Azithromycin-loaded respirable microparticles for targeted pulmonary delivery for the treatment of pneumonia.

abstract：:Starvation therapy to slow down the tumor growth by cutting off its energy supply has been proposed to be an alternative therapeutic strategy for cancer treatment. Herein, glucose oxidase (GOx) is loaded into stealth liposomes and act as the glucose and oxygen elimination agent to trigger the conversion of glucose and...

journal_title：Biomaterials

authors： Zhang R,Feng L,Dong Z,Wang L,Liang C,Chen J,Ma Q,Zhang R,Chen Q,Wang Y,Liu Z

更新日期：2018-04-01 00:00:00

abstract：:Although photothermal therapy (PTT) and photodynamic therapy (PDT) are widely commended for tumor treatment recently, they still suffer severe challenges due to the non-specificity of photothermal agents (PTAs)/photosensitizers (PSs) and hypoxic tumor microenvironment. Here, an oxygen independent biomimetic nanoplatfo...

journal_title：Biomaterials

authors： Zhang C,Liu WL,Bai XF,Cheng SX,Zhong ZL,Zhang XZ

更新日期：2019-04-01 00:00:00

abstract：:Using the recently developed surface modification technique, free amino groups have been introduced onto polyester-type polyurethane (PU) scaffolds. The introduction of these free amino groups increases the surface energy and provides a convenient way to further immobilize bioactive species such as gelatin, collagen o...

journal_title：Biomaterials

authors： Zhu Y,Gao C,He T,Shen J

更新日期：2004-02-01 00:00:00

abstract：:Poly(ortho esters) with a low glass transition temperature are semi-solid materials so that therapeutic agents can be incorporated at room temperature, without the use of solvents, by a simple mixing procedure. When molecular weights are limited to < 5 kDa, such materials are directly injectable using a needle size no...

journal_title：Biomaterials

authors： Helle J,Barr J,Ng SY,Shen HR,Schwach-Abdellaoui K,Gurny R,Vivien-Castioni N,Loup PJ,Baehni P,Mombelli A

更新日期：2002-11-01 00:00:00

abstract：:The objective of this study was to investigate the moisture absorption, physical-mechanical and bioadhesive properties of hot-melt extruded hydroxypropylcellulose (HPC) films containing polymer additives. These additives included polyethylene glycol (PEG) 5%, polycarbophil 5%, carbomer 5%, Eudragit E-100 5%, and sodiu...

journal_title：Biomaterials

authors： Repka MA,McGinity JW

更新日期：2000-07-01 00:00:00

abstract：:This study examined the nature of the surface presented by a machinable feldspathic porcelain and by a machinable glass-ceramic for bonding to conventional composite luting agents and measured the bond strengths which may be achieved with various surface treatments. There was no significant difference between the bond...

journal_title：Biomaterials

authors： Jedynakiewicz NM,Martin N

更新日期：2001-04-01 00:00:00

abstract：:A growing number of protein-based fibrous biomaterials have been produced with a cross-β amyloid core yet the long-term effect of these materials on cell viability and the influence of core and non-core protein sequences on viability is not well understood. Here, synthetic bioactive TTR1-RGD and control TTR1-RAD or TT...

journal_title：Biomaterials

authors： Bongiovanni MN,Gras SL

更新日期：2015-04-01 00:00:00

abstract：:Poly(trimethylene carbonate) (PTMC) with molecular weights greater than 100 kg/mol is known to degrade readily in vivo while PTMC of less than 70 kg/mol is resistant to degradation. The reason for the molecular weight dependent degradation rate of PTMC is unclear, and may be due to differences in macrophage behavior o...

journal_title：Biomaterials

authors： Vyner MC,Li A,Amsden BG

更新日期：2014-11-01 00:00:00

abstract：:The changes in protein adsorption onto aluminium surfaces coated with different thicknesses of oxide layers were examined. The oxide layers on aluminium substrates were derived by the anodizing technique. Protein adsorption studies were conducted using 125I-labelled albumin and the amount of albumin adsorbed was estim...

journal_title：Biomaterials

authors： Sharma CP,Sunny MC

更新日期：1990-05-01 00:00:00

abstract：:Notorious bacterial biofilms are becoming severe threats to public health worldwide. As the important component in biofilm extracellular polymeric substances (EPS), extracellular DNA (eDNA) has been manifested to connect different EPS components and bacteria together, leading biofilms hard to eliminate. Herein a serie...

journal_title：Biomaterials

authors： Liu Z,Wang F,Ren J,Qu X

更新日期：2019-07-01 00:00:00

abstract：:For chronic non-viral gene therapy, biodegradable carriers with low cytotoxicity are essential. To create a series of non-toxic and biodegradable gene carriers, hyperbranched polymers based on 2,2-bis-(methylol)propionic acid (bis-MPA); (Boltorn H) were modified by introducing tertiary amines. The terminal OH groups w...

journal_title：Biomaterials

authors： Reul R,Nguyen J,Kissel T

更新日期：2009-10-01 00:00:00

abstract：:A human-human oligodendroglial cell line MO3.13 was chosen in this study to model the loss of oligodendrocytes that occurs during episodes of multiple sclerosis. The influence of mercuric chloride (HgCl(2)) upon cell viability specifically the mode of cell death, whether by an active apoptotic mechanism or passive nec...

journal_title：Biomaterials

authors： Issa Y,Watts DC,Duxbury AJ,Brunton PA,Watson MB,Waters CM

更新日期：2003-03-01 00:00:00

abstract：:Osteoarthritis (OA) is a progressively degenerative disease that is accompanied by articular cartilage deterioration, sclerosis of the underlying bone and ultimately joint destruction. Although therapeutic medicine and surgical treatment are done to alleviate the symptoms of OA, it is difficult to restore normal carti...

journal_title：Biomaterials

authors： Kim SJ,Kim JE,Kim SH,Kim SJ,Jeon SJ,Kim SH,Jung Y

更新日期：2016-01-01 00:00:00

abstract：:Because tissues are characterized by a well-defined three-dimensional arrangement of cells, tissue engineering scaffolds that facilitate the organization and differentiation of new tissue will have improved performance in comparison to scaffolds that only provide surfaces for cell attachment and growth. We hypothesize...

journal_title：Biomaterials

authors： Koegler WS,Griffith LG

更新日期：2004-06-01 00:00:00

abstract：:We have investigated the interface between bone and hydroxyapatite (HA) chronically implanted in man. By light microscopy, HA appeared to bind directly to bone without intervening fibrous tissue. By transmission electron microscopy, two patterns were noted: (1) HA either bound directly to bone; or (2) electron-dense m...

journal_title：Biomaterials

authors： Oguchi H,Ishikawa K,Mizoue K,Seto K,Eguchi G

更新日期：1995-01-01 00:00:00

abstract：:Geliperm hydrogel provides optimal physiological conditions for wound healing. The material is composed of two interlaced networks, one of polyacrylamide and one of agar, and contains about 96% firmly bound water. It is supplied in smooth, elastic, transparent sheets which are impermeable to bacteria but permeable to ...

journal_title：Biomaterials

authors： Kickhöfen B,Wokalek H,Scheel D,Ruh H

更新日期：1986-01-01 00:00:00

abstract：:Non-viral carriers for gene therapy have been developed to minimize carrier cytotoxicity and to enhance transfection efficiency. Previously, we synthesized a 9-arginine-based reducible high molecular weight peptide for gene delivery. For the reducible poly(oligo-D-arginines) (rPOA), 9-arginine oligopeptides are connec...

journal_title：Biomaterials

authors： Hyun H,Won YW,Kim KM,Lee J,Lee M,Kim YH

更新日期：2010-12-01 00:00:00

abstract：:We determined whether a two-part space-conforming polyethylene glycol/dopa polymer-based gel promoted healing of contaminated wounds in mice. This silver-catalysed gel was previously developed to be broadly microbiocidal in vitro while being biocompatible with human wound cell functioning. Full-thickness wounds were c...

journal_title：Biomaterials

authors： Yates CC,Whaley D,Babu R,Zhang J,Krishna P,Beckman E,Pasculle AW,Wells A

更新日期：2007-09-01 00:00:00

abstract：:Magnesium (Mg), a potential biodegradable material, has recently received increasing attention due to its unique antibacterial property. However, rapid corrosion in the physiological environment and potential toxicity limit clinical applications. In order to improve the corrosion resistance meanwhile not compromise th...

journal_title：Biomaterials

authors： Qin H,Zhao Y,An Z,Cheng M,Wang Q,Cheng T,Wang Q,Wang J,Jiang Y,Zhang X,Yuan G

更新日期：2015-06-01 00:00:00

abstract：:The effect of surface characteristics on the interaction of sterically stabilized polystyrene particles with mouse peritoneal macrophages was studied using a range of poloxamers and poloxamine as coating agents. The coated particles were characterized in terms of thickness of coating layer, surface charge and critical...

journal_title：Biomaterials

authors： Illum L,Jacobsen LO,Müller RH,Mak E,Davis SS

更新日期：1987-03-01 00:00:00

abstract：:Biological surface engineering using synthetic biological materials has a great potential for advances in our understanding of complex biological phenomena. We developed a simple system to engineer biologically relevant surfaces using a combination of self-assembling oligopeptide monolayers and microcontact printing (...

journal_title：Biomaterials

authors： Zhang S,Yan L,Altman M,Lässle M,Nugent H,Frankel F,Lauffenburger DA,Whitesides GM,Rich A

更新日期：1999-07-01 00:00:00

abstract：:Enterococcus faecalis is an opportunistic pathogen, which today represents one of the leading aetiologic agents of nosocomial infections and, increasingly, of implant infections. Here, in a collection of 43 E. faecalis isolated from implant orthopaedic infections, virulence-related phenotypes (biofilm and gelatinase p...

journal_title：Biomaterials

authors： Arciola CR,Baldassarri L,Campoccia D,Creti R,Pirini V,Huebner J,Montanaro L

更新日期：2008-02-01 00:00:00

abstract：:Upconversion fluorescent nanoparticles are becoming more widely used as imaging contrast agents, owing to their high resolution and penetration depth, and avoidance of tissue auto-fluorescence and photodamage to cells. Here, we synthesized upconversion fluorescent crystals from rare-earth Yb3+ and Ho3+ co-doped fluora...

journal_title：Biomaterials

authors： Hu X,Zhu J,Li X,Zhang X,Meng Q,Yuan L,Zhang J,Fu X,Duan X,Chen H,Ao Y

更新日期：2015-06-01 00:00:00

abstract：:Nanoparticles have been widely used for delivering various chemical and biomolecular drugs, such as anti-cancer drugs and therapeutic proteins. Among nanoparticles, protein nanoparticles have advantages of non-cytotoxicity and biodegradability. In this study, a recombinant 30Kc19 protein was applied to human serum alb...

journal_title：Biomaterials

authors： Lee HJ,Park HH,Kim JA,Park JH,Ryu J,Choi J,Lee J,Rhee WJ,Park TH

更新日期：2014-02-01 00:00:00

abstract：:Combination therapy is usually considered as a promising strategy owing to its advantages such as reduced doses, minimized side effects and improved therapeutic efficiency in a variety of diseases including diabetes. Here we synthesized a new highly intracellular stimuli-sensitive chitosan-graft-metformin (CS-MET) pro...

journal_title：Biomaterials

authors： Wang FZ,Xie ZS,Xing L,Zhang BF,Zhang JL,Cui PF,Qiao JB,Shi K,Cho CS,Cho MH,Xu X,Li P,Jiang HL

更新日期：2015-12-01 00:00:00

abstract：:An oxidizing treatment of carbon fibres in boiling nitric acid leads to significant changes in the chemical state of their surface. As a result of the chemical treatment on a hydrophobic carbon surface, hydrophilic domains are formed and phenolic, carbonyl and carboxyl groups appear. In this work the intensity of phag...

journal_title：Biomaterials

authors： Czajkowska B,Błazewicz M

更新日期：1997-01-01 00:00:00

abstract：:In order to increase the functionality of islets encapsulated in a biohybrid artificial pancreas (BAP), it was proposed that co-encapsulation with insulinotropic agents would improve insulin secretion from islets. To prevent agents from leaking out, conjugation with high-molecular-weight polymers was inevitable. In th...

journal_title：Biomaterials

authors： Kim S,Wan Kim S,Bae YH

更新日期：2005-06-01 00:00:00

abstract：:Bone tissue engineering strategies are fundamentally based upon porous scaffold materials that serve as a support for ingrowth of host cells and/or provide a substrate for exogenously delivered cells. Here we report the application of a surface calcium phosphate (CaP) mineral layer to a macroporous polymeric/CaP compo...

journal_title：Biomaterials

authors： Lickorish D,Guan L,Davies JE

更新日期：2007-03-01 00:00:00

abstract：:Stem cell-based gene therapies, wherein stem cells are genetically engineered to express therapeutic molecules, have shown tremendous potential for cancer applications owing to their innate ability to home to tumors. However, traditional stem cell-based gene therapies are hampered by our current inability to control w...

journal_title：Biomaterials

authors： Yin PT,Shah S,Pasquale NJ,Garbuzenko OB,Minko T,Lee KB

更新日期：2016-03-01 00:00:00

abstract：:Wounded tissues and cells may be treated with growth factors and specific genes for the purpose of tissue repair and regeneration. To deliver specific genes into tissues and cells, this study presents the use of fabricated poly (DL-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) complexed with the cationic polymer...

journal_title：Biomaterials

authors： Park JS,Yang HN,Woo DG,Jeon SY,Park KH

更新日期：2013-01-01 00:00:00