Enhanced expression of the osteoblastic phenotype on substrates that modulate fibronectin conformation and integrin receptor binding.

abstract：:Polymerized high internal phase emulsion (polyHIPE) foams are extremely versatile materials for investigating cell-substrate interactions in vitro. Foam morphologies can be controlled by polymerization conditions to result in either open or closed pore structures with different levels of connectivity, consequently ena...

journal_title：Biomaterials

authors： Viswanathan P,Ondeck MG,Chirasatitsin S,Ngamkham K,Reilly GC,Engler AJ,Battaglia G

更新日期：2015-06-01 00:00:00

abstract：:The maximum capacity of a hydrophobic adsorbent is interpreted in terms of square or hexagonal (cubic and face-centered-cubic, FCC) interfacial packing models of adsorbed blood proteins in a way that accommodates experimental measurements by the solution-depletion method and quartz-crystal-microbalance (QCM) for the h...

journal_title：Biomaterials

authors： Kao P,Parhi P,Krishnan A,Noh H,Haider W,Tadigadapa S,Allara DL,Vogler EA

更新日期：2011-02-01 00:00:00

abstract：:To prevent wear debris-induced osteolysis and aseptic loosening, cross-linked ultra-high molecular weight polyethylene's (UHMWPE) with improved wear resistance have been developed. Hip simulator studies have demonstrated very low wear rates with these new materials leading to their widespread clinical use. However, th...

journal_title：Biomaterials

authors： Sethi RK,Neavyn MJ,Rubash HE,Shanbhag AS

更新日期：2003-07-01 00:00:00

abstract：:The removal of tenacious dental plaque is of paramount importance; however, early diagnosis can be a challenging task in dental clinics due to the limitations of current approaches, specifically X-ray-based techniques. We have approached this problem by integrating antibacterial properties and X-ray contrast enhanceme...

journal_title：Biomaterials

authors： Ostadhossein F,Misra SK,Tripathi I,Kravchuk V,Vulugundam G,LoBato D,Selmic LE,Pan D

更新日期：2018-10-01 00:00:00

abstract：:Poly(vinyl alcohol)-heparin hydrogels with varying water content were synthesized for use as sensor catheter membranes. Films were cast from aqueous mixtures of poly(vinyl alcohol) (PVA), a photosensitive cross-linker p-diazonium diphenyl amine polymer (PA), glutaraldehyde (GA) and heparin. After drying, the films wer...

journal_title：Biomaterials

authors： Brinkman E,van der Does L,Bantjes A

更新日期：1991-01-01 00:00:00

abstract：:Cationic polymer PEI-CyD is doped with Nd by plasma technology to produce the gene vector: Nd@PEI-CyD. Luciferase expression and EGFP transfection experiments performed in vitro reveal that Nd@PEI-CyD has significantly higher transfection efficiency than lipofectamine 2000 and PEI-CyD and the mechanism is studied and ...

journal_title：Biomaterials

authors： Wang Q,Jin W,Wu G,Zhao Y,Jin X,Hu X,Zhou J,Tang G,Chu PK

更新日期：2014-01-01 00:00:00

abstract：:A human-human oligodendroglial cell line MO3.13 was chosen in this study to model the loss of oligodendrocytes that occurs during episodes of multiple sclerosis. The influence of mercuric chloride (HgCl(2)) upon cell viability specifically the mode of cell death, whether by an active apoptotic mechanism or passive nec...

journal_title：Biomaterials

authors： Issa Y,Watts DC,Duxbury AJ,Brunton PA,Watson MB,Waters CM

更新日期：2003-03-01 00:00:00

abstract：:This study reports the effect of varying the thickness of a commercial zinc polycarboxylate dental cement on its adhesion in a metal-to-metal single lap joint. The thickness was controlled externally in a specially designed apparatus, rather than by the inclusion of isodimensional glass spheres, as has been done previ...

journal_title：Biomaterials

authors： Akinmade AO,Nicholson JW

更新日期：1995-01-01 00:00:00

abstract：:Nitric oxide is a cell signaling molecule that can be a potent inducer of cell death in cancers at elevated concentrations. However, NO is also toxic to normal tissues and chronic exposure at low levels can induce tumor growth. We have designed a polymeric carrier system to deliver nitric oxide locoregionally to tumor...

journal_title：Biomaterials

authors： Duan S,Cai S,Yang Q,Forrest ML

更新日期：2012-04-01 00:00:00

abstract：:Generation of specific lineages of cells from embryonic stem (ES) cells is pre-requisite to use these cells in pre-clinical applications. Here, we developed a recombinant E-cadherin substratum for generation of hepatic progenitor populations at single cell level. This artificial acellular feeder layer supports the ste...

journal_title：Biomaterials

authors： Haque A,Hexig B,Meng Q,Hossain S,Nagaoka M,Akaike T

更新日期：2011-03-01 00:00:00

abstract：:Collagen has been widely used for tissue engineering. Here, we applied bioactive laminin-derived peptides as an additive for collagen, laminin-111, and fibronectin matrices resulting in peptide/collagen, peptide/laminin-111, and peptide/fibronectin matrices. Several syndecan-binding peptides, including AG73 (RKRLQVQLS...

journal_title：Biomaterials

authors： Yamada Y,Katagiri F,Hozumi K,Kikkawa Y,Nomizu M

更新日期：2011-07-01 00:00:00

abstract：:Besides as an inert carrier for hydrophobic anticancer agents, polymeric micelles composed of di-block copolymer poly(ethylene glycol)-poly(lactic acid) (PEG-b-PLA) function as biological response modifiers including reversal of multidrug resistance in cancer. However, the uptake mechanisms and the subsequent intracel...

journal_title：Biomaterials

authors： Zhang Z,Xiong X,Wan J,Xiao L,Gan L,Feng Y,Xu H,Yang X

更新日期：2012-10-01 00:00:00

abstract：:Porous gelatin scaffolds were prepared using a salt-leaching method and these were compared to scaffolds fabricated using a freeze-drying method. The salt-leached gelatin scaffolds were easily formed into desired shapes with a uniformly distributed and interconnected pore structure with an average pore size of around ...

journal_title：Biomaterials

authors： Lee SB,Kim YH,Chong MS,Hong SH,Lee YM

更新日期：2005-05-01 00:00:00

abstract：:Silk fibers have potential biomedical applications beyond their traditional use as sutures. The physical properties of silk fibers and films make it a promising candidate for tissue engineering scaffold applications, particularly where high mechanical loads or tensile forces are applied or in cases where low rates of ...

journal_title：Biomaterials

authors： Panilaitis B,Altman GH,Chen J,Jin HJ,Karageorgiou V,Kaplan DL

更新日期：2003-08-01 00:00:00

abstract：:The design of bioartificial liver assist device requires an effective attachment of primary hepatocytes on polymeric biomaterials. A better understanding of this cell-surface interaction would aid the optimal choice of biomaterials. In this study, the adhesion contact dynamics of primary hepatocytes on poly(ethylene t...

journal_title：Biomaterials

authors： Tan WJ,Teo GP,Liao K,Leong KW,Mao HQ,Chan V

更新日期：2005-03-01 00:00:00

abstract：:Poly(trimethylene carbonate) (PTMC) with molecular weights greater than 100 kg/mol is known to degrade readily in vivo while PTMC of less than 70 kg/mol is resistant to degradation. The reason for the molecular weight dependent degradation rate of PTMC is unclear, and may be due to differences in macrophage behavior o...

journal_title：Biomaterials

authors： Vyner MC,Li A,Amsden BG

更新日期：2014-11-01 00:00:00

abstract：:Endothelial cells derived from the bovine pulmonary artery (line CPAE, CCL 209, American Tissue Culture Collection, Rockville, MD, USA) were cultured on pristine or fluorine ion-irradiated polystyrene (5 x 10(12) or 5 x 10(14) F ions/cm2, 150 keV). At 24-h post-seeding interval, the number of cells which adhered to th...

journal_title：Biomaterials

authors： Bacáková L,Mares V,Lisá V,Svorcík V

更新日期：2000-06-01 00:00:00

abstract：:Hydrogels are a promising type of biomaterial for articular cartilage constructs since they have been shown to enable encapsulated chondrocytes to express their predominant phenotypic marker, type II collagen. Endogenously expressed signaling molecules, such as insulin-like growth factor-1 (IGF-1), are also known to f...

journal_title：Biomaterials

authors： Yoon DM,Hawkins EC,Francke-Carroll S,Fisher JP

更新日期：2007-01-01 00:00:00

abstract：:New adjuvants and delivery strategies are needed to optimize the ability of protein-based vaccines to elicit CD8(+) T cell responses. We have developed a model vaccine formulation containing ovalbumin (OVA) and the double-stranded RNA analog poly(inosinic acid)-poly(cytidylic acid) (poly(I:C)), a TLR3 agonist. OVA and...

journal_title：Biomaterials

authors： Heffernan MJ,Kasturi SP,Yang SC,Pulendran B,Murthy N

更新日期：2009-02-01 00:00:00

abstract：:Multilayered coatings composed of mixtures of HA and P2O5-based bioactive glasses are of potential clinical benefit in orthopaedic and dental surgery. Pre-immersion of these materials has been reported to further enhance their efficacy in vivo, although the precise biological effects of this treatment are not yet know...

journal_title：Biomaterials

authors： Ferraz MP,Knowles JC,Olsen I,Monteiro FJ,Santos JD

更新日期：2000-04-01 00:00:00

abstract：:Tumor-activatable ultrasmall nanozyme generation is an unprecedented strategy to overcome intrinsically fatal defects of traditional reactive oxygen species (ROS)-based nanoagents for deep tumor penetration, including limited tissue-penetrating depth of external energy, heavy reliance on oxygen and nonspecific toxicit...

journal_title：Biomaterials

authors： Liu X,Liu Z,Dong K,Wu S,Sang Y,Cui T,Zhou Y,Ren J,Qu X

更新日期：2020-11-01 00:00:00

abstract：:Tarsal repair is an important part for eyelid reconstruction. Presently traditional clinic treatments do not produce satisfactory repair effects. The key is to find a proper tarsal repair material. Microbial poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) was studied for application as tarsal substitute in this...

journal_title：Biomaterials

authors： Zhou J,Peng SW,Wang YY,Zheng SB,Wang Y,Chen GQ

更新日期：2010-10-01 00:00:00

abstract：:Two commercially available amalgam alloy powders (one lathe-cut, the other spherical) were characterized in terms of density, surface area, particle size distribution and appearance under the scanning electron microscope. A third, experimental alloy powder, prepared by electrodeposition, was subjected to a similar ana...

journal_title：Biomaterials

authors： Davies EH,Kuhn AT

更新日期：1984-11-01 00:00:00

abstract：:A novel class of hyperbranched polymers based on polyglycerol (PG) and poly(ethylene glycol) (PEG) are synthesized by multibranching anionic ring opening polymerization. Multivalent cationic sites are added to these polymers by a post-amination and quarternization reactions. Blood compatibility studies using these pol...

journal_title：Biomaterials

authors： Kainthan RK,Gnanamani M,Ganguli M,Ghosh T,Brooks DE,Maiti S,Kizhakkedathu JN

更新日期：2006-11-01 00:00:00

abstract：:This animal study (domestic pig) examined the bone formation after filling defined defects with autogenous bone or a collagen lyophilisat in combination with Platelet-rich-plasma (PRP) by evaluating bone matrix proteins. Six groups, both materials with and without PRP in two concentrations (+ 1, + 2) were compared to ...

journal_title：Biomaterials

authors： Thorwarth M,Rupprecht S,Falk S,Felszeghy E,Wiltfang J,Schlegel KA

更新日期：2005-05-01 00:00:00

abstract：:In this study, the intra-articular tolerability and suitability for local and sustained release of an in situ forming gel composed of an acetyl-capped poly(ε-caprolactone-co-lactide)-b-poly(ethylene glycol)-b-poly(ε-caprolactone-co-lactide) (PCLA-PEG-PCLA) copolymer loaded with celecoxib was investigated in horse join...

journal_title：Biomaterials

authors： Petit A,Redout EM,van de Lest CH,de Grauw JC,Müller B,Meyboom R,van Midwoud P,Vermonden T,Hennink WE,René van Weeren P

更新日期：2015-01-01 00:00:00

abstract：:Adhesion of cells to surfaces is a basic and important requirement in cell culture and tissue engineering. Here, we designed artificial extracellular matrix (ECM) mimics for efficient cellular attachment, based on mussel adhesive protein (MAP) fusion with biofunctional peptides originating from ECM materials, includin...

journal_title：Biomaterials

authors： Choi BH,Choi YS,Kang DG,Kim BJ,Song YH,Cha HJ

更新日期：2010-12-01 00:00:00

abstract：:Designing biomaterial scaffolds remains a major challenge in tissue engineering. Key to this challenge is improved understanding of the relationships between the scaffold properties and its degradation kinetics, as well as the cell interactions and the promotion of new matrix deposition. Here we present the use of non...

journal_title：Biomaterials

authors： Rice WL,Firdous S,Gupta S,Hunter M,Foo CW,Wang Y,Kim HJ,Kaplan DL,Georgakoudi I

更新日期：2008-05-01 00:00:00

abstract：:The aim of the present study was to test the hypothesis that oligonucleotides can be used for anchorage and slow release of osteogenic growth factors such as BMP to enhance the osteogenic activity of a titanium implant surface. Strands of 60-mer non-coding DNA oligonucleotides (ODN) were bound to an acid-etched sandbl...

journal_title：Biomaterials

authors： Schliephake H,Bötel C,Förster A,Schwenzer B,Reichert J,Scharnweber D

更新日期：2012-02-01 00:00:00

abstract：:The regulation of endothelial cell (EC) and smooth muscle cell (SMC) proliferation following vascular interventions is critical to clinical efficacy. Our laboratory has developed a method of impregnating biomaterials with suspensions containing bioactive proteins resulting in the capability of differentially modulatin...

journal_title：Biomaterials

authors： Greisler HP,Gosselin C,Ren D,Kang SS,Kim DU

更新日期：1996-02-01 00:00:00