Abstract：
:To enable the synthesis of hydrogels containing microporosity, a family of pore generating additives (porogens) were synthesized from poly(ethylene glycols) (PEGs) with different molecular weights using naphthyl acetic acid. The products formed were characterized by UV-vis, differential scanning calorimetry and solution nuclear magnetic resonance techniques. Subsequently, poly(ethylene oxide)-urethane hydrogels were synthesized incorporating the above mentioned PEG porogens to modify the structure of the hydrogel. These highly water soluble PEG porogens were inert and extracted out in water. The hydrogels obtained exhibited significant increase in the equilibrium water uptake. This was attributed to the formation of a microporous structure in the hydrogel. It was also evidenced by the observed increase in the diffusion coefficients of the drugs proxyphylline and vitamin B12 through this hydrogel. The proportional increase was greater for the higher molecular weight vitamin B12 than for the proxyphylline. These results may be useful in developing porous hydrogels for controlled release technology.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Badiger MV,McNeill ME,Graham NBdoi
10.1016/0142-9612(93)90206-hsubject
Has Abstractpub_date
1993-11-01 00:00:00pages
1059-63issue
14eissn
0142-9612issn
1878-5905pii
0142-9612(93)90206-Hjournal_volume
14pub_type
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