Effect of different Ti-6Al-4V surface treatments on osteoblasts behaviour.

abstract：:We previously reported that modification of GALA peptide on the surface of liposomes enhanced fusion with endosomal membrane, and cytoplasmic release of encapsulated macromolecules. We report herein that an additional coating of GALA-modified liposomes with 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer result...

journal_title：Biomaterials

authors： Ukawa M,Akita H,Masuda T,Hayashi Y,Konno T,Ishihara K,Harashima H

更新日期：2010-08-01 00:00:00

abstract：:Nanovectors hold substantial promise in abating the off-target effects of therapeutics by providing a means to selectively accumulate payloads at the target lesion, resulting in an increase in the therapeutic index. A sophisticated understanding of the factors that govern the degradation and release dynamics of these ...

journal_title：Biomaterials

authors： Martinez JO,Chiappini C,Ziemys A,Faust AM,Kojic M,Liu X,Ferrari M,Tasciotti E

更新日期：2013-11-01 00:00:00

abstract：:A new system of single piece electrodes was applied to in vivo and in vitro measurements of anodic polarization of several alloys used in orthopaedic implants. The tested surface was scrutinized with a stereomicroscope after each experiment. This confirmed pit formation and excluded the possibility of other sudden inc...

journal_title：Biomaterials

authors： Nakayama Y,Yamamuro T,Kotoura Y,Oka M

更新日期：1989-08-01 00:00:00

abstract：:Theranostic biomaterials have been creating great new opportunities in developing precision medicine in cancer treatment. Moreover, there exist up-coming potentials to find a new paradigm change in cancer treatment when theranostic biomaterials can precisely image a biological process at the exact tumor sites. With ai...

journal_title：Biomaterials

authors： Kim H,Kwak G,Kim K,Yoon HY,Kwon IC

更新日期：2019-08-01 00:00:00

abstract：:Devices implanted within the central nervous system (CNS) are subjected to tissue reactivity due to the lack of biocompatibility between implanted material and the cells' microenvironment. Studies have attributed blood-brain barrier disruption, inflammation, and oxidative stress as main contributing factors that lead ...

journal_title：Biomaterials

authors： Bennett C,Álvarez-Ciara A,Franklin M,Dietrich WD,Prasad A

更新日期：2021-01-01 00:00:00

abstract：:Myotube formation is crucial to restoring muscular functions, and biomaterials that enhance the myoblast differentiation into myotubes are highly desirable for muscular repair. Here, we report the synthesis of electroactive, ductile, and degradable copolymers and their application in enhancing the differentiation of m...

journal_title：Biomaterials

authors： Xie M,Wang L,Guo B,Wang Z,Chen YE,Ma PX

更新日期：2015-12-01 00:00:00

abstract：:Biomedical alloys may release nickel ions during corrosion phenomena and, in addition to their interaction with oral tissues, these ions may also influence characteristic properties of the immune system cells. The aim of this study was to evaluate the effect of nickel chloride on the expression of functionally distinc...

journal_title：Biomaterials

authors： D'Antò V,Eckhardt A,Hiller KA,Spagnuolo G,Valletta R,Ambrosio L,Schmalz G,Schweikl H

更新日期：2009-03-01 00:00:00

abstract：:Hydrogels, microgels and nanogels have emerged as versatile and viable platforms for sustained protein release, targeted drug delivery, and tissue engineering due to excellent biocompatibility, a microporous structure with tunable porosity and pore size, and dimensions spanning from human organs, cells to viruses. In ...

journal_title：Biomaterials

authors： Jiang Y,Chen J,Deng C,Suuronen EJ,Zhong Z

更新日期：2014-06-01 00:00:00

abstract：:Films of polyoxyethylene network were prepared from two types of triethoxysilane-terminated prepolymers. In this way, films of polyoxyethylene network with possible applications in the biomedical field could be made easier. To test their biocompatibility, these networks were added to organ cultures of adult human skin...

journal_title：Biomaterials

authors： Beele H,Thierens H,Deveux R,Goethals E,de Ridder L

更新日期：1992-01-01 00:00:00

abstract：:Integrins represent the primary mechanism of cell-extracellular matrix interactions and control cell morphology, proliferation, and differentiation. We have previously shown that substrate-dependent modulation of adsorbed fibronectin (Fn) conformation alters alpha5beta1 integrin binding to Fn and directs C2C12 myoblas...

journal_title：Biomaterials

authors： Stephansson SN,Byers BA,García AJ

更新日期：2002-06-01 00:00:00

abstract：:Nanomedicine options for colon cancer therapy have been limited by the lack of suitable carriers capable of delivering sufficient drug into tumors to cause lethal toxicity. To circumvent this limitation, we fabricated a camptothecin (CPT)-loaded poly(lactic-co-glycolic acid) nanoparticle (NP) with dual-surface functio...

journal_title：Biomaterials

authors： Xiao B,Zhang M,Viennois E,Zhang Y,Wei N,Baker MT,Jung Y,Merlin D

更新日期：2015-04-01 00:00:00

abstract：:The suitability of chitosan-based hydrogels as scaffolds for the encapsulation of intervertebral disc (IVD) cells and the accumulation of a functional extracellular matrix mimicking that of the nucleus pulposus (NP) was investigated. The specific hypothesis under study was that the cationic chitosan would form an idea...

journal_title：Biomaterials

authors： Roughley P,Hoemann C,DesRosiers E,Mwale F,Antoniou J,Alini M

更新日期：2006-01-01 00:00:00

abstract：:The efficient delivery of short interfering RNA (siRNA) is an enormous challenge in the field of gene therapy. Herein, we report a delivery nanosystem based on programmed DNA self-assembly mammalian target of rapamycin (mTOR) siRNA-loaded DNA nanotubes (DNA-NTs). We demonstrate that these siRNA-DNA-NTs can be effectiv...

journal_title：Biomaterials

authors： You Z,Qian H,Wang C,He B,Yan J,Mao C,Wang G

更新日期：2015-10-01 00:00:00

abstract：:Polytetrafluoroethylene (PTFE) is a commonly used medical polymer due to its biological stability and other attractive properties such as high hardness and wear resistance. However, the low surface energy and lack of functional groups to interact with the cellular environment have severely limited its applications in ...

journal_title：Biomaterials

authors： Wang H,Kwok DT,Wang W,Wu Z,Tong L,Zhang Y,Chu PK

更新日期：2010-01-01 00:00:00

abstract：:Effects of squalane-dissolved fullerene-C60 (Sql-fullerene) on macrophage activation and adipose conversion with oxidative stress were studied using an inflammatory adipose-tissue equivalent (ATE) and OP9 mouse stromal preadipocyte-U937 lymphoma cell co-culture systems. Differentiation of OP9 cells was initiated by in...

journal_title：Biomaterials

authors： Xiao L,Aoshima H,Saitoh Y,Miwa N

更新日期：2010-08-01 00:00:00

abstract：:We report on the fabrication of multifunctional polymeric unimolecular micelles as an integrated platform for cancer targeted drug delivery and magnetic resonance imaging (MRI) contrast enhancement under in vitro and in vivo conditions. Starting from a fractionated fourth-generation hyperbranched polyester (Boltorn H4...

journal_title：Biomaterials

authors： Li X,Qian Y,Liu T,Hu X,Zhang G,You Y,Liu S

更新日期：2011-09-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) play an important role in regulating osteoblastic differentiation and bone formation. But the diffuse of BMPs into muscle tissues around bone injury sites often leads to heterotopic ossification, which has been regarded as one of major side-effects of BMP implementation in bone defec...

journal_title：Biomaterials

authors： Zhang J,Zhao Y,Hou X,Chen B,Xiao Z,Han J,Shi C,Liu J,Miao Q,Dai J

更新日期：2014-11-01 00:00:00

abstract：:Effective global control of tuberculosis (TB) is increasingly threatened by the convergence of multidrug-resistant TB and the human immunodeficiency virus (HIV) infection. TB/HIV coinfections exert a tremendous burden on the host's immune system, and this has prompted the clinical use of immunomodulators to enhance ho...

journal_title：Biomaterials

authors： Wang Y,Ke XY,Khara JS,Bahety P,Liu S,Seow SV,Yang YY,Ee PL

更新日期：2014-03-01 00:00:00

abstract：:Study of axonal growth and ligand-receptor interactions requires specificity and careful characterization of the biomaterial substrates to which the neurons bind. It would be impossible to predict the effects of important variables such as composition, surface density, spatial distribution, and conformation of the lig...

journal_title：Biomaterials

authors： Zhang Z,Yoo R,Wells M,Beebe TP Jr,Biran R,Tresco P

更新日期：2005-01-01 00:00:00

abstract：:The in vivo performance of 250 retrieved internal fixation plates was evaluated. The corrosion characteristics and metallurgical properties of each implant were assessed and correlated with respective clinical performance. Screw-plate interface corrosion and screw surface corrosion were graded; Rockwell hardness, grai...

journal_title：Biomaterials

authors： Cook SD,Thomas KA,Harding AF,Collins CL,Haddad RJ Jr,Milicic M,Fischer WL

更新日期：1987-05-01 00:00:00

abstract：:We design a class of water-dispersible hybrid nanogels for intracellular delivery of hydrophobic curcumin. The core-shell structured hybrid nanogels were synthesized by coating the Ag/Au bimetallic nanoparticles (NPs) with a hydrophobic polystyrene (PS) gel layer as inner shell, and a subsequent thin hydrophilic nonli...

journal_title：Biomaterials

authors： Wu W,Shen J,Banerjee P,Zhou S

更新日期：2011-01-01 00:00:00

abstract：:Angiogenesis is critical in the early stage of reparative processes and tissue regeneration, but the persistence of a vascular network may interfere with later transformation/maturation in naturally avascular tissues such as articular cartilage. Our supposition is that the timed delivery of an anti-angiogenic factor i...

journal_title：Biomaterials

authors： Sun XD,Jeng L,Bolliet C,Olsen BR,Spector M

更新日期：2009-02-01 00:00:00

abstract：:Glioblastoma (GBM) is the deadliest and most common type of primary brain tumor in adults with a grim prognosis despite multimodal treatments. Dendritic cell (DC)-based immunotherapy has emerged as a promising therapeutic modality for GBM, whose efficacy is nonetheless fundamentally undermined by GBM-induced immunosup...

journal_title：Biomaterials

authors： Li TF,Li K,Zhang Q,Wang C,Yue Y,Chen Z,Yuan SJ,Liu X,Wen Y,Han M,Komatsu N,Xu YH,Zhao L,Chen X

更新日期：2018-10-01 00:00:00

abstract：:Multi-layered poly(glycerol-sebacate) (PGS) scaffolds with controlled pore microarchitectures were fabricated, combined with heart cells, and cultured with perfusion to engineer contractile cardiac muscle constructs. First, one-layered (1L) scaffolds with accordion-like honeycomb shaped pores and elastomeric mechanica...

journal_title：Biomaterials

authors： Park H,Larson BL,Guillemette MD,Jain SR,Hua C,Engelmayr GC Jr,Freed LE

更新日期：2011-03-01 00:00:00

abstract：:In this study, we quantified the adsorption of immunoglobulin G (IgG) protein onto several polyelectrolyte-modified sintered porous polyethylene (PPE) membranes. The polymer surfaces had both cationic and anionic charges obtained via the adsorption of polyethylenimine (PEI) and polyacrylic acid (PAA), respectively, on...

journal_title：Biomaterials

authors： Greene G,Radhakrishna H,Tannenbaum R

更新日期：2005-10-01 00:00:00

abstract：:Biological heart prostheses present medium and long-term problems, owing to progressive deterioration and calcification of the tissue. To study the latter problem, we compared the effectiveness of anticalcification treatments in calf pericardium samples implanted into female Wistar rats after the following procedures:...

journal_title：Biomaterials

authors： Jorge-Herrero E,Gutiérrez MP,Castillo-Olivares JL

更新日期：1991-03-01 00:00:00

abstract：:Over the past two decades, in vitro autologous endothelial cell (EC) coverage of expanded polytetrafluoroethylene (ePTFE) graft has been developed and clinically applied with success in infrainguinal bypasses. Before endothelialization, the luminal surface of the graft has to be coated with a currently used fibrinolyt...

journal_title：Biomaterials

authors： Fernandez P,Deguette A,Pothuaud L,Belleannée G,Coste P,Bordenave L

更新日期：2005-08-01 00:00:00

abstract：:For H5N1 influenza immunization, we developed a thermal-sensitive hydrogel as intranasal vaccine delivery system, which was formulated with N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride (HTCC) and α, β-glycerophosphate (α, β-GP). The flowing solution of HTCC/GP under room temperature could gelate rapidl...

journal_title：Biomaterials

authors： Wu Y,Wei W,Zhou M,Wang Y,Wu J,Ma G,Su Z

更新日期：2012-03-01 00:00:00

abstract：:Although synergistic therapy for tumors has displayed significant promise for effective treatment of cancer, developing a simple and effective strategy to build a multi-functional nanoplatform is still a huge challenge. By virtue of the characteristics of tumor microenvironment, such as hypoxia, slight acidity and H2O...

journal_title：Biomaterials

authors： Wang M,Chang M,Chen Q,Wang D,Li C,Hou Z,Lin J,Jin D,Xing B

更新日期：2020-09-01 00:00:00

abstract：:The non-specific interaction between nanoparticles (NPs) and plasma proteins occurs immediately after NPs enter the blood, resulting in the formation of the protein corona that thereafter replaces the original NPs and becomes what the organs and cells really see. Consequently, the in vivo fate of NPs and the biologica...

journal_title：Biomaterials

authors： Peng Q,Zhang S,Yang Q,Zhang T,Wei XQ,Jiang L,Zhang CL,Chen QM,Zhang ZR,Lin YF

更新日期：2013-11-01 00:00:00