Parameters influencing the stealthiness of colloidal drug delivery systems.

abstract：:Keratins are a family of structural proteins that can be isolated from a variety of tissues. "Soft" keratins are cytoskeletal elements found in epithelial tissues while protective tissues such as nails, hooves, and hair are composed of "hard" keratins. Hard keratins have been the subject of biomaterials investigations...

journal_title：Biomaterials

authors： Hill P,Brantley H,Van Dyke M

更新日期：2010-02-01 00:00:00

abstract：:Cytotherapeutic approaches have been investigated to overcome the limitations of existing procedures for periodontal regeneration. In this study, cell sheet transplantation was performed using three kinds of mesenchymal tissue (periodontal ligament, alveolar periosteum, and bone marrow)-derived cells to compare the di...

journal_title：Biomaterials

authors： Tsumanuma Y,Iwata T,Washio K,Yoshida T,Yamada A,Takagi R,Ohno T,Lin K,Yamato M,Ishikawa I,Okano T,Izumi Y

更新日期：2011-09-01 00:00:00

abstract：:Human induced pluripotent stem cell (hiPSC) derived angiogenesis models present a unique opportunity for patient-specific platforms to study the complex process of angiogenesis and the endothelial cell response to biomaterial and biophysical changes in a defined microenvironment. We present a refined method for differ...

journal_title：Biomaterials

authors： Natividad-Diaz SL,Browne S,Jha AK,Ma Z,Hossainy S,Kurokawa YK,George SC,Healy KE

更新日期：2019-02-01 00:00:00

abstract：:Novel acid-base reaction cements have been developed for use as controlled release formulations. Many new ones have been discovered and assessed; these include those which are capable of releasing copper, cobalt or selenium singly or in combination. A selection was made of the most suitable formulations for this purpo...

journal_title：Biomaterials

authors： Prosser HJ,Wilson AD,Groffman DM,Brookman PJ,Allen WM,Gleed PT,Manston R,Sansom BF

更新日期：1986-03-01 00:00:00

abstract：:Cationic nanoparticles are a promising class of transfection agents for oligonucleotide and gene delivery, but vary greatly in their effectiveness and cytotoxicity. Recently, we developed a new class of cationic transfection agents based on cationic shell-crosslinked knedel-like nanoparticles (cSCKs) that efficiently ...

journal_title：Biomaterials

authors： Zhang K,Fang H,Wang Z,Li Z,Taylor JS,Wooley KL

更新日期：2010-03-01 00:00:00

abstract：:Induced pluripotent stem (iPS) cells have been generated from various somatic cells; however, a major restriction of the technology is the use of potentially harmful genome-integrating viral DNAs. Here, without a viral vector, we generated iPS cells from fibroblasts using a non-viral magnetic nanoparticle-based transf...

journal_title：Biomaterials

authors： Lee CH,Kim JH,Lee HJ,Jeon K,Lim H,Choi Hy,Lee ER,Park SH,Park JY,Hong S,Kim S,Cho SG

更新日期：2011-10-01 00:00:00

abstract：:Tissue engineering and regenerative medicine technologies offer promising therapies for both medicine and dentistry. Our long-term goal is to create functional biomimetic tooth buds for eventual tooth replacement in humans. Here, our objective was to create a biomimetic 3D tooth bud model consisting of dental epitheli...

journal_title：Biomaterials

authors： Monteiro N,Smith EE,Angstadt S,Zhang W,Khademhosseini A,Yelick PC

更新日期：2016-11-01 00:00:00

abstract：:Pancreatic cancer has the worst prognosis of all cancers due to disease aggressiveness and paucity of early detection platforms. We developed biomaterial scaffolds that recruit metastatic tumor cells and reflect the immune dysregulation of native metastatic sites. While this platform has shown promise in orthotopic br...

journal_title：Biomaterials

authors： Bushnell GG,Orbach SM,Ma JA,Crawford HC,Wicha MS,Jeruss JS,Shea LD

更新日期：2020-12-23 00:00:00

abstract：:Photopolymerizable hydrogels, formed by UV-exposure of photosensitive polymers in the presence of photoinitiators, are widely used materials in tissue engineering research employed for cellular entrapment and patterning. During photopolymerization, the entrapped cells are directly exposed to polymer and photoinitiator...

journal_title：Biomaterials

authors： Fedorovich NE,Oudshoorn MH,van Geemen D,Hennink WE,Alblas J,Dhert WJ

更新日期：2009-01-01 00:00:00

abstract：:Knee arthroplasty has reached a high degree of reliability. Many of the remaining long-term loosening cases are due to the polyethylene wear debris. The introduction of the alumina ceramic to polyethylene bearing couple had been a promising means for its reduction. The discussion of its applications in total knee repl...

journal_title：Biomaterials

authors： Heimke G,Leyen S,Willmann G

更新日期：2002-04-01 00:00:00

abstract：:Xenogeneic extracellular matrix (ECM) can be harvested and configured to function as a bioscaffold for tissue and organ reconstruction. The mechanical properties of the ECM vary depending upon the tissue from which it is harvested. Likewise, the manufacturing steps required to develop ECMs into medical grade devices w...

journal_title：Biomaterials

authors： Freytes DO,Badylak SF,Webster TJ,Geddes LA,Rundell AE

更新日期：2004-05-01 00:00:00

abstract：:Elucidation of relationship among cellular uptake, localization and biological activities of metal complexes could make great breakthrough in the understanding of their action mechanisms and provide useful information for rational design of metal-based anticancer drugs. Iron(II) complexes have emerged as potential ant...

journal_title：Biomaterials

authors： Chen J,Luo Z,Zhao Z,Xie L,Zheng W,Chen T

更新日期：2015-12-01 00:00:00

abstract：:Breast cancer cells (BCC) and macrophages are known to interact via epidermal growth factor (EGF) produced by macrophages and colony stimulating factor-1 (CSF-1) produced by BCC. Despite contradictory findings, this interaction is perceived as a paracrine loop. Further, the underlying mechanism of interaction remains ...

journal_title：Biomaterials

authors： Onal S,Turker-Burhan M,Bati-Ayaz G,Yanik H,Pesen-Okvur D

更新日期：2021-01-01 00:00:00

abstract：:Fluorescent Ⅱ-Ⅳ Quantum dots (QDs) have demonstrated to be highly promising biological probes for various biological and biomedical applications due to their many attractive merits, such as robust photostabilty, strong photoluminescence, and size-tunable fluorescence. Along with wide ranging bioapplications, concerns ...

journal_title：Biomaterials

authors： Su Y,Peng F,Jiang Z,Zhong Y,Lu Y,Jiang X,Huang Q,Fan C,Lee ST,He Y

更新日期：2011-09-01 00:00:00

abstract：:Bioactive glass granules were implanted in the tibiae of rabbits in order to determine the pathway of the silicon released from bioactive glass in vivo. We traced and quantified the silicon released by obtaining 24-h urine samples and blood samples for up to 7 months after implantation. Bone tissue as well as the foll...

journal_title：Biomaterials

authors： Lai W,Garino J,Ducheyne P

更新日期：2002-01-01 00:00:00

abstract：:Non-covalent interactions are often regarded as insufficient to construct macroscopic materials of substantial integrity and cohesion. However, the low binding energy of such reversible interactions can be compensated by increasing their number to work in concert to create strong materials. Here we present the success...

journal_title：Biomaterials

authors： Nejadnik MR,Yang X,Bongio M,Alghamdi HS,van den Beucken JJ,Huysmans MC,Jansen JA,Hilborn J,Ossipov D,Leeuwenburgh SC

更新日期：2014-08-01 00:00:00

abstract：:Nanofiber scaffold-mediated delivery of small-interfering RNA (siRNA) holds great potential in regenerative medicine by providing biomimicking topographical signals and enhanced gene silencing effects to seeded cells. While the delivery of naked siRNA was demonstrated previously using poly (ε-caprolactone) (PCL) nanof...

journal_title：Biomaterials

authors： Rujitanaroj PO,Wang YC,Wang J,Chew SY

更新日期：2011-09-01 00:00:00

abstract：:Bone defects caused by fractures or cancer-mediated destruction are debilitating. Chitosan is commonly used in scaffold matrices for bone healing, but rarely as a free drug. We demonstrate that free chitosan promotes osteoblast proliferation and osteogenesis in mesenchymal stem cells, increases osteopontin and collage...

journal_title：Biomaterials

authors： Tan ML,Shao P,Friedhuber AM,van Moorst M,Elahy M,Indumathy S,Dunstan DE,Wei Y,Dass CR

更新日期：2014-09-01 00:00:00

abstract：:As a chronic and lifelong disease, obesity not only significant impairs health but also dramatically shortens life span (at least 10 years). Obesity requires a life-long effort for the successful treatment because a number of abnormalities would appear in the development of obesity. Nanomaterials possess large specifi...

journal_title：Biomaterials

authors： Li J,Cha R,Luo H,Hao W,Zhang Y,Jiang X

更新日期：2019-12-01 00:00:00

abstract：:A class of designed self-assembling peptide nanofiber scaffolds with more than 99% water content has been shown to be a good biological material for cell culture. Here, we report the functionalization of one of these peptide scaffolds, RAD16-I (AcN-RADARADARADARADA-CONH2), by direct solid phase synthesis extension at ...

journal_title：Biomaterials

authors： Genové E,Shen C,Zhang S,Semino CE

更新日期：2005-06-01 00:00:00

abstract：:Gold nanoparticles have been conceived as a radiosensitizer in cancer radiation therapy, but one of the important questions for primary drug screening is what size of gold nanoparticles can optimally enhance radiation effects. Herein, we perform in vitro and in vivo radiosensitization studies of 4.8, 12.1, 27.3, and 4...

journal_title：Biomaterials

authors： Zhang XD,Wu D,Shen X,Chen J,Sun YM,Liu PX,Liang XJ

更新日期：2012-09-01 00:00:00

abstract：:Biomaterial-supported culture methods, allowing for directed three-dimensional differentiation of stem cells are an alternative to canonical two-dimensional cell cultures. In this paper, we evaluate the suitability of alginate for three-dimensional cultures to enhance differentiation of mouse embryonic stem cells (mES...

journal_title：Biomaterials

authors： Bozza A,Coates EE,Incitti T,Ferlin KM,Messina A,Menna E,Bozzi Y,Fisher JP,Casarosa S

更新日期：2014-05-01 00:00:00

abstract：:We have prepared unique macroporous and ordered dextran-based hydrogels using a single-step biocatalytic transesterification reaction between dextran and divinyladipate in neat dimethylsulfoxide. These hydrogels show a unimodal distribution of interconnected pores with average diameters from 0.4 to 2.0 microm dependin...

journal_title：Biomaterials

authors： Ferreira L,Gil MH,Cabrita AM,Dordick JS

更新日期：2005-08-01 00:00:00

abstract：:Articular cartilage injuries do not heal and large defects result in osteoarthritis with major personal and socioeconomic costs. Osteochondral transplantation is an effective treatment for large joint defects but its use is limited by the inability to store cartilage for long periods of time. Cryopreservation/vitrific...

journal_title：Biomaterials

authors： Jomha NM,Elliott JA,Law GK,Maghdoori B,Forbes JF,Abazari A,Adesida AB,Laouar L,Zhou X,McGann LE

更新日期：2012-09-01 00:00:00

abstract：:Inspired by nature's toughening mechanisms, we designed a new polyhedral oligomeric silsesquioxane (POSS)-derived hybrid glass (PHG) that has covalent interactions on the molecular scale between the inorganic POSS cage and organic phase. These features allow "elastic deformation" of the inorganic POSS cage in limited ...

journal_title：Biomaterials

authors： Zhou X,Sahai N,Qi L,Mankoci S,Zhao W

更新日期：2015-05-01 00:00:00

abstract：:Retinal degenerations cause permanent visual loss and affect millions world-wide. Presently, a novel treatment highlights the potential of using biodegradable polymer scaffolds to induce differentiation and deliver retinal progenitor cells for cell replacement therapy. In this study, we engineered and analyzed a micro...

journal_title：Biomaterials

authors： Redenti S,Neeley WL,Rompani S,Saigal S,Yang J,Klassen H,Langer R,Young MJ

更新日期：2009-07-01 00:00:00

abstract：:Protein delivery allows a clinical effect to be directly realized without genetic modification of the host cells. We have developed a cationic bolaamphiphile as a non-viral vector for protein delivery application. The relatively low toxicity and efficient protein delivery by the cationic bolaamphiphile prompted us to ...

journal_title：Biomaterials

authors： Khan M,Narayanan K,Lu H,Choo Y,Du C,Wiradharma N,Yang YY,Wan AC

更新日期：2013-07-01 00:00:00

abstract：:Patients regularly taking non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin (IND) have a risk of small intestinal injuries. In this study, we have developed an oral nanotherapeutics by using a redox nanoparticle (RNP(O)), which is prepared by self-assembly of an amphiphilic block copolymer that posse...

journal_title：Biomaterials

authors： Sha S,Vong LB,Chonpathompikunlert P,Yoshitomi T,Matsui H,Nagasaki Y

更新日期：2013-11-01 00:00:00

abstract：:The authors aimed to develop a liquid material for embolization of aneurysms. In vitro and in vivo performances of the new embolic material were examined by cell culture and using an aneurysm model made in common carotid arteries (CCAs) of adult rats. Engineered protein ProNectin F (PnF), which contains 13 sites of an...

journal_title：Biomaterials

authors： Ohyama T,Ko IK,Miura A,Iwata H,Taki W

更新日期：2004-08-01 00:00:00

abstract：:Heat treatment of an MgO-CaO-SiO2-P2O5 glass gave a glass ceramic containing crystalline apatite (Ca10(PO4)6O,F2] and beta-wollastonite (CaO,SiO2) in an MgO-CaO-SiO2 glassy matrix. It showed bioactivity and a fairly high mechanical strength which decreased only slowly, even under load-bearing conditions in the body. I...

journal_title：Biomaterials

authors： Kokubo T

更新日期：1991-03-01 00:00:00