Adsorption of bovine serum albumin on to titanium powder.

abstract：:Recent advances in biomaterial surface engineering have shown that surface biomechanical, spatial and topographical properties can elicit control over fundamental biological processes such as cell shape, proliferation, differentiation and apoptosis. Along these lines, we have very recently shown that the self-assembly...

journal_title：Biomaterials

authors： George PA,Quinn K,Cooper-White JJ

更新日期：2010-02-01 00:00:00

abstract：:The purpose of the present work was to examine the effect of different Ti-6Al-4V surface treatments on osteoblasts behaviour. Previous work in this laboratory has demonstrated that an ageing treatment reduces metal ion release from this alloy compared to standard passivation procedures. In this study. human osteosarco...

journal_title：Biomaterials

authors： Ku CH,Pioletti DP,Browne M,Gregson PJ

更新日期：2002-03-01 00:00:00

abstract：:Mononuclear phagocyte system is the first target for injected nanomaterials. Monocytes/macrophages are the central actors for trafficking and clearance of magnetic nanoparticles in vivo. However the fate of nanosized magnetic label is an ongoing issue. Here we demonstrate that the monocyte/macrophage system shows a co...

journal_title：Biomaterials

authors： Luciani N,Wilhelm C,Gazeau F

更新日期：2010-09-01 00:00:00

abstract：:As a common receptor for three myelin associated inhibitors, Nogo-66 receptor (NgR) mediates their inhibitory activities on neurite outgrowth in the adult mammalian central nervous system (CNS). Therapeutic vaccination protocol targeting NgR emulsified with Freund's adjuvant (FA) has been used in spinal cord injury (S...

journal_title：Biomaterials

authors： Wang YT,Lu XM,Zhu F,Huang P,Yu Y,Zeng L,Long ZY,Wu YM

更新日期：2011-11-01 00:00:00

abstract：:Improving the immunogenicity of subunit vaccines, in particular skewing of the immune response towards Th1 type immunity, is crucial for the development of effective vaccines against intracellular infections and for the development of anti-cancer vaccines. Small molecule TLR7/8 agonist hold high potential for this pur...

journal_title：Biomaterials

authors： Nuhn L,Van Hoecke L,Deswarte K,Schepens B,Li Y,Lambrecht BN,De Koker S,David SA,Saelens X,De Geest BG

更新日期：2018-09-01 00:00:00

abstract：:Chitosan (CHT)/poly(ɛ-caprolactone) (PCL) blend 3D fiber-mesh scaffolds were studied as possible support structures for articular cartilage tissue (ACT) repair. Micro-fibers were obtained by wet-spinning of three different polymeric solutions: 100:0 (100CHT), 75:25 (75CHT) and 50:50 (50CHT) wt.% CHT/PCL, using a commo...

journal_title：Biomaterials

authors： Neves SC,Moreira Teixeira LS,Moroni L,Reis RL,Van Blitterswijk CA,Alves NM,Karperien M,Mano JF

更新日期：2011-02-01 00:00:00

abstract：:Tumor-homing cytotoxic stem cell (SC) therapy is a promising new approach for treating the incurable brain cancer glioblastoma (GBM). However, problems of retaining cytotoxic SCs within the post-surgical GBM resection cavity are likely to significantly limit the clinical utility of this strategy. Here, we describe a n...

journal_title：Biomaterials

authors： Bagó JR,Pegna GJ,Okolie O,Hingtgen SD

更新日期：2016-04-01 00:00:00

abstract：:Chemotherapy is a popular treatment approach against cancer but significant uptake of drugs by normal tissues is still a major limitation. Magnetic drug targeting (MDT) has been used to improve localized drug delivery to interstitial tumor targets. MDT is now being developed to improve drug delivery to tumor vessels. ...

journal_title：Biomaterials

authors： Dandamudi S,Campbell RB

更新日期：2007-11-01 00:00:00

abstract：:Neural tissue engineering holds great promise in repairing damaged nerve tissues. However, despite the promising results in regenerating the injured nervous system, tissue engineering approaches are still insufficient to result in full functional recovery in severe nerve damages. Majority of these approaches only focu...

journal_title：Biomaterials

authors： Chooi WH,Chew SY

更新日期：2019-03-01 00:00:00

abstract：:Drug-loaded implants have attracted considerable attention in cancer treatment due to their precise delivery of drugs into cancer tissues. Contrary to injected drug delivery, the application of drug-loaded implants remains underutilized given the requirement for a surgical operation. Nevertheless, drug-loaded implants...

journal_title：Biomaterials

authors： Yang Y,Qiao X,Huang R,Chen H,Shi X,Wang J,Tan W,Tan Z

更新日期：2020-02-01 00:00:00

abstract：:In this study, we used deoxyribozyme (DNAzyme) functionalized gold nanoparticles (AuNPs) to catalytically silence tumor necrosis factor-α (TNF-α) in vivo as a potential therapeutic for myocardial infarction (MI). Using primary macrophages as a model, we demonstrated 50% knockdown of TNF-α, which was not attainable usi...

journal_title：Biomaterials

authors： Somasuntharam I,Yehl K,Carroll SL,Maxwell JT,Martinez MD,Che PL,Brown ME,Salaita K,Davis ME

更新日期：2016-03-01 00:00:00

abstract：:Fibrous polyurethane (FPU) prostheses with or without fibronectin coating and gelatin impregnation and FPU prostheses with or without fibronectin coating were seeded with 4.8 x 10(5) subcultivated dog endothelial cells per cm2 prosthesis. Expanded polytetrafluoroethylene (ePTFE) prostheses with and without fibronectin...

journal_title：Biomaterials

authors： Hess F,Jerusalem R,Reijnders O,Jerusalem C,Steeghs S,Braun B,Grande P

更新日期：1992-01-01 00:00:00

abstract：:Reconstruction of the genitourinary tract, using engineered urological tissues, requires a mechanically stable biodegradable and biocompatible scaffold and cultured cells. Such engineered autologous tissue would have many clinical implications. In this study a highly porous biodegradable polyesterurethane-foam, DegraP...

journal_title：Biomaterials

authors： Danielsson C,Ruault S,Simonet M,Neuenschwander P,Frey P

更新日期：2006-03-01 00:00:00

abstract：:Cytoxicity is an essential concern for polyethyleneimine 25 kDa (PEI 25 kDa), a widely reported, highly effective transfection agent used in gene delivery. In our recent experiments, Small molecular weight cross-linked poly(ethylene imine) by biscarbamate linkage (PEI-Bu) (Mn: 3278, Mw: 4289) can reduce target cell ap...

journal_title：Biomaterials

authors： Xiang S,Su J,Tong H,Yang F,Tong W,Yuan W,Wu F,Wang C,Jin T,Dai K,Zhang X

更新日期：2012-09-01 00:00:00

abstract：:In the present work, we designed and synthesized a novel mono-guanidine heterolipid (MGH) and confirmed its structure by NMR and ESI-MS. The MGH was used as cationic lipid in developing etoposide loaded cationic self-microemulsifying drug delivery system (ECS) intended to be delivered by intratumoral route. The ECS ex...

journal_title：Biomaterials

authors： Shete H,Sable S,Tidke P,Selkar N,Pawar Y,Chakraborty A,De A,Vanage G,Patravale V

更新日期：2015-07-01 00:00:00

abstract：:This highly absorbent, biodegradable dressing derived from seaweed can be successfully applied to cleanse a wide variety of secreting lesions. The high absorption of exudate is achieved via strong hydrophilic gel formation and this serves to control wound secretion levels and to minimize bacterial contamination. Algin...

journal_title：Biomaterials

authors： Gilchrist T,Martin AM

更新日期：1983-10-01 00:00:00

abstract：:To enable the synthesis of hydrogels containing microporosity, a family of pore generating additives (porogens) were synthesized from poly(ethylene glycols) (PEGs) with different molecular weights using naphthyl acetic acid. The products formed were characterized by UV-vis, differential scanning calorimetry and soluti...

journal_title：Biomaterials

authors： Badiger MV,McNeill ME,Graham NB

更新日期：1993-11-01 00:00:00

abstract：:The clinical usefulness of brain machine interfaces that employ penetrating silicon microelectrode arrays is limited by inconsistent performance at chronic time points. While it is widely believed that elements of the foreign body response (FBR) contribute to inconsistent single unit recording performance, the relatio...

journal_title：Biomaterials

authors： Nolta NF,Christensen MB,Crane PD,Skousen JL,Tresco PA

更新日期：2015-01-01 00:00:00

abstract：:DNA vaccine is a milestone in contemporary vaccine development. It has considerably offset many shortcomings in conventional vaccines. Although DNA vaccines applied through 'traditional' high-pressure gene guns generally elicit high titers of protective immunity, such a practice however requires enormous investment in...

journal_title：Biomaterials

authors： Huang HN,Li TL,Chan YL,Chen CL,Wu CJ

更新日期：2009-10-01 00:00:00

abstract：:Glioma is still hard to be treated due to their complex microenvironment. In this study, a gold nanoparticle-based delivery system was developed. The system, An-PEG-DOX-AuNPs, was loaded with doxorubicin (DOX) through hydrazone, an acid-responsive linker, and was functionalized with angiopep-2, a specific ligand of lo...

journal_title：Biomaterials

authors： Ruan S,Yuan M,Zhang L,Hu G,Chen J,Cun X,Zhang Q,Yang Y,He Q,Gao H

更新日期：2015-01-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) with four reprogramming factors (Oct-4/Sox2/Klf-4/c-Myc) have been shown to differentiate into hepatic lineages. However, it was unclear whether obviation of the c-Myc oncogene in iPSCs affected hepatic differentiation or inhibited in vivo tumor formation. In this study, we demon...

journal_title：Biomaterials

authors： Li HY,Chien Y,Chen YJ,Chen SF,Chang YL,Chiang CH,Jeng SY,Chang CM,Wang ML,Chen LK,Hung SI,Huo TI,Lee SD,Chiou SH

更新日期：2011-09-01 00:00:00

abstract：:Esterified hyaluronic acid (HYAFF) is routinely used for clinical tissue engineering applications such as skin and cartilage. In a previous study we developed a technique for in vitro generation of cylindrical constructs from cellularized HYAFF flat sheets. In the present investigation we studied the possibility to im...

journal_title：Biomaterials

authors： Arrigoni C,Camozzi D,Imberti B,Mantero S,Remuzzi A

更新日期：2006-02-01 00:00:00

abstract：:Thermosensitive polymers poly(N-isopropylacrylamide) (PNIPAM), poly(N-vinylcaprolactam) (PVCL) and PVCL grafted with amphiphilic poly(ethylene oxide) (PEO) chains (PVCL-graft-C11EO42) were prepared and characterized and their putative cytotoxicity was evaluated. The cytotoxicity of these thermosensitive polymers and t...

journal_title：Biomaterials

authors： Vihola H,Laukkanen A,Valtola L,Tenhu H,Hirvonen J

更新日期：2005-06-01 00:00:00

abstract：:A nanohybrid vesicle was developed from cholesteryl succinyl silane(CSS) in combination of sol-gel process and self-assembly technique. The silicalike surface adds CSS vesicles remarkably high stability against destabilization in blood or leakage of drug cargos. It was found that CSS vesicles alone exhibited selective...

journal_title：Biomaterials

authors： Ma Y,Dai Z,Zha Z,Gao Y,Yue X

更新日期：2011-12-01 00:00:00

abstract：:A 29 amino-acid peptide derived from the rabies virus glycoprotein (RVG29) was exploited as a ligand for efficient brain-targeting gene delivery. RVG29 was modified on polyamidoamine dendrimers (PAMAM) through bifunctional PEG, then complexed with DNA, yielding PAMAM-PEG-RVG29/DNA nanoparticles (NPs). The NPs were obs...

journal_title：Biomaterials

authors： Liu Y,Huang R,Han L,Ke W,Shao K,Ye L,Lou J,Jiang C

更新日期：2009-09-01 00:00:00

abstract：:Copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) are prototypic and well-characterized polymeric drug carriers that have been broadly implemented in the delivery of anticancer therapeutics. To demonstrate that polymers, as liposomes, can be used for simultaneously delivering multiple chemotherapeutic agents to t...

journal_title：Biomaterials

authors： Lammers T,Subr V,Ulbrich K,Peschke P,Huber PE,Hennink WE,Storm G

更新日期：2009-07-01 00:00:00

abstract：:Human adipose-derived stem cells (hADSCs) were purified from a suspension of human adipose tissue cells (stromal vascular fraction) by the conventional culture method and by membrane filtration through polyurethane (PU) foam membranes. hADSCs can be obtained from a suspension of human adipose tissue cells using the me...

journal_title：Biomaterials

authors： Wu CH,Lee FK,Suresh Kumar S,Ling QD,Chang Y,Chang Y,Wang HC,Chen H,Chen DC,Hsu ST,Higuchi A

更新日期：2012-11-01 00:00:00

abstract：:The objective of the current investigation is to determine the soft-tissue biocompatibility of sol-gel matrices which can be used to optimize the properties of implantable glucose sensors. The biocompatibility of sol-gel matrices with heparin, dextran sulphate, Nafion, polyethylene glycol, and polystyrene sulphonate w...

journal_title：Biomaterials

authors： Gerritsen M,Kros A,Sprakel V,Lutterman JA,Nolte RJ,Jansen JA

更新日期：2000-01-01 00:00:00

abstract：:A major hindrance in islet transplantation as a feasible therapeutic approach for patients with type 1 diabetes is the insufficient oxygenation of the grafts, which results in cell death in portions of the implant. Here we address this limitation through the application of oxygen-generating microparticles (MP) and a f...

journal_title：Biomaterials

authors： Montazeri L,Hojjati-Emami S,Bonakdar S,Tahamtani Y,Hajizadeh-Saffar E,Noori-Keshtkar M,Najar-Asl M,Ashtiani MK,Baharvand H

更新日期：2016-05-01 00:00:00

abstract：:A challenge in combating many major diseases is breaching the skin's tough outer layer (the stratum corneum (SC)) and delivering drugs and genes into the underlying abundant immunologically sensitive viable epidermal cells with safe, practical physical technologies. To achieve this effectively and accurately, design i...

journal_title：Biomaterials

authors： Kendall MA,Chong YF,Cock A

更新日期：2007-11-01 00:00:00