The fate of ultrafast degrading polymeric implants in the brain.

Abstract:

:We have recently reported on an ultrafast degrading tyrosine-derived terpolymer that degrades and resorbs within hours, and is suitable for use in cortical neural prosthetic applications. Here we further characterize this polymer, and describe a new tyrosine-derived fast degrading terpolymer in which the poly(ethylene glycol) (PEG) is replaced by poly(trimethylene carbonate) (PTMC). This PTMC containing terpolymer showed similar degradation characteristics but its resorption was negligible in the same period. Thus, changes in the polymer chemistry allowed for the development of two ultrafast degrading polymers with distinct difference in resorption properties. The in vivo tissue response to both polymers used as intraparenchymal cortical devices was compared to poly(lactic-co-glycolic acid) (PLGA). Slow resorbing, indwelling implant resulted in continuous glial activation and loss of neural tissue. In contrast, the fast degrading tyrosine-derived terpolymer that is also fast resorbing, significantly reduced both the glial response in the implantation site and the neuronal exclusion zone. Such polymers allow for brain tissue recovery, thus render them suitable for neural interfacing applications.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Lewitus DY,Smith KL,Shain W,Bolikal D,Kohn J

doi

10.1016/j.biomaterials.2011.04.052

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

5543-50

issue

24

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(11)00474-1

journal_volume

32

pub_type

杂志文章
  • Reaction of Ca2+ and phosphate ester.

    abstract::The reaction of calcium ions and organic phosphate ester monomer at varying pHs was examined. Above pH 10, poorly crystallized hydroxyapatite was formed, which had lower crystallinity than that synthesized with inorganic phosphate as a source of P under the same conditions. On the other hand, the results of X-ray diff...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(89)90045-8

    authors: Okazaki M,Hattori M

    更新日期:1989-03-01 00:00:00

  • Meniscal repair by fibrocartilage in the dog: characterization of the repair tissue and the role of vascularity.

    abstract::Lesions in the avascular part of 20 canine menisci were repaired by implantation of a porous polyurethane. Seven menisci were not repaired and served as controls. The repair tissue was characterized by biochemical and immunological analysis. The role of vascularity in healing was studied by perfusion of menisci with I...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(96)87648-4

    authors: Klompmaker J,Veth RP,Jansen HW,Nielsen HK,de Groot JH,Pennings AJ,Kuijer R

    更新日期:1996-09-01 00:00:00

  • Intercalation behavior and tensile strength of DNA-lipid films for the dental application.

    abstract::In this study, we prepared DNA-lipid films and examined their intercalation behavior and tensile strength as an indicator for usefulness as a dental material. The lipids were synthesized from the reaction of glycine, l-alanine, or l-glutamic acid with n-alkyl alcohol in the presence of p-toluenesulfonic acid. The self...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2004.01.006

    authors: Fukushima T,Hayakawa T,Inoue Y,Miyazaki K,Okahata Y

    更新日期:2004-11-01 00:00:00

  • Nanofiber-mediated controlled release of siRNA complexes for long term gene-silencing applications.

    abstract::Nanofiber scaffold-mediated delivery of small-interfering RNA (siRNA) holds great potential in regenerative medicine by providing biomimicking topographical signals and enhanced gene silencing effects to seeded cells. While the delivery of naked siRNA was demonstrated previously using poly (ε-caprolactone) (PCL) nanof...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2011.04.065

    authors: Rujitanaroj PO,Wang YC,Wang J,Chew SY

    更新日期:2011-09-01 00:00:00

  • Biostability and biological performance of a PDMS-based polyurethane for controlled drug release.

    abstract::Polymers have been used to deliver therapeutic agents in a range of medical devices with drug eluting stents being the most widespread current application. Although polymers enable controlled release of a therapeutic agent, the polymeric surface has been reported to provide suboptimal biocompatibility and haemocompati...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2008.04.007

    authors: Simmons A,Padsalgikar AD,Ferris LM,Poole-Warren LA

    更新日期:2008-07-01 00:00:00

  • A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles.

    abstract::The application of poly(hydroxybutyrate-co-hydroxyhexanoate) (PHBHHx) for sustained and controlled delivery of hydrophilic insulin was made possible by preparing insulin phospholipid complex loaded biodegradable PHBHHx nanoparticles (INS-PLC-NPs). The INS-PLC-NPs produced by a solvent evaporation method showed a spher...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2011.10.072

    authors: Peng Q,Zhang ZR,Gong T,Chen GQ,Sun X

    更新日期:2012-02-01 00:00:00

  • Shelf-life of bioprosthetic heart valves: a structural and mechanical study.

    abstract::This study was undertaken to evaluate the influence of storage conditions on the shelf-life of porcine bioprosthetic valves. Fifty-five unimplanted porcine bioprostheses have been evaluated. The valves were stored in 0.5% buffered glutaraldehyde solution for different periods of time (7, 23 and 32 months). Twenty-eigh...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(96)00155-x

    authors: Julien M,Létouneau DR,Marois Y,Cardou A,King MW,Guidoin R,Chachra D,Lee JM

    更新日期:1997-04-01 00:00:00

  • Localised delivery of doxorubicin to prostate cancer cells through a PSMA-targeted hyperbranched polymer theranostic.

    abstract::The therapeutic potential of hyperbranched polymers targeted to prostate cancer and loaded with doxorubicin was investigated. Polyethylene glycol hyperbranched polymers were synthesised via RAFT polymerisation to feature glutamate urea targeting ligands for PSMA on the periphery. The chemotherapeutic, doxorubicin, was...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2017.07.004

    authors: Pearce AK,Simpson JD,Fletcher NL,Houston ZH,Fuchs AV,Russell PJ,Whittaker AK,Thurecht KJ

    更新日期:2017-10-01 00:00:00

  • Intratumoral injection of thermogelling and sustained-release carboplatin-loaded hydrogel simplifies the administration and remains the synergistic effect with radiotherapy for mice gliomas.

    abstract:BACKGROUND:Carboplatin, an antineoplastic agent, binds DNA and enhances radiotherapy (RT) effects. Carboplatin-loaded hydrogel (oxidized hyaluronic acid/adipic acid dihydrazide) enables the sustained drug release and facilitates the synergistic effect with RT. PURPOSE:We investigated the effectiveness and convenience ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2017.10.015

    authors: Liang HT,Lai XS,Wei MF,Lu SH,Wen WF,Kuo SH,Chen CM,Tseng WI,Lin FH

    更新日期:2018-01-01 00:00:00

  • Osteoblast response to PLGA tissue engineering scaffolds with PEO modified surface chemistries and demonstration of patterned cell response.

    abstract::Because tissues are characterized by a well-defined three-dimensional arrangement of cells, tissue engineering scaffolds that facilitate the organization and differentiation of new tissue will have improved performance in comparison to scaffolds that only provide surfaces for cell attachment and growth. We hypothesize...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2003.09.064

    authors: Koegler WS,Griffith LG

    更新日期:2004-06-01 00:00:00

  • Biodegradable poly(ethylene glycol) hydrogels based on a self-elimination degradation mechanism.

    abstract::Two vinyl sulfone functionalized crosslinkers were developed for the purpose of preparing degradable poly(ethylene glycol) (PEG) hydrogels (EMXL and GABA-EMXL hydrogels). A self-elimination degradation mechanism in which an N-terminal residue of a glutamine is converted to pyroglutamic acid with subsequent release of ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2010.05.021

    authors: Deshmukh M,Singh Y,Gunaseelan S,Gao D,Stein S,Sinko PJ

    更新日期:2010-09-01 00:00:00

  • Molecular mechanisms of improved adhesion and growth of an endothelial cell line cultured on polystyrene implanted with fluorine ions.

    abstract::Endothelial cells derived from the bovine pulmonary artery (line CPAE, CCL 209, American Tissue Culture Collection, Rockville, MD, USA) were cultured on pristine or fluorine ion-irradiated polystyrene (5 x 10(12) or 5 x 10(14) F ions/cm2, 150 keV). At 24-h post-seeding interval, the number of cells which adhered to th...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(00)00009-0

    authors: Bacáková L,Mares V,Lisá V,Svorcík V

    更新日期:2000-06-01 00:00:00

  • Non-invasive optical imaging of cathepsin B with activatable fluorogenic nanoprobes in various metastatic models.

    abstract::An increasing number of treatments of metastases rely on diagnostics and imaging these days. The facts that the activity of cathepsin B (CB) is markedly linked to the metastatic process and that CB is found highly expressed in the pericellular regions in this process make CB an attractive target for diagnosing metasta...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2013.11.080

    authors: Ryu JH,Na JH,Ko HK,You DG,Park S,Jun E,Yeom HJ,Seo DH,Park JH,Jeong SY,Kim IS,Kim BS,Kwon IC,Choi K,Kim K

    更新日期:2014-02-01 00:00:00

  • Development of in situ thermosensitive drug vehicles for glaucoma therapy.

    abstract::The goal of this research was to design thermosensitive drug vehicles for glaucoma therapy. Thermosensitive ophthalmic drop was prepared by mixing linear poly(N-isopropylacrylamide-g-2-hydroxyethyl methacrylate) (PNIPAAm-g-PHEMA), PNIPAAm-g-PHEMA gel particles and antiglaucoma drug. This produced polymeric eyedrop con...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(03)00035-8

    authors: Hsiue GH,Chang RW,Wang CH,Lee SH

    更新日期:2003-06-01 00:00:00

  • Mechanical properties and aesthetics of FRP orthodontic wire fabricated by hot drawing.

    abstract::The FRP wires 0.5 mm in diameter with a multiple fiber structure were fabricated by drawing the fiber polymer complex at 250 degrees C for an esthetic, transparent orthodontic wire. Biocompatible CaO-P2O5-SiO2-Al2O3 (CPSA) glass fibers of 8-20 microm in diameter were oriented unidirectionally in the longitudinal direc...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(98)00127-6

    authors: Imai T,Watari F,Yamagata S,Kobayashi M,Nagayama K,Toyoizumi Y,Nakamura S

    更新日期:1998-12-01 00:00:00

  • Templated agarose scaffolds for the support of motor axon regeneration into sites of complete spinal cord transection.

    abstract::Bioengineered scaffolds have the potential to support and guide injured axons after spinal cord injury, contributing to neural repair. In previous studies we have reported that templated agarose scaffolds can be fabricated into precise linear arrays and implanted into the partially injured spinal cord, organizing grow...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2012.10.070

    authors: Gao M,Lu P,Bednark B,Lynam D,Conner JM,Sakamoto J,Tuszynski MH

    更新日期:2013-02-01 00:00:00

  • Diaminododecane-based cationic bolaamphiphile as a non-viral gene delivery carrier.

    abstract::The advancement in gene therapy relies upon the discovery of safe and efficient delivery agents and methods. In this study, we report the design and synthesis of a cationic bolaamphiphile as a non-viral gene delivery agent. The bolaamphiphile is composed of 1,12-diaminododecane as the central hydrophobic unit linked t...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2012.02.067

    authors: Khan M,Ang CY,Wiradharma N,Yong LK,Liu S,Liu L,Gao S,Yang YY

    更新日期:2012-06-01 00:00:00

  • Cell attachment functionality of bioactive conducting polymers for neural interfaces.

    abstract::Bioactive coatings for neural electrodes that are tailored for cell interactions have the potential to produce superior implants with improved charge transfer capabilities. In this study synthetically produced anionically modified laminin peptides DEDEDYFQRYLI and DCDPGYIGSR were used to dope poly(3,4-ethylenedioxythi...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2009.03.043

    authors: Green RA,Lovell NH,Poole-Warren LA

    更新日期:2009-08-01 00:00:00

  • Boundary lubrication and maxillofacial prosthetic polydimethylsiloxanes.

    abstract::Polydimethylsiloxanes exhibit hydrophobic behaviour and poor wettability. These features impose some problems with the clinical performance of the material when used for the construction of intraoral and extraoral facial prostheses. Surface active agents were added to modify the surface energy of the polydimethylsilox...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(91)90137-y

    authors: Polyzois GL,Winter RW,Stafford GD

    更新日期:1991-01-01 00:00:00

  • In vitro behavior of silicate glass coatings on Ti6A14V.

    abstract::The in vitro response in simulated body fluid (SBF) of silicate glass coatings on Ti6A14V was evaluated. Glasses belonging to the SiO2-CaO-MgO-Na2O-K2O-P2O5 system were used to prepare 50-70 m thick coatings on Ti6Al4V, employing a simple enameling technique. Glasses with silica content higher than 55 wt% can be used ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(02)00109-6

    authors: Saiz E,Goldman M,Gomez-Vega JM,Tomsia AP,Marshall GW,Marshall SJ

    更新日期:2002-09-01 00:00:00

  • Study of Galfenol direct cytotoxicity and remote microactuation in cells.

    abstract::Remote microactuators are of great interest in biology and medicine as minimally-invasive tools for cellular stimulation. Remote actuation can be achieved by active magnetostrictive transducers which are capable of changing shape in response to external magnetic fields thereby creating controlled displacements. Among ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2017.05.049

    authors: Vargas-Estevez C,Blanquer A,Dulal P,Pérez Del Real R,Duch M,Ibáñez E,Barrios L,Murillo G,Torras N,Nogués C,Stadler BJH,Plaza JA,Esteve J

    更新日期:2017-09-01 00:00:00

  • Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist.

    abstract::Improving the immunogenicity of subunit vaccines, in particular skewing of the immune response towards Th1 type immunity, is crucial for the development of effective vaccines against intracellular infections and for the development of anti-cancer vaccines. Small molecule TLR7/8 agonist hold high potential for this pur...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2018.03.026

    authors: Nuhn L,Van Hoecke L,Deswarte K,Schepens B,Li Y,Lambrecht BN,De Koker S,David SA,Saelens X,De Geest BG

    更新日期:2018-09-01 00:00:00

  • Use of telechelic cis-1,4-polyisoprene cationomers in the synthesis of antibacterial ionic polyurethanes and copolyurethanes bearing ammonium groups.

    abstract::New crosslinked ionic polyurethanes and copolyurethanes were yielded by reaction of telechelic cis-1,4-oligoisoprenes, bearing a variable number of ammonium and hydroxy groups, with isocyanurate of isophorone diisocyanate (I-IPDI). Aiming for a comparative study, polyurethane elastomers based on non-ionic telechelic o...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2007.06.006

    authors: Kébir N,Campistron I,Laguerre A,Pilard JF,Bunel C,Jouenne T

    更新日期:2007-10-01 00:00:00

  • The morphological characterization of dental amalgam alloy powders.

    abstract::Two commercially available amalgam alloy powders (one lathe-cut, the other spherical) were characterized in terms of density, surface area, particle size distribution and appearance under the scanning electron microscope. A third, experimental alloy powder, prepared by electrodeposition, was subjected to a similar ana...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(84)90028-0

    authors: Davies EH,Kuhn AT

    更新日期:1984-11-01 00:00:00

  • Vitamin E TPGS as a molecular biomaterial for drug delivery.

    abstract::D-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS, or simply TPGS) is a water-soluble derivative of natural Vitamin E, which is formed by esterification of Vitamin E succinate with polyethylene glycol (PEG). As such, it has advantages of PEG and Vitamin E in application of various nanocarriers for drug deli...

    journal_title:Biomaterials

    pub_type: 杂志文章,评审

    doi:10.1016/j.biomaterials.2012.03.046

    authors: Zhang Z,Tan S,Feng SS

    更新日期:2012-06-01 00:00:00

  • Long-term maintenance of human hepatocytes in oxygen-permeable membrane bioreactor.

    abstract::An oxygen-permeable membrane bioreactor utilizing human hepatocytes has been tested in this study. In the bioreactor, human hepatocytes were cultured between flat-sheet gas-permeable polymeric membranes, which ensure the diffusion of O(2) and CO(2) providing a support for cell anchorage and growth and permit the onlin...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2006.05.015

    authors: De Bartolo L,Salerno S,Morelli S,Giorno L,Rende M,Memoli B,Procino A,Andreucci VE,Bader A,Drioli E

    更新日期:2006-09-01 00:00:00

  • The influence of substrate stiffness on the behavior and functions of Schwann cells in culture.

    abstract::Solid tissues in the body possess a range of stiffness and provide cells with an instructive microenvironment. Scaffolds in tissue engineering should be rationally designed to become an adhesion substrate friendly to cells. Schwann cells are the principal glial cell in the peripheral nervous system and used as support...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2012.06.006

    authors: Gu Y,Ji Y,Zhao Y,Liu Y,Ding F,Gu X,Yang Y

    更新日期:2012-10-01 00:00:00

  • Combining poly-arginine with the hydrophobic counter-anion 4-(1-pyrenyl)-butyric acid for protein transduction in transdermal delivery.

    abstract::Topical therapy is the most favored form of treatment for whitening against hyperpigmentation and sunburn because it lends itself to self-administration, patient compliance, and absence of systemic adverse effects. However, transdermal delivery of hydrophilic chemicals is difficult. The main purpose of this study is t...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2012.04.056

    authors: Candan G,Michiue H,Ishikawa S,Fujimura A,Hayashi K,Uneda A,Mori A,Ohmori I,Nishiki T,Matsui H,Tomizawa K

    更新日期:2012-09-01 00:00:00

  • Therapeutic effects of neuropeptide substance P coupled with self-assembled peptide nanofibers on the progression of osteoarthritis in a rat model.

    abstract::Osteoarthritis (OA) is a progressively degenerative disease that is accompanied by articular cartilage deterioration, sclerosis of the underlying bone and ultimately joint destruction. Although therapeutic medicine and surgical treatment are done to alleviate the symptoms of OA, it is difficult to restore normal carti...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2015.09.040

    authors: Kim SJ,Kim JE,Kim SH,Kim SJ,Jeon SJ,Kim SH,Jung Y

    更新日期:2016-01-01 00:00:00

  • Towards a methodology for the effective surface modification of porous polymer scaffolds.

    abstract::A novel low-pressure radio-frequency plasma treatment protocol was developed to achieve the effective through-thickness surface modification of large porous poly (D,L-lactide) (PDLLA) polymer scaffolds using air or water: ammonia plasma treatments. Polymer films were modified as controls. Scanning electron micrographs...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2005.05.078

    authors: Safinia L,Datan N,Höhse M,Mantalaris A,Bismarck A

    更新日期:2005-12-01 00:00:00