VEGFR targeting leads to significantly enhanced tumor uptake of nanographene oxide in vivo.


:Although graphene oxide (GO) has recently been considered as a highly attractive nanomaterial for future cancer imaging and therapy, it is still a major challenge to improve its in vivo tumor active targeting efficiency. Here in this full article, we demonstrated the successful and significantly enhanced in vivo tumor vasculature targeting efficacy of well-functionalized GO nanoconjugates by using vascular endothelial growth factor 121 (VEGF121) as the targeting ligand. As-developed GO nanoconjugate exhibits excellent in vivo stability, specific in vitro and in vivo vascular endothelial growth factor receptor (VEGFR) targeting, significantly enhanced tumor accumulation (>8 %ID/g) as well as high tumor-to-muscle contrast, showing great potential for future tumor targeted imaging and therapy.






Shi S,Yang K,Hong H,Chen F,Valdovinos HF,Goel S,Barnhart TE,Liu Z,Cai W




Has Abstract


2015-01-01 00:00:00












  • Effect of streptavidin affinity mutants on the integrin-independent adhesion of biotinylated endothelial cells.

    abstract::We have previously shown that the high-affinity streptavidin (SA)-biotin interaction enhanced the initial integrin-mediated adhesion of biotinylated endothelial cells to SA-coated surface by serving as an extrinsic bond to stabilize and enhance the intrinsic fibronectin-integrin binding between the cell and surface. H...


    pub_type: 杂志文章


    authors: Chan BP,Chilkoti A,Reichert WM,Truskey GA

    更新日期:2003-02-01 00:00:00

  • Some properties of keratin biomaterials: kerateines.

    abstract::Keratins are a family of structural proteins that can be isolated from a variety of tissues. "Soft" keratins are cytoskeletal elements found in epithelial tissues while protective tissues such as nails, hooves, and hair are composed of "hard" keratins. Hard keratins have been the subject of biomaterials investigations...


    pub_type: 杂志文章


    authors: Hill P,Brantley H,Van Dyke M

    更新日期:2010-02-01 00:00:00

  • Delivery of a granzyme B inhibitor gene using carbamate-mannose modified PEI protects against cytotoxic lymphocyte killing.

    abstract::Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells protect vertebrates by killing infected or transformed cells using granzyme B (GrB) to induce apoptosis. However, GrB-induced apoptosis of target cells causes inflammatory disease and chronic transplant rejection and so is an important disease target. The aim...


    pub_type: 杂志文章


    authors: Cheng W,Yang C,Hedrick JL,Williams DF,Yang YY,Ashton-Rickardt PG

    更新日期:2013-05-01 00:00:00

  • Advanced technique for long term culture of epithelia in a continuous luminal-basal medium gradient.

    abstract::The majority of epithelia in our organism perform barrier functions on being exposed to different fluids at the luminal and basal sides. To simulate this natural situation under in vitro conditions for biomaterial testing and tissue engineering the epithelia have to withstand mechanical and fluid stress over a prolong...


    pub_type: 杂志文章


    authors: Schumacher K,Strehl R,de VU,Minuth WW

    更新日期:2002-02-01 00:00:00

  • The incorporation of daunorubicin in cancer cells through the use of titanium dioxide whiskers.

    abstract::Porous nanostructure with its unique properties is found to be able to hold promise in drug delivery. We fabricated the one-dimensional titanium dioxide whiskers (TiO2 Ws) and designed a strategy to explore their drug delivery application and anti-tumor function combined with daunorubicin (DNR). We observed good bioco...


    pub_type: 杂志文章


    authors: Li Q,Wang X,Lu X,Tian H,Jiang H,Lv G,Guo D,Wu C,Chen B

    更新日期:2009-09-01 00:00:00

  • A biaxial rotating bioreactor for the culture of fetal mesenchymal stem cells for bone tissue engineering.

    abstract::The generation of effective tissue engineered bone grafts requires efficient exchange of nutrients and mechanical stimulus. Bioreactors provide a manner in which this can be achieved. We have recently developed a biaxial rotating bioreactor with efficient fluidics through in-silico modeling. Here we investigated its p...


    pub_type: 杂志文章


    authors: Zhang ZY,Teoh SH,Chong WS,Foo TT,Chng YC,Choolani M,Chan J

    更新日期:2009-05-01 00:00:00

  • Albumin adsorption on alkyl chain derivatized polyurethanes. II. The effect of alkyl chain length.

    abstract::Linear alkyl chains containing 2, 10 and 18 carbon atoms were grafted to 10% of the urethane nitrogens in a polyether-polyurethane. The polyurethane was synthesized from methylene bis(p-phenyl isocyanate), 1,4-butanediol, and polytetramethylene oxide of 1000 molecular weight in a molar ratio of 3/2/1. Fourier transfor...


    pub_type: 杂志文章


    authors: Pitt WG,Grasel TG,Cooper SL

    更新日期:1988-01-01 00:00:00

  • A comparative radiological assessment of polylactide pins over 3 years in vivo.

    abstract::Biodegradable polylactide implants allow secure fixation of osteochondral fractures with minimal adverse effects. The goal of this prospective, randomized animal study was to show whether osteoconductive effects can be achieved through the development of poly-L/DL(70/30)lactide composite implants with 10% beta-tricalc...


    pub_type: 杂志文章


    authors: Prokop A,Jubel A,Hahn U,Dietershagen M,Bleidistel M,Peters C,Höfl A,Rehm KE

    更新日期:2005-07-01 00:00:00

  • The impact of structure on elasticity, switchability, stability and functionality of an all-in-one carboxybetaine elastomer.

    abstract::In this work, we designed and synthesized an all-in-one zwitterionic material (poly2-((2-hydroxyethyl)(2-methacrylamidoethyl)(methyl)ammonio)acetate (pCBMAA-1)) bearing elasticity, switchable antimicrobial/antifouling properties, and stability. Zwitterionic materials have drawn special attention due to their outstandi...


    pub_type: 杂志文章


    authors: Cao B,Li L,Tang Q,Cheng G

    更新日期:2013-10-01 00:00:00

  • Synthesis, characterization and ex vivo evaluation of polydimethylsiloxane polyurea-urethanes.

    abstract::A series of segmented polydimethylsiloxane (PDMS) polyurea-urethanes was synthesized based on hexane diisocyanate modified polyether-PDMS soft segments. The hard segments consisted of 4,4'-methylene diphenylene diisocyanate, which was chain extended with 1,4-butanediol. The effect of chemical composition of the polyet...


    pub_type: 杂志文章


    authors: Lim F,Yang CZ,Cooper SL

    更新日期:1994-05-01 00:00:00

  • Metronomic oral doxorubicin in combination of Chk1 inhibitor MK-8776 for p53-deficient breast cancer treatment.

    abstract::Metronomic chemotherapy, which is defined as a low-dose and frequent administration of cytotoxic drugs without drug-free breaks, has been recently emerged as an alternative to traditional MTD therapy and has shown therapeutic benefit in breast cancer patients in numbers of clinical studies. Unlike MTD, metronomic chem...


    pub_type: 杂志文章


    authors: Chung SW,Kim GC,Kweon S,Lee H,Choi JU,Mahmud F,Chang HW,Kim JW,Son WC,Kim SY,Byun Y

    更新日期:2018-11-01 00:00:00

  • Histological reaction to titanium alloy and hydroxyapatite particles in the rabbit tibia.

    abstract::The interfacial membrane harvested from failed joint replacements contains particulate debris from the materials used for the implant. To define the tissue response to particulate titanium alloy and hydroxyapatite (HA) alone, 16 mature New Zealand white rabbits were divided into 2 groups of 8 rabbits. Using sterile te...


    pub_type: 杂志文章


    authors: Goodman SB,Davidson JA,Fornasier VL

    更新日期:1993-08-01 00:00:00

  • The effect of photopolymerization on stem cells embedded in hydrogels.

    abstract::Photopolymerizable hydrogels, formed by UV-exposure of photosensitive polymers in the presence of photoinitiators, are widely used materials in tissue engineering research employed for cellular entrapment and patterning. During photopolymerization, the entrapped cells are directly exposed to polymer and photoinitiator...


    pub_type: 杂志文章


    authors: Fedorovich NE,Oudshoorn MH,van Geemen D,Hennink WE,Alblas J,Dhert WJ

    更新日期:2009-01-01 00:00:00

  • Effect of bilobalide on peripheral nerve regeneration.

    abstract::The present study provides in vivo trials of silicone rubber chambers filled with different concentrations of bilobalide (0, 50, 100, 200, 400 microM) to bridge a 15 mm sciatic nerve defect in rats. Collagen was also filled in the chambers to prevent the bilobalide from leakage. Histological and electrophysiological t...


    pub_type: 杂志文章


    authors: Chen YS,Liu CJ,Cheng CY,Yao CH

    更新日期:2004-02-01 00:00:00

  • Mineralisation of two phosphate ceramics in HBSS: role of albumin.

    abstract::The role of albumin in the mineralisation process of commercial hydroxyapatite (HAp) and synthesised biphasic (HAp-tricalcium phosphate) ceramics in a bufferless simulated inorganic plasma (HBSS) was investigated by conventional in vitro tests and static and dynamic wettability measurements. Albumin was either pre-ads...


    pub_type: 杂志文章


    authors: Marques PA,Serro AP,Saramago BJ,Fernandes AC,Magalhães MC,Correia RN

    更新日期:2003-02-01 00:00:00

  • Developing mechanically robust, triazole-zwitterionic hydrogels to mitigate foreign body response (FBR) for islet encapsulation.

    abstract::Zwitterionic hydrogels such as those based on polycarboxybetaine (PCB) or polysulfobetaine (PSB) have potential for various biomedical applications, due to their biocompatibility and low biofouling properties. However, the poor mechanical properties of zwitterionic hydrogels developed to date remain a challenge, sever...


    pub_type: 杂志文章


    authors: Liu Q,Chiu A,Wang L,An D,Li W,Chen EY,Zhang Y,Pardo Y,McDonough SP,Liu L,Liu WF,Chen J,Ma M

    更新日期:2020-02-01 00:00:00

  • The recruitment of primitive Lin(-) Sca-1(+), CD34(+), c-kit(+) and CD271(+) cells during the early intraperitoneal foreign body reaction.

    abstract::Implanted materials, such as medical devices, provoke the body to initiate an inflammatory reaction, known as the foreign body reaction (FBR), which causes several complications for example in hip prostheses, silicone implants, peritoneal dialysis catheters and left ventricular assist devices. FBR is initiated by macr...


    pub_type: 杂志文章


    authors: Vranken I,De Visscher G,Lebacq A,Verbeken E,Flameng W

    更新日期:2008-03-01 00:00:00

  • On the mechanisms of biocompatibility.

    abstract::The manner in which a mutually acceptable co-existence of biomaterials and tissues is developed and sustained has been the focus of attention in biomaterials science for many years, and forms the foundation of the subject of biocompatibility. There are many ways in which materials and tissues can be brought into conta...


    pub_type: 杂志文章,评审


    authors: Williams DF

    更新日期:2008-07-01 00:00:00

  • Celastrol nanoemulsion induces immunogenicity and downregulates PD-L1 to boost abscopal effect in melanoma therapy.

    abstract::Programmed cell death-ligand 1 (PD-L1)-based immune checkpoint blockade therapy using the anti-PD-L1 antibody is effective for a subset of patients with advanced metastatic melanoma but about half of the patients do not respond to the therapy because of the tumor immunosuppressive microenvironment. Immunogenic cell de...


    pub_type: 杂志文章


    authors: Qiu N,Liu Y,Liu Q,Chen Y,Shen L,Hu M,Zhou X,Shen Y,Gao J,Huang L

    更新日期:2020-12-17 00:00:00

  • Tailoring polymeric hybrid micelles with lymph node targeting ability to improve the potency of cancer vaccines.

    abstract::It has been widely accepted that lymph nodes (LNs) are critical targets of cancer vaccines and particles sized between 10 and 100 nm with a neutral or negative surface charge are preferred for lymphatic transfer after subcutaneous or intradermal injection. However their limited uptake by antigen presenting cells (APCs...


    pub_type: 杂志文章


    authors: Zeng Q,Li H,Jiang H,Yu J,Wang Y,Ke H,Gong T,Zhang Z,Sun X

    更新日期:2017-04-01 00:00:00

  • Controlled release of platelet-derived growth factor using ethylene vinyl acetate copolymer (EVAc) coated on stainless-steel wires.

    abstract::Controlled delivery of bioactive molecules to modulate or control biological processes has a number of clinical applications. The present study reports a delivery system which was designed to deliver growth factors locally to a fracture site. Ethylene vinyl acetate copolymer (EVAc), bovine serum albumin (BSA) and plat...


    pub_type: 杂志文章


    authors: Walsh WR,Kim HD,Jong YS,Valentini RF

    更新日期:1995-11-01 00:00:00

  • Metabolic glycan labeling and chemoselective functionalization of native biomaterials.

    abstract::Decellularized native extracellular matrix (ECM) biomaterials are widely used in tissue engineering and have reached clinical application as biomesh implants. To enhance their regenerative properties and postimplantation performance, ECM biomaterials could be functionalized via immobilization of bioactive molecules. T...


    pub_type: 杂志文章


    authors: Ren X,Evangelista-Leite D,Wu T,Rajab TK,Moser PT,Kitano K,Economopoulos KP,Gorman DE,Bloom JP,Tan JJ,Gilpin SE,Zhou H,Mathisen DJ,Ott HC

    更新日期:2018-11-01 00:00:00

  • Bacterial adherence to self-reinforced polyglycolic acid and self-reinforced polylactic acid 96 urological spiral stents in vitro.

    abstract::The aim of this study was to evaluate the bacterial adherence to biodegradable self-reinforced polyglycolic acid (SR-PGA) and self-reinforced poly-DL-lactic acid (SR-PLA 96) spiral stents in vitro. They are used as temporary urethral stents in urology. Gold-plated metal wire, polyurethane and latex were used as contro...


    pub_type: 杂志文章


    authors: Pétas A,Vuopio-Varkila J,Siitonen A,Välimaa T,Talja M,Taari K

    更新日期:1998-04-01 00:00:00

  • A targeted nanoglobular contrast agent from host-guest self-assembly for MR cancer molecular imaging.

    abstract::The clinical application of nanoparticular Gd(III) based contrast agents for tumor molecular MRI has been hindered by safety concerns associated with prolonged tissue retention, although they can produce strong tumor enhancement. In this study, a targeted well-defined cyclodextrin-based nanoglobular contrast agent was...


    pub_type: 杂志文章


    authors: Zhou Z,Han Z,Lu ZR

    更新日期:2016-04-01 00:00:00

  • Differentiation of liver progenitor cell line to functional organotypic cultures in 3D nanofibrillar cellulose and hyaluronan-gelatin hydrogels.

    abstract::Physiologically relevant hepatic cell culture models must be based on three-dimensional (3D) culture of human cells. However, liver cells are generally cultured in two-dimensional (2D) format that deviates from the normal in vivo morphology. We generated 3D culture environment for HepaRG liver progenitor cells using w...


    pub_type: 杂志文章


    authors: Malinen MM,Kanninen LK,Corlu A,Isoniemi HM,Lou YR,Yliperttula ML,Urtti AO

    更新日期:2014-06-01 00:00:00

  • Use of telechelic cis-1,4-polyisoprene cationomers in the synthesis of antibacterial ionic polyurethanes and copolyurethanes bearing ammonium groups.

    abstract::New crosslinked ionic polyurethanes and copolyurethanes were yielded by reaction of telechelic cis-1,4-oligoisoprenes, bearing a variable number of ammonium and hydroxy groups, with isocyanurate of isophorone diisocyanate (I-IPDI). Aiming for a comparative study, polyurethane elastomers based on non-ionic telechelic o...


    pub_type: 杂志文章


    authors: Kébir N,Campistron I,Laguerre A,Pilard JF,Bunel C,Jouenne T

    更新日期:2007-10-01 00:00:00

  • Sustained regeneration of high-volume adipose tissue for breast reconstruction using computer aided design and biomanufacturing.

    abstract::Adipose tissue engineering offers a promising alternative to the current breast reconstruction options. Here we investigated patient-specific breast scaffolds fabricated from poly(d,l)-lactide polymer with pore sizes>1 mm for their potential in long-term sustained regeneration of high volume adipose tissue. An optimis...


    pub_type: 杂志文章


    authors: Chhaya MP,Melchels FP,Holzapfel BM,Baldwin JG,Hutmacher DW

    更新日期:2015-06-01 00:00:00

  • Live cell imaging of mouse intestinal organoids reveals heterogeneity in their oxygenation.

    abstract::Intestinal organoids are widely applied in stem cell research, regenerative medicine, toxicology, pharmacology, and host-microbe interactions research. The variability of oxidative metabolism for stem and differentiated cell types constituting organoid is known to be important but so far it has not been studied in det...


    pub_type: 杂志文章


    authors: Okkelman IA,Foley T,Papkovsky DB,Dmitriev RI

    更新日期:2017-11-01 00:00:00

  • Structural characterization of room-temperature synthesized nano-sized beta-tricalcium phosphate.

    abstract::A simple route for synthesizing nano-sized beta-tricalcium phosphate (beta-TCP) at room temperature has been developed in methanol solvent. The phase evolution from CaHPO4, intermediate amorphous calcium phosphate (ACP) phases (including ACP1 and ACP2 with different structures) to final beta-TCP with increasing aging ...


    pub_type: 杂志文章


    authors: Bow JS,Liou SC,Chen SY

    更新日期:2004-07-01 00:00:00

  • Anti-HIF-1alpha antibody-conjugated pluronic triblock copolymers encapsulated with Paclitaxel for tumor targeting therapy.

    abstract::Targeted uptake of nanoscale controlled release polymer micelles encapsulated with drugs represents a potential powerful therapeutic technology. Herein we reported the development of anti-HIF-1alpha antibody-conjugated unimolecular polymer nano micelles filled with Paclitaxel for cancer targeting therapy. Pluronic tri...


    pub_type: 杂志文章


    authors: Song H,He R,Wang K,Ruan J,Bao C,Li N,Ji J,Cui D

    更新日期:2010-03-01 00:00:00