VEGFR targeting leads to significantly enhanced tumor uptake of nanographene oxide in vivo.

Abstract:

:Although graphene oxide (GO) has recently been considered as a highly attractive nanomaterial for future cancer imaging and therapy, it is still a major challenge to improve its in vivo tumor active targeting efficiency. Here in this full article, we demonstrated the successful and significantly enhanced in vivo tumor vasculature targeting efficacy of well-functionalized GO nanoconjugates by using vascular endothelial growth factor 121 (VEGF121) as the targeting ligand. As-developed GO nanoconjugate exhibits excellent in vivo stability, specific in vitro and in vivo vascular endothelial growth factor receptor (VEGFR) targeting, significantly enhanced tumor accumulation (>8 %ID/g) as well as high tumor-to-muscle contrast, showing great potential for future tumor targeted imaging and therapy.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Shi S,Yang K,Hong H,Chen F,Valdovinos HF,Goel S,Barnhart TE,Liu Z,Cai W

doi

10.1016/j.biomaterials.2014.10.061

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

39-46

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(14)01125-9

journal_volume

39

pub_type

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