Spinal cord repair with PHPMA hydrogel containing RGD peptides (NeuroGel).

abstract：:Cancer stem cells (CSCs) play pivotal roles in cancer metastasis, and strategies targeting cancer stemness may greatly reduce cancer metastasis and improve patients' survival. The canonical Wnt/β-catenin pathway plays critical roles in CSC generation and maintenance as well as in normal stem cells. Non-specifically su...

journal_title：Biomaterials

authors： Li Y,Xiao Y,Lin HP,Reichel D,Bae Y,Lee EY,Jiang Y,Huang X,Yang C,Wang Z

更新日期：2019-01-01 00:00:00

abstract：:A series of in vitro screening assays for the preliminary selection of biomaterials for use in the fabrication of artificial corneas (keratoprostheses) (KPros) have been investigated. These screening assays assessed the initial binding of inflammatory and cell adhesive proteins, activation of inflammatory proteins, ad...

journal_title：Biomaterials

authors： Sandeman SR,Lloyd AW,Tighe BJ,Franklin V,Li J,Lydon F,Liu CS,Mann DJ,James SE,Martin R

更新日期：2003-11-01 00:00:00

abstract：:A variety of approaches have been investigated to address the problems associated with oral insulin delivery, but the bioavailability of oral insulin is still low. Insulin is rapidly degraded by the enzymes in the GI tract and is not transported across the epithelial barrier easily. The oral insulin formulation develo...

journal_title：Biomaterials

authors： Kavimandan NJ,Losi E,Peppas NA

更新日期：2006-07-01 00:00:00

abstract：:Glioma is still hard to be treated due to their complex microenvironment. In this study, a gold nanoparticle-based delivery system was developed. The system, An-PEG-DOX-AuNPs, was loaded with doxorubicin (DOX) through hydrazone, an acid-responsive linker, and was functionalized with angiopep-2, a specific ligand of lo...

journal_title：Biomaterials

authors： Ruan S,Yuan M,Zhang L,Hu G,Chen J,Cun X,Zhang Q,Yang Y,He Q,Gao H

更新日期：2015-01-01 00:00:00

abstract：:A challenge in combating many major diseases is breaching the skin's tough outer layer (the stratum corneum (SC)) and delivering drugs and genes into the underlying abundant immunologically sensitive viable epidermal cells with safe, practical physical technologies. To achieve this effectively and accurately, design i...

journal_title：Biomaterials

authors： Kendall MA,Chong YF,Cock A

更新日期：2007-11-01 00:00:00

abstract：:Seven nominally identical samples of Na-free carbonate apatite (CO(3)Ap) were prepared by reaction of CaHPO(4) with ammonium carbonate solution at 70 degrees C over 3 days. They were studied by chemical analysis, Rietveld analysis of powder X-ray diffraction (XRD) data, Ca/P ratio determinations (quantitative phase an...

journal_title：Biomaterials

authors： Wilson RM,Dowker SE,Elliott JC

更新日期：2006-09-01 00:00:00

abstract：:Although graphene oxide (GO) has recently been considered as a highly attractive nanomaterial for future cancer imaging and therapy, it is still a major challenge to improve its in vivo tumor active targeting efficiency. Here in this full article, we demonstrated the successful and significantly enhanced in vivo tumor...

journal_title：Biomaterials

authors： Shi S,Yang K,Hong H,Chen F,Valdovinos HF,Goel S,Barnhart TE,Liu Z,Cai W

更新日期：2015-01-01 00:00:00

abstract：:The in vivo properties of a new kind of calcium phosphate cement were investigated in this study. Calcium phosphate cement was implanted as paste into femoral bone and dorsal muscle of dogs for 3 and 6 months, and as prehardened form into thigh muscles of dogs for 1, 2 and 6 months. Histology was performed on thin un-...

journal_title：Biomaterials

authors： Yuan H,Li Y,de Bruijn JD,de Groot K,Zhang X

更新日期：2000-06-01 00:00:00

abstract：:The aim of this study was to characterize the relation of dimensional changes of dental ceramic materials as function of temperature. The thermal dimensional behavior of one glass ceramic core, four commercially available veneering porcelains and two experimental veneering porcelain materials was determined on cooling...

journal_title：Biomaterials

authors： Isgrò G,Kleverlaan CJ,Wang H,Feilzer AJ

更新日期：2004-05-01 00:00:00

abstract：:Pneumonia is a major contributor to infection-based hospitalizations and deaths in the United States. Antibiotics such as azithromycin (AZM), although effective at managing pneumonia, often suffer from off-target diffusion and poor bioavailability when administered orally or via intravenous injection. The formation of...

journal_title：Biomaterials

authors： Wang Q,Mi G,Hickey D,Li Y,Tu J,Webster TJ,Shen Y

更新日期：2018-04-01 00:00:00

abstract：:In this paper we describe the mechanical and biological features of a thermosetting polyester synthesized from glycerol and dodecanedioic acid named Poly-Glycerol-Dodecanoate (PGD). This polymer shows a glass transition temperature (T(g)) around 32 degrees C, and this accounts for its mechanical properties. At room te...

journal_title：Biomaterials

authors： Migneco F,Huang YC,Birla RK,Hollister SJ

更新日期：2009-11-01 00:00:00

abstract：:Articular cartilage injuries do not heal and large defects result in osteoarthritis with major personal and socioeconomic costs. Osteochondral transplantation is an effective treatment for large joint defects but its use is limited by the inability to store cartilage for long periods of time. Cryopreservation/vitrific...

journal_title：Biomaterials

authors： Jomha NM,Elliott JA,Law GK,Maghdoori B,Forbes JF,Abazari A,Adesida AB,Laouar L,Zhou X,McGann LE

更新日期：2012-09-01 00:00:00

abstract：:Polystyrene and phenylated polyacrolein microspheres of different diameters, as well as modified cellulose microspheres with different surface charges, were prepared in order to study the size and surface charge effect on their phagocytosis by mouse peritoneal macrophages. It was found that the maximal phagocytosis of...

journal_title：Biomaterials

authors： Tabata Y,Ikada Y

更新日期：1988-07-01 00:00:00

abstract：:Neuromuscular circuits (NMCs) are vital for voluntary movement, and effective models of NMCs are needed to understand the pathogenesis of, as well as to identify effective treatments for, multiple diseases, including Duchenne's muscular dystrophy and amyotrophic lateral sclerosis. Microfluidics are ideal for recapitul...

journal_title：Biomaterials

authors： Bellmann J,Goswami RY,Girardo S,Rein N,Hosseinzadeh Z,Hicks MR,Busskamp V,Pyle AD,Werner C,Sterneckert J

更新日期：2019-12-01 00:00:00

abstract：:The suitability of chitosan-based hydrogels as scaffolds for the encapsulation of intervertebral disc (IVD) cells and the accumulation of a functional extracellular matrix mimicking that of the nucleus pulposus (NP) was investigated. The specific hypothesis under study was that the cationic chitosan would form an idea...

journal_title：Biomaterials

authors： Roughley P,Hoemann C,DesRosiers E,Mwale F,Antoniou J,Alini M

更新日期：2006-01-01 00:00:00

abstract：:Fibrillar type I collagen is nontoxic, biocompatible, and possesses considerable strength and stability. In a study of scaffolds for use in laminated tissue substitutes, we examined the properties of membranes made from air-dried hydrogels of collagen fibrils that were polymerized from native, monomeric collagen. Plan...

journal_title：Biomaterials

authors： Vernon RB,Gooden MD,Lara SL,Wight TN

更新日期：2005-04-01 00:00:00

abstract：:The interfacial membrane harvested from failed joint replacements contains particulate debris from the materials used for the implant. To define the tissue response to particulate titanium alloy and hydroxyapatite (HA) alone, 16 mature New Zealand white rabbits were divided into 2 groups of 8 rabbits. Using sterile te...

journal_title：Biomaterials

authors： Goodman SB,Davidson JA,Fornasier VL

更新日期：1993-08-01 00:00:00

abstract：:Osteoclasts resorb bone at surfaces, leaving behind pits and trails where both mineral and organic phases of bone have been dissolved. Rough surface structures are deliberately imparted to synthetic implants, in order to improve osseointegration. The aim of this study is to characterize osteoclastic resorption pits on...

journal_title：Biomaterials

authors： Hefti T,Frischherz M,Spencer ND,Hall H,Schlottig F

更新日期：2010-10-01 00:00:00

abstract：:Osteonecrosis of the femoral head (ONFH) is a debilitating disease that may progress to femoral head collapse and subsequently, degenerative arthritis. Although injection of bone marrow-derived mononuclear cells (BMMCs) is often performed with core decompression (CD) in the early stage of ONFH, these treatments are no...

journal_title：Biomaterials

authors： Maruyama M,Nabeshima A,Pan CC,Behn AW,Thio T,Lin T,Pajarinen J,Kawai T,Takagi M,Goodman SB,Yang YP

更新日期：2018-12-01 00:00:00

abstract：:Remarkable water-stimulated shape memory effect was revealed in a natural biopolymer of peacock's tail covert feathers of which the innate shape can almost be fully recovered after severe deformation by a short hydration step. The shape memory effect manifests a good stability of high recovery rate and ratio during cy...

journal_title：Biomaterials

authors： Liu ZQ,Jiao D,Zhang ZF

更新日期：2015-10-01 00:00:00

abstract：:A micro-X-ray diffraction (micro-XRD) technique has been employed to determine the phases in two superelastic nickel-titanium orthodontic wires that exhibit shape memory in the oral environment and one superelastic nickel-titanium wire that does not exhibit shape memory in vivo. The micro-XRD analyses were performed o...

journal_title：Biomaterials

authors： Iijima M,Brantley WA,Kawashima I,Ohno H,Guo W,Yonekura Y,Mizoguchi I

更新日期：2004-01-01 00:00:00

abstract：:Metal sensitivity (MS) reactions to implant metals represent a rare but well-documented complication following total joint arthroplasty (TJA). Although 20-25% of post-TJA patients develop MS, only a few highly susceptible patients (< 1%) exhibit symptoms. Whether surgeons should perform screening for MS is currently a...

journal_title：Biomaterials

authors： Niki Y,Matsumoto H,Otani T,Yatabe T,Kondo M,Yoshimine F,Toyama Y

更新日期：2005-03-01 00:00:00

abstract：:Cationic polymers are currently being studied as non-viral vectors to deliver therapeutic DNA into cells. In this study, a series of trehalose-based glycopolymers containing four secondary amines in the repeat unit were synthesized via the 'click reaction' [degrees of polymerization (n(w))=35, 53, 75, or 100] to eluci...

journal_title：Biomaterials

authors： Srinivasachari S,Liu Y,Prevette LE,Reineke TM

更新日期：2007-06-01 00:00:00

abstract：:RNA interference holds tremendous potential as a therapeutic approach of malignant tumors. However, safe and efficient nanovectors are extremely lack for systemic delivery of small interfering RNA (siRNA). The study aimed to develop a biomimetic nanovector, reconstituted high density lipoprotein (rHDL), mediating targ...

journal_title：Biomaterials

authors： Ding Y,Wang W,Feng M,Wang Y,Zhou J,Ding X,Zhou X,Liu C,Wang R,Zhang Q

更新日期：2012-12-01 00:00:00

abstract：:Hydrogels have been widely used for 3-dimensional (3D) cell culture and tissue regeneration due to their tunable biochemical and physicochemical properties as well as their high water content, which resembles the aqueous microenvironment of the natural extracellular matrix. While many properties of natural hydrogel ma...

journal_title：Biomaterials

authors： Zhang S,Liu X,Barreto-Ortiz SF,Yu Y,Ginn BP,DeSantis NA,Hutton DL,Grayson WL,Cui FZ,Korgel BA,Gerecht S,Mao HQ

更新日期：2014-03-01 00:00:00

abstract：:Premature ovarian failure (POF) is the most frequently occurred disease in ovary. Direct inhibition of mammalian target of rapamycin (mTOR) activity can treat woman POF but brings adverse effects to women. Herein, by rational design of a hydrogelator Nap-Phe-Phe-Asp-Arg-Leu-Tyr-OH (Y) and co-assembling Y with an inhib...

journal_title：Biomaterials

authors： Shi Z,Li X,Wei M,Chen P,Zhang T,Ling X,Zhang J,Zhao C,Wang F,Liang G

更新日期：2020-11-16 00:00:00

abstract：:FT-IR analysis was performed for the hydroxyapatite (HAp)/collagen (COL) nanocomposite cross-linked by glutaraldehyde (GA). The amide bands I, II and III from COL matrix, and phosphate and carbonate bands from HAp were identified. The amide B band arising from C-H stretching mode showed a sensitive conformation by the...

journal_title：Biomaterials

authors： Chang MC,Tanaka J

更新日期：2002-12-01 00:00:00

abstract：:Vaccine efficacy is improved upon specific delivery to professional antigen (Ag) presenting cells, such as dendritic cells (DCs). Antigenicity and adjuvanticity of vaccine components can be enhanced by encapsulation within nanoparticle (NP) vaccine carriers that are targeted to the human DC-specific C-type lectin rece...

journal_title：Biomaterials

authors： Cruz LJ,Tacken PJ,Pots JM,Torensma R,Buschow SI,Figdor CG

更新日期：2012-06-01 00:00:00

abstract：:Bone marrow is the primary hematopoietic organ, which is involved in multiple malignant diseases including acute and chronic leukemia, multiple myeloma, myelodysplastic syndromes, and bone metastases from solid tumors. These malignancies affect normal homeostasis and reshape the bone marrow microenvironment. There are...

journal_title：Biomaterials

authors： Mu CF,Shen J,Liang J,Zheng HS,Xiong Y,Wei YH,Li F

更新日期：2018-02-01 00:00:00

abstract：:Finding bioactive short peptides derived from proteins is a critical step to the advancement of tissue engineering and regenerative medicine, because the former maintains the functions of the latter without immunogenicity in biological systems. Here, we discovered a bioactive core nonapeptide sequence, PPFEGCIWN (resi...

journal_title：Biomaterials

authors： Yeo IS,Min SK,Kang HK,Kwon TK,Jung SY,Min BM

更新日期：2015-12-01 00:00:00