Abstract：
:The aim of this study was to determine the biocompatibility and osteoconductive potential of a high-strength canasite glass ceramic. Glass-ceramic rods were produced using the lost-wax casting technique and implanted in the mid-shafts rabbit femurs. Implants were harvested at 4, 13 and 22 weeks and prepared for light and electron microscopy. Hydroxyapatite was used as a control material. Hydroxyapatite implants were surrounded by new mineralised bone tissue after 4 weeks of implantation. The amount of bone surrounding the implant increased slightly at 13 weeks. In contrast, canasite glass and glass ceramic implants were almost entirely surrounded by soft tissue during all the time periods. Close contact between bone and canasite glass-ceramic implant without the intervening fibrous tissue was observed in only a few regions. The canasite formulation evaluated was not osteoconductive and appeared to degrade in the biological environment. It was therefore concluded that the canasite formulation used was unsuitable for use as implant. Further work is required to improve the biocompatibility of these materials with bone tissue. It is possible that this could be achieved by reducing the solubility of the glass and glass ceramic.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
da Rocha Barros VM,Salata LA,Sverzut CE,Xavier SP,van Noort R,Johnson A,Hatton PVdoi
10.1016/s0142-9612(01)00417-3keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
2895-900issue
14eissn
0142-9612issn
1878-5905pii
S0142-9612(01)00417-3journal_volume
23pub_type
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