Transplantation of human mesenchymal stem cells loaded on collagen scaffolds for the treatment of traumatic brain injury in rats.

abstract：:This work reports the development of new non-thrombogenic polymers based on the linear polymers of polyamidoamines (PAAs), having heparin binding ability, obtained by polyaddition of secondary amines to N,N'-methylene bis-acrylamide. PAAs could not be used directly in the making of blood-contacting materials due to th...

journal_title：Biomaterials

authors： Dey RK,Ray AR

更新日期：2003-08-01 00:00:00

abstract：:The search for a cell-supporting scaffold with controlled topography and surface chemistry is a constant topic within tissue engineering. Here we have employed M13 phages, which are genetically modifiable biological nanofibers (∼ 880 nm long and ∼ 6.6 nm wide) non-toxic to human beings, to form films for supporting th...

journal_title：Biomaterials

authors： Zhu H,Cao B,Zhen Z,Laxmi AA,Li D,Liu S,Mao C

更新日期：2011-07-01 00:00:00

abstract：:Calcium phosphate bioceramics have been applied as bone substitutes for several decades. Aseptic loosening after total joint arthroplasty is a major problem in orthopaedic surgery. Hydroxyapatite particles from materials wear have been reported as the main cause of implant failure. For this reason, an investigation in...

journal_title：Biomaterials

authors： Laquerriere P,Grandjean-Laquerriere A,Jallot E,Balossier G,Frayssinet P,Guenounou M

更新日期：2003-07-01 00:00:00

abstract：:This experimental investigation aims at revealing the mechanical behaviour and failure pattern of direct fibre-reinforced resin-bonded dental bridge with various designs. To evaluate the overall effects of some newly developed dental materials, in the experiment, genuine composite dental bridge specimens are prepared ...

journal_title：Biomaterials

authors： Li W,Swain MV,Li Q,Ironside J,Steven GP

更新日期：2004-09-01 00:00:00

abstract：:Bone is the most frequent metastasis site for breast cancer. As well as dramatically increasing disease burden, bone metastases are also an indicator of poor prognosis. One of the main challenges in investigating bone metastasis in breast cancer is engineering in vitro models that replicate the features of in vivo bon...

journal_title：Biomaterials

authors： Han W,El Botty R,Montaudon E,Malaquin L,Deschaseaux F,Espagnolle N,Marangoni E,Cottu P,Zalcman G,Parrini MC,Assayag F,Sensebe L,Silberzan P,Vincent-Salomon A,Dutertre G,Roman-Roman S,Descroix S,Camonis J

更新日期：2020-12-24 00:00:00

abstract：:In this study, we used deoxyribozyme (DNAzyme) functionalized gold nanoparticles (AuNPs) to catalytically silence tumor necrosis factor-α (TNF-α) in vivo as a potential therapeutic for myocardial infarction (MI). Using primary macrophages as a model, we demonstrated 50% knockdown of TNF-α, which was not attainable usi...

journal_title：Biomaterials

authors： Somasuntharam I,Yehl K,Carroll SL,Maxwell JT,Martinez MD,Che PL,Brown ME,Salaita K,Davis ME

更新日期：2016-03-01 00:00:00

abstract：:The concentrations of soluble copper and tin which were generated by the corrosion of a number of different amalgams in both an artificial saliva and Ringer's solution are reported. Besides variations in solution composition, the effects of solution agitation and abrasive particle wear upon the release of soluble spec...

journal_title：Biomaterials

authors： Mueller HJ,Edahl A

更新日期：1984-07-01 00:00:00

abstract：:Tissue engineering scaffolds with complex geometries can provide an architecture that directs tissue formation. Drug delivery from these scaffolds to promote regeneration is often challenging due to the complex fabrication processes. Surface-mediated DNA delivery from multiple channel bridges was applied to deliver li...

journal_title：Biomaterials

authors： De Laporte L,Yan AL,Shea LD

更新日期：2009-04-01 00:00:00

abstract：:A growing number of protein-based fibrous biomaterials have been produced with a cross-β amyloid core yet the long-term effect of these materials on cell viability and the influence of core and non-core protein sequences on viability is not well understood. Here, synthetic bioactive TTR1-RGD and control TTR1-RAD or TT...

journal_title：Biomaterials

authors： Bongiovanni MN,Gras SL

更新日期：2015-04-01 00:00:00

abstract：:Titanium is known for its biocompatibility and is widely used in dental and orthopedic reconstructive surgery. There are reports that osteointegration of these implants is not optimal. The objective of this study was to modify titanium dioxide particles and examine the resultant effects on protein adsorption to these ...

journal_title：Biomaterials

authors： MacDonald DE,Deo N,Markovic B,Stranick M,Somasundaran P

更新日期：2002-02-01 00:00:00

abstract：:The aminohexyl derivative of the copolymer of 2-hydroxyethyl methacrylate and ethylene dimethacrylate (p(HEMA)-Hex) in the form of regular spherical particles was used as a polymeric carrier for chemically sorbed methotrexate (MTX). The effect of the washed p(HEMA)-Hex-MTX carrier on the morphological structure of don...

journal_title：Biomaterials

authors： Horák D,Svec F,Adamyan A,Titova M,Skuba N,Voronkova O,Trostenyuk N,Vishnevskii V,Gumargalieva K

更新日期：1992-01-01 00:00:00

abstract：:We report a facile polyethyleneimine (PEI)-mediated approach to synthesizing folic acid (FA)-targeted magnetic iron oxide nanoparticles (Fe3O4 NPs) for in vivo magnetic resonance (MR) imaging of tumors. In this study, stable PEI-coated Fe3O4 NPs were prepared by a one-pot hydrothermal route. The aminated Fe3O4 NPs wit...

journal_title：Biomaterials

authors： Li J,Zheng L,Cai H,Sun W,Shen M,Zhang G,Shi X

更新日期：2013-11-01 00:00:00

abstract：:Nordihydroguaiaretic acid (NDGA), an antioxidant with two functional ortho-catechols from the creosote bush, has been shown to increase the mechanical properties of synthetic collagen fibers, producing biologically based, biocompatible fibers with material properties in uniaxial tensile tests to failure that are compa...

journal_title：Biomaterials

authors： Koob TJ,Hernandez DJ

更新日期：2003-03-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) play an important role in regulating osteoblastic differentiation and bone formation. But the diffuse of BMPs into muscle tissues around bone injury sites often leads to heterotopic ossification, which has been regarded as one of major side-effects of BMP implementation in bone defec...

journal_title：Biomaterials

authors： Zhang J,Zhao Y,Hou X,Chen B,Xiao Z,Han J,Shi C,Liu J,Miao Q,Dai J

更新日期：2014-11-01 00:00:00

abstract：:Local contact stresses at the bone-cement interface are thought to play an important role in the initiation of component loosening. A reduced-modulus bone cement can lower these local contact stresses. The viscoelastic properties of such a cement raised the question of long term subsidence of the implant system. In th...

journal_title：Biomaterials

authors： Yetkinler DN,Litsky AS

更新日期：1998-09-01 00:00:00

abstract：:Interventional closure of intracardiac wall defects using occluder devices has evolved as a highly attractive treatment option. However, incomplete and delayed healing reactions often result in a major risk of residual defects, thromboembolism, or device fractures. Biodegradable living tissue engineered occluder membr...

journal_title：Biomaterials

authors： Weber B,Schoenauer R,Papadopulos F,Modregger P,Peter S,Stampanoni M,Mauri A,Mazza E,Gorelik J,Agarkova I,Frese L,Breymann C,Kretschmar O,Hoerstrup SP

更新日期：2011-12-01 00:00:00

abstract：:Implantation of skeletal myoblasts to the heart has been investigated as a means to regenerate and protect the myocardium from damage after myocardial infarction. While several animal studies utilizing skeletal myoblasts have reported positive findings, results from clinical studies have been mixed. In this study we u...

journal_title：Biomaterials

authors： McGinn AN,Nam HY,Ou M,Hu N,Straub CM,Yockman JW,Bull DA,Kim SW

更新日期：2011-01-01 00:00:00

abstract：:This study examined the nature of the surface presented by a machinable feldspathic porcelain and by a machinable glass-ceramic for bonding to conventional composite luting agents and measured the bond strengths which may be achieved with various surface treatments. There was no significant difference between the bond...

journal_title：Biomaterials

authors： Jedynakiewicz NM,Martin N

更新日期：2001-04-01 00:00:00

abstract：:A novel low-pressure radio-frequency plasma treatment protocol was developed to achieve the effective through-thickness surface modification of large porous poly (D,L-lactide) (PDLLA) polymer scaffolds using air or water: ammonia plasma treatments. Polymer films were modified as controls. Scanning electron micrographs...

journal_title：Biomaterials

authors： Safinia L,Datan N,Höhse M,Mantalaris A,Bismarck A

更新日期：2005-12-01 00:00:00

abstract：:Mesenchymal stromal cells (hMSCs) are advancing into the clinic but the therapeutic efficacy of hMSCs faces the problem of donor variability. In bone tissue engineering, no reliable markers have been identified which are able to predict the bone-forming capacity of hMSCs prior to implantation. To this end, we isolated...

journal_title：Biomaterials

authors： Mentink A,Hulsman M,Groen N,Licht R,Dechering KJ,van der Stok J,Alves HA,Dhert WJ,van Someren EP,Reinders MJ,van Blitterswijk CA,de Boer J

更新日期：2013-06-01 00:00:00

abstract：:As part of a study of elicited angiogenesis, hyaluronan (HA)-based hydrogels crosslinked by polyethylene glycol diacrylate (PEGDA) were loaded with combinations of the cytokine growth factors vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1), keratinocyte growth factor (KGF) and platelet-derived growth...

journal_title：Biomaterials

authors： Elia R,Fuegy PW,VanDelden A,Firpo MA,Prestwich GD,Peattie RA

更新日期：2010-06-01 00:00:00

abstract：:This study aimed to assess the biocompatibility of two cordierite ceramics (DF and Cord 1014), with similar chemical composition and different porosity, as a potential support for cell growth in a continuous-flow, solid-bed reactor. The Chinese hamster ovary (CHO) cell line transfected with HBV-DHFR recombinant plasmi...

journal_title：Biomaterials

authors： Orlandi L,Solmi R,Krajewski A,Bearzatto A,Biagini G,Ciccopiedi E,Ravaglioli A

更新日期：1997-07-01 00:00:00

abstract：:In normal tissue repair, macrophages exhibit a pro-inflammatory phenotype (M1) at early stages and a pro-healing phenotype (M2) at later stages. We have previously shown that M1 macrophages initiate angiogenesis while M2 macrophages promote vessel maturation. Therefore, we reasoned that scaffolds that promote sequenti...

journal_title：Biomaterials

authors： Spiller KL,Nassiri S,Witherel CE,Anfang RR,Ng J,Nakazawa KR,Yu T,Vunjak-Novakovic G

更新日期：2015-01-01 00:00:00

abstract：:Efficient and site-specific delivery of anticancer drugs to tumors is important in the development of effective cancer chemotherapy. As an undecapeptide of the tachykinin neuropeptide family, the substance P (SP)/neurokinin-1 receptor (NK1R) system has been identified as a promising ligand-receptor pair in tumor-speci...

journal_title：Biomaterials

authors： Wu J,Zhou Y,Li S,Qu D,Zhu WH,Tian H

更新日期：2017-03-01 00:00:00

abstract：:Effective antimicrobial agents are important arsenals in our perennial fight against communicable diseases, hospital-acquired and surgical site multidrug-resistant infections. In this study, we devise a strategy for the development of highly efficacious and skin compatible yet inexpensive water-soluble macromolecular ...

journal_title：Biomaterials

authors： Liu S,Ono RJ,Wu H,Teo JY,Liang ZC,Xu K,Zhang M,Zhong G,Tan JP,Ng M,Yang C,Chan J,Ji Z,Bao C,Kumar K,Gao S,Lee A,Fevre M,Dong H,Ying JY,Li L,Fan W,Hedrick JL,Yang YY

更新日期：2017-05-01 00:00:00

abstract：:Polycaprolactone (PCL) membrane was modified by grafting copolymerization of methacrylic acid (MAA) initiated under UV light. The covalent immobilization of gelatin on PCL-g-PMAA surface was consequently performed by using condensing agent, 1-ethyl-3-(3-dimethylamino propyl) carbodiimide hydrochloride. The occurrence ...

journal_title：Biomaterials

authors： Zhu Y,Gao C,Shen J

更新日期：2002-12-01 00:00:00

abstract：:We design a class of water-dispersible hybrid nanogels for intracellular delivery of hydrophobic curcumin. The core-shell structured hybrid nanogels were synthesized by coating the Ag/Au bimetallic nanoparticles (NPs) with a hydrophobic polystyrene (PS) gel layer as inner shell, and a subsequent thin hydrophilic nonli...

journal_title：Biomaterials

authors： Wu W,Shen J,Banerjee P,Zhou S

更新日期：2011-01-01 00:00:00

abstract：:Endochondral ossification plays a key role in the bone healing process, which requires normal cartilage callus formation. Progranulin (PGRN) growth factor is known to enhance chondrocyte differentiation and endochondral ossification during development, yet whether PGRN also plays a role in bone regeneration remains un...

journal_title：Biomaterials

authors： Zhao YP,Tian QY,Frenkel S,Liu CJ

更新日期：2013-09-01 00:00:00

abstract：:Realization of systems able to both recruit cells and influence their fate (affecting their processes) represents a new approach for tissue regeneration. We investigated the potency of gene activated matrix (GAM) and implemented the GAM strategy in order to achieve a control of gene expression, as well as a specific c...

journal_title：Biomaterials

authors： Orsi S,De Capua A,Guarnieri D,Marasco D,Netti PA

更新日期：2010-01-01 00:00:00

abstract：:Current tissue engineering strategies are focused on the restoration of pathologically altered tissue architecture by transplantation of cells in combination with supportive scaffolds and biomolecules. In recent years, considerable attention has been given to chitosan (CS)-based materials and their applications in the...

journal_title：Biomaterials

authors： Di Martino A,Sittinger M,Risbud MV

更新日期：2005-10-01 00:00:00