Inhibition of intrinsic coagulation improves safety and tumor-targeted drug delivery of cationic solid lipid nanoparticles.

abstract：:Effects of the granularity of the raw materials on the hydration and hardening process of calcium phosphate cement (CPC) composed of equimolar tetracalcium phosphate (TECP) and dicalcium phosphate anhydrous (DCPA) were investigated systematically. The variation of pH value in CPC slurry indicated that the control step...

journal_title：Biomaterials

authors： Liu C,Shao H,Chen F,Zheng H

更新日期：2003-10-01 00:00:00

abstract：:Matrix anisotropy is important for long term in vivo functionality. However, it is not fully understood how to guide matrix anisotropy in vitro. Experiments suggest actin-mediated cell traction contributes. Although F-actin in 2D displays a stretch-avoidance response, 3D data are lacking. We questioned how cyclic stre...

journal_title：Biomaterials

authors： Foolen J,Deshpande VS,Kanters FM,Baaijens FP

更新日期：2012-10-01 00:00:00

abstract：:Multivalent effect plays an important role in biological processes, particularly in the specific recognition of virus with its host cell during the first step of infection. Here we report the synthesis of multivalent pentacyclic triterpene grafted on cyclodextrin core and potency of against influenza entry activity. N...

journal_title：Biomaterials

authors： Xiao S,Si L,Tian Z,Jiao P,Fan Z,Meng K,Zhou X,Wang H,Xu R,Han X,Fu G,Zhang Y,Zhang L,Zhou D

更新日期：2016-02-01 00:00:00

abstract：:The functionalization of polytetrafluoroethylene (PTFE) for human thrombomodulin (hTM) binding has been achieved by CO2 plasma activation and subsequent vapour phase graft polymerization of acrylic acid (AA). The PTFE surfaces after CO2 plasma treatment, AA grafting and hTM immobilization were characterized by attenua...

journal_title：Biomaterials

authors： Vasilets VN,Hermel G,König U,Werner C,Müller M,Simon F,Grundke K,Ikada Y,Jacobasch HJ

更新日期：1997-09-01 00:00:00

abstract：:Conventional amputation prosthetics are problematic because they rely on the stump-socket interface for attachment. Intraosseous transcutaneous amputation prostheses (ITAP) could solve these problems; however they rely on the integrity of the soft tissue-implant interface as a barrier to exogenous agents, and in the p...

journal_title：Biomaterials

authors： Pendegrass CJ,Goodship AE,Blunn GW

更新日期：2006-08-01 00:00:00

abstract：:Hydrogels have been widely used as artificial cell niche to mimic extracellular matrix with tunable properties. However, changing biochemical cues in hydrogels developed-to-date would often induce simultaneous changes in mechanical properties, which do not support mechanistic studies on stem cell-niche interactions. H...

journal_title：Biomaterials

authors： Tong X,Yang F

更新日期：2014-02-01 00:00:00

abstract：:This study reports the effect of varying the thickness of a commercial zinc polycarboxylate dental cement on its adhesion in a metal-to-metal single lap joint. The thickness was controlled externally in a specially designed apparatus, rather than by the inclusion of isodimensional glass spheres, as has been done previ...

journal_title：Biomaterials

authors： Akinmade AO,Nicholson JW

更新日期：1995-01-01 00:00:00

abstract：:Biodegradable polylactide implants allow secure fixation of osteochondral fractures with minimal adverse effects. The goal of this prospective, randomized animal study was to show whether osteoconductive effects can be achieved through the development of poly-L/DL(70/30)lactide composite implants with 10% beta-tricalc...

journal_title：Biomaterials

authors： Prokop A,Jubel A,Hahn U,Dietershagen M,Bleidistel M,Peters C,Höfl A,Rehm KE

更新日期：2005-07-01 00:00:00

abstract：:This paper describes a method of foaming a polymer system comprising poly(ethyl methacrylate)/tetrahydrofurfuryl methacrylate (PEMA/THFMA), characterisation of the resulting porosity and use of the foam for chondrocyte culture. The potential for this polymer system to support cartilage repair has been investigated pre...

journal_title：Biomaterials

authors： Barry JJ,Gidda HS,Scotchford CA,Howdle SM

更新日期：2004-08-01 00:00:00

abstract：:Endocytosis is a fundamental biological process and is also the key mechanism for drug and non-viral gene delivery. The importance of topographical cues in modulating cell behaviors has become increasingly evident, but the influence of topography on endocytosis has however only been sparsely studied. We hypothesize th...

journal_title：Biomaterials

authors： Teo BK,Goh SH,Kustandi TS,Loh WW,Low HY,Yim EK

更新日期：2011-12-01 00:00:00

abstract：:Wound dressing is critical important for cutaneous wound healing. However, the application of current products is limited due to poor mechanical property, unsuitable water vapor transmission rate (WVTR), poor anti-infective property or poor biocompatibility, etc. In the present study, a microporous silicone rubber mem...

journal_title：Biomaterials

authors： Xu R,Luo G,Xia H,He W,Zhao J,Liu B,Tan J,Zhou J,Liu D,Wang Y,Yao Z,Zhan R,Yang S,Wu J

更新日期：2015-02-01 00:00:00

abstract：:The metastatic spread of cancer cells from the primary tumor to distant sites leads to a poor prognosis in cancers originating from multiple organs. Increasing evidence has linked selectin-based adhesion between circulating tumor cells (CTCs) and endothelial cells of the microvasculature to metastatic dissemination, i...

journal_title：Biomaterials

authors： Mitchell MJ,Castellanos CA,King MR

更新日期：2015-07-01 00:00:00

abstract：:In the present study, the effects of implant design and surface properties on peri-implant bone response were evaluated with both conventional histomorphometry and micro-computed tomography (micro-CT), using two geometrically different dental implants (Screw type, St; Push-in, Pi) either or not surface-modified (non-c...

journal_title：Biomaterials

authors： Schouten C,Meijer GJ,van den Beucken JJ,Spauwen PH,Jansen JA

更新日期：2009-09-01 00:00:00

abstract：:This paper is concerned with the entrapment of an enzyme within an aggregated metallic matrix and the development of a bioactive enzyme-metal composite. Whereas the use of organic polymers and metal oxides for the preparation of enzymatically active materials is well developed, the third principle enzyme-material comb...

journal_title：Biomaterials

authors： Ben-Knaz R,Avnir D

更新日期：2009-03-01 00:00:00

abstract：:Brushite (dicalcium phosphate dihydrate, DCPD, CaHPO4 x 2H2O) was deposited electrolytically from calcium dihydrogen phosphate solution with and without potassium chloride (KCl) as a supporting electrolyte. The kinetics of brushite transformation to hydroxyapatite (HA, Ca5(PO4)3OH) in the presence of calcium and prote...

journal_title：Biomaterials

authors： Kumar M,Xie J,Chittur K,Riley C

更新日期：1999-08-01 00:00:00

abstract：:RNA interference holds tremendous potential as a therapeutic approach of malignant tumors. However, safe and efficient nanovectors are extremely lack for systemic delivery of small interfering RNA (siRNA). The study aimed to develop a biomimetic nanovector, reconstituted high density lipoprotein (rHDL), mediating targ...

journal_title：Biomaterials

authors： Ding Y,Wang W,Feng M,Wang Y,Zhou J,Ding X,Zhou X,Liu C,Wang R,Zhang Q

更新日期：2012-12-01 00:00:00

abstract：:An increasing number of treatments of metastases rely on diagnostics and imaging these days. The facts that the activity of cathepsin B (CB) is markedly linked to the metastatic process and that CB is found highly expressed in the pericellular regions in this process make CB an attractive target for diagnosing metasta...

journal_title：Biomaterials

authors： Ryu JH,Na JH,Ko HK,You DG,Park S,Jun E,Yeom HJ,Seo DH,Park JH,Jeong SY,Kim IS,Kim BS,Kwon IC,Choi K,Kim K

更新日期：2014-02-01 00:00:00

abstract：:Islet-like cells derived from embryonic stem (ES) cells may be a promising therapeutic option for future diabetes treatment. Here, we demonstrated a five-stage protocol with adding exendin-4 instead of nicotinamide finally could generate islet-like cells from human embryonic stem (ES) cells. Immunofluorescence analysi...

journal_title：Biomaterials

authors： Mao GH,Chen GA,Bai HY,Song TR,Wang YX

更新日期：2009-03-01 00:00:00

abstract：:Using laser Raman microprobe spectroscopy, we have characterized the degree of hydroxylation and the state of atomic order of several natural and synthetic calcium phosphate phases, including apatite of biological (human bone, heated human bone, mouse bone, human and boar dentin, and human and boar enamel), geological...

journal_title：Biomaterials

authors： Pasteris JD,Wopenka B,Freeman JJ,Rogers K,Valsami-Jones E,van der Houwen JA,Silva MJ

更新日期：2004-01-01 00:00:00

abstract：:H2O2-specific peroxalate chemiluminescence is recognized as a potential signal for sensitive in vivo imaging of inflammation but the effect of underlying peroxalate-emitter energetics on its efficiency has rarely been understood. Here we report a simple nanophotonic way of boosting near-infrared chemiluminescence with...

journal_title：Biomaterials

authors： Seo YH,Singh A,Cho HJ,Kim Y,Heo J,Lim CK,Park SY,Jang WD,Kim S

更新日期：2016-04-01 00:00:00

abstract：:Co-polymeric hydrogels of collagen and poly(hydroxyethyl methacrylate) (pHEMA) were prepared using an ammonium persulphate-sodium metabisulphite redox initiation technique. Fluorescein isothiocyanate (FITC)-labelled bovine serum albumin (BSA) was entrapped into these hydrogels. These gels were modified differently by ...

journal_title：Biomaterials

authors： Rao JK,Ramesh DV,Rao KP

更新日期：1994-04-01 00:00:00

abstract：:The creep strain rate and fracture of several dental amalgams has been shown to be markedly dependent on the type of loading applied. Cyclic loading typical of the in vivo situation increases creep rates and reduces times to fracture when analysis is based on a Mechanical Equation of State. The cyclic strain rate enha...

journal_title：Biomaterials

authors： Williams KR

更新日期：1983-10-01 00:00:00

abstract：:Calcification and mechanical failure are the major causes of the loss of cardiac bioprostheses. The chemical treatments used to stabilize the tissue employed are considered to play a fundamental role in the development of these two phenomena, although the problem is multifactorial and the underlying causes are yet to ...

journal_title：Biomaterials

authors： Garcia Páez JM,Jorge-Herrero E,Carrera A,Millán I,Rocha A,Calero P,Cordón A,Salvador J,Sainz N,Méndez J,Castillo-Olivares JL

更新日期：2001-10-01 00:00:00

abstract：:In recent years, graphene and graphene-based nanocomposites owning to their highly enriched physical and chemical properties have been widely explored for applications in many different fields including biomedicine. In the present work, we decorate graphene oxide (GO) by both iron oxide nanoparticles (IONPs) and gold,...

journal_title：Biomaterials

authors： Shi X,Gong H,Li Y,Wang C,Cheng L,Liu Z

更新日期：2013-07-01 00:00:00

abstract：:Healing soft-tissue wounds with an irregular, complicated topography in a bleeding environment demands the development of a dressing that is wet-adhesive, haemostatic, and antibacterial. To meet this unmet demand, we designed a flexible nanosheet (~77 nm thick) made of two layers, one is the antibacterial and haemosta...

journal_title：Biomaterials

authors： Xuan C,Hao L,Liu X,Zhu Y,Yang H,Ren Y,Wang L,Fujie T,Wu H,Chen Y,Shi X,Mao C

更新日期：2020-09-01 00:00:00

abstract：:Monocytes/Macrophages have long been recognized as key players in inflammation and wound healing and are often employed in vitro to gain an understanding of the inflammatory response to biomaterials. Previous work has demonstrated a drastic decrease in primary monocyte adherent density on biomaterial surfaces coupled ...

journal_title：Biomaterials

authors： Waldeck H,Wang X,Joyce E,Kao WJ

更新日期：2012-01-01 00:00:00

abstract：:Starvation therapy to slow down the tumor growth by cutting off its energy supply has been proposed to be an alternative therapeutic strategy for cancer treatment. Herein, glucose oxidase (GOx) is loaded into stealth liposomes and act as the glucose and oxygen elimination agent to trigger the conversion of glucose and...

journal_title：Biomaterials

authors： Zhang R,Feng L,Dong Z,Wang L,Liang C,Chen J,Ma Q,Zhang R,Chen Q,Wang Y,Liu Z

更新日期：2018-04-01 00:00:00

abstract：:Pneumonia is a major contributor to infection-based hospitalizations and deaths in the United States. Antibiotics such as azithromycin (AZM), although effective at managing pneumonia, often suffer from off-target diffusion and poor bioavailability when administered orally or via intravenous injection. The formation of...

journal_title：Biomaterials

authors： Wang Q,Mi G,Hickey D,Li Y,Tu J,Webster TJ,Shen Y

更新日期：2018-04-01 00:00:00

abstract：:Eye drops producing long-acting ocular anesthesia would be desirable for corneal pain management. Here we present liposome-based formulations to achieve very long ocular anesthetic effect after a single eye drop instillation. The liposomes were functionalized with succinyl-Concanavalin A (sConA-Lip), which can bind co...

journal_title：Biomaterials

authors： Zhan C,Santamaria CM,Wang W,McAlvin JB,Kohane DS

更新日期：2018-10-01 00:00:00

abstract：:This study suggests a novel method of stabilizing fragile porcine islets to prevent the dissociation after isolation and reducing immune cell invasion in a combination therapy of 'surface camouflaging' and immunosuppressive drugs (FK506, Rapamycin, MR-1, anti-CD19 mAb, and Clodrosome(®)) to effectively alleviate overa...

journal_title：Biomaterials

authors： Haque MR,Jeong JH,Byun Y

更新日期：2016-04-01 00:00:00