Towards a methodology for the effective surface modification of porous polymer scaffolds.

abstract：:A series of segmented polydimethylsiloxane (PDMS) polyurea-urethanes was synthesized based on hexane diisocyanate modified polyether-PDMS soft segments. The hard segments consisted of 4,4'-methylene diphenylene diisocyanate, which was chain extended with 1,4-butanediol. The effect of chemical composition of the polyet...

journal_title：Biomaterials

authors： Lim F,Yang CZ,Cooper SL

更新日期：1994-05-01 00:00:00

abstract：:Calcium phosphate bioceramics have been applied as bone substitutes for several decades. Aseptic loosening after total joint arthroplasty is a major problem in orthopaedic surgery. Hydroxyapatite particles from materials wear have been reported as the main cause of implant failure. For this reason, an investigation in...

journal_title：Biomaterials

authors： Laquerriere P,Grandjean-Laquerriere A,Jallot E,Balossier G,Frayssinet P,Guenounou M

更新日期：2003-07-01 00:00:00

abstract：:B cells play a major role in the adaptive immune response by producing antigen-specific antibodies against pathogens and imparting immunological memory. Following infection or vaccination, antibody-secreting B cells and memory B cells are generated in specialized regions of lymph nodes and spleens, called germinal cen...

journal_title：Biomaterials

authors： Roh KH,Song HW,Pradhan P,Bai K,Bohannon CD,Dale G,Leleux J,Jacob J,Roy K

更新日期：2018-05-01 00:00:00

abstract：:Novel biological adhesives made from chitin derivatives were prepared and evaluated for their adhesive properties and biocompatibility. Chitin derivatives with acrylic groups, such as 2-hydroxy-3-methacryloyloxypropylated carboxymethyl chitin (HMA-CM-chitin), were synthesized and cured by the addition of an aqueous hy...

journal_title：Biomaterials

authors： Azuma K,Nishihara M,Shimizu H,Itoh Y,Takashima O,Osaki T,Itoh N,Imagawa T,Murahata Y,Tsuka T,Izawa H,Ifuku S,Minami S,Saimoto H,Okamoto Y,Morimoto M

更新日期：2015-02-01 00:00:00

abstract：:Glucose oxidase was immobilized into photographic gelatin hardened by chromium(III) sulphate. The enzyme-gelatin mixture was coated on polyester film strips which allowed easy and simple handling during assays. The effect of gelatin and cross-linker concentrations on water content and enzymatic activity was studied. T...

journal_title：Biomaterials

authors： Elçin YM,Akbulut U

更新日期：1992-01-01 00:00:00

abstract：:A biocompatible hydrogel of poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) which includes the cell-adhesive region of fibronectin Arg-Gly-Asp was synthesized and its structure, rheological and dielectric properties were characterized. The ability of a PHPMA-RGD hydrogel to promote tissue regeneration and support axon...

journal_title：Biomaterials

authors： Woerly S,Pinet E,de Robertis L,Van Diep D,Bousmina M

更新日期：2001-05-01 00:00:00

abstract：:New light-activation units equipped with high-illuminant blue light-emitting diodes (LEDs) have recently been proposed as a replacement for the halogen units that are widely used in dentistry to polymerize light-cured resins. The photoinitiators in light-cured dental resins, typified by the camphorquinone (CQ)/amine p...

journal_title：Biomaterials

authors： Teshima W,Nomura Y,Tanaka N,Urabe H,Okazaki M,Nahara Y

更新日期：2003-05-01 00:00:00

abstract：:Recent studies suggest that bone marrow stromal cells are a potential source of osteoblasts and chondrocytes and can be used to regenerate damaged tissues using a tissue-engineering (TE) approach. However, these strategies require the use of an appropriate scaffold architecture that can support the formation de novo o...

journal_title：Biomaterials

authors： Oliveira JM,Rodrigues MT,Silva SS,Malafaya PB,Gomes ME,Viegas CA,Dias IR,Azevedo JT,Mano JF,Reis RL

更新日期：2006-12-01 00:00:00

abstract：:High throughput cellular studies require small sample volume to reduce costs and enhance sensitivity. Microfluidics-generated water-in-oil (W/O) single emulsion droplet systems, in particular, provide uniform, well defined and discrete microenvironment for cell culture, screening, and sorting. However, these single em...

journal_title：Biomaterials

authors： Zhang Y,Ho YP,Chiu YL,Chan HF,Chlebina B,Schuhmann T,You L,Leong KW

更新日期：2013-06-01 00:00:00

abstract：:Poly(ε-caprolactone)-b-Poly(N-vinylpyrrolidone) (PCL-b-PVP) copolymers with different PVP block length were synthesized by xanthate-mediated reverse addition fragment transfer polymerization (RAFT) and the xanthate chain transfer agent on chain end was readily translated to hydroxy or aldehyde for conjugating various ...

journal_title：Biomaterials

authors： Zhu Z,Xie C,Liu Q,Zhen X,Zheng X,Wu W,Li R,Ding Y,Jiang X,Liu B

更新日期：2011-12-01 00:00:00

abstract：:This study was designed to examine the adhesion, proliferation, and morphology of chondrocytes on new scaffolds; and to examine these cells histologically for the ability of the chondrocytes to maintain chondrogenic properties after subcutaneous implantation into nude mice. Both 75:25 poly (L-lactide-co-epsilon-caprol...

journal_title：Biomaterials

authors： Honda M,Morikawa N,Hata K,Yada T,Morita S,Ueda M,Kimata K

更新日期：2003-09-01 00:00:00

abstract：:The creation of 3D scaffolds that mimic the structure of physiological tissue required for normal cell function is a major bioengineering challenge. For corneal stroma reconstruction this necessitates the creation of a stroma-like scaffold consisting of a stack of orthogonally disposed sheets of aligned collagen fibri...

journal_title：Biomaterials

authors： Torbet J,Malbouyres M,Builles N,Justin V,Roulet M,Damour O,Oldberg A,Ruggiero F,Hulmes DJ

更新日期：2007-10-01 00:00:00

abstract：:Polypyrrole (PPy) is a conducting polymer and is obtained electrochemically on an electrode such as indium-tin oxide (ITO). In this study, in order to develop a novel cell-culture system which makes it possible to communicate with cultured mammalian cells, bovine adrenal chromaffin cells were cultured on PPy-coated IT...

journal_title：Biomaterials

authors： Aoki T,Tanino M,Sanui K,Ogata N,Kumakura K

更新日期：1996-10-01 00:00:00

abstract：:The efficacy of colloidal particles as drug carriers is closely related to their interaction with proteins and enzymes in different body fluids. In the present work, we analysed the interaction phenomenon between lysozyme (LZM), a positively charged enzyme that is highly concentrated in mucosas, and two different drug...

journal_title：Biomaterials

authors： Calvo P,Vila-Jato JL,Alonso MJ

更新日期：1997-10-01 00:00:00

abstract：:Extracellular matrix (ECM) based biomaterials have an established place as medical devices for wound healing and tissue regeneration. In the search for biomaterials we have identified ovine forestomach matrix (OFM), a thick, large format ECM which is biochemically diverse and biologically functional. OFM was purified ...

journal_title：Biomaterials

authors： Lun S,Irvine SM,Johnson KD,Fisher NJ,Floden EW,Negron L,Dempsey SG,McLaughlin RJ,Vasudevamurthy M,Ward BR,May BC

更新日期：2010-06-01 00:00:00

abstract：:A range of poly(alkyl methacrylate)s in the range C5 to C13 with varying degrees of crosslinking, have been studied with respect to stress-strain behaviour. Where the extensions to break were sufficiently high, stress-strain properties conformed well to the statistical theory of rubber elasticity, the Mooney/Rivlin C2...

journal_title：Biomaterials

authors： Davy KW,Braden M

更新日期：1987-09-01 00:00:00

abstract：:Thrombomodulin (TM) is a newly described endothelial cell-associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. In this study, focussing on the application of TM for biomedical materials, recombinant human TM (hTM) was immobilized o...

journal_title：Biomaterials

authors： Kishida A,Ueno Y,Fukudome N,Yashima E,Maruyama I,Akashi M

更新日期：1994-08-01 00:00:00

abstract：:A UV-hardening lacquer material based on polyurethane, used in Philips compact disc lens systems, was tested as suitable material for low-cost intraocular lenses (IOLs). A slightly changed composition (code number I-0.5A) came out as the best and was subsequently tested, with reference to poly(methyl methacrylate) (PM...

journal_title：Biomaterials

authors： Jongebloed WL,van der Veen G,Kalicharan D,van Andel MV,Bartman G,Worst JG

更新日期：1994-08-01 00:00:00

abstract：:Membranes, clinically used to improve bone regeneration according to the osteopromotion principle, have primarily been made of expanded polytetrafluoroethylene (Gore-Tex Membrane). Recently, different types of biodegradable membranes have become available. This investigation explored the osteopromotive potential of 10...

journal_title：Biomaterials

authors： Zellin G,Gritli-Linde A,Linde A

更新日期：1995-05-01 00:00:00

abstract：:Unlike silkworm and spider silks assembled from very large and repetitive fibrous proteins, the bee and ant silks were recently demonstrated to consist of four small and non-repetitive coiled-coil proteins. The design principle for this silk family remains largely unknown and so far no structural study is available on...

journal_title：Biomaterials

authors： Shi J,Lua S,Du N,Liu X,Song J

更新日期：2008-06-01 00:00:00

abstract：:Nordihydroguaiaretic acid (NDGA), an antioxidant with two functional ortho-catechols from the creosote bush, has been shown to increase the mechanical properties of synthetic collagen fibers, producing biologically based, biocompatible fibers with material properties in uniaxial tensile tests to failure that are compa...

journal_title：Biomaterials

authors： Koob TJ,Hernandez DJ

更新日期：2003-03-01 00:00:00

abstract：:Adhesion of cells to surfaces is a basic and important requirement in cell culture and tissue engineering. Here, we designed artificial extracellular matrix (ECM) mimics for efficient cellular attachment, based on mussel adhesive protein (MAP) fusion with biofunctional peptides originating from ECM materials, includin...

journal_title：Biomaterials

authors： Choi BH,Choi YS,Kang DG,Kim BJ,Song YH,Cha HJ

更新日期：2010-12-01 00:00:00

abstract：:A comparative in vitro assessment of 4 types of tubing representative of the materials currently used in cardiopulmonary bypass (CPB) procedures was conducted under static conditions using liquid extracts of the materials or direct contact with fresh human blood or serum. The parameters monitored were biomarkers of co...

journal_title：Biomaterials

authors： Harmand MF,Briquet F

更新日期：1999-09-01 00:00:00

abstract：:Combined treatment using nonviral agent-mediated enzyme/prodrug therapy and immunotherapy had been proposed as a powerful alternative method of cancer therapy. The present study was aimed to evaluate the cytotoxicity in vitro and the therapeutic efficacy in vivo when the cytosine deaminase/5-fluorocytosine (CD/5-FC) a...

journal_title：Biomaterials

authors： Liang B,He ML,Chan CY,Chen YC,Li XP,Li Y,Zheng D,Lin MC,Kung HF,Shuai XT,Peng Y

更新日期：2009-08-01 00:00:00

abstract：:Vasculopathy due to ischemia in damaged tissues is a major cause of morbidity and mortality. To treat these conditions, endothelial progenitor cells (EPCs) from various sources, such as umbilical cord or peripheral blood, have been the focus of the regenerative medicine field due to their proliferative and vasculogeni...

journal_title：Biomaterials

authors： Kim J,Jeon YJ,Kim HE,Shin JM,Chung HM,Chae JI

更新日期：2013-02-01 00:00:00

abstract：:To study the effect of ionizable functional groups on the adhesion of leucocytes to surfaces, both poly(ethyleneimine) and poly(acrylic acid) were immobilized on polyurethane films, resulting in the introduction of amine and carboxylic acid groups, respectively. This was confirmed by contact angle measurements and XPS...

journal_title：Biomaterials

authors： Bruil A,Terlingen JG,Beugeling T,van Aken WG,Feijen J

更新日期：1992-01-01 00:00:00

abstract：:Bone tissue is an anisotropic non-homogeneous composite material composed of inorganic, bone mineral fibres (hydroxyapatite) embedded in an organic matrix (type I collagen and non-collagenous proteins). Factors contributing to the overall mechanical behaviour include constituent volume fraction, mechanical properties,...

journal_title：Biomaterials

authors： Walsh WR,Guzelsu N

更新日期：1994-01-01 00:00:00

abstract：:Two commercially available amalgam alloy powders (one lathe-cut, the other spherical) were characterized in terms of density, surface area, particle size distribution and appearance under the scanning electron microscope. A third, experimental alloy powder, prepared by electrodeposition, was subjected to a similar ana...

journal_title：Biomaterials

authors： Davies EH,Kuhn AT

更新日期：1984-11-01 00:00:00

abstract：OBJECTIVES:To analyze the biocompatibility of multifilament polyester (PET) meshes used for the implantation of auditory brainstem implants in a standardized Wistar rat model (n=29). METHODS:The physical properties of the meshes were examined during surgery. Using a modified plastic embedding, the local tissue reactio...

journal_title：Biomaterials

authors： Quester R,Hermanns B,Klosterhalfen B,Schröder R,Klug N

更新日期：2003-02-01 00:00:00

abstract：:Immune response testing of biomaterials is an essential component of biocompatibility assessment, particularly when the materials of interest are used to design bioresorbable scaffolds with the potential to promote in situ regeneration. Current trends in immune response testing of biomaterials typically examine few el...

journal_title：Biomaterials

authors： Smith MJ,White KL Jr,Smith DC,Bowlin GL

更新日期：2009-01-01 00:00:00