Therapeutic effects of neuropeptide substance P coupled with self-assembled peptide nanofibers on the progression of osteoarthritis in a rat model.

abstract：:Intraperitoneal (IP) chemotherapy is a promising post-surgical therapy of solid carcinomas confined within the peritoneal cavity, with potential benefits in locoregional and systemic management of residual tumors. In this study, we intended to increase local retention of platinum in the peritoneal cavity over a prolon...

journal_title：Biomaterials

authors： Cho EJ,Sun B,Doh KO,Wilson EM,Torregrosa-Allen S,Elzey BD,Yeo Y

更新日期：2015-01-01 00:00:00

abstract：:Physicochemical features of a cell nanoenvironment exert important influence on stem cell behavior and include the influence of matrix elasticity and topography on differentiation processes. The presence of growth factors such as TGF-β and BMPs on these matrices provides chemical cues and thus plays vital role in dire...

journal_title：Biomaterials

authors： Das RK,Zouani OF

更新日期：2014-07-01 00:00:00

abstract：:Hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) were studied by computer graphics with a personal computer. Crystal models of fluoridated hydroxyapatite and fluorapatite, in which F- ions are substituted into some or all OH- positions, were also drawn. Data on the structural coordinates of the hydroxyapatite a...

journal_title：Biomaterials

authors： Okazaki M,Sato M

更新日期：1990-10-01 00:00:00

abstract：:The currently available surgical options to repair the diaphragm are associated with significant risks of defect recurrence, lack of growth potential and restored functionality. A tissue engineered diaphragm has the potential to improve surgical outcomes for patients with congenital or acquired disorders. Here we show...

journal_title：Biomaterials

authors： Gubareva EA,Sjöqvist S,Gilevich IV,Sotnichenko AS,Kuevda EV,Lim ML,Feliu N,Lemon G,Danilenko KA,Nakokhov RZ,Gumenyuk IS,Grigoriev TE,Krasheninnikov SV,Pokhotko AG,Basov AA,Dzhimak SS,Gustafsson Y,Bautista G,Beltrán Ro

更新日期：2016-01-01 00:00:00

abstract：:Patient-derived tumor organoids offer potentially useful models of cancer tissue physiology. Yet, conventional organoid cultures utilize generic matrices that are difficult to tailor for various unique tumor microenvironments. Here, we employ synthetic, enzymatically crosslinked hydrogels to define mechanical and bioc...

journal_title：Biomaterials

authors： Ng S,Tan WJ,Pek MMX,Tan MH,Kurisawa M

更新日期：2019-10-01 00:00:00

abstract：:A new thiolating reagent is used to introduce sulphur groups into denatured atelocollagen. The procedure is easy to control and applicable on a large scale. The reagent is a reactive dicarboxylic acid compound containing sulphur in the form of a disulphide functionality. It is prepared by reacting N,N'-disuccinoylcyst...

journal_title：Biomaterials

authors： Nicolas FL,Gagnieu CH

更新日期：1997-06-01 00:00:00

abstract：:Albumin is a promising surface modifier of nanoparticulate drug delivery systems. Serving as a dysopsonin, albumin can protect circulating nanoparticles (NPs) from the recognition and clearance by the mononuclear phagocytic system (MPS). Albumin may also help transport the NPs to solid tumors based on the increased co...

journal_title：Biomaterials

authors： Hyun H,Park J,Willis K,Park JE,Lyle LT,Lee W,Yeo Y

更新日期：2018-10-01 00:00:00

abstract：:Generation of specific lineages of cells from embryonic stem (ES) cells is pre-requisite to use these cells in pre-clinical applications. Here, we developed a recombinant E-cadherin substratum for generation of hepatic progenitor populations at single cell level. This artificial acellular feeder layer supports the ste...

journal_title：Biomaterials

authors： Haque A,Hexig B,Meng Q,Hossain S,Nagaoka M,Akaike T

更新日期：2011-03-01 00:00:00

abstract：:Realizing the potential of human pluripotent stem cell (hPSC)-based therapy requires the development of defined scalable culture systems with efficient expansion, differentiation and isolation protocols. We report an engineered 3D microfiber system that efficiently supports long-term hPSCs self-renewal under chemicall...

journal_title：Biomaterials

authors： Lu HF,Narayanan K,Lim SX,Gao S,Leong MF,Wan AC

更新日期：2012-03-01 00:00:00

abstract：:Anchorage-dependent cells (NRK 49F) were grown at 37 degrees C in serum containing medium on glass coated with a N-isopropyl acrylamide/N-t-butyl acrylamide copolymer (NIPAaM/NTBAM) with a lower critical solution temperature (LCST) of 8 degrees C. After incubating the dishes and adherent cells at 4 degrees C for 1 h, ...

journal_title：Biomaterials

authors： Rollason G,Davies JE,Sefton MV

更新日期：1993-01-01 00:00:00

abstract：:The adsorption of bovine serum albumin (BSA) on to titanium powder has been studied as a function of protein concentration and pH, and in the presence of calcium and phosphate ions. Isotherm data have shown that the adsorption process does not follow the Langmuir model (inflection points). The maximum adsorption (Adma...

journal_title：Biomaterials

authors： Wassell DT,Embery G

更新日期：1996-05-01 00:00:00

abstract：:Smad3 mediates the intracellular signaling of TGF-beta1 superfamily and plays a critical role in the cellular proliferation, differentiation and elaboration of matrix pivotal to cutaneous wound healing. Smad3 antisense oligonucleotides (ASOs) impregnated polyelectrolyte complex (PEC) containing chitosan and sodium alg...

journal_title：Biomaterials

authors： Hong HJ,Jin SE,Park JS,Ahn WS,Kim CK

更新日期：2008-12-01 00:00:00

abstract：:Recent developments in cell culture techniques have made it possible to study the cellular mechanisms involved in carcinogenesis and to apply these methods as screening tools in vitro. This study investigated and compared the ability of the metals most commonly used in orthopedic implants to induce toxicity and neopla...

journal_title：Biomaterials

authors： Doran A,Law FC,Allen MJ,Rushton N

更新日期：1998-04-01 00:00:00

abstract：:A nanocarrier delivery system that can simultaneously deliver a chemotherapeutic drug and siRNA to the tumor is emerging as a promising treatment strategy for cancer treatment. In this study, a multifunctional PHD/PPF/siRNA complexes was developed by one-step assembly of prefunctionalized polymers: PEI-HZ-DOX (PHD) an...

journal_title：Biomaterials

authors： Dong DW,Xiang B,Gao W,Yang ZZ,Li JQ,Qi XR

更新日期：2013-07-01 00:00:00

abstract：:We investigated the production of free radicals on a poly(ether-ether-ketone) (PEEK) substrate under ultraviolet (UV) irradiation. The amount of the ketyl radicals produced from the benzophenone (BP) units in the PEEK molecular structure initially increased rapidly and then became almost constant. Our observations rev...

journal_title：Biomaterials

authors： Kyomoto M,Moro T,Yamane S,Hashimoto M,Takatori Y,Ishihara K

更新日期：2013-10-01 00:00:00

abstract：:Hydroxylated and methylated surfaces were prepared by the self-assembled monolayer technique (SAM) of alkane thiols on gold. The surfaces were used to evaluate the influence of implant surface chemistry on protein deposition and inflammatory cell response. Implants were inserted subcutaneously in the rat for 3 and 24 ...

journal_title：Biomaterials

authors： Källtorp M,Oblogina S,Jacobsson S,Karlsson A,Tengvall P,Thomsen P

更新日期：1999-11-01 00:00:00

abstract：:As a common receptor for three myelin associated inhibitors, Nogo-66 receptor (NgR) mediates their inhibitory activities on neurite outgrowth in the adult mammalian central nervous system (CNS). Therapeutic vaccination protocol targeting NgR emulsified with Freund's adjuvant (FA) has been used in spinal cord injury (S...

journal_title：Biomaterials

authors： Wang YT,Lu XM,Zhu F,Huang P,Yu Y,Zeng L,Long ZY,Wu YM

更新日期：2011-11-01 00:00:00

abstract：:Cerium oxide nanoparticles (nanoceria) are promising materials for intracellular oxygen free radical scavenging providing a potential therapy for reactive oxygen species (ROS)-mediated inflammatory processes. In this study rhombohedral-shaped nanoceria were synthesized by flame spray pyrolysis with tuneable particle d...

journal_title：Biomaterials

authors： Lord MS,Jung M,Teoh WY,Gunawan C,Vassie JA,Amal R,Whitelock JM

更新日期：2012-11-01 00:00:00

abstract：:Two types of isoelastic endosseous dental implants were produced and their functionality was tested. One type consisted of a porous sintered TiTa30 alloy, the other had a special surface structure consisting of titanium wire loops. Their mechanical properties were optimized by the production parameter (sintering and d...

journal_title：Biomaterials

authors： Breme J,Biehl V,Schulte W,d'Hoedt B,Donath K

更新日期：1993-10-01 00:00:00

abstract：:We have developed nanoparticles based on Murine Leukemia Virus virus-like-particles (VLPs) that efficiently deliver therapeutic bioactive proteins in their native state into target cells. Nuclear transcription factors and toxic proteins were incorporated into the VLPs from stable producer cells without transducing vir...

journal_title：Biomaterials

authors： Wu DT,Roth MJ

更新日期：2014-09-01 00:00:00

abstract：:Healing soft-tissue wounds with an irregular, complicated topography in a bleeding environment demands the development of a dressing that is wet-adhesive, haemostatic, and antibacterial. To meet this unmet demand, we designed a flexible nanosheet (~77 nm thick) made of two layers, one is the antibacterial and haemosta...

journal_title：Biomaterials

authors： Xuan C,Hao L,Liu X,Zhu Y,Yang H,Ren Y,Wang L,Fujie T,Wu H,Chen Y,Shi X,Mao C

更新日期：2020-09-01 00:00:00

abstract：:Intervertebral disc (IVD) herniation causes pain and disability, but current discectomy procedures alleviate pain without repairing annulus fibrosus (AF) defects. Tissue engineering strategies seal AF defects by utilizing hydrogel systems to prevent recurrent herniation, however current biomaterials are limited by poo...

journal_title：Biomaterials

authors： DiStefano TJ,Shmukler JO,Danias G,Di Pauli von Treuheim T,Hom WW,Goldberg DA,Laudier DM,Nasser PR,Hecht AC,Nicoll SB,Iatridis JC

更新日期：2020-11-01 00:00:00

abstract：:Both positively and negatively charged residues play pivotal roles in recruiting precursor ions or ion clusters, and lowering interfacial energy in natural biomineralization process. Synergistic utilization of opposite charges, however, has rarely been implemented in the design of cytocompatible synthetic scaffolds pr...

journal_title：Biomaterials

authors： Liu P,Song J

更新日期：2013-03-01 00:00:00

abstract：:Implantation of a medical implant within the body inevitably triggers a host inflammatory response that negatively impacts its function and longevity. Nevertheless, the degree and severity of this response may be reduced by selecting appropriate materials, implant geometry, surface topography and surface treatment. He...

journal_title：Biomaterials

authors： Li J,Chu MK,Gordijo CR,Abbasi AZ,Chen K,Adissu HA,Löhn M,Giacca A,Plettenburg O,Wu XY

更新日期：2015-04-01 00:00:00

abstract：:The interactions between alginate and polycations have been studied by using different labelling techniques. Binding of poly-L-lysine (PLL) to alginate in the gel state is mainly governed by the amount of dissociable negative charges on the bead surface. PLL was found to bind more rapidly to gel beads made from algina...

journal_title：Biomaterials

authors： Thu B,Bruheim P,Espevik T,Smidsrød O,Soon-Shiong P,Skjåk-Braek G

更新日期：1996-05-01 00:00:00

abstract：:Combined and targeted therapy have been extensively employed to achieve more effective elimination of tumor tissues. In this study, biocompatible multifunctional lipid-coated calcium phosphate nanoparticles (LCP NPs) were designed and constructed as an efficient targeted delivery system for combined gene/photothermal ...

journal_title：Biomaterials

authors： Tang J,Li B,Howard CB,Mahler SM,Thurecht KJ,Wu Y,Huang L,Xu ZP

更新日期：2019-09-01 00:00:00

abstract：:A novel biodegradable polymer blend was developed for potential biomedical applications. A 50:50 poly(lactide-co-glycolide) (PLAGA) was blended in a 50:50 ratio with the followiing polyphosphazenes (PPHOS): poly[(25% ethyl glycinato)(75% p-methylphenoxy)phosphazene[, poly[(50% ethyl glycinato)(50% p-methylphenoxy)phos...

journal_title：Biomaterials

authors： Ibim SE,Ambrosio AM,Kwon MS,El-Amin SF,Allcock HR,Laurencin CT

更新日期：1997-12-01 00:00:00

abstract：:Biologic scaffolds composed of extracellular matrix (ECM) have been used to facilitate the repair and reconstruction of a variety of tissues in clinical and pre-clinical studies. The clinical utility of such scaffolds can be limited by the geometric and mechanical properties of the tissue or organ from which the ECM i...

journal_title：Biomaterials

authors： Freytes DO,Martin J,Velankar SS,Lee AS,Badylak SF

更新日期：2008-04-01 00:00:00

abstract：:Collagen has been widely used for tissue engineering. Here, we applied bioactive laminin-derived peptides as an additive for collagen, laminin-111, and fibronectin matrices resulting in peptide/collagen, peptide/laminin-111, and peptide/fibronectin matrices. Several syndecan-binding peptides, including AG73 (RKRLQVQLS...

journal_title：Biomaterials

authors： Yamada Y,Katagiri F,Hozumi K,Kikkawa Y,Nomizu M

更新日期：2011-07-01 00:00:00

abstract：:Achieving and maintaining safe and reliable lineage specific differentiation of stem cells is important for clinical translation of tissue engineering strategies. In an effort to circumvent the multitude of problems arising from the usage of growth factors and growth factor delivery systems, we have explored the use o...

journal_title：Biomaterials

authors： Huang CC,Narayanan R,Alapati S,Ravindran S

更新日期：2016-12-01 00:00:00