Abstract：
:Healing soft-tissue wounds with an irregular, complicated topography in a bleeding environment demands the development of a dressing that is wet-adhesive, haemostatic, and antibacterial. To meet this unmet demand, we designed a flexible nanosheet (~77 nm thick) made of two layers, one is the antibacterial and haemostatic gelatin modified with dopamine (DA) and antimicrobial peptide (AMP) and mixed with Ca2+ ions as coagulation factors, and another is the mechanically strong polycaprolactone (PCL). This flexible nanosheet exhibited robust mechanical strength, continuous and effective adhesion to a topographically irregular tissue surface under a wet condition, and a high platelet adhesion capacity. Moreover, the nanosheet presented a significantly reduced clotting time of 4 min and a high bactericidal rate of nearly 100%. An in vivo evaluation of the nanosheet using both murine dorsal skin and liver models further revealed that the nanosheet could successfully seal and heal the wounds in a bleeding environment, efficiently control haemorrhaging, and exert an excellent antibacterial effect in two weeks. Our work suggests that this nanosheet holds great promise in healing the bleeding soft-tissue wounds for treating acute trauma.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Xuan C,Hao L,Liu X,Zhu Y,Yang H,Ren Y,Wang L,Fujie T,Wu H,Chen Y,Shi X,Mao Cdoi
10.1016/j.biomaterials.2020.120018subject
Has Abstractpub_date
2020-09-01 00:00:00pages
120018eissn
0142-9612issn
1878-5905pii
S0142-9612(20)30264-7journal_volume
252pub_type
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