Tissue engineering scaffolds using superstructures.

abstract：:Two vinyl sulfone functionalized crosslinkers were developed for the purpose of preparing degradable poly(ethylene glycol) (PEG) hydrogels (EMXL and GABA-EMXL hydrogels). A self-elimination degradation mechanism in which an N-terminal residue of a glutamine is converted to pyroglutamic acid with subsequent release of ...

journal_title：Biomaterials

authors： Deshmukh M,Singh Y,Gunaseelan S,Gao D,Stein S,Sinko PJ

更新日期：2010-09-01 00:00:00

abstract：:Hydrogels are commonly used as artificial extracellular matrices for 3D cell culture and for tissue engineering. Viscoelastic hydrogels with tunable stress relaxation have recently been developed, and stress relaxation in the hydrogels has been found to play a key role in regulating cell behaviors such as differentiat...

journal_title：Biomaterials

authors： Nam S,Stowers R,Lou J,Xia Y,Chaudhuri O

更新日期：2019-04-01 00:00:00

abstract：:The micro-environment is an important factor in the differentiation of cultured stem cells for the purpose of site specific transplantation. In an attempt to optimize differentiation conditions, co-culture systems composed of both stem cells and primary cells or cell lines were used in hydrogel with in vitro and in vi...

journal_title：Biomaterials

authors： Park JS,Yang HN,Woo DG,Kim H,Na K,Park KH

更新日期：2010-10-01 00:00:00

abstract：:In vivo tracking of transplanted stem cells has been a central aim of stem cell therapy. Although many tracking systems have been introduced, no method has yet been validated for clinical applications. We developed a novel sophisticated peptide (GV1001) that mimics hTERT (human telomerase reverse transcriptase) and an...

journal_title：Biomaterials

authors： Park HH,Lee KY,Park DW,Choi NY,Lee YJ,Son JW,Kim S,Moon C,Kim HW,Rhyu IJ,Koh SH

更新日期：2018-02-01 00:00:00

abstract：:Endothelial cells derived from the bovine pulmonary artery (line CPAE, CCL 209, American Tissue Culture Collection, Rockville, MD, USA) were cultured on pristine or fluorine ion-irradiated polystyrene (5 x 10(12) or 5 x 10(14) F ions/cm2, 150 keV). At 24-h post-seeding interval, the number of cells which adhered to th...

journal_title：Biomaterials

authors： Bacáková L,Mares V,Lisá V,Svorcík V

更新日期：2000-06-01 00:00:00

abstract：:An independent assessment was performed of the results of woven carbon implants of mesh or rods into articular cartilage defects performed by two surgeons in the knees of 96 patients. Eight had symptomatic osteochondritis, 31 had chondromalacia patellae and 57 had early osteoarthritis. They were reviewed up to 5 yr af...

journal_title：Biomaterials

authors： Pongor P,Betts J,Muckle DS,Bentley G

更新日期：1992-01-01 00:00:00

abstract：:We have recently reported on an ultrafast degrading tyrosine-derived terpolymer that degrades and resorbs within hours, and is suitable for use in cortical neural prosthetic applications. Here we further characterize this polymer, and describe a new tyrosine-derived fast degrading terpolymer in which the poly(ethylene...

journal_title：Biomaterials

authors： Lewitus DY,Smith KL,Shain W,Bolikal D,Kohn J

更新日期：2011-08-01 00:00:00

abstract：:Introducing drugs into gene delivery systems to fabricate co-delivery systems for synergy therapy has become a promising strategy for tumor therapy. In this study, a dual responsive co-delivery system RHD/p53 was fabricated to enhance the antitumor efficacy with a low dose of doxorubicin (DOX). The reducible branched ...

journal_title：Biomaterials

authors： Chen S,Lei Q,Li SY,Qin SY,Jia HZ,Cheng YJ,Zhang XZ

更新日期：2016-06-01 00:00:00

abstract：:The in vitro adhesion and spreading of human endothelial cells (HEC) on hydrophobic poly(ethylene terephthalate) (PETP) and moderately wettable tissue culture poly(ethylene terephthalate) (TCPETP) were studied with light microscopy and electron microscopy. Numbers of HEC adhering on TCPETP were always higher than thos...

journal_title：Biomaterials

authors： van Wachem PB,Schakenraad JM,Feijen J,Beugeling T,van Aken WG,Blaauw EH,Nieuwenhuis P,Molenaar I

更新日期：1989-10-01 00:00:00

abstract：:Fluorapatite (FA)-collagen composites were synthesized via a biomimetic coprecipitation method in order to improve the structural stability and cellular responses. Different amounts of ammonium fluoride (NH4F), acting as a fluorine source for FA, were added to the precipitation of the composites. The precipitated comp...

journal_title：Biomaterials

authors： Yoon BH,Kim HW,Lee SH,Bae CJ,Koh YH,Kong YM,Kim HE

更新日期：2005-06-01 00:00:00

abstract：:A range of poly(alkyl methacrylate)s in the range C5 to C13 with varying degrees of crosslinking, have been studied with respect to stress-strain behaviour. Where the extensions to break were sufficiently high, stress-strain properties conformed well to the statistical theory of rubber elasticity, the Mooney/Rivlin C2...

journal_title：Biomaterials

authors： Davy KW,Braden M

更新日期：1987-09-01 00:00:00

abstract：:Bioactive hydrogels formed from the Michael-type addition reactions of end-functionalized poly (ethylene glycol) macromers with thiol-containing protease-sensitive peptide crosslinkers have previously been described as matrices for cell-induced enzymatic remodeling. In this study, we sought to develop materials formul...

journal_title：Biomaterials

authors： Patterson J,Hubbell JA

更新日期：2011-02-01 00:00:00

abstract：:The first calcium phosphate cements (CPCs) were discovered in the 1980s. Two decades later, the interest for these materials is still rising. The goal of the present document is to review the most recent achievements in the field and to analyze future directions in research and development. ...

journal_title：Biomaterials

authors： Bohner M,Gbureck U,Barralet JE

更新日期：2005-11-01 00:00:00

abstract：:Cationic solid lipid nanoparticles (cSLNs) are promising nanoparticles for controlled drug delivery. Increasing surface charge and/or reducing PEG density enhance cellular uptake of cSLNs in vitro, but for unknown reasons fail to improve drug delivery in vivo. Herein, we show that cSLNs present a risk for systemic pla...

journal_title：Biomaterials

authors： Wu X,Chen H,Wu C,Wang J,Zhang S,Gao J,Wang H,Sun T,Yang YG

更新日期：2018-02-01 00:00:00

abstract：:The aim of this work was to develop a new type of D-alpha-tocopheryl polyethylene glycol 1000 succinate mono-ester (TPGS) coated multi-functional (theranostic) liposomes, which contain both docetaxel and quantum dots (QDs) for cancer imaging and therapy. Non-targeting and folate receptor targeting TPGS coated theranos...

journal_title：Biomaterials

authors： Muthu MS,Kulkarni SA,Raju A,Feng SS

更新日期：2012-04-01 00:00:00

abstract：:Bioactive glass is used as both a bone filler and as a coating on implants, and has been advocated as a potential osteogenic scaffold for tissue engineering. Rat-derived mesenchymal stem cells (MSCs) show elevated levels of alkaline phosphatase activity when grown on 45S5 bioactive glass as compared to standard tissue...

journal_title：Biomaterials

authors： Reilly GC,Radin S,Chen AT,Ducheyne P

更新日期：2007-10-01 00:00:00

abstract：:Decellularization techniques have been widely used as an alternative strategy for organ reconstruction. However, the compliance of tracheal or laryngeal tissues can be increased during the decellularization process, which might cause postoperative stenosis due to elimination of chondrocytes. The purpose of our study w...

journal_title：Biomaterials

authors： Ma R,Li M,Luo J,Yu H,Sun Y,Cheng S,Cui P

更新日期：2013-02-01 00:00:00

abstract：:High throughput cellular studies require small sample volume to reduce costs and enhance sensitivity. Microfluidics-generated water-in-oil (W/O) single emulsion droplet systems, in particular, provide uniform, well defined and discrete microenvironment for cell culture, screening, and sorting. However, these single em...

journal_title：Biomaterials

authors： Zhang Y,Ho YP,Chiu YL,Chan HF,Chlebina B,Schuhmann T,You L,Leong KW

更新日期：2013-06-01 00:00:00

abstract：:Osteoinductive biomaterials are promising for bone repair. There is no direct proof that bone marrow mesenchymal stem cells (BMSCs) home to non-osseous sites and participate in ectopic bone formation induced by osteoinductive bioceramics. The objective of this study was to use a sex-mismatched beagle dog model to inve...

journal_title：Biomaterials

authors： Song G,Habibovic P,Bao C,Hu J,van Blitterswijk CA,Yuan H,Chen W,Xu HH

更新日期：2013-03-01 00:00:00

abstract：:Photodynamic therapy (PDT) induced hypoxia can significantly upregulate the expression of vascular endothelial growth factor (VEGF) at the tumor-stromal interface, resulting in a promoted angiogenesis. Thus, an angiogenesis vessel-targeting nanoparticle (AVT-NP) consisting of photosensitizer, angiogenic vessel-targeti...

journal_title：Biomaterials

authors： Guo D,Xu S,Wang N,Jiang H,Huang Y,Jin X,Xue B,Zhang C,Zhu X

更新日期：2017-11-01 00:00:00

abstract：:In this study, we quantified the adsorption of immunoglobulin G (IgG) protein onto several polyelectrolyte-modified sintered porous polyethylene (PPE) membranes. The polymer surfaces had both cationic and anionic charges obtained via the adsorption of polyethylenimine (PEI) and polyacrylic acid (PAA), respectively, on...

journal_title：Biomaterials

authors： Greene G,Radhakrishna H,Tannenbaum R

更新日期：2005-10-01 00:00:00

abstract：:We present a new ultrasonic technique for monitoring the entire setting process of injectable bone cement. The problem with existing standards is their subjectivity. Because of this the results are not comparable between different research groups. A strong advantage with the proposed technique is that it is non-invasi...

journal_title：Biomaterials

authors： Carlson J,Nilsson M,Fernández E,Planell JA

更新日期：2003-01-01 00:00:00

abstract：:A bilayer artificial skin composed of a silicone sheet and a collagen sponge sheet was developed by us in 1986, modifying Yannas and Burke's technique. It was used in experimental animals and clinically, both with success; but the artificial skin was inconvenient for clinical use in terms of disinfection and preservat...

journal_title：Biomaterials

authors： Matsuda K,Suzuki S,Isshiki N,Ikada Y

更新日期：1993-10-01 00:00:00

abstract：:The engineering of living tissues in vivo requires new concepts in cell culture technology. In contrast to conventional cell cultures, the development of tissues depends on a three-dimensional arrangement of cells and the formation or synthesis of an appropriate extracellular matrix. Special emphasis is given to the m...

journal_title：Biomaterials

authors： Sittinger M,Bujia J,Rotter N,Reitzel D,Minuth WW,Burmester GR

更新日期：1996-02-01 00:00:00

abstract：:We investigated the biological response of human pluripotent stem cells (hPSCs) cultured on a carbon nanotube (CNT) array-based substrate with the long term goal to direct hPSC germ layer specification for a wide variety of tissue engineering applications. CNT arrays were fabricated using a chemical vapor deposition s...

journal_title：Biomaterials

authors： Pryzhkova MV,Aria I,Cheng Q,Harris GM,Zan X,Gharib M,Jabbarzadeh E

更新日期：2014-06-01 00:00:00

abstract：:Polyvinyl alcohol (PVA) cylindrical hydrogel with a stiffness gradient was prepared using a simple liquid nitrogen (LN2)-contacting gradual freezing and thawing method in order to investigate the effects of substrate stiffness on stem cell differentiation into specific cell types. The prepared cylindrical PVA hydrogel...

journal_title：Biomaterials

authors： Kim TH,An DB,Oh SH,Kang MK,Song HH,Lee JH

更新日期：2015-02-01 00:00:00

abstract：:The present work demonstrates that Cy5.5 conjugated Fe(3)O(4)/SiO(2) core/shell nanoparticles could allow us to control movement of human natural killer cells (NK-92MI) by an external magnetic field. Required concentration of the nanoparticles for the cell manipulation is as low as ~20 μg Fe/mL. However, the relative ...

journal_title：Biomaterials

authors： Jang ES,Shin JH,Ren G,Park MJ,Cheng K,Chen X,Wu JC,Sunwoo JB,Cheng Z

更新日期：2012-08-01 00:00:00

abstract：:Recapitulation of the cellular microenvironment of the heart, which promotes cell contraction, remains a key challenge in cardiac tissue engineering. We report here on our work, where for the first time, a 3-dimensional (3D) spring-like fiber scaffold was fabricated, successfully mimicking the coiled perimysial fibers...

journal_title：Biomaterials

authors： Fleischer S,Feiner R,Shapira A,Ji J,Sui X,Daniel Wagner H,Dvir T

更新日期：2013-11-01 00:00:00

abstract：:Prostate cancer (PCa) is a leading cause of death for men worldwide. Most PCa patients die from metastasis and bone is the most common metastatic site. Three dimensional (3D) porous chitosan-alginate (CA) scaffolds were developed for bone tissue engineering and demonstrated for culture of cancer cells and enrichment o...

journal_title：Biomaterials

authors： Xu K,Ganapathy K,Andl T,Wang Z,Copland JA,Chakrabarti R,Florczyk SJ

更新日期：2019-10-01 00:00:00

abstract：:We have developed a family of synthetic biodegradable polymers that are composed of structural units endogenous to the human metabolism, designated poly(polyol sebacate) (PPS) polymers. Material properties of PPS polymers can be tuned by altering the polyol monomer and reacting stiochiometric ratio of sebacic acid. Th...

journal_title：Biomaterials

authors： Bruggeman JP,de Bruin BJ,Bettinger CJ,Langer R

更新日期：2008-12-01 00:00:00