当前位置： SCI文献检索 > BIOMATERIALS期刊下所有文献 > Promotion of cardiac differentiation of brown adipose derived stem cells by chitosan hydrogel for repair after myocardial infarction.

Promotion of cardiac differentiation of brown adipose derived stem cells by chitosan hydrogel for repair after myocardial infarction.

Abstract：

:The ability to restore heart function by replacement of diseased myocardium is one of the great challenges in biomaterials and regenerative medicine. Brown adipose derived stem cells (BADSCs) present a new source of cardiomyocytes to regenerate the myocardium after infarction. In this study, we explored an injectable tissue engineering strategy to repair damaged myocardium, in which chitosan hydrogels were investigated as a carrier for BADSCs. In vitro, the effect and mechanism of chitosan components on the cardiac differentiation of BADSCs were investigated. In vivo, BADSCs carrying double-fusion reporter gene (firefly luciferase and monomeric red fluorescent protein (fluc-mRFP)) were transplanted into infarcted rat hearts with or without chitosan hydrogel. Multi-techniques were used to assess the effects of treatments. We observed that chitosan components significantly enhanced cardiac differentiation of BADSCs, which was assessed by percentages of cTnT(+) cells and expression of cardiac-specific markers, including GATA-4, Nkx2.5, Myl7, Myh6, cTnI, and Cacna1a. Treatment with collagen synthesis inhibitors, cis-4-hydroxy-D-proline (CIS), significantly inhibited the chitosan-enhanced cardiac differentiation, indicating that the enhanced collagen synthesis by chitosan accounts for its promotive role in cardiac differentiation of BADSCs. Longitudinal in vivo bioluminescence imaging and histological staining revealed that chitosan enhanced the survival of engrafted BADSCs and significantly increased the differentiation rate of BADSCs into cardiomyocytes in vivo. Furthermore, BADSCs delivered by chitosan hydrogel prevented adverse matrix remodeling, increased angiogenesis, and preserved heart function. These results suggested that the injectable cardiac tissue engineering based on chitosan hydrogel and BADSCs is a useful strategy for myocardium regeneration.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Wang H,Shi J,Wang Y,Yin Y,Wang L,Liu J,Liu Z,Duan C,Zhu P,Wang C

doi

10.1016/j.biomaterials.2014.01.021

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

3986-98

issue

13

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(14)00023-4

journal_volume

35

pub_type

杂志文章

相关文献

BIOMATERIALS文献大全
  • Moderation of prekallkrein-factor XII interactions in surface activation of coagulation by protein-adsorption competition.

    abstract：:Traditional biochemistry of contact activation of blood coagulation suggesting that anionic hydrophilic surfaces are specific activators of the cascade is inconsistent with known trends in protein adsorption. To investigate contact activation reactions, a chromogenic assay was used to measure prekallkrein (PK) hydroly...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.05.076

    authors： Chatterjee K,Thornton JL,Bauer JW,Vogler EA,Siedlecki CA

    更新日期：2009-10-01 00:00:00

  • Bile acid transporter mediated endocytosis of oral bile acid conjugated nanocomplex.

    abstract：:The development of highly funtional and orally available nanoparticles is the ultimate goal in nanoparticle delivery. Various functional nanoparticles have been studied to that end but there has yet to be an oral nanoparticle that can be successfully applied. Here, we describe for the first time a novel bile acid conj...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2017.09.022

    authors： Park J,Choi JU,Kim K,Byun Y

    更新日期：2017-12-01 00:00:00

  • Reversal of P-glycoprotein-mediated multidrug resistance by CD44 antibody-targeted nanocomplexes for short hairpin RNA-encoding plasmid DNA delivery.

    abstract：:Multidrug resistance (MDR) remains one of the major reasons for the reductions in efficacy of many chemotherapeutic agents in cancer therapy. As a classical MDR phenotype of human malignancies, the adenosine triphosphate binding cassette (ABC)-transporter P-glycoprotein (MDR1/P-gp) is an efflux protein with aberrant a...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.12.030

    authors： Gu J,Fang X,Hao J,Sha X

    更新日期：2015-03-01 00:00:00

  • Effect of dual ion implantation of calcium and phosphorus on the properties of titanium.

    abstract：:This study is concerned with the effect of dual implantation of calcium and phosphorus upon the structure, corrosion resistance and biocompatibility of titanium. The ions were implanted in sequence, first Ca and then P, both at a dose of 10(17) ions/cm2 at a beam energy of 25 keV. Transmission electron microscopy was ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2004.08.015

    authors： Krupa D,Baszkiewicz J,Kozubowski JA,Barcz A,Sobczak JW,Biliński A,Lewandowska-Szumieł M,Rajchel B

    更新日期：2005-06-01 00:00:00

  • Transplantation of human mesenchymal stem cells loaded on collagen scaffolds for the treatment of traumatic brain injury in rats.

    abstract：:Studies have suggested that mesenchymal stem cells (MSCs) have therapeutic effects following traumatic brain injury (TBI). However, cell distribution and survival rate are two major barriers to their success as therapeutic treatment. The improvement of cell therapy using collagen delivery matrices had been reported. H...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.04.047

    authors： Guan J,Zhu Z,Zhao RC,Xiao Z,Wu C,Han Q,Chen L,Tong W,Zhang J,Han Q,Gao J,Feng M,Bao X,Dai J,Wang R

    更新日期：2013-08-01 00:00:00

  • Suppression of NSAID-induced small intestinal inflammation by orally administered redox nanoparticles.

    abstract：:Patients regularly taking non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin (IND) have a risk of small intestinal injuries. In this study, we have developed an oral nanotherapeutics by using a redox nanoparticle (RNP(O)), which is prepared by self-assembly of an amphiphilic block copolymer that posse...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.06.032

    authors： Sha S,Vong LB,Chonpathompikunlert P,Yoshitomi T,Matsui H,Nagasaki Y

    更新日期：2013-11-01 00:00:00

  • Thermal sprayed hydroxyapatite splats: nanostructures, pore formation mechanisms and TEM characterization.

    abstract：:Microstructure of thermal sprayed hydroxyapatite (HA) splats was characterized using transmission electron microscopy (TEM), and the formation mechanisms of micropores within the splats were investigated with the aid of simulated body fluids (SBF). High-velocity oxy-fuel and direct current (DC) plasma spray techniques...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2003.10.051

    authors： Li H,Khor KA,Cheang P

    更新日期：2004-08-01 00:00:00

  • Synthetic β-sheet forming peptide amphiphiles for treatment of fungal keratitis.

    abstract：:Fungal keratitis is a leading cause of ocular morbidity. It is frequently misdiagnosed as bacterial keratitis, causing a delay in proper treatment. Furthermore, due to the lack of safe and effective anti-fungal agents for clinical use, treatment of fugal keratitis remains a challenge. In recent years, antimicrobial pe...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.11.052

    authors： Wu H,Ong ZY,Liu S,Li Y,Wiradharma N,Yang YY,Ying JY

    更新日期：2015-03-01 00:00:00

  • Biocompatible polymeric nanocomplexes as an intracellular stimuli-sensitive prodrug for type-2 diabetes combination therapy.

    abstract：:Combination therapy is usually considered as a promising strategy owing to its advantages such as reduced doses, minimized side effects and improved therapeutic efficiency in a variety of diseases including diabetes. Here we synthesized a new highly intracellular stimuli-sensitive chitosan-graft-metformin (CS-MET) pro...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.09.013

    authors： Wang FZ,Xie ZS,Xing L,Zhang BF,Zhang JL,Cui PF,Qiao JB,Shi K,Cho CS,Cho MH,Xu X,Li P,Jiang HL

    更新日期：2015-12-01 00:00:00

  • Behavior and properties of neat and filled gelatins.

    abstract：:The purpose of this study was to determine the mechanical properties and the atomistic structures of various gelatin hydrogels as a preliminary to using these in bioengineering applications. The hydrogels were investigated as neat materials and as particulate-reinforced composites both in the as-formed state and follo...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(02)00274-0

    authors： Usta M,Piech DL,MacCrone RK,Hillig WB

    更新日期：2003-01-01 00:00:00

  • Attachment of glycosaminoglycans to collagenous matrices modulates the tissue response in rats.

    abstract：:Biocompatibility and tissue regenerating capacity are essential characteristics in the design of collagenous biomaterials for tissue engineering. Attachment of glycosaminoglycans (GAGs) to collagen may add to these characteristics by creating an appropriate micro-environment. In this study, porous type I collagen matr...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(00)00052-1

    authors： Pieper JS,van Wachem PB,van Luyn MJA,Brouwer LA,Hafmans T,Veerkamp JH,van Kuppevelt TH

    更新日期：2000-08-01 00:00:00

  • Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect.

    abstract：:Multivalent effect plays an important role in biological processes, particularly in the specific recognition of virus with its host cell during the first step of infection. Here we report the synthesis of multivalent pentacyclic triterpene grafted on cyclodextrin core and potency of against influenza entry activity. N...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.11.034

    authors： Xiao S,Si L,Tian Z,Jiao P,Fan Z,Meng K,Zhou X,Wang H,Xu R,Han X,Fu G,Zhang Y,Zhang L,Zhou D

    更新日期：2016-02-01 00:00:00

  • Enhanced expression of the osteoblastic phenotype on substrates that modulate fibronectin conformation and integrin receptor binding.

    abstract：:Integrins represent the primary mechanism of cell-extracellular matrix interactions and control cell morphology, proliferation, and differentiation. We have previously shown that substrate-dependent modulation of adsorbed fibronectin (Fn) conformation alters alpha5beta1 integrin binding to Fn and directs C2C12 myoblas...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(01)00387-8

    authors： Stephansson SN,Byers BA,García AJ

    更新日期：2002-06-01 00:00:00

  • Histological reaction to titanium alloy and hydroxyapatite particles in the rabbit tibia.

    abstract：:The interfacial membrane harvested from failed joint replacements contains particulate debris from the materials used for the implant. To define the tissue response to particulate titanium alloy and hydroxyapatite (HA) alone, 16 mature New Zealand white rabbits were divided into 2 groups of 8 rabbits. Using sterile te...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(93)90035-z

    authors： Goodman SB,Davidson JA,Fornasier VL

    更新日期：1993-08-01 00:00:00

  • Modulation of cell-cell interactions for neural tissue engineering: Potential therapeutic applications of cell adhesion molecules in nerve regeneration.

    abstract：:Neural tissue engineering holds great promise in repairing damaged nerve tissues. However, despite the promising results in regenerating the injured nervous system, tissue engineering approaches are still insufficient to result in full functional recovery in severe nerve damages. Majority of these approaches only focu...

    journal_title：Biomaterials

    pub_type： 杂志文章,评审

    doi：10.1016/j.biomaterials.2019.01.030

    authors： Chooi WH,Chew SY

    更新日期：2019-03-01 00:00:00

  • Glucose & oxygen exhausting liposomes for combined cancer starvation and hypoxia-activated therapy.

    abstract：:Starvation therapy to slow down the tumor growth by cutting off its energy supply has been proposed to be an alternative therapeutic strategy for cancer treatment. Herein, glucose oxidase (GOx) is loaded into stealth liposomes and act as the glucose and oxygen elimination agent to trigger the conversion of glucose and...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2018.02.004

    authors： Zhang R,Feng L,Dong Z,Wang L,Liang C,Chen J,Ma Q,Zhang R,Chen Q,Wang Y,Liu Z

    更新日期：2018-04-01 00:00:00

  • Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with beta-cyclodextrin.

    abstract：:The aim of this study was to evaluate the physical-chemical properties, in vivo biocompatibility and antimicrobial activity of bioactive glasses (BG) used as a controlled release device for tetracycline hydrochloride and an inclusion complex formed by tetracycline and beta-cyclodextrin at 1:1 molar ratio. The BG as we...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(03)00524-6

    authors： Domingues ZR,Cortés ME,Gomes TA,Diniz HF,Freitas CS,Gomes JB,Faria AM,Sinisterra RD

    更新日期：2004-01-01 00:00:00

  • An improvement in sintering property of beta-tricalcium phosphate by addition of calcium pyrophosphate.

    abstract：:The sintering behavior of calcium pyrophosphate (CPP, Ca2P2O7)-doped beta-tricalcium phosphate [TCP, Ca3(PO4)2], prepared by solid state reaction, was investigated in-situ, using dilatometry. Pure beta-TCP undergoes phase transition to alpha-TCP at about 1200 degrees C; hence pure beta-TCP ceramics should be sintered ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(01)00201-0

    authors： Ryu HS,Youn HJ,Hong KS,Chang BS,Lee CK,Chung SS

    更新日期：2002-02-01 00:00:00

  • The quantitative assessment of peri-implant bone responses using histomorphometry and micro-computed tomography.

    abstract：:In the present study, the effects of implant design and surface properties on peri-implant bone response were evaluated with both conventional histomorphometry and micro-computed tomography (micro-CT), using two geometrically different dental implants (Screw type, St; Push-in, Pi) either or not surface-modified (non-c...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.05.017

    authors： Schouten C,Meijer GJ,van den Beucken JJ,Spauwen PH,Jansen JA

    更新日期：2009-09-01 00:00:00

  • Surface properties and biocompatibility of solvent-cast poly[-caprolactone] films.

    abstract：:Poly(epsilon-caprolactone) (PCL) was dissolved in four solvent systems, chloroform, tetrahydrofuran, acetone and ethyl acetate, and cast onto glass Petri dishes. The surface properties of the resulting films were investigated. The extent to which their properties were determined by the solvent used in each case was qu...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2003.12.003

    authors： Tang ZG,Black RA,Curran JM,Hunt JA,Rhodes NP,Williams DF

    更新日期：2004-08-01 00:00:00

  • Degradation of five polyurethane gastric bubbles following in vivo use: SEC, ATR-IR and DSC studies.

    abstract：:Five Garren-Edwards Gastric Bubbles were characterized, following up to 4 months use in vivo, using size exclusion chromatography, differential scanning calorimetry and attenuated total reflectance infrared spectroscopy. These techniques show that the material used to construct the bubble is probably an aromatic polye...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(92)90191-p

    authors： Dillon JG,Hughes MK

    更新日期：1992-01-01 00:00:00

  • The formation of poly(ester-urea) networks in the absence of isocyanate monomers.

    abstract：:The polymerization of N,N' carbonylbis (caprolactam) (CBC) and polyol in the presence of alcoholate as catalyst produced cross-linked poly(ester-urea)s via ring opening addition reaction. In contrast to conventional synthetic routes, the use of non-toxic CBC eliminates the need for toxic isocyanate-based monomers. The...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2003.09.110

    authors： Zimmermann J,Loontjens T,Scholtens BJ,Mülhaupt RR

    更新日期：2004-06-01 00:00:00

  • Combining adult stem cells and polymeric devices for tissue engineering in infarcted myocardium.

    abstract：:An increasing number of studies in cardiac cell therapy have provided encouraging results for cardiac repair. Adult stem cells may overcome ethical and availability concerns, with the additional advantages, in some cases, to allow autologous grafts to be performed. However, the major problems of cell survival, cell fa...

    journal_title：Biomaterials

    pub_type： 杂志文章,评审

    doi：10.1016/j.biomaterials.2012.04.028

    authors： Karam JP,Muscari C,Montero-Menei CN

    更新日期：2012-08-01 00:00:00

  • A review of nanocarriers for the delivery of small interfering RNA.

    abstract：:Increasing knowledge about molecular mechanisms of endogenous RNA interference (RNAi) and small interfering RNAs (siRNAs) has been incorporated into innovative nucleic acid medicines for treatment of diseases such as cancers. Although RNAi and siRNA have the potential to become powerful therapeutic drugs, their delive...

    journal_title：Biomaterials

    pub_type： 杂志文章,评审

    doi：10.1016/j.biomaterials.2012.06.068

    authors： Kesharwani P,Gajbhiye V,Jain NK

    更新日期：2012-10-01 00:00:00

  • The role of low levels of fullerene C60 nanocrystals on enhanced learning and memory of rats through persistent CaMKII activation.

    abstract：:Engineered nanomaterials are known to exhibit diverse and sometimes unexpected biological effects. Fullerene nanoparticles have been reported to specifically bind to and elicit persistent activation of hippocampal Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), a multimeric intracellular serine/threonine kinas...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.07.030

    authors： Chen L,Miao Y,Chen L,Xu J,Wang X,Zhao H,Shen Y,Hu Y,Bian Y,Shen Y,Chen J,Zha Y,Wen LP,Wang M

    更新日期：2014-11-01 00:00:00

  • Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas.

    abstract：:The successful delivery of anti-cancer drugs relies on the simultaneous capability to actively target a specific location, a sufficient lifetime in the active form in the circulation, and traceability and quantification of drug distribution via in vivo medical imaging. Herein, a highly magnetic nanocarrier (HMNC) comp...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.05.047

    authors： Yang HW,Hua MY,Liu HL,Huang CY,Tsai RY,Lu YJ,Chen JY,Tang HJ,Hsien HY,Chang YS,Yen TC,Chen PY,Wei KC

    更新日期：2011-09-01 00:00:00

  • Fibrin matrices enhance the transplant and efficacy of cytotoxic stem cell therapy for post-surgical cancer.

    abstract：:Tumor-homing cytotoxic stem cell (SC) therapy is a promising new approach for treating the incurable brain cancer glioblastoma (GBM). However, problems of retaining cytotoxic SCs within the post-surgical GBM resection cavity are likely to significantly limit the clinical utility of this strategy. Here, we describe a n...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2016.01.007

    authors： Bagó JR,Pegna GJ,Okolie O,Hingtgen SD

    更新日期：2016-04-01 00:00:00

  • Comparison of cell viability on anorganic bone matrix with or without P-15 cell binding peptide.

    abstract：:Cell-extracellular cell matrix (ECM) interactions play a vital role in development including cytoskeletal structure, growth and differentiation. A 15 amino acid, non-RGD containing, peptide that is derived from type I collagen was tested for its ability to confer cell survival. Two routinely utilized bone graft materi...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2003.12.007

    authors： Hanks T,Atkinson BL

    更新日期：2004-08-01 00:00:00

  • Separation of non-collagenous proteins of bone formed in titanium implants: experimental study in the rabbit tibia, using a bone harvest chamber.

    abstract：:The non-collagenous proteins of mature cortical rabbit bone and 3 wk old bone specimens formed in titanium implant bone harvest chambers, were separated by means of fine pressure liquid chromatography. It was found that a sufficient amount of bone could be obtained from five bone harvest chambers in five rabbits durin...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(90)90158-m

    authors： Lundgren T,Sennerby L

    更新日期：1990-04-01 00:00:00

  • Amphiphilic multiarm star block copolymer-based multifunctional unimolecular micelles for cancer targeted drug delivery and MR imaging.

    abstract：:We report on the fabrication of multifunctional polymeric unimolecular micelles as an integrated platform for cancer targeted drug delivery and magnetic resonance imaging (MRI) contrast enhancement under in vitro and in vivo conditions. Starting from a fractionated fourth-generation hyperbranched polyester (Boltorn H4...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.05.049

    authors： Li X,Qian Y,Liu T,Hu X,Zhang G,You Y,Liu S

    更新日期：2011-09-01 00:00:00