Chitosan/poly(epsilon-caprolactone) blend scaffolds for cartilage repair.

abstract：:Direct delivery of proteins to the cytosol of cells holds tremendous potential in biological and medical applications. Engineering vehicles for escorting proteins to the cytosol in a controlled release fashion has thus generated considerable interest. We report here the preparation of redox-responsive single-protein n...

journal_title：Biomaterials

authors： Zhao M,Biswas A,Hu B,Joo KI,Wang P,Gu Z,Tang Y

更新日期：2011-08-01 00:00:00

abstract：:The water absorption characteristics of resins, upon which many composite filling materials are based, have been studied. In general, the equilibrium uptake is less than that predicted from the water absorption of composite filling materials, if it is assumed that the polymer alone absorbs the water. Also, whereas the...

journal_title：Biomaterials

authors： Braden M,Davy KW

更新日期：1986-11-01 00:00:00

abstract：:Modified high shear homogenization and ultrasound techniques were employed to produce solid lipid nanoparticles (SLNs). Model drug mifepristone had been incorporated in SLNs. The mean particle size measured by laser diffractometry (LD) was found to be 106 nm with a narrow particle distribution of polydispersity index,...

journal_title：Biomaterials

authors： Hou D,Xie C,Huang K,Zhu C

更新日期：2003-05-01 00:00:00

abstract：:Glioblastoma (GBM) is the deadliest and most common type of primary brain tumor in adults with a grim prognosis despite multimodal treatments. Dendritic cell (DC)-based immunotherapy has emerged as a promising therapeutic modality for GBM, whose efficacy is nonetheless fundamentally undermined by GBM-induced immunosup...

journal_title：Biomaterials

authors： Li TF,Li K,Zhang Q,Wang C,Yue Y,Chen Z,Yuan SJ,Liu X,Wen Y,Han M,Komatsu N,Xu YH,Zhao L,Chen X

更新日期：2018-10-01 00:00:00

abstract：:Theranostic nanoagents which integrate diagnostic and therapeutic moieties into a single platform have attracted broad attention in cancer therapy, however the development of more effective and less toxic diagnostic and therapeutic interventions is still of great urgency. Herein, novel core-shell PB@MIL-100(Fe) dual m...

journal_title：Biomaterials

authors： Wang D,Zhou J,Chen R,Shi R,Zhao G,Xia G,Li R,Liu Z,Tian J,Wang H,Guo Z,Wang H,Chen Q

更新日期：2016-09-01 00:00:00

abstract：:An increased demand for soft-tissue substitutes has impelled the development of an in vitro adipose tissue. Ideally, such a tissue should contain a vascular network that can deliver blood throughout the construct following its engraftment. This study describes the in vitro fabrication of a pre-vascularized adipose tis...

journal_title：Biomaterials

authors： Sorrell JM,Baber MA,Traktuev DO,March KL,Caplan AI

更新日期：2011-12-01 00:00:00

abstract：:Controlled delivery of bioactive molecules to modulate or control biological processes has a number of clinical applications. The present study reports a delivery system which was designed to deliver growth factors locally to a fracture site. Ethylene vinyl acetate copolymer (EVAc), bovine serum albumin (BSA) and plat...

journal_title：Biomaterials

authors： Walsh WR,Kim HD,Jong YS,Valentini RF

更新日期：1995-11-01 00:00:00

abstract：:We investigated the feasibility and efficacy of target thrombolysis with recombinant tissue plasminogen activator (rtPA) covalently bound to magnetic nanoparticle (MNP) and retained to the target site in vivo by an external magnet. Polyacrylic acid-coated magnetite (PAA-MNP, 246 nm) was synthesized and characterized; ...

journal_title：Biomaterials

authors： Ma YH,Wu SY,Wu T,Chang YJ,Hua MY,Chen JP

更新日期：2009-07-01 00:00:00

abstract：:Non-invasive assay for the early stage diagnosis of methicillin resistant Staphylococcus aureus (MRSA) related pneumonia is of great clinical importance and still a great challenge. In this paper, we reported a novel kind of Au@Ag core-shell theranostic nanoparticles (NPs) conjugated with MRSA specific antibody on the...

journal_title：Biomaterials

authors： Huo D,Ding J,Cui YX,Xia LY,Li H,He J,Zhou ZY,Wang HW,Hu Y

更新日期：2014-08-01 00:00:00

abstract：:Experimental and histological studies on the reaction of surrounding gingiva to permucosal implants of dense calcium hydroxyapatite were carried out in dogs. Epithelial attachment and connection of supra-alveolar collagen fibres to the implant surface seemed to form a biological seal around implants similar to that ar...

journal_title：Biomaterials

authors： Kurashina K,de Lange GL,de Putter C,de Groot K

更新日期：1984-07-01 00:00:00

abstract：:In the stem-cell niche, the extracellular matrix (ECM) serves as a structural support that additionally provides stem cells with signals that contribute to the regulation of stem-cell function, via reciprocal interactions between cells and components of the ECM. Recently, cell-derived ECMs have emerged as in vitro cel...

journal_title：Biomaterials

authors： Ragelle H,Naba A,Larson BL,Zhou F,Prijić M,Whittaker CA,Del Rosario A,Langer R,Hynes RO,Anderson DG

更新日期：2017-06-01 00:00:00

abstract：:The purpose of this study is to analyze the roles of two non-invasive techniques, bone scintigraphy and resonance frequency analysis (RFA), in the osseointegration assessment. Sixty implants with sandblasted/acid-etched (SA) or machined (MA) surface were placed into the distal femur condyles of 30 rabbits. At 1, 2, 4,...

journal_title：Biomaterials

authors： Zhou Y,Jiang T,Qian M,Zhang X,Wang J,Shi B,Xia H,Cheng X,Wang Y

更新日期：2008-02-01 00:00:00

abstract：:Islet transplantation is considered the most promising treatment for type 1 diabetes. However, the clinical success is limited by islet dysfunction in long-term culture. In this study, we have utilized the rapid self-gelation and injectability offered by blending of mulberry silk (Bombyx mori) with non-mulberry (Anthe...

journal_title：Biomaterials

authors： Kumar M,Gupta P,Bhattacharjee S,Nandi SK,Mandal BB

更新日期：2018-12-01 00:00:00

abstract：:Photodynamic therapy (PDT) induced hypoxia can significantly upregulate the expression of vascular endothelial growth factor (VEGF) at the tumor-stromal interface, resulting in a promoted angiogenesis. Thus, an angiogenesis vessel-targeting nanoparticle (AVT-NP) consisting of photosensitizer, angiogenic vessel-targeti...

journal_title：Biomaterials

authors： Guo D,Xu S,Wang N,Jiang H,Huang Y,Jin X,Xue B,Zhang C,Zhu X

更新日期：2017-11-01 00:00:00

abstract：:Type I collagen constitutes a major portion of the extracellular matrix (ECM) in arterial wall and it is the major substrate for cell growth and differentiation. The goal of this study was to evaluate the differentiation and proliferation of placenta-derived multipotent cells (PDMCs) on polymerized type I collagen fib...

journal_title：Biomaterials

authors： Chou MT,Chang SN,Ke C,Chang HI,Sung ML,Kuo HC,Chen CN

更新日期：2010-05-01 00:00:00

abstract：:Cerium oxide nanoparticles (nanoceria) are promising materials for intracellular oxygen free radical scavenging providing a potential therapy for reactive oxygen species (ROS)-mediated inflammatory processes. In this study rhombohedral-shaped nanoceria were synthesized by flame spray pyrolysis with tuneable particle d...

journal_title：Biomaterials

authors： Lord MS,Jung M,Teoh WY,Gunawan C,Vassie JA,Amal R,Whitelock JM

更新日期：2012-11-01 00:00:00

abstract：:A facile and efficient method to immobilize bioactive proteins onto polymeric substrate was established. Testis-specific protease 50 (TSP50) was immobilized on ultrafine biodegradable polymer fibers, i.e., (1) to prepare a propargyl-containing polymer P(LA90-co-MPC10) by introducing propargyl group into a cyclic carbo...

journal_title：Biomaterials

authors： Shi Q,Chen X,Lu T,Jing X

更新日期：2008-03-01 00:00:00

abstract：:Highly crosslinked UHMWPEs have demonstrated improved in vitro wear properties; however, there is concern regarding loss of fracture resistance and ductility. The goals of this study were to evaluate the micromechanisms of failure under uniaxial tension and to determine the effect of gamma radiation-induced crosslinki...

journal_title：Biomaterials

authors： Gencur SJ,Rimnac CM,Kurtz SM

更新日期：2003-10-01 00:00:00

abstract：:In this study, a type of intracellular redox-triggered hollow mesoporous silica nanoreservoirs (HMSNs) with tumor specificity was developed in order to deliver anticancer drug (i.e., doxorubicin (DOX)) to the target tumor cells with high therapeutic efficiency and reduced side effects. Firstly, adamantanamine was graf...

journal_title：Biomaterials

authors： Luo Z,Hu Y,Cai K,Ding X,Zhang Q,Li M,Ma X,Zhang B,Zeng Y,Li P,Li J,Liu J,Zhao Y

更新日期：2014-09-01 00:00:00

abstract：:The present in vitro study investigates the cellular interaction of primary human osteoblasts with human and bovine solvent dehydrated cancellous bone (SDCB) discs. These are bio-implants from solvent dehydrated, gamma-irradiated preserved human and bovine cancellous bone, pre-treated to remove all cells, genetic comp...

journal_title：Biomaterials

authors： Trentz OA,Hoerstrup SP,Sun LK,Bestmann L,Platz A,Trentz OL

更新日期：2003-09-01 00:00:00

abstract：:Endotoxemia is a severe pathophysiology induced by bacterial endotoxin (also known as lipopolysaccharide, LPS), causing high mortality in clinic due to the life-threatening syndromes, such as sepsis, shock, and multiple organ dysfunction. Removing or neutralizing endotoxin from the circulatory system has been proven t...

journal_title：Biomaterials

authors： Shen S,Han F,Yuan A,Wu L,Cao J,Qian J,Qi X,Yan Y,Ge Y

更新日期：2019-01-01 00:00:00

abstract：:Polytetrafluoroethylene (PTFE) is a commonly used medical polymer due to its biological stability and other attractive properties such as high hardness and wear resistance. However, the low surface energy and lack of functional groups to interact with the cellular environment have severely limited its applications in ...

journal_title：Biomaterials

authors： Wang H,Kwok DT,Wang W,Wu Z,Tong L,Zhang Y,Chu PK

更新日期：2010-01-01 00:00:00

abstract：:The generation of effective tissue engineered bone grafts requires efficient exchange of nutrients and mechanical stimulus. Bioreactors provide a manner in which this can be achieved. We have recently developed a biaxial rotating bioreactor with efficient fluidics through in-silico modeling. Here we investigated its p...

journal_title：Biomaterials

authors： Zhang ZY,Teoh SH,Chong WS,Foo TT,Chng YC,Choolani M,Chan J

更新日期：2009-05-01 00:00:00

abstract：:Bioengineering of whole hearts using human embryonic stem cells (hESCs)-derived cardiovascular progenitor cells (CPCs) and natural matrices is a promising approach to overcome organ donor shortage threatening millions of patients awaiting for heart transplantation. Here, we developed a novel strategy for generation of...

journal_title：Biomaterials

authors： Rajabi S,Pahlavan S,Ashtiani MK,Ansari H,Abbasalizadeh S,Sayahpour FA,Varzideh F,Kostin S,Aghdami N,Braun T,Baharvand H

更新日期：2018-02-01 00:00:00

abstract：:Demineralised bone matrix (DBM) is a form of allogeneic tissue graft widely used in oral and maxillofacial procedures. There is a long history of controversy relating to the suitability of ethylene oxide gas (EtOx) as a terminal sterilisation agent for this graft, relating to its effects on the clinical performance of...

journal_title：Biomaterials

authors： Lomas RJ,Gillan HL,Matthews JB,Ingham E,Kearney JN

更新日期：2001-05-01 00:00:00

abstract：:Microspheres comprised of particulate hydroxyapatites dispersed in fibrous collagen matrices were prepared. The procedure involved the droplet formation of hydroxyapatite/collagen mixture emulsified in olive oil, followed by the reconstitution of collagen in the presence of hydroxyapatite particles at 37 degrees C. Va...

journal_title：Biomaterials

authors： Hsu FY,Chueh SC,Wang YJ

更新日期：1999-10-01 00:00:00

abstract：:Hydrogels of crosslinked poly(2-vinylpyridine-1-oxide), PVNO, and poly(2-vinylpyridine-1-oxide)-poly(N-vinyl-pyrrolidone), PNVO-PVP, were synthesized. PVNO hydrogels were found to be degradable in a pseudo-biological medium and their stability could be increased by increasing the relative concentration of the crosslin...

journal_title：Biomaterials

authors： Hasirci VN

更新日期：1981-01-01 00:00:00

abstract：:Very pure hydroxyapatite is diamagnetic and shows no electron paramagnetic resonance (EPR) spectrum. Plasma-sprayed coatings made with such a pure hydroxyapatite contain paramagnetic point-defects. Irradiated deposits show a strong EPR absorption assigned to an O2- anion adjacent to a calcium vacancy, with anisotropic...

journal_title：Biomaterials

authors： Sharrock P,Bonel G

更新日期：1992-01-01 00:00:00

abstract：:Exosomes have emerged as appealing candidate therapeutic agents and delivery nanoplatforms due to their endogenous features and unique biological properties. However, obstacles such as low isolation yield, considerable complexity and potential safety concerns, and inefficient drug payload substantially hamper their th...

journal_title：Biomaterials

authors： Lu M,Huang Y

更新日期：2020-03-02 00:00:00

abstract：:The development of a method that can efficiently deliver nucleic acids into the nucleus of living systems remains one of the key challenges for experimental and therapeutic use of nonbiological gene delivery agents. In the current study, we demonstrate a functionalized gold nanoparticle (AuNP) that can serve as a univ...

journal_title：Biomaterials

authors： Kim DW,Kim JH,Park M,Yeom JH,Go H,Kim S,Han MS,Lee K,Bae J

更新日期：2011-04-01 00:00:00