Engineering retinal progenitor cell and scrollable poly(glycerol-sebacate) composites for expansion and subretinal transplantation.

abstract：:Hydrogels are frequently employed as medical device biomaterials due to their advantageous biological properties, e.g. resistance to infection and encrustation, biocompatibility; however, their poor mechanical properties generally limit the scope of application to coatings of medical devices. To address this limitatio...

journal_title：Biomaterials

authors： Jones DS,McLaughlin DW,McCoy CP,Gorman SP

更新日期：2005-05-01 00:00:00

abstract：:Solid tissues in the body possess a range of stiffness and provide cells with an instructive microenvironment. Scaffolds in tissue engineering should be rationally designed to become an adhesion substrate friendly to cells. Schwann cells are the principal glial cell in the peripheral nervous system and used as support...

journal_title：Biomaterials

authors： Gu Y,Ji Y,Zhao Y,Liu Y,Ding F,Gu X,Yang Y

更新日期：2012-10-01 00:00:00

abstract：:In designing and developing various biomaterials, the influence of substrate properties, like surface topography, stiffness and wettability on the cell functionality has been investigated widely. However, such study to probe into the influence of the substrate conductivity on cell fate processes is rather limited. In ...

journal_title：Biomaterials

authors： Thrivikraman G,Mallik PK,Basu B

更新日期：2013-09-01 00:00:00

abstract：:Recent advances in materials development and tissue engineering has resulted in a substantial number of bioinspired materials that recapitulate cardinal features of bone extracellular matrix (ECM) such as dynamic inorganic and organic environment(s), hierarchical organization, and topographical features. Bone mimickin...

journal_title：Biomaterials

authors： Shih YV,Varghese S

更新日期：2019-04-01 00:00:00

abstract：:A new implant surface has been developed with the purpose of avoiding as much stress shielding as possible, and thus prolong the prosthesis lifespan. The aim of this study was to investigate the in vitro effect of this new ultra-high roughness and dense Titanium (Ti) surface (PG60, Ra = 74 microm) in comparison with m...

journal_title：Biomaterials

authors： Borsari V,Giavaresi G,Fini M,Torricelli P,Tschon M,Chiesa R,Chiusoli L,Salito A,Volpert A,Giardino R

更新日期：2005-08-01 00:00:00

abstract：:Bacterial infection has been a threat to human health, and so early diagnosis and treatment of bacterial infection is an urgent problem that needs to be solved. In this work, a multifunctional theranostic selenium nanoplatform (Se@PEP-Ru NPs) with early imaging diagnosis and efficient treatment of bacterial infections...

journal_title：Biomaterials

authors： Huang N,Chen X,Zhu X,Xu M,Liu J

更新日期：2017-10-01 00:00:00

abstract：:Inherent neuronal and circulating progenitor cells play important roles in facilitating neuronal and functional recovery post stroke. However, this endogenous repair process is rather limited, primarily due to unfavorable conditions in the infarcted brain involving reactive oxygen species (ROS)-mediated oxidative stre...

journal_title：Biomaterials

authors： Petro M,Jaffer H,Yang J,Kabu S,Morris VB,Labhasetwar V

更新日期：2016-03-01 00:00:00

abstract：:We have designed a dual-aptamer complex specific to both prostate-specific membrane antigens (PSMA) (+) and (-) prostate cancer cells. In the complex, an A10 RNA aptamer targeting PSMA (+) cells and a DUP-1 peptide aptamer specific to PSMA (-) cells were conjugated through streptavidin. Doxorubicin-loaded onto the ste...

journal_title：Biomaterials

authors： Min K,Jo H,Song K,Cho M,Chun YS,Jon S,Kim WJ,Ban C

更新日期：2011-03-01 00:00:00

abstract：:The iron-containing fluoridated hydroxyapatites Fe-FeFAp and FeF-FeAp were synthesized heterogeneously in the presence of ferrous ions at 80 degrees C and pH 7.4 in two different types of solution, i.e. fluoride-free solution during the initial half of the experimental period and fluoride-containing solution during th...

journal_title：Biomaterials

authors： Okazaki M,Takahashi J

更新日期：1997-01-01 00:00:00

abstract：:We have recently developed a polymer which contains silsesquioxane in the form of nano-bridges poly(carbonate-silsesquioxane-bridge-urea)urethane (PCBSU) for cardiovascular device applications. The polymer has been characterised and the durability has been confirmed with long-term in vivo tests. The aim of this study ...

journal_title：Biomaterials

authors： Punshon G,Vara DS,Sales KM,Kidane AG,Salacinski HJ,Seifalian AM

更新日期：2005-11-01 00:00:00

abstract：:Stroke, traumatic brain injuries, and other similar conditions often lead to significant loss of functional brain tissue and associated disruption of neuronal signaling. A common strategy for replacing lost neurons is the injection of dissociated neural stem cells or differentiated neurons. However, this method is unl...

journal_title：Biomaterials

authors： Liaudanskaya V,Jgamadze D,Berk AN,Bischoff DJ,Gu BJ,Hawks-Mayer H,Whalen MJ,Chen HI,Kaplan DL

更新日期：2019-02-01 00:00:00

abstract：:Frequent outbreaks and the rapid global spread of infectious diseases have increased the urgent need for massive vaccination especially in countries with limited resources. Intranasal vaccination facilitates the mass vaccination via needle-free delivery of vaccine through nasal mucosal surfaces. Inspired by the strong...

journal_title：Biomaterials

authors： Wang X,Yang D,Li S,Xu X,Qin CF,Tang R

更新日期：2016-11-01 00:00:00

abstract：:Conventional cancer chemotherapy often fails as most anti-cancer drugs are not effective against drug-resistant cancer stem cells. These surviving cancer stem cells lead to relapse and metastasis. In this study, an anti-diabetic drug, phenformin, capable of eliminating cancer stem cells was loaded into micelles via se...

journal_title：Biomaterials

authors： Krishnamurthy S,Ng VW,Gao S,Tan MH,Yang YY

更新日期：2014-11-01 00:00:00

abstract：:A glass of nominal composition (wt%) 17.25 MgO-52.75 3CaO.P2O5-30 SiO2 and a glass-ceramic obtained from it showed surface modifications when immersed in an acellular medium having a composition similar to that of human blood plasma. A (Ca, P)-rich layer, with an approximate Ca/P atomic ratio of 1.7, identified as hyd...

journal_title：Biomaterials

authors： Oliveira JM,Correia RN,Fernandes MH

更新日期：1995-07-01 00:00:00

abstract：:In normal tissue repair, macrophages exhibit a pro-inflammatory phenotype (M1) at early stages and a pro-healing phenotype (M2) at later stages. We have previously shown that M1 macrophages initiate angiogenesis while M2 macrophages promote vessel maturation. Therefore, we reasoned that scaffolds that promote sequenti...

journal_title：Biomaterials

authors： Spiller KL,Nassiri S,Witherel CE,Anfang RR,Ng J,Nakazawa KR,Yu T,Vunjak-Novakovic G

更新日期：2015-01-01 00:00:00

abstract：:The adhesion and growth of cells on silicon dioxide substrata are analysed. The adhesion of human red blood cells to silicon dioxide layers of different depth and doping compares well with that to glass. Rat pheochromocytoma cells also grow on the same substrata. The adhesion of these two biological systems is charact...

journal_title：Biomaterials

authors： Grattarola M,Tedesco M,Cambiaso A,Perlo G,Giannetti G,Sanguineti A

更新日期：1988-01-01 00:00:00

abstract：:Human cell therapy applications in tissue engineering, such as the ex vivo production of hematopoietic cells for transplantation, have recently entered the clinic. Although considerable effort has been focused on the development of biological processes to generate therapeutic cells, little has been published on the de...

journal_title：Biomaterials

authors： Koller MR,Palsson MA,Manchel I,Maher RJ,Palsson BO

更新日期：1998-11-01 00:00:00

abstract：:Ex-vivo blood-brain barrier (BBB) model is of great value for studying brain function and drug development, but it is still challenging to engineer macroscale three-dimensional (3D) tissue constructs to recapitulate physiological and functional aspects of BBB. Here, we describe a delicate 3D vascularized neural constr...

journal_title：Biomaterials

authors： Yue H,Xie K,Ji X,Xu B,Wang C,Shi P

更新日期：2020-07-01 00:00:00

abstract：:Scaffold design plays a crucial role in developing graft-based regenerative strategies, especially when intended to be used in a highly ordered nerve tissue. Here we describe a hybrid matrix approach, which combines the structural properties of collagen (type I) with the epitope-presenting ability of peptide amphiphil...

journal_title：Biomaterials

authors： Sur S,Pashuck ET,Guler MO,Ito M,Stupp SI,Launey T

更新日期：2012-01-01 00:00:00

abstract：:Cells form hollow, spheroidal structures during the development of many tissues, including the ocular lens, inner ear, and many glands. Therefore, techniques for in vitro formation of hollow spheroids are valued for studying developmental and disease processes. Current in vitro methods require cells to self-organize i...

journal_title：Biomaterials

authors： Wang E,Wang D,Geng A,Seo R,Gong X

更新日期：2017-10-01 00:00:00

abstract：:The design of bioartificial liver assist device requires an effective attachment of primary hepatocytes on polymeric biomaterials. A better understanding of this cell-surface interaction would aid the optimal choice of biomaterials. In this study, the adhesion contact dynamics of primary hepatocytes on poly(ethylene t...

journal_title：Biomaterials

authors： Tan WJ,Teo GP,Liao K,Leong KW,Mao HQ,Chan V

更新日期：2005-03-01 00:00:00

abstract：:Titanium (Ti) osseointegration is critical for the success of dental and orthopedic implants. Previous studies have shown that surface roughness at the micro- and submicro-scales promotes osseointegration by enhancing osteoblast differentiation and local factor production. Only relatively recently have the effects of ...

journal_title：Biomaterials

authors： Gittens RA,McLachlan T,Olivares-Navarrete R,Cai Y,Berner S,Tannenbaum R,Schwartz Z,Sandhage KH,Boyan BD

更新日期：2011-05-01 00:00:00

abstract：:Current approaches for topical vaginal administration of nanoparticles result in poor retention and extensive leakage. To overcome these challenges, we developed a nanoparticle-releasing nanofiber delivery platform and evaluated its ability to improve nanoparticle retention in a murine model. We individually tailored ...

journal_title：Biomaterials

authors： Krogstad EA,Ramanathan R,Nhan C,Kraft JC,Blakney AK,Cao S,Ho RJY,Woodrow KA

更新日期：2017-11-01 00:00:00

abstract：:An in vitro cell-implant mineralization model system was used to study the effect of transforming growth factor-beta 1(TGF-beta1) on mineralization in human osteoblast cultures. SaOs-2 and primary human osteoblast (HOB) cells were cultured on Tivanium (Ti-6Al-4V) disks. Administration of different concentrations of TG...

journal_title：Biomaterials

authors： Zhang H,Ahmad M,Gronowicz G

更新日期：2003-05-01 00:00:00

abstract：:Branched polyesters of the general structure poly[vinyl-3-(dialkylamino)alkylcarbamate-co-vinyl acetate-co-vinyl alcohol]-graft-poly(d,l-lactide-co-glycolide) have shown potential for nano- and micro-scale drug delivery systems. For further optimization of this polymer class their cytotoxicity needs to be characterize...

journal_title：Biomaterials

authors： Unger F,Wittmar M,Kissel T

更新日期：2007-03-01 00:00:00

abstract：:Reconstruction of the genitourinary tract, using engineered urological tissues, requires a mechanically stable biodegradable and biocompatible scaffold and cultured cells. Such engineered autologous tissue would have many clinical implications. In this study a highly porous biodegradable polyesterurethane-foam, DegraP...

journal_title：Biomaterials

authors： Danielsson C,Ruault S,Simonet M,Neuenschwander P,Frey P

更新日期：2006-03-01 00:00:00

abstract：:Palladium additions to a dispersed phase high-copper amalgam have been shown recently to suppress markedly the eta' (Cu6Sn5) concentration and decrease creep. A detailed study of the dental and 24 h creep for Pd containing high-copper amalgams and six commercial controls as a function of applied temperature and stress...

journal_title：Biomaterials

authors： Greener EH,Chung KH,Lin JH

更新日期：1988-05-01 00:00:00

abstract：:Although transplantation of pancreatic islets is a promising approach for treatment of type 1 diabetes mellitus, the engraftment efficiency of these islets is limited by host immune responses. Extensive efforts have been made to immunoisolate these islets by introducing barriers on the islet surface. To date, these ba...

journal_title：Biomaterials

authors： Izadi Z,Hajizadeh-Saffar E,Hadjati J,Habibi-Anbouhi M,Ghanian MH,Sadeghi-Abandansari H,Ashtiani MK,Samsonchi Z,Raoufi M,Moazenchi M,Izadi M,Nejad ASSH,Namdari H,Tahamtani Y,Ostad SN,Akbari-Javar H,Baharvand H

更新日期：2018-11-01 00:00:00

abstract：:The ability to influence the direction of polymerization of a self-assembling biomolecular system has the potential to generate materials with extremely high anisotropy. In biological systems where highly-oriented cellular populations give rise to aligned and often load-bearing tissue such organized molecular scaffold...

journal_title：Biomaterials

authors： Saeidi N,Sander EA,Ruberti JW

更新日期：2009-12-01 00:00:00

abstract：:The commercial availability of peptides and proteins and their advantages as therapeutic agents have been the basis for tremendous efforts in designing delivery systems for such agents. The protection of these agents from biological fluids and physiological interactions is crucial for the treatment efficacy. One such ...

journal_title：Biomaterials

authors： Torres-Lugo M,Peppas NA

更新日期：2000-06-01 00:00:00