Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophage.

abstract：:Multifunctional and water-soluble superparamagnetic iron oxide (SPIO) nanocarriers were developed for targeted drug delivery and positron emission tomography/magnetic resonance imaging (PET/MRI) dual-modality imaging of tumors with integrin α(v)β₃ expression. An anticancer drug was conjugated onto the PEGylated SPIO n...

journal_title：Biomaterials

authors： Yang X,Hong H,Grailer JJ,Rowland IJ,Javadi A,Hurley SA,Xiao Y,Yang Y,Zhang Y,Nickles RJ,Cai W,Steeber DA,Gong S

更新日期：2011-06-01 00:00:00

abstract：:We determined whether a two-part space-conforming polyethylene glycol/dopa polymer-based gel promoted healing of contaminated wounds in mice. This silver-catalysed gel was previously developed to be broadly microbiocidal in vitro while being biocompatible with human wound cell functioning. Full-thickness wounds were c...

journal_title：Biomaterials

authors： Yates CC,Whaley D,Babu R,Zhang J,Krishna P,Beckman E,Pasculle AW,Wells A

更新日期：2007-09-01 00:00:00

abstract：:Lipoproteins are a family of plasma nanoparticles responsible for the transportation of lipids throughout the body. High-density lipoprotein (HDL), the smallest of the lipoprotein family, measures 7-13 nm in diameter and consists of a cholesteryl ester and triglyceride core that is covered with a monolayer of phosphol...

journal_title：Biomaterials

authors： Skajaa T,Cormode DP,Jarzyna PA,Delshad A,Blachford C,Barazza A,Fisher EA,Gordon RE,Fayad ZA,Mulder WJ

更新日期：2011-01-01 00:00:00

abstract：:Mesenchymal stromal cells (hMSCs) are advancing into the clinic but the therapeutic efficacy of hMSCs faces the problem of donor variability. In bone tissue engineering, no reliable markers have been identified which are able to predict the bone-forming capacity of hMSCs prior to implantation. To this end, we isolated...

journal_title：Biomaterials

authors： Mentink A,Hulsman M,Groen N,Licht R,Dechering KJ,van der Stok J,Alves HA,Dhert WJ,van Someren EP,Reinders MJ,van Blitterswijk CA,de Boer J

更新日期：2013-06-01 00:00:00

abstract：:Multiple ophthalmic pathologies, such as retinal detachment and diabetic retinopathy, require the removal and replacement of the vitreous humor. Clinical tamponades such as silicone oil and fluorinated gases are utilized but limited due to complications and toxicity. Therefore, there is a need for biocompatible, stabl...

journal_title：Biomaterials

authors： Raia NR,Jia D,Ghezzi CE,Muthukumar M,Kaplan DL

更新日期：2020-03-01 00:00:00

abstract：:Tetragonal zirconia polycrystal (TZP) is a new interesting ceramic for the manufacture of medical devices. Its wide use in orthopedic and odontoiatric implants was limited till now by the high chemical and radiochemical impurities of the raw materials. Purification processes now available allow to obtain high purity c...

journal_title：Biomaterials

authors： Covacci V,Bruzzese N,Maccauro G,Andreassi C,Ricci GA,Piconi C,Marmo E,Burger W,Cittadini A

更新日期：1999-02-01 00:00:00

abstract：:In addition to unidirectional laminates and short fiber reinforcements for compression bone plate developments in the literature, we have proposed using a textile structure, i.e. braid preform, for this purpose. In the present paper, the influence of braiding angles and plate thicknesses on the bending performance of ...

journal_title：Biomaterials

authors： Fujihara K,Huang ZM,Ramakrishna S,Satknanantham K,Hamada H

更新日期：2003-07-01 00:00:00

abstract：:Realizing the potential of human pluripotent stem cell (hPSC)-based therapy requires the development of defined scalable culture systems with efficient expansion, differentiation and isolation protocols. We report an engineered 3D microfiber system that efficiently supports long-term hPSCs self-renewal under chemicall...

journal_title：Biomaterials

authors： Lu HF,Narayanan K,Lim SX,Gao S,Leong MF,Wan AC

更新日期：2012-03-01 00:00:00

abstract：:A practical method of photocrosslinking high molecular weight poly(trimethylene carbonate)(PTMC) is presented. Flexible, elastomeric and biodegradable networks could be readily prepared by UV irradiating PTMC films containing pentaerythritol triacrylate (PETA) and a photoinitiator. The network characteristics, mechani...

journal_title：Biomaterials

authors： Bat E,Kothman BH,Higuera GA,van Blitterswijk CA,Feijen J,Grijpma DW

更新日期：2010-11-01 00:00:00

abstract：:Microcontact printing techniques were used to modify silicon substrates with arrays of hexagonal features of N1[3-(trimethoxysilyl) propyl]diethylenetriamine (DETA) surrounded by octadecyltrichlorosilane (OTS), which are hydrophilic, cell-adhesive and hydrophobic, non-adhesive organosilanes, respectively. In the prese...

journal_title：Biomaterials

authors： Kam L,Shain W,Turner JN,Bizios R

更新日期：1999-12-01 00:00:00

abstract：:AuCu and AuAg alloys (30 at. % Au) have been immersed in aqueous solutions of chloride and sulphide with additions of protein (mucin). The surfaces of the alloys were subsequently analysed by means of ESCA and compared with previous and similar tests without addition of mucin. No noticeable effect of the mucin additio...

journal_title：Biomaterials

authors： Herø H,Hultquist G,Odén A

更新日期：1985-11-01 00:00:00

abstract：:Because of the ability to induce cell death in certain conditions, the fullerenes (C(60)) are potential anticancer and toxic agents. The colloidal suspension of crystalline C(60) (nano-C(60), nC(60)) is extremely toxic, but the mechanisms of its cytotoxicity are not completely understood. By combining experimental ana...

journal_title：Biomaterials

authors： Markovic Z,Todorovic-Markovic B,Kleut D,Nikolic N,Vranjes-Djuric S,Misirkic M,Vucicevic L,Janjetovic K,Isakovic A,Harhaji L,Babic-Stojic B,Dramicanin M,Trajkovic V

更新日期：2007-12-01 00:00:00

abstract：:A study on the evolution with age of the mineral composition of bones was performed on samples belonging to human and other common mammalian species (cattle, sheep, dog). The study was carried out on the ashes obtained by calcination of the bone samples (1 h at 900 degrees C). The calcined powders were carefully exami...

journal_title：Biomaterials

authors： Ravaglioli A,Krajewski A,Celotti GC,Piancastelli A,Bacchini B,Montanari L,Zama G,Piombi L

更新日期：1996-03-01 00:00:00

abstract：:Magnetic microcarrier particles useful for delivering chemotherapeutic drug molecules are described. The particles are formed by joint deformation of iron and carbon in a ball mill. Physical, chemical, and functional characterization has been carried out on the particles. Physical characteristics include microscopy, p...

journal_title：Biomaterials

authors： Rudge SR,Kurtz TL,Vessely CR,Catterall LG,Williamson DL

更新日期：2000-07-01 00:00:00

abstract：:A simple and sensitive method for the quantitative determination of solid-supported primary and/or secondary amino groups using commercially available reagents is described. The solid supports are treated in an aqueous environment with either 2-iminothiolane (ITL) or sulpho-succinimidyl-3-(4-hydroxyphenyl)propionate (...

journal_title：Biomaterials

authors： Kakabakos SE,Tyllianakis PE,Evangelatos GP,Ithakissios DS

更新日期：1994-03-01 00:00:00

abstract：:Realization of systems able to both recruit cells and influence their fate (affecting their processes) represents a new approach for tissue regeneration. We investigated the potency of gene activated matrix (GAM) and implemented the GAM strategy in order to achieve a control of gene expression, as well as a specific c...

journal_title：Biomaterials

authors： Orsi S,De Capua A,Guarnieri D,Marasco D,Netti PA

更新日期：2010-01-01 00:00:00

abstract：:The development of more selective delivery systems for cancer diagnosis and chemotherapy is one of the most important goals of current anticancer research. The purpose of this study is to evaluate various self-assembled nanoparticles as candidates to shuttle radionuclide and/or drugs into tumors and to investigate the...

journal_title：Biomaterials

authors： Cho YW,Park SA,Han TH,Son DH,Park JS,Oh SJ,Moon DH,Cho KJ,Ahn CH,Byun Y,Kim IS,Kwon IC,Kim SY

更新日期：2007-02-01 00:00:00

abstract：:Generation of specific lineages of cells from embryonic stem (ES) cells is pre-requisite to use these cells in pre-clinical applications. Here, we developed a recombinant E-cadherin substratum for generation of hepatic progenitor populations at single cell level. This artificial acellular feeder layer supports the ste...

journal_title：Biomaterials

authors： Haque A,Hexig B,Meng Q,Hossain S,Nagaoka M,Akaike T

更新日期：2011-03-01 00:00:00

abstract：:Dense, reconstituted collagen membranes, using an optimized cross-linking protocol, were implanted subcutaneously into rats. After implantation, only a mild inflammatory response in the surrounding tissues was observed. The morphology of the fibroblasts around the membranes was seen to go through characteristic stages...

journal_title：Biomaterials

authors： Boon ME,Ruijgrok JM,Vardaxis MJ

更新日期：1995-09-01 00:00:00

abstract：:Because tissues are characterized by a well-defined three-dimensional arrangement of cells, tissue engineering scaffolds that facilitate the organization and differentiation of new tissue will have improved performance in comparison to scaffolds that only provide surfaces for cell attachment and growth. We hypothesize...

journal_title：Biomaterials

authors： Koegler WS,Griffith LG

更新日期：2004-06-01 00:00:00

abstract：:Elasticity of cellular microenvironments strongly influences cell motility, phagocytosis, growth and differentiation. Currently, the relationship between the cell behaviour and matrix stiffness is being studied for cells seeded on planar substrates, however in three-dimensional (3D) microenvironments cells may experie...

journal_title：Biomaterials

authors： Kumachev A,Greener J,Tumarkin E,Eiser E,Zandstra PW,Kumacheva E

更新日期：2011-02-01 00:00:00

abstract：:Chemotherapy is a popular treatment approach against cancer but significant uptake of drugs by normal tissues is still a major limitation. Magnetic drug targeting (MDT) has been used to improve localized drug delivery to interstitial tumor targets. MDT is now being developed to improve drug delivery to tumor vessels. ...

journal_title：Biomaterials

authors： Dandamudi S,Campbell RB

更新日期：2007-11-01 00:00:00

abstract：:Supramolecular assemblies have attracted a great attention, due to their intriguing topologies and their application in various fields such as nanodevices, sensors, molecular switches, and drug delivery systems. In this study, we prepared the monosubstituted insulin with poly(ethylene glycol) (PEG, MW about 2200) and ...

journal_title：Biomaterials

authors： Higashi T,Hirayama F,Misumi S,Arima H,Uekama K

更新日期：2008-10-01 00:00:00

abstract：:Tumor-homing cytotoxic stem cell (SC) therapy is a promising new approach for treating the incurable brain cancer glioblastoma (GBM). However, problems of retaining cytotoxic SCs within the post-surgical GBM resection cavity are likely to significantly limit the clinical utility of this strategy. Here, we describe a n...

journal_title：Biomaterials

authors： Bagó JR,Pegna GJ,Okolie O,Hingtgen SD

更新日期：2016-04-01 00:00:00

abstract：:The present work assesses the potential of three-dimensional porous titanium scaffolds produced by a novel powder metallurgy process for applications in bone engineering through in vitro experimentation. Mouse MC3T3-E1 pre-osteoblasts were used to investigate the proliferation (DNA content), differentiation (alkaline ...

journal_title：Biomaterials

authors： St-Pierre JP,Gauthier M,Lefebvre LP,Tabrizian M

更新日期：2005-12-01 00:00:00

abstract：:Membranes, clinically used to improve bone regeneration according to the osteopromotion principle, have primarily been made of expanded polytetrafluoroethylene (Gore-Tex Membrane). Recently, different types of biodegradable membranes have become available. This investigation explored the osteopromotive potential of 10...

journal_title：Biomaterials

authors： Zellin G,Gritli-Linde A,Linde A

更新日期：1995-05-01 00:00:00

abstract：:Efficient delivery of small interfering RNA (siRNA) or small hairpin RNA (shRNA) is a critical concern in RNA interference (RNAi) studies. In the present study, we evaluated biodegradable poly(beta-amino ester) (PAE) carrier composed of low molecular weight polyethylenimine and poly(ethylene glycol) for si/shRNA deliv...

journal_title：Biomaterials

authors： Jere D,Xu CX,Arote R,Yun CH,Cho MH,Cho CS

更新日期：2008-06-01 00:00:00

abstract：:The overwhelming majority of drugs exert their pharmacological effects after reaching their target sites of action, however, these target sites are mainly located in the cytosol or intracellular organelles. Consequently, delivering drugs to the specific organelle is the key to achieve maximum therapeutic effects and m...

journal_title：Biomaterials

authors： Chen Z,Zhang L,Song Y,He J,Wu L,Zhao C,Xiao Y,Li W,Cai B,Cheng H,Li W

更新日期：2015-06-01 00:00:00

abstract：:Dextran T40 was modified with carboxylic, benzylamide and benzylamine-sulphonated groups (samples 1-10). The polymers were incubated with dextranase and the decrease of molecular weight was determined by high performance size exclusion chromatography. It was shown that the higher the substitution of dextrans, the lowe...

journal_title：Biomaterials

authors： Crepon B,Jozefonvicz J,Chytry V,Rihová B,Kopecek J

更新日期：1991-08-01 00:00:00

abstract：:In this study, modifications of glass ionomer cements (GICs) were made by adding bioactive glass (BAG) to GIC to obtain bioactive restorative materials. This study used SEM, EDS and visual analysis to examine the bioactivity and the ability of the study materials to mineralize dentin. Conventional cure and resin-modif...

journal_title：Biomaterials

authors： Yli-Urpo H,Närhi M,Närhi T

更新日期：2005-10-01 00:00:00