advances, biosafety aspects still remain to be improved. Here, we describe a complete characterization of t...


    pub_type: 杂志文章


    authors: Santos E,Larzabal L,Calvo A,Orive G,Pedraz JL,Hernández RM

    更新日期:2013-01-01 00:00:00

  • The promotion of functional recovery and nerve regeneration after spinal cord injury by lentiviral vectors encoding Lingo-1 shRNA delivered by Pluronic F-127.

    abstract::Lingo-1 is selectively expressed on both oligodendrocytes and neurons in the central nervous system (CNS) and serves as a key negative regulator of nerve regeneration, implying a therapeutic target for spinal cord injury (SCI). Here we described a strategy to knock-down Lingo-1 expression in vivo using lentiviral vect...


    pub_type: 杂志文章


    authors: Wu HF,Cen JS,Zhong Q,Chen L,Wang J,Deng DY,Wan Y

    更新日期:2013-02-01 00:00:00

  • When stem cells meet graphene: Opportunities and challenges in regenerative medicine.

    abstract::Recent advances in stem cell research and nanotechnology have significantly influenced the landscape of tissue engineering and regenerative medicine. Precise and reproducible control of the fate of stem cells and their lineage specification have, therefore, become more crucial than ever for the success of stem cell-ba...


    pub_type: 杂志文章,评审


    authors: Kenry,Lee WC,Loh KP,Lim CT

    更新日期:2018-02-01 00:00:00

  • Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates.

    abstract::Three-dimensional (3D) culture of hepatocytes leads to improved and prolonged synthetic and metabolic functions, but the underlying molecular mechanisms are unknown. In order to investigate the role of 3D cell-cell interactions in maintaining hepatocyte differentiated functions ex vivo, primary mouse hepatocytes were ...


    pub_type: 杂志文章


    authors: Chang TT,Hughes-Fulford M

    更新日期:2014-02-01 00:00:00

  • Effect of lysozyme on the stability of polyester nanocapsules and nanoparticles: stabilization approaches.

    abstract::The efficacy of colloidal particles as drug carriers is closely related to their interaction with proteins and enzymes in different body fluids. In the present work, we analysed the interaction phenomenon between lysozyme (LZM), a positively charged enzyme that is highly concentrated in mucosas, and two different drug...


    pub_type: 杂志文章


    authors: Calvo P,Vila-Jato JL,Alonso MJ

    更新日期:1997-10-01 00:00:00

  • Multifunctional rare-earth self-assembled nanosystem for tri-modal upconversion luminescence /fluorescence /positron emission tomography imaging.

    abstract::Rare-earth upconversion nanoparticles (UCNP) which can absorb low-energy photons and emit high energy photons have attracted great interest not only because of their unique application in upconversion luminescence imaging, but also because they can be used as ideal building blocks for multimodal bioimaging probes. Imp...


    pub_type: 杂志文章


    authors: Liu Q,Chen M,Sun Y,Chen G,Yang T,Gao Y,Zhang X,Li F

    更新日期:2011-11-01 00:00:00

  • Modulation of cell-cell interactions for neural tissue engineering: Potential therapeutic applications of cell adhesion molecules in nerve regeneration.

    abstract::Neural tissue engineering holds great promise in repairing damaged nerve tissues. However, despite the promising results in regenerating the injured nervous system, tissue engineering approaches are still insufficient to result in full functional recovery in severe nerve damages. Majority of these approaches only focu...


    pub_type: 杂志文章,评审


    authors: Chooi WH,Chew SY

    更新日期:2019-03-01 00:00:00

  • Targeted reversal and phosphorescence lifetime imaging of cancer cell metabolism via a theranostic rhenium(I)-DCA conjugate.

    abstract::Cancer cell metabolism is quite different from normal cells. Targeting cancer metabolism and untuning the tumor metabolic machine has emerged as a promising strategy for cancer therapy. We have developed a multi-functional Re-dca conjugate (Re-dca 2) by conjugating the metabolic modulator dichloroacetate (DCA) to mito...


    pub_type: 杂志文章


    authors: Yang J,Cao Q,Zhang H,Hao L,Zhou D,Gan Z,Li Z,Tong YX,Ji LN,Mao ZW

    更新日期:2018-09-01 00:00:00

  • Mechanical properties and aesthetics of FRP orthodontic wire fabricated by hot drawing.

    abstract::The FRP wires 0.5 mm in diameter with a multiple fiber structure were fabricated by drawing the fiber polymer complex at 250 degrees C for an esthetic, transparent orthodontic wire. Biocompatible CaO-P2O5-SiO2-Al2O3 (CPSA) glass fibers of 8-20 microm in diameter were oriented unidirectionally in the longitudinal direc...


    pub_type: 杂志文章


    authors: Imai T,Watari F,Yamagata S,Kobayashi M,Nagayama K,Toyoizumi Y,Nakamura S

    更新日期:1998-12-01 00:00:00

  • The use of PVP as a polymeric carrier to improve the plasma half-life of drugs.

    abstract::To achieve an optimum drug delivery such as targeting or controlled release utilizing bioconjugation with polymeric modifier, the conjugate between drugs and polymeric modifiers must be designed to show desirable pharmacokinetic characteristics in vivo. In this study, we assessed the biopharmaceutical properties of va...


    pub_type: 杂志文章


    authors: Kaneda Y,Tsutsumi Y,Yoshioka Y,Kamada H,Yamamoto Y,Kodaira H,Tsunoda S,Okamoto T,Mukai Y,Shibata H,Nakagawa S,Mayumi T

    更新日期:2004-07-01 00:00:00

  • Trilayer micelles for combination delivery of rapamycin and siRNA targeting Y-box binding protein-1 (siYB-1).

    abstract::A three layer (trilayer) polymeric micelle system based on the self-association of the triblock polymer poly(ethylene glycol)-b-poly{N-[N-(2-aminoethyl)-2-aminoethyl] aspartamide}-b-poly(ε-caprolactone) (PEG-b-PAsp(DET)-b-PCL) has been synthesized and investigated for combination delivery of rapamycin (RAP) and siRNA ...


    pub_type: 杂志文章


    authors: Zeng S,Xiong MP

    更新日期:2013-09-01 00:00:00

  • Drug delivery from gold and titanium surfaces using self-assembled monolayers.

    abstract::Currently available drug-eluting stents (DES) use polymers for coating and releasing drugs. Increasing evidence suggests that inflammatory and hypersensitive reactions are caused by such polymer coatings. This study focused on developing new techniques for delivering drugs directly from metal implant surfaces. Hydroxy...


    pub_type: 杂志文章


    authors: Mani G,Johnson DM,Marton D,Feldman MD,Patel D,Ayon AA,Agrawal CM

    更新日期:2008-12-01 00:00:00

  • Stimulated release of photosensitizers from graft and diblock micelles for photodynamic therapy.

    abstract::To understand the effect of photosensitizer (PS) release from graft copolymer based micelles in photodynamic therapy (PDT), the two pH-sensitive and non-pH-sensitive graft copolymers, (poly(N-vinyly caprolactam)-g-poly(D,L-lactide) and poly(N-vinyly caprolactam-co-N-vinyl imidazole)-g-poly(D,L-lactide)), were synthesi...


    pub_type: 杂志文章


    authors: Tsai HC,Tsai CH,Lin SY,Jhang CR,Chiang YS,Hsiue GH

    更新日期:2012-02-01 00:00:00

  • Relationship between 3T3 cell spreading and the strength of adhesion on glass and silane surfaces.

    abstract::Cell detachment by laminar shear stresses was used to characterize cellular interactions with hydrophilic glass and hydrophobic silane. In this study, we examined whether smaller, rounder cells were preferentially detached by laminar flow, and whether cell detachment occurred by dissociation of adhesion proteins and t...


    pub_type: 杂志文章


    authors: Truskey GA,Proulx TL

    更新日期:1993-01-01 00:00:00

  • Differential internalization of amphotericin B--conjugated nanoparticles in human cells and the expression of heat shock protein 70.

    abstract::Although a variety of nanoparticles (NPs) functionalized with amphotericin B, an antifungal agent widely used in the clinic, have been studied in the last years their cytotoxicity profile remains elusive. Here we show that human endothelial cells take up high amounts of silica nanoparticles (SNPs) conjugated with amph...


    pub_type: 杂志文章


    authors: Paulo CS,Lino MM,Matos AA,Ferreira LS

    更新日期:2013-07-01 00:00:00

  • Lactose mediated liver-targeting effect observed by ex vivo imaging technology.

    abstract::Two kinds of micelles containing Rhodamine B were prepared by a solvent evaporation method. One (Lac-f-micelles: lactose-free micelles) was from a Rhodamine-containing copolymer, poly(ethylene glycol)-b-poly(l-lactide-co-2,2-dihydroxylmethyl-propylene carbonate/Rhodamine) [PEG(5000)-b-P(LA(4000)-co-DHP(600)/Rhodamine)...


    pub_type: 杂志文章


    authors: Ma P,Liu S,Huang Y,Chen X,Zhang L,Jing X

    更新日期:2010-03-01 00:00:00

  • Extraction of high quality RNA from polysaccharide matrices using cetyltrimethylammonium bromide.

    abstract::Polysaccharides are increasingly being used as biomaterials for tissue engineering and regenerative medicine. Quantitative analysis of gene expression from cells in three-dimensional (3D) scaffolds requires extraction of messenger RNA, which is complicated in polysaccharide materials by ionic complexing between nuclei...


    pub_type: 杂志文章


    authors: Wang L,Stegemann JP

    更新日期:2010-03-01 00:00:00

  • Histological evaluation of the biocompatibility of a glass-ionomer cement in rat alveolus.

    abstract::A type III glass-ionomer cement (Vidrion F), currently used as fast-setting lining material and fissure sealant, was implanted into rat dental alveolus immediately after tooth extraction and its biocompatibility was analysed in terms of incorporation into alveolar bone in the wound healing process. Histological and hi...


    pub_type: 杂志文章


    authors: Brentegani LG,Bombonato KF,Carvalho TL

    更新日期:1997-01-01 00:00:00

  • Phase-contrast imaging of thin biomaterials.

    abstract::The necessity of information about the inner microscopical features of low absorbing materials is one of the most important goals in the structural research field. So far, non destructive analysis have been performed using contact radiography giving the scope for great advances in the production and application of new...


    pub_type: 杂志文章


    authors: Baruchel J,Lodini A,Romanzetti S,Rustichelli F,Scrivani A

    更新日期:2001-06-01 00:00:00

  • Anti-Flt1 peptide - hyaluronate conjugate for the treatment of retinal neovascularization and diabetic retinopathy.

    abstract::Anti-angiogenic therapeutics has been investigated extensively for the treatment of retinal and choroidal vascular diseases, and diabetic retinopathy. Anti-Flt1 peptide of GNQWFI is an antagonistic peptide for vascular endothelial growth factor receptor 1 (VEGFR1 or Flt1) inhibiting VEGFR1-mediated endothelial cell mi...


    pub_type: 杂志文章


    authors: Oh EJ,Choi JS,Kim H,Joo CK,Hahn SK

    更新日期:2011-04-01 00:00:00

  • The synovial response to intra-articular acrylic cement particles in guinea pigs.

    abstract::The histology and cytology of the tissue response to intra-articular insertion of particles of acrylic bone cement containing barium sulphate has been studied in the guinea pig knee joint. Following insertion of the acrylic, fibrinous debris admixed with particles became adherent to the synovial membrane. Cell prolife...


    pub_type: 杂志文章


    authors: Meachim G,Brooke G

    更新日期:1984-03-01 00:00:00

  • Tear and rupture of elastomeric dental impression materials.

    abstract::The curing time dependence of the tear energy, tensile strength and ultimate extension ratio of a range of characterized elastomeric impression materials was investigated. This variation of tensile strength and ultimate extension ratio was correlated with the development of the network structure. The tear energy showe...


    pub_type: 杂志文章


    authors: Cook WD,Liem F,Russo P,Scheiner M,Simkiss G,Woodruff P

    更新日期:1984-09-01 00:00:00

  • Metal release from dental biomaterials.

    abstract::Levels of corrosion products released from dental alloys in natural or synthetic saliva, i.e. from amalgams, cobalt, gold, nickel, iron, or titanium based alloys have been surveyed. The amounts of Ag, Au, Cd, Co, Cr, Cu, Hg, Mo, Ti or Ni released from such alloys, either in vitro or in vivo during animal tests or duri...


    pub_type: 杂志文章,评审


    authors: Brune D

    更新日期:1986-05-01 00:00:00

  • Phospholipid decoration of microcapsules containing perfluorooctyl bromide used as ultrasound contrast agents.

    abstract::We present here an easy method to modify the surface chemistry of polymeric microcapsules of perfluorooctyl bromide used as ultrasound contrast agents (UCAs). Capsules were obtained by a solvent emulsification-evaporation process with phospholipids incorporated in the organic phase before emulsification. Several phosp...


    pub_type: 杂志文章


    authors: Díaz-López R,Tsapis N,Libong D,Chaminade P,Connan C,Chehimi MM,Berti R,Taulier N,Urbach W,Nicolas V,Fattal E

    更新日期:2009-03-01 00:00:00

  • Cartilage regeneration using mesenchymal stem cells and a PLGA-gelatin/chondroitin/hyaluronate hybrid scaffold.

    abstract::The study was to produce a novel hybrid poly-(lactic-co-glycolic acid) (PLGA)-gelatin/chondroitin/hyaluronate (PLGA-GCH) scaffold and evaluate its potentials in cartilage repair. The porous PLGA-GCH scaffold was developed to mimic the natural extra cellular matrix of cartilage. The differentiated mesenchymal stem cell...


    pub_type: 杂志文章


    authors: Fan H,Hu Y,Zhang C,Li X,Lv R,Qin L,Zhu R

    更新日期:2006-09-01 00:00:00