Glucose & oxygen exhausting liposomes for combined cancer starvation and hypoxia-activated therapy.

abstract：:Low back pain is one of the most common medical conditions in the Western world. Disc degeneration, an inevitable process of aging, of variable rate and degree, is one of the major causes of low back pain. Currently, there are two major surgical interventions for treating conditions related to the degenerative disc: d...

journal_title：Biomaterials

authors： Bao QB,McCullen GM,Higham PA,Dumbleton JH,Yuan HA

更新日期：1996-06-01 00:00:00

abstract：:Rapid prototyping is a novel process for the production of scaffolds of predetermined size and three-dimensional shape. The aim of the study was to determine the feasibility of this technology for producing scaffolds for tissue engineering an aortic valve and the optimal concentration of collagen processed in this man...

journal_title：Biomaterials

authors： Taylor PM,Sachlos E,Dreger SA,Chester AH,Czernuszka JT,Yacoub MH

更新日期：2006-05-01 00:00:00

abstract：:Upconversion fluorescent nanoparticles are becoming more widely used as imaging contrast agents, owing to their high resolution and penetration depth, and avoidance of tissue auto-fluorescence and photodamage to cells. Here, we synthesized upconversion fluorescent crystals from rare-earth Yb3+ and Ho3+ co-doped fluora...

journal_title：Biomaterials

authors： Hu X,Zhu J,Li X,Zhang X,Meng Q,Yuan L,Zhang J,Fu X,Duan X,Chen H,Ao Y

更新日期：2015-06-01 00:00:00

abstract：:Injectable, biodegradable scaffolds are important biomaterials for tissue engineering and drug delivery. Hydrogels derived from natural polysaccharides are ideal scaffolds as they resemble the extracellular matrices of tissues comprised of various glycosaminoglycans (GAGs). Here, we report a new class of biocompatible...

journal_title：Biomaterials

authors： Tan H,Chu CR,Payne KA,Marra KG

更新日期：2009-05-01 00:00:00

abstract：:Severe wear of the ultra-high molecular weight polyethylene (UHMWPE) components of total joint replacements limits their long-term success. In previous studies, the infrared spectra obtained on retrieved UHMWPE components were interpreted as evidence that the UHMWPE oxidizes in vivo. In direct contrast, infrared spect...

journal_title：Biomaterials

authors： James SP,Blazka S,Merrill EW,Jasty M,Lee KR,Bragdon CR,Harris WH

更新日期：1993-07-01 00:00:00

abstract：:Nanodiamond application in biotechnological and medical fields is nowadays in continuous progress. In fact, biocompatibility, reduced dimensions and high surface chemical interaction are specific features that make nanodiamonds perfect intracellular carriers of bioactive compounds. By confocal microscopy, we confirmed...

journal_title：Biomaterials

authors： Gismondi A,Reina G,Orlanducci S,Mizzoni F,Gay S,Terranova ML,Canini A

更新日期：2015-01-01 00:00:00

abstract：:Glioma is still hard to be treated due to their complex microenvironment. In this study, a gold nanoparticle-based delivery system was developed. The system, An-PEG-DOX-AuNPs, was loaded with doxorubicin (DOX) through hydrazone, an acid-responsive linker, and was functionalized with angiopep-2, a specific ligand of lo...

journal_title：Biomaterials

authors： Ruan S,Yuan M,Zhang L,Hu G,Chen J,Cun X,Zhang Q,Yang Y,He Q,Gao H

更新日期：2015-01-01 00:00:00

abstract：:Cutaneous melanoma is an increasingly common and potentially lethal malignancy of melanocytes, the melanin producing cells normally located in the basal layer of the skin epidermis. Despite major advances in cancer chemotherapeutics and immunotherapy, the success in treating metastatic melanoma remains poor. The notio...

journal_title：Biomaterials

authors： Chandrasekaran S,DeLouise LA

更新日期：2011-12-01 00:00:00

abstract：:Cyclic RGD peptide-decorated polymeric micellar-like nanoparticles (MNP) based on PEGylated poly (trimethylene carbonate) (PEG-PTMC) were prepared for active targeting to integrin-rich cancer cells. An amphiphilic diblock copolymer, α-carboxyl poly (ethylene glycol)-poly (trimethylene carbonate) (HOOC-PEG-PTMC), was s...

journal_title：Biomaterials

authors： Jiang X,Sha X,Xin H,Chen L,Gao X,Wang X,Law K,Gu J,Chen Y,Jiang Y,Ren X,Ren Q,Fang X

更新日期：2011-12-01 00:00:00

abstract：:Tissue engineering of clinical-relevant large tissue constructs remains a big challenge due to the mass transfer limit. A modular approach via the assembling of modular tissues thus eliminating the mass transfer limit holds great promise for fabricating centimeter-sized constructs. In the present study, we investigate...

journal_title：Biomaterials

authors： Chen M,Wang X,Ye Z,Zhang Y,Zhou Y,Tan WS

更新日期：2011-10-01 00:00:00

abstract：:Brain tissue inflammatory responses, including neuronal loss and gliosis at the neural electrode/tissue interface, limit the recording stability and longevity of neural probes. The neural adhesion molecule L1 specifically promotes neurite outgrowth and neuronal survival. In this study, we covalently immobilized L1 on ...

journal_title：Biomaterials

authors： Azemi E,Lagenaur CF,Cui XT

更新日期：2011-01-01 00:00:00

abstract：:Polyvinyl alcohol (PVA) cylindrical hydrogel with a stiffness gradient was prepared using a simple liquid nitrogen (LN2)-contacting gradual freezing and thawing method in order to investigate the effects of substrate stiffness on stem cell differentiation into specific cell types. The prepared cylindrical PVA hydrogel...

journal_title：Biomaterials

authors： Kim TH,An DB,Oh SH,Kang MK,Song HH,Lee JH

更新日期：2015-02-01 00:00:00

abstract：:As radio- and chemotherapy-based cancer treatments affect both tumors and healthy tissue, cancer immunotherapy attempts to specifically enhance the natural immune response to tumor cells. In mouse models of cancer, we tested uniform dimercaptosuccinic acid (DMSA)-coated monodisperse magnetic nanoparticles as a deliver...

journal_title：Biomaterials

authors： Mejías R,Pérez-Yagüe S,Gutiérrez L,Cabrera LI,Spada R,Acedo P,Serna CJ,Lázaro FJ,Villanueva A,Morales Mdel P,Barber DF

更新日期：2011-04-01 00:00:00

abstract：:A surface functionalization strategy that produces substrates with well-controlled ligand density is critical to investigating the role of cell-substrate interactions in regulating cell adhesion, viability, migration, proliferation and differentiation. Towards this end, we have designed and synthesized a triblock prot...

journal_title：Biomaterials

authors： Fischer SE,Liu X,Mao HQ,Harden JL

更新日期：2007-08-01 00:00:00

abstract：:Brushite (dicalcium phosphate dihydrate, DCPD, CaHPO4 x 2H2O) was deposited electrolytically from calcium dihydrogen phosphate solution with and without potassium chloride (KCl) as a supporting electrolyte. The kinetics of brushite transformation to hydroxyapatite (HA, Ca5(PO4)3OH) in the presence of calcium and prote...

journal_title：Biomaterials

authors： Kumar M,Xie J,Chittur K,Riley C

更新日期：1999-08-01 00:00:00

abstract：:The nanopore size and roughness of nanoporous surface are two critical variables in determining stem cell fate, but little is known about the contribution from each cue individually. To address this gap, we use two-dimensional nanoporous membranes with controlled nanopore size and roughness to culture bone marrow-deri...

journal_title：Biomaterials

authors： Xia J,Yuan Y,Wu H,Huang Y,Weitz DA

更新日期：2020-07-01 00:00:00

abstract：:For clinical application of human embryonic stem cells (hESCs), it is critical to develop hESC culture techniques that completely exclude the use of animal feeder cells, mitotic inhibition, and enzyme treatments used in conventional hESC culture systems. Toward this goal, we attempted to maintain hESCs and induced plu...

journal_title：Biomaterials

authors： Hwang ST,Kang SW,Lee SJ,Lee TH,Suh W,Shim SH,Lee DR,Taite LJ,Kim KS,Lee SH

更新日期：2010-11-01 00:00:00

abstract：:Hydrogels provide three-dimensional frameworks with tissue-like elasticity and high permeability for culturing therapeutically relevant cells or tissues. While recent research efforts have created diverse macromer chemistry to form hydrogels, the mechanisms of hydrogel polymerization for in situ cell encapsulation rem...

journal_title：Biomaterials

authors： Lin CC,Raza A,Shih H

更新日期：2011-12-01 00:00:00

abstract：:Controlled delivery of bioactive molecules to modulate or control biological processes has a number of clinical applications. The present study reports a delivery system which was designed to deliver growth factors locally to a fracture site. Ethylene vinyl acetate copolymer (EVAc), bovine serum albumin (BSA) and plat...

journal_title：Biomaterials

authors： Walsh WR,Kim HD,Jong YS,Valentini RF

更新日期：1995-11-01 00:00:00

abstract：:Metastasis is the major cause of high mortality in head and neck squamous cell carcinoma (HNSCC), in which HNSCC-derived cancer stem cells (CSCs) may be involved. Several reports have coupled non-viral gene delivery with RNA interference (RNAi) to target specific genes in cancer cells. However, the delivery efficiency...

journal_title：Biomaterials

authors： Lo WL,Chien Y,Chiou GY,Tseng LM,Hsu HS,Chang YL,Lu KH,Chien CS,Wang ML,Chen YW,Huang PI,Hu FW,Yu CC,Chu PY,Chiou SH

更新日期：2012-05-01 00:00:00

abstract：:Endotoxemia is a severe pathophysiology induced by bacterial endotoxin (also known as lipopolysaccharide, LPS), causing high mortality in clinic due to the life-threatening syndromes, such as sepsis, shock, and multiple organ dysfunction. Removing or neutralizing endotoxin from the circulatory system has been proven t...

journal_title：Biomaterials

authors： Shen S,Han F,Yuan A,Wu L,Cao J,Qian J,Qi X,Yan Y,Ge Y

更新日期：2019-01-01 00:00:00

abstract：:Polymer-siRNA complexes (siRNA polyplexes) are being actively developed to improve the therapeutic application of siRNA. A major limitation for many siRNA polyplexes, however, is insufficient mRNA suppression. Given that modifying the sense strand of siRNA with 3' cholesterol (chol-siRNA) increases the activity of fre...

journal_title：Biomaterials

authors： Ambardekar VV,Han HY,Varney ML,Vinogradov SV,Singh RK,Vetro JA

更新日期：2011-02-01 00:00:00

abstract：:The aim of this study was to determine the biocompatibility and osteoconductive potential of a high-strength canasite glass ceramic. Glass-ceramic rods were produced using the lost-wax casting technique and implanted in the mid-shafts rabbit femurs. Implants were harvested at 4, 13 and 22 weeks and prepared for light ...

journal_title：Biomaterials

authors： da Rocha Barros VM,Salata LA,Sverzut CE,Xavier SP,van Noort R,Johnson A,Hatton PV

更新日期：2002-07-01 00:00:00

abstract：:Polytetrafluoroethylene (PTFE) is a commonly used medical polymer due to its biological stability and other attractive properties such as high hardness and wear resistance. However, the low surface energy and lack of functional groups to interact with the cellular environment have severely limited its applications in ...

journal_title：Biomaterials

authors： Wang H,Kwok DT,Wang W,Wu Z,Tong L,Zhang Y,Chu PK

更新日期：2010-01-01 00:00:00

abstract：:In this study, we investigate the molecular mechanisms by which human osteoblasts (HOB) challenged with wear debris promote the differentiation of osteoclast precursors. HOB were obtained from trabecular bone and exposed to alumina (Al(2)O(3)) or 'ultra-high molecular weight polyethylene' (UHMWPE) particles for 24h. T...

journal_title：Biomaterials

authors： Granchi D,Amato I,Battistelli L,Ciapetti G,Pagani S,Avnet S,Baldini N,Giunti A

更新日期：2005-05-01 00:00:00

abstract：:Poly(epsilon-caprolactone) (PCL) was dissolved in four solvent systems, chloroform, tetrahydrofuran, acetone and ethyl acetate, and cast onto glass Petri dishes. The surface properties of the resulting films were investigated. The extent to which their properties were determined by the solvent used in each case was qu...

journal_title：Biomaterials

authors： Tang ZG,Black RA,Curran JM,Hunt JA,Rhodes NP,Williams DF

更新日期：2004-08-01 00:00:00

abstract：:Reverse phase protein microarrays (RPMA) enable high throughput screening of posttranslational modifications of important signaling proteins within diseased cells. One limitation of protein-based molecular profiling is the lack of a PCR-like intrinsic amplification system for proteins. Enhancement of protein microarra...

journal_title：Biomaterials

authors： Nijdam AJ,Ming-Cheng Cheng M,Geho DH,Fedele R,Herrmann P,Killian K,Espina V,Petricoin EF 3rd,Liotta LA,Ferrari M

更新日期：2007-01-01 00:00:00

abstract：:Exosomes have emerged as appealing candidate therapeutic agents and delivery nanoplatforms due to their endogenous features and unique biological properties. However, obstacles such as low isolation yield, considerable complexity and potential safety concerns, and inefficient drug payload substantially hamper their th...

journal_title：Biomaterials

authors： Lu M,Huang Y

更新日期：2020-03-02 00:00:00

abstract：:Non-linear optical microscopy methods can characterize over time multiple functional properties of engineered tissues during development. Here, we demonstrate how the combined use of third-harmonic generation (THG) and two-photon excited fluorescence (2PEF) imaging can provide direct quantitative biomarkers of adipoge...

journal_title：Biomaterials

authors： Chang T,Zimmerley MS,Quinn KP,Lamarre-Jouenne I,Kaplan DL,Beaurepaire E,Georgakoudi I

更新日期：2013-11-01 00:00:00

abstract：:Nanocrystalline diamond (NCD) films and nanoparticulate diamond powder (DP) are the two main representatives of diamond at the nanoscale. This study was designed to investigate the suitability of these biomaterials as cell growth supports and to determine surface characteristic properties best suited to cell attachmen...

journal_title：Biomaterials

authors： Lechleitner T,Klauser F,Seppi T,Lechner J,Jennings P,Perco P,Mayer B,Steinmüller-Nethl D,Preiner J,Hinterdorfer P,Hermann M,Bertel E,Pfaller K,Pfaller W

更新日期：2008-11-01 00:00:00