Tissue engineering scaffolds using superstructures.

abstract：:The introduction of metal-on-metal total disc replacements motivated studies to evaluate the effects of cobalt-chromium (CoCr) nanoparticles on cells of the dura mater. Porcine fibroblasts and epithelial cells isolated from the dura mater were cultured with clinically-relevant CoCr nanoparticles and the ions, generate...

journal_title：Biomaterials

authors： Behl B,Papageorgiou I,Brown C,Hall R,Tipper JL,Fisher J,Ingham E

更新日期：2013-05-01 00:00:00

abstract：:In this study, a type of intracellular redox-triggered hollow mesoporous silica nanoreservoirs (HMSNs) with tumor specificity was developed in order to deliver anticancer drug (i.e., doxorubicin (DOX)) to the target tumor cells with high therapeutic efficiency and reduced side effects. Firstly, adamantanamine was graf...

journal_title：Biomaterials

authors： Luo Z,Hu Y,Cai K,Ding X,Zhang Q,Li M,Ma X,Zhang B,Zeng Y,Li P,Li J,Liu J,Zhao Y

更新日期：2014-09-01 00:00:00

abstract：:Enterococcus faecalis is an opportunistic pathogen, which today represents one of the leading aetiologic agents of nosocomial infections and, increasingly, of implant infections. Here, in a collection of 43 E. faecalis isolated from implant orthopaedic infections, virulence-related phenotypes (biofilm and gelatinase p...

journal_title：Biomaterials

authors： Arciola CR,Baldassarri L,Campoccia D,Creti R,Pirini V,Huebner J,Montanaro L

更新日期：2008-02-01 00:00:00

abstract：:The genesis of bone and teeth involves highly coordinated processes, which involve multiple cell types and proteins that direct the nucleation and crystallization of inorganic hydroxyapatite (HA). Recent studies have shown that peptides mediate the nucleation process, control HA microstructure or even inhibit HA miner...

journal_title：Biomaterials

authors： Weiger MC,Park JJ,Roy MD,Stafford CM,Karim A,Becker ML

更新日期：2010-04-01 00:00:00

abstract：:Local signals from tissue-specific extracellular matrix (ECM) microenvironments, including matrix adhesive ligand, mechanical elasticity and micro-scale geometry, are known to instruct a variety of stem cell differentiation processes. Likewise, these signals converge to provide multifaceted, mechanochemical cues for h...

journal_title：Biomaterials

authors： Floren M,Tan W

更新日期：2015-08-01 00:00:00

abstract：:Riboflavin (Rf) and its metabolic analogs flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are essential for normal cellular growth and function. Their intracellular transport is regulated by the riboflavin carrier protein (RCP), which has been shown to be over-expressed by metabolically active cancer...

journal_title：Biomaterials

authors： Jayapaul J,Arns S,Lederle W,Lammers T,Comba P,Gätjens J,Kiessling F

更新日期：2012-12-01 00:00:00

abstract：:Physicochemical features of a cell nanoenvironment exert important influence on stem cell behavior and include the influence of matrix elasticity and topography on differentiation processes. The presence of growth factors such as TGF-β and BMPs on these matrices provides chemical cues and thus plays vital role in dire...

journal_title：Biomaterials

authors： Das RK,Zouani OF

更新日期：2014-07-01 00:00:00

abstract：:Rapid prototyping is a novel process for the production of scaffolds of predetermined size and three-dimensional shape. The aim of the study was to determine the feasibility of this technology for producing scaffolds for tissue engineering an aortic valve and the optimal concentration of collagen processed in this man...

journal_title：Biomaterials

authors： Taylor PM,Sachlos E,Dreger SA,Chester AH,Czernuszka JT,Yacoub MH

更新日期：2006-05-01 00:00:00

abstract：:Biologic scaffold materials composed of extracellular matrix (ECM) are typically derived by processes that involve decellularization of tissues or organs. Preservation of the complex composition and three-dimensional ultrastructure of the ECM is highly desirable but it is recognized that all methods of decellularizati...

journal_title：Biomaterials

authors： Crapo PM,Gilbert TW,Badylak SF

更新日期：2011-04-01 00:00:00

abstract：:Recent advances in materials development and tissue engineering has resulted in a substantial number of bioinspired materials that recapitulate cardinal features of bone extracellular matrix (ECM) such as dynamic inorganic and organic environment(s), hierarchical organization, and topographical features. Bone mimickin...

journal_title：Biomaterials

authors： Shih YV,Varghese S

更新日期：2019-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the loss of neurogenesis and excessive induction of apoptosis. The induction of neurogenesis and inhibition of apoptosis may be a promising therapeutic approach to combating the disease. Celecoxib (CB), a cyclooxygenase-2 specific inhibitor, could offer neuroprotection. Spe...

journal_title：Biomaterials

authors： Guo JW,Guan PP,Ding WY,Wang SL,Huang XS,Wang ZY,Wang P

更新日期：2017-11-01 00:00:00

abstract：:Bacterial infection has been a threat to human health, and so early diagnosis and treatment of bacterial infection is an urgent problem that needs to be solved. In this work, a multifunctional theranostic selenium nanoplatform (Se@PEP-Ru NPs) with early imaging diagnosis and efficient treatment of bacterial infections...

journal_title：Biomaterials

authors： Huang N,Chen X,Zhu X,Xu M,Liu J

更新日期：2017-10-01 00:00:00

abstract：:Biodegradable polylactide implants allow secure fixation of osteochondral fractures with minimal adverse effects. The goal of this prospective, randomized animal study was to show whether osteoconductive effects can be achieved through the development of poly-L/DL(70/30)lactide composite implants with 10% beta-tricalc...

journal_title：Biomaterials

authors： Prokop A,Jubel A,Hahn U,Dietershagen M,Bleidistel M,Peters C,Höfl A,Rehm KE

更新日期：2005-07-01 00:00:00

abstract：:The long-term patency rates of vascular grafts and stents are limited by the lack of surface endothelialisation of the implanted materials. We have previously reported that GRGDS and WQPPRARI peptide micropatterns increase the endothelialisation of prosthetic materials in vitro. To investigate the mechanisms by which ...

journal_title：Biomaterials

authors： Hoesli CA,Garnier A,Juneau PM,Chevallier P,Duchesne C,Laroche G

更新日期：2014-01-01 00:00:00

abstract：:The curing time dependence of the tear energy, tensile strength and ultimate extension ratio of a range of characterized elastomeric impression materials was investigated. This variation of tensile strength and ultimate extension ratio was correlated with the development of the network structure. The tear energy showe...

journal_title：Biomaterials

authors： Cook WD,Liem F,Russo P,Scheiner M,Simkiss G,Woodruff P

更新日期：1984-09-01 00:00:00

abstract：:Local delivery systems that provide sustained, high concentrations of antitumor cytokines in the tumor microenvironment while minimizing systemic dissemination are needed to realize the potential of cytokine-based immunotherapies. Recently, co-formulations of cytokines with chitosan solutions have been shown to increa...

journal_title：Biomaterials

authors： Yang L,Zaharoff DA

更新日期：2013-05-01 00:00:00

abstract：:Hydroxy-fluorapatites (OH-FAps) occur biologically in teeth and form the basis for application as biomaterials. This work aims to synthesize a series of fluoride substituted calcium hydroxyapatites (OHAps) to determine how fluoride influences the synthesis and the resulting characteristics of solid solutions. OH-FAPs ...

journal_title：Biomaterials

authors： Rodríguez-Lorenzo LM,Hart JN,Gross KA

更新日期：2003-09-01 00:00:00

abstract：:The use of biochemical signaling to derive smooth muscle cells (SMCs) from mesenchymal stem cells (MSCs) has been explored, but the induction of a fully functional SMC phenotype remains to be a major challenge. Cell morphology has been shown to regulate MSC differentiation into various lineages, including SMCs. We eng...

journal_title：Biomaterials

authors： Yeh YT,Wei J,Thorossian S,Nguyen K,Hoffman C,Del Álamo JC,Serrano R,Li YJ,Wang KC,Chien S

更新日期：2019-06-01 00:00:00

abstract：:Bioceramic coatings, created by the high velocity oxy-fuel combustion spraying of hydroxyapatite (HA) powders onto commercially pure titanium, were characterized in order to determine whether this relatively new coating process can be successfully applied to bioceramic coatings of orthopaedic and dental implants. Four...

journal_title：Biomaterials

authors： Haman JD,Lucas LC,Crawmer D

更新日期：1995-02-01 00:00:00

abstract：:Adipose tissue engineering offers a promising alternative to the current breast reconstruction options. Here we investigated patient-specific breast scaffolds fabricated from poly(d,l)-lactide polymer with pore sizes>1 mm for their potential in long-term sustained regeneration of high volume adipose tissue. An optimis...

journal_title：Biomaterials

authors： Chhaya MP,Melchels FP,Holzapfel BM,Baldwin JG,Hutmacher DW

更新日期：2015-06-01 00:00:00

abstract：:Hydrophobically derivatized hyperbranched polyglycerol (HPG)-polyethylene glycol (PEG) polymers bearing stearoyl chains (HPG-C18-PEG) were originally developed as human serum albumin substitutes and further as a unimolecular drug delivery system. In view of these in vivo applications and the potential for membrane int...

journal_title：Biomaterials

authors： Liu Z,Janzen J,Brooks DE

更新日期：2010-04-01 00:00:00

abstract：:A technique for preparing micropatterns and gradients of proteins on polymeric substrates has been developed in this work. Peroxides were generated on the substrate surface by UV preirradiation and they initiated graft polymerization of acrylic acid (AA) onto the surface upon a second UV irradiation. Micropatterns and...

journal_title：Biomaterials

authors： Li B,Ma Y,Wang S,Moran PM

更新日期：2005-05-01 00:00:00

abstract：:The purpose of this study was to access tissue reactions to the outer prismatic (prism) and the inner nacreous (nacre) layers of the fresh water Margaritifera shell. The materials, in granule form, were implanted into the back muscles and femurs of rats for 1, 2, 4, 8 and 16 weeks. In the back muscles, a foreign body ...

journal_title：Biomaterials

authors： Liao H,Mutvei H,Sjöström M,Hammarström L,Li J

更新日期：2000-03-01 00:00:00

abstract：:The purpose of this work was to investigate new bone formation in macroporous iron foams coated with strontium (FeSr) or bisphosphonate (FeBiP) compared to plain iron foam (Fe) and empty defect in a critical size metaphyseal bone defect model in ovariectomized rats. 60 female rats were subjected to bilateral ovariecto...

journal_title：Biomaterials

authors： Ray S,Thormann U,Eichelroth M,Budak M,Biehl C,Rupp M,Sommer U,El Khassawna T,Alagboso FI,Kampschulte M,Rohnke M,Henß A,Peppler K,Linke V,Quadbeck P,Voigt A,Stenger F,Karl D,Schnettler R,Heiss C,Lips KS,Alt V

更新日期：2018-03-01 00:00:00

abstract：:Thrombomodulin (TM) is a newly described endothelial cell-associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. In this study, focussing on the application of TM for biomedical materials, recombinant human TM (hTM) was immobilized o...

journal_title：Biomaterials

authors： Kishida A,Ueno Y,Fukudome N,Yashima E,Maruyama I,Akashi M

更新日期：1994-08-01 00:00:00

abstract：:Myotube formation is crucial to restoring muscular functions, and biomaterials that enhance the myoblast differentiation into myotubes are highly desirable for muscular repair. Here, we report the synthesis of electroactive, ductile, and degradable copolymers and their application in enhancing the differentiation of m...

journal_title：Biomaterials

authors： Xie M,Wang L,Guo B,Wang Z,Chen YE,Ma PX

更新日期：2015-12-01 00:00:00

abstract：:Implanted materials, such as medical devices, provoke the body to initiate an inflammatory reaction, known as the foreign body reaction (FBR), which causes several complications for example in hip prostheses, silicone implants, peritoneal dialysis catheters and left ventricular assist devices. FBR is initiated by macr...

journal_title：Biomaterials

authors： Vranken I,De Visscher G,Lebacq A,Verbeken E,Flameng W

更新日期：2008-03-01 00:00:00

abstract：:Potential applications of engineered, functional, cardiac muscle extends from basic research through drug discovery to engineering heart tissue for transplantation. One of the central questions in cardiac tissue engineering is to understand and control the complex interactions between the cardiac muscle cells and thei...

journal_title：Biomaterials

authors： Das M,Molnar P,Gregory C,Riedel L,Jamshidi A,Hickman JJ

更新日期：2004-11-01 00:00:00

abstract：:One of the main issues in orthopaedic implant design is the fabrication of scaffolds that closely mimic the biomechanical properties of the surrounding bone. This research reports on a multi-stage rapid prototyping technique that was successfully developed to produce porous titanium scaffolds with fully interconnected...

journal_title：Biomaterials

authors： Ryan GE,Pandit AS,Apatsidis DP

更新日期：2008-09-01 00:00:00

abstract：:The aim of this study was to investigate the effects of alginate and agarose on the response of bone marrow stromal cells (BMSCs) to chondrogenic stimuli. Rat BMSCs were expanded in monolayer culture with or without FGF-2 supplementation. Cells were then seeded in 2% alginate and agarose gels and cultured in media wit...

journal_title：Biomaterials

authors： Coleman RM,Case ND,Guldberg RE

更新日期：2007-04-01 00:00:00