VEGFR targeting leads to significantly enhanced tumor uptake of nanographene oxide in vivo.

abstract：:Degradable hydrogels to deliver bioactive proteins represent an emerging platform for promoting tissue repair and vascularization in various applications. However, implanting these biomaterials requires invasive surgery, which is associated with complications such as inflammation, scarring, and infection. To address t...

journal_title：Biomaterials

authors： Foster GA,Headen DM,González-García C,Salmerón-Sánchez M,Shirwan H,García AJ

更新日期：2017-01-01 00:00:00

abstract：:This study aimed to assess the biocompatibility of two cordierite ceramics (DF and Cord 1014), with similar chemical composition and different porosity, as a potential support for cell growth in a continuous-flow, solid-bed reactor. The Chinese hamster ovary (CHO) cell line transfected with HBV-DHFR recombinant plasmi...

journal_title：Biomaterials

authors： Orlandi L,Solmi R,Krajewski A,Bearzatto A,Biagini G,Ciccopiedi E,Ravaglioli A

更新日期：1997-07-01 00:00:00

abstract：:Modified high shear homogenization and ultrasound techniques were employed to produce solid lipid nanoparticles (SLNs). Model drug mifepristone had been incorporated in SLNs. The mean particle size measured by laser diffractometry (LD) was found to be 106 nm with a narrow particle distribution of polydispersity index,...

journal_title：Biomaterials

authors： Hou D,Xie C,Huang K,Zhu C

更新日期：2003-05-01 00:00:00

abstract：:Poly(γ-4-((2-(piperidin-1-yl)ethyl)aminomethyl)benzyl-l-glutamate) (PPABLG), a cationic helical polypeptide, has been recently developed by us as an effective non-viral gene delivery vector. In attempts to elucidate the effect of molecular architecture on the gene delivery efficiencies and thereby identify a potential...

journal_title：Biomaterials

authors： Yin L,Song Z,Kim KH,Zheng N,Tang H,Lu H,Gabrielson N,Cheng J

更新日期：2013-03-01 00:00:00

abstract：:A series of latex particles, having different sizes and surface structures, were prepared and the dependence of phagocytosis of latex particles by leucocytes on the particle size and surface potential was investigated by measuring the oxygen consumption of leucocytes. Most of the phagocytic behaviour in the initial st...

journal_title：Biomaterials

authors： Kawaguchi H,Koiwai N,Ohtsuka Y,Miyamoto M,Sasakawa S

更新日期：1986-01-01 00:00:00

abstract：:Nanoparticle-induced autophagy is crucial for its metabolism, cytotoxicity and therapy potency, but little is known about how the host immune system would respond to it. In this study, we demonstrated that two clinically used superparamagnetic iron oxide nanoparticles (SPIONs) specifically induced macrophage autophagy...

journal_title：Biomaterials

authors： Jin R,Liu L,Zhu W,Li D,Yang L,Duan J,Cai Z,Nie Y,Zhang Y,Gong Q,Song B,Wen L,Anderson JM,Ai H

更新日期：2019-05-01 00:00:00

abstract：:Polymer-siRNA complexes (siRNA polyplexes) are being actively developed to improve the therapeutic application of siRNA. A major limitation for many siRNA polyplexes, however, is insufficient mRNA suppression. Given that modifying the sense strand of siRNA with 3' cholesterol (chol-siRNA) increases the activity of fre...

journal_title：Biomaterials

authors： Ambardekar VV,Han HY,Varney ML,Vinogradov SV,Singh RK,Vetro JA

更新日期：2011-02-01 00:00:00

abstract：:In this work, we designed and synthesized an all-in-one zwitterionic material (poly2-((2-hydroxyethyl)(2-methacrylamidoethyl)(methyl)ammonio)acetate (pCBMAA-1)) bearing elasticity, switchable antimicrobial/antifouling properties, and stability. Zwitterionic materials have drawn special attention due to their outstandi...

journal_title：Biomaterials

authors： Cao B,Li L,Tang Q,Cheng G

更新日期：2013-10-01 00:00:00

abstract：:Fracture toughness and hardness properties of CaO-P2O5 glass-reinforced hydroxyapatite composites have been assessed using indentation techniques and results calculated according to Laugier and Evans' equations. Both properties showed to be dependent upon several microstructural characteristics, namely residual porosi...

journal_title：Biomaterials

authors： Lopes MA,Monteiro FJ,Santos JD

更新日期：1999-11-01 00:00:00

abstract：:At high concentrations, manganese (Mn) promotes cellular neurodevelopment but causes toxicity. Here, we report that Mn ion at high concentrations can be delivered to pheochromocytoma 12 (PC12) cells using gold nanoparticles (AuNPs) to enhance cellular neurodevelopment without toxicity. Mn(2+) release from AuNPs was de...

journal_title：Biomaterials

authors： Bhang SH,Han J,Jang HK,Noh MK,La WG,Yi M,Kim WS,Kwon YK,Yu T,Kim BS

更新日期：2015-07-01 00:00:00

abstract：:Conventional amputation prosthetics are problematic because they rely on the stump-socket interface for attachment. Intraosseous transcutaneous amputation prostheses (ITAP) could solve these problems; however they rely on the integrity of the soft tissue-implant interface as a barrier to exogenous agents, and in the p...

journal_title：Biomaterials

authors： Pendegrass CJ,Goodship AE,Blunn GW

更新日期：2006-08-01 00:00:00

abstract：:Transcutaneous immunization (TCI) is an attractive vaccination method compared with conventional injectable vaccines because it is easier to administer without pain. We developed a dissolving microneedle patch (MicroHyala, MH) made of hyaluronic acid and showed that transcutaneous vaccination using MH induced a strong...

journal_title：Biomaterials

authors： Hirobe S,Azukizawa H,Hanafusa T,Matsuo K,Quan YS,Kamiyama F,Katayama I,Okada N,Nakagawa S

更新日期：2015-07-01 00:00:00

abstract：:A nanohybrid vesicle was developed from cholesteryl succinyl silane(CSS) in combination of sol-gel process and self-assembly technique. The silicalike surface adds CSS vesicles remarkably high stability against destabilization in blood or leakage of drug cargos. It was found that CSS vesicles alone exhibited selective...

journal_title：Biomaterials

authors： Ma Y,Dai Z,Zha Z,Gao Y,Yue X

更新日期：2011-12-01 00:00:00

abstract：:Experimental and histological studies on the reaction of surrounding gingiva to permucosal implants of dense calcium hydroxyapatite were carried out in dogs. Epithelial attachment and connection of supra-alveolar collagen fibres to the implant surface seemed to form a biological seal around implants similar to that ar...

journal_title：Biomaterials

authors： Kurashina K,de Lange GL,de Putter C,de Groot K

更新日期：1984-07-01 00:00:00

abstract：:Adoptive cell transfer of targeted chimeric antigen receptor (CAR) T cells has emerged as a highly promising cancer therapy. The pharmacodynamic action or CAR T cells is closely related to their pharmacokinetic profile; because of this as well as the risk of non-specific action, it is important to monitor their biodis...

journal_title：Biomaterials

authors： Harmsen S,Medine EI,Moroz M,Nurili F,Lobo J,Dong Y,Turkekul M,Pillarsetty NVK,Ting R,Ponomarev V,Akin O,Aras O

更新日期：2020-12-23 00:00:00

abstract：:Apart from partial or total joint replacement, no surgical procedure is currently available to treat large and deep cartilage defects associated with advanced diseases such as osteoarthritis. In this work, we developed a perfusion bioreactor system to engineer human cartilage grafts in a size with clinical relevance f...

journal_title：Biomaterials

authors： Santoro R,Olivares AL,Brans G,Wirz D,Longinotti C,Lacroix D,Martin I,Wendt D

更新日期：2010-12-01 00:00:00

abstract：:Programmable hydrogels are defined as hydrogels that are able to change their properties and functions periodically, reversibly and/or sequentially on demand. They are different from those responsive hydrogels whose changes are passive or cannot be stopped or reversed once started and vice versa. The purpose of this r...

journal_title：Biomaterials

authors： Wang Y

更新日期：2018-09-01 00:00:00

abstract：:Novel collagen scaffolds possessing predefined and reproducible internal channels with widths of 135 microm and greater have been produced. The process employed to make the collagen scaffold utilises a sacrificial mould, manufactured using solid freeform fabrication technology, and critical point drying technique. A c...

journal_title：Biomaterials

authors： Sachlos E,Reis N,Ainsley C,Derby B,Czernuszka JT

更新日期：2003-04-01 00:00:00

abstract：:Titanium (Ti) osseointegration is critical for the success of dental and orthopedic implants. Previous studies have shown that surface roughness at the micro- and submicro-scales promotes osseointegration by enhancing osteoblast differentiation and local factor production. Only relatively recently have the effects of ...

journal_title：Biomaterials

authors： Gittens RA,McLachlan T,Olivares-Navarrete R,Cai Y,Berner S,Tannenbaum R,Schwartz Z,Sandhage KH,Boyan BD

更新日期：2011-05-01 00:00:00

abstract：:Poly(glycerol-sebacate) (PGS) is an elastomeric biodegradable polyester that could potentially be used to engineer blood vessels in vivo. However, its blood-material interactions are unknown. The objectives of this study were to: (a) fabricate PGS-based biphasic tubular scaffolds and (b) assess the blood compatibility...

journal_title：Biomaterials

authors： Motlagh D,Yang J,Lui KY,Webb AR,Ameer GA

更新日期：2006-08-01 00:00:00

abstract：:Concerns over disease transmission, high costs and limited supply have led to interest in synthetic grafts in the field of impaction bone grafting (IBG). Poly(DL-lactic acid) (PLA) grafts are attractive alternatives due to their biocompatibility, established safety and versatile manufacturing process. This study exami...

journal_title：Biomaterials

authors： Bolland BJ,Kanczler JM,Ginty PJ,Howdle SM,Shakesheff KM,Dunlop DG,Oreffo RO

更新日期：2008-08-01 00:00:00

abstract：:Thrombomodulin (TM) is a newly described endothelial cell associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. In this study, the immobilization of hTM was investigated in detail using surface modified polymers. As the basis of imm...

journal_title：Biomaterials

authors： Kishida A,Ueno Y,Maruyama I,Akashi M

更新日期：1994-11-01 00:00:00

abstract：:Besides toxicity tests, biokinetic studies are a fundamental part of investigations to evaluate a safe and sustainable use of nanoparticles. Today, gold nanoparticles (Au NPs) are known to be a versatile tool in different areas such as science, engineering or medicine. In this study, we investigated the biokinetics af...

journal_title：Biomaterials

authors： Lipka J,Semmler-Behnke M,Sperling RA,Wenk A,Takenaka S,Schleh C,Kissel T,Parak WJ,Kreyling WG

更新日期：2010-09-01 00:00:00

abstract：:The ability of different calcium phosphate to activate the complement system is studied by crossed immunoelectrophoresis demonstrating conversion of C3 to C3b. Complement consumption is determined by a haemolytic assay CH50. Hydroxyapatite powders after sintering induce a significant conversion of C3 and reduction of ...

journal_title：Biomaterials

authors： Klein CP,de Groot K,van Kamp G

更新日期：1983-07-01 00:00:00

abstract：:A series of mesoporous silica nanoparticles (MSNs) were synthesized using the co-structure directing method. A non-cytotoxic anionic surfactant, undec-1-en-11-yltetra(ethylene glycol) phosphate monoester surfactant (PMES), was used as a structure directing agent (SDA) together with aminopropyltrimethoxysilane that fun...

journal_title：Biomaterials

authors： Tsai CH,Vivero-Escoto JL,Slowing II,Fang IJ,Trewyn BG,Lin VS

更新日期：2011-09-01 00:00:00

abstract：:Artificial meniscal lesions extending into the avascular part of the meniscus, which do not heal by any other means, were repaired by suturing either a porous polymer implant or a synovial flap into the defect. The implant guided the ingrowth of vascular repair tissue into the defect. This fibrous tissue later on tran...

journal_title：Biomaterials

authors： Klompmaker J,Jansen HW,Veth RP,de Groot JH,Nijenhuis AJ,Pennings AJ

更新日期：1991-11-01 00:00:00

abstract：:Cerium oxide nanoparticles (nanoceria) are effective in scavenging intracellular reactive oxygen species (ROS). In this study nanoceria synthesized by flame spray pyrolysis (dXRD = 12 nm) were functionalised with heparin via an organosilane linker, 3-aminopropyltriethoxysilane. Nanoceria were functionalised with appro...

journal_title：Biomaterials

authors： Ting SR,Whitelock JM,Tomic R,Gunawan C,Teoh WY,Amal R,Lord MS

更新日期：2013-06-01 00:00:00

abstract：:Poly(ether-ether-ketone) (PEEK)s are a group of polymeric biomaterials with excellent mechanical properties and chemical stability. In the present study, we demonstrate the fabrication of an antibiofouling and highly hydrophilic high-density nanometer-scaled layer on the surface of PEEK by photo-induced graft polymeri...

journal_title：Biomaterials

authors： Kyomoto M,Moro T,Takatori Y,Kawaguchi H,Nakamura K,Ishihara K

更新日期：2010-02-01 00:00:00

abstract：:Polyelectrolyte complexes (PEC) were prepared from chitosan as the polycation and several synthesized functional anion polysaccharides, and their effects on cell attachment, morphology, proliferation and differentiation were estimated using normal human osteoblasts (NHOst). After a 1-week incubation, PEC made from pol...

journal_title：Biomaterials

authors： Nagahata M,Nakaoka R,Teramoto A,Abe K,Tsuchiya T

更新日期：2005-09-01 00:00:00

abstract：:A-B-type block copolymers, consisting of polystyrene (PST) or poly(methyl methacrylate) (PMMA) forming segment (A) and poly(gamma-benzyl L-glutamate) (P[Glu(OBzl)]) segment (B), were synthesized and the thrombus formation on these block copolymer films was investigated in relation to the adsorption of plasma proteins ...

journal_title：Biomaterials

authors： Mori A,Ito Y,Sisido M,Imanishi Y

更新日期：1986-09-01 00:00:00