The influence of substrate stiffness on the behavior and functions of Schwann cells in culture.

abstract：:In this study, we quantified the adsorption of immunoglobulin G (IgG) protein onto several polyelectrolyte-modified sintered porous polyethylene (PPE) membranes. The polymer surfaces had both cationic and anionic charges obtained via the adsorption of polyethylenimine (PEI) and polyacrylic acid (PAA), respectively, on...

journal_title：Biomaterials

authors： Greene G,Radhakrishna H,Tannenbaum R

更新日期：2005-10-01 00:00:00

abstract：:Premature ovarian failure (POF) is the most frequently occurred disease in ovary. Direct inhibition of mammalian target of rapamycin (mTOR) activity can treat woman POF but brings adverse effects to women. Herein, by rational design of a hydrogelator Nap-Phe-Phe-Asp-Arg-Leu-Tyr-OH (Y) and co-assembling Y with an inhib...

journal_title：Biomaterials

authors： Shi Z,Li X,Wei M,Chen P,Zhang T,Ling X,Zhang J,Zhao C,Wang F,Liang G

更新日期：2020-11-16 00:00:00

abstract：:Amphiphilic 4-armed star-shaped chlorin-core diblock copolymers based on methoxy poly(ethylene glycol) (mPEG) and poly (epsilon-caprolactone) (PCL) were synthesized and characterized in this study. The synthesized photosensitizer-centered amphiphilic star block copolymer that forms assembled micelle-like structures ca...

journal_title：Biomaterials

authors： Peng CL,Shieh MJ,Tsai MH,Chang CC,Lai PS

更新日期：2008-09-01 00:00:00

abstract：:Non-invasive approaches to assess tissue function could improve significantly current methods to diagnose diseases and optimize engineered tissues. In this study, we describe a two-photon excited fluorescence microscopy approach that relies entirely on endogenous fluorophores to dynamically quantify functional metabol...

journal_title：Biomaterials

authors： Quinn KP,Bellas E,Fourligas N,Lee K,Kaplan DL,Georgakoudi I

更新日期：2012-07-01 00:00:00

abstract：:Resurfacing of cartilage defects using cell-seeded, biomaterial grafts is a promising approach for articular cartilage repair and in this study we investigated the ability of human chondrocytes from osteoarthritic joints to generate cartilage tissue under standard conditions in cultured over 21 days on Hyalograft matr...

journal_title：Biomaterials

authors： Katopodi T,Tew SR,Clegg PD,Hardingham TE

更新日期：2009-02-01 00:00:00

abstract：:The overwhelming majority of drugs exert their pharmacological effects after reaching their target sites of action, however, these target sites are mainly located in the cytosol or intracellular organelles. Consequently, delivering drugs to the specific organelle is the key to achieve maximum therapeutic effects and m...

journal_title：Biomaterials

authors： Chen Z,Zhang L,Song Y,He J,Wu L,Zhao C,Xiao Y,Li W,Cai B,Cheng H,Li W

更新日期：2015-06-01 00:00:00

abstract：:Reduced expression of autophagy regulators has been observed in pathological cartilage in humans and mice. The present study aimed to investigate the synergistic therapeutic effect of promotion of chondrocyte autophagy via exposure to sinomenium (SIN) encapsulated by chitosan microspheres (CM-SIN) and photo-crosslinke...

journal_title：Biomaterials

authors： Chen P,Xia C,Mei S,Wang J,Shan Z,Lin X,Fan S

更新日期：2016-03-01 00:00:00

abstract：:Lingo-1 is selectively expressed on both oligodendrocytes and neurons in the central nervous system (CNS) and serves as a key negative regulator of nerve regeneration, implying a therapeutic target for spinal cord injury (SCI). Here we described a strategy to knock-down Lingo-1 expression in vivo using lentiviral vect...

journal_title：Biomaterials

authors： Wu HF,Cen JS,Zhong Q,Chen L,Wang J,Deng DY,Wan Y

更新日期：2013-02-01 00:00:00

abstract：:The calcination and natural sintering of calcium deficient hydroxyapatite powders Ca(10-x)(PO4)(6-x)(HPO4)x(OH)(2-x) (with 0 < or = x < or = 1) were studied. For temperature below 700 degrees C, particle coalescence occurs without densification. The particle coalescence is associated with a reduction of the specific s...

journal_title：Biomaterials

authors： Raynaud S,Champion E,Bernache-Assollant D

更新日期：2002-02-01 00:00:00

abstract：:A glass of nominal composition (wt%) 17.25 MgO-52.75 3CaO.P2O5-30 SiO2 and a glass-ceramic obtained from it showed surface modifications when immersed in an acellular medium having a composition similar to that of human blood plasma. A (Ca, P)-rich layer, with an approximate Ca/P atomic ratio of 1.7, identified as hyd...

journal_title：Biomaterials

authors： Oliveira JM,Correia RN,Fernandes MH

更新日期：1995-07-01 00:00:00

abstract：:The aim of this in vitro study was to investigate the effect of low-level laser therapy (LLLT) on the attachment, proliferation, differentiation and production of transforming growth factor-ss(1) (TGF-beta(1)) by human osteoblast-like cells (HOB). Cells derived from human mandibular bone were exposed to GaAlAs diode l...

journal_title：Biomaterials

authors： Khadra M,Lyngstadaas SP,Haanaes HR,Mustafa K

更新日期：2005-06-01 00:00:00

abstract：:Human platelet lysates (PLs), which contain multiple neurotrophins, have been proposed for treating neurodegenerative disorders, including Parkinson's disease (PD). However, current PLs suspended in plasma have high protein content and contain fibrinogen/fibrin and, following activation, also proteolytic and thromboge...

journal_title：Biomaterials

authors： Chou ML,Wu JW,Gouel F,Jonneaux A,Timmerman K,Renn TY,Laloux C,Chang HM,Lin LT,Devedjian JC,Devos D,Burnouf T

更新日期：2017-10-01 00:00:00

abstract：:This study reported the encapsulation of liver microsomes into a thermosensitive hydrogel to characterize drug metabolism and predict drug effects. Pluronic(®)F-127 (F127) and acrylamide-bisacrylamide (Acr-Bis) were utilized as the two precursors. After chemical crosslinking catalyzed by ammonium persulfate (APS) and ...

journal_title：Biomaterials

authors： Yang H,Zheng Y,Zhao B,Shao T,Shi Q,Zhou N,Cai W

更新日期：2013-12-01 00:00:00

abstract：:A new diamond ATR FTIR method has been developed to quantify the processes occurring in the resin-modified glass-ionomer cement (RMGIC). Fuji II LC (Improved), at 1 mm depth from the cement/water interface. With Fuji II LC (Improved) various changes in the spectra due to 90% monomer polymerisation were observed within...

journal_title：Biomaterials

authors： Young AM

更新日期：2002-08-01 00:00:00

abstract：:Previous work developing particle-based acellular, artificial antigen presenting cells (aAPCs) has focused exclusively on spherical platforms. To explore the role of shape, we generated ellipsoidal PLGA microparticles with varying aspect ratios (ARs) and synthesized aAPCs from them. The ellipsoidal biomimetic aAPCs wi...

journal_title：Biomaterials

authors： Sunshine JC,Perica K,Schneck JP,Green JJ

更新日期：2014-01-01 00:00:00

abstract：:Although folate exhibits many advantages over other targeting ligands, it has one major defect: poor water solubility. Once it was conjugated to hydrophilic drug carrier such as N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer, the hydrophobic folate may be buried inside the random polymer coil and not exposed to b...

journal_title：Biomaterials

authors： Li L,Yang Q,Zhou Z,Zhong J,Huang Y

更新日期：2014-06-01 00:00:00

abstract：:RNA interference holds tremendous potential as a therapeutic approach of malignant tumors. However, safe and efficient nanovectors are extremely lack for systemic delivery of small interfering RNA (siRNA). The study aimed to develop a biomimetic nanovector, reconstituted high density lipoprotein (rHDL), mediating targ...

journal_title：Biomaterials

authors： Ding Y,Wang W,Feng M,Wang Y,Zhou J,Ding X,Zhou X,Liu C,Wang R,Zhang Q

更新日期：2012-12-01 00:00:00

abstract：:The development of artificial microstructures suited for interfacing of peripheral nerves is not only relevant for basic neurophysiological research but also for future prosthetic approaches. Aim of the present study was to provide a detailed analysis of axonal sprouting and reactive tissue changes after implantation ...

journal_title：Biomaterials

authors： Klinge PM,Vafa MA,Brinker T,Brandis A,Walter GF,Stieglitz T,Samii M,Wewetzer K

更新日期：2001-09-01 00:00:00

abstract：:The porous TiO2/perlite composite Ecopore is a synthetic biomaterial with possible clinical application in bone substitution. In our previous work, we demonstrated that surface modification of Ecopore with fibronectin (FN) enhanced spreading and growth of human osteoblasts in vitro. In the present study, we implanted ...

journal_title：Biomaterials

authors： Erli HJ,Rüger M,Ragoss C,Jahnen-Dechent W,Hollander DA,Paar O,von Walter M

更新日期：2006-03-01 00:00:00

abstract：:The effects of chitin [(1 --> 4)-2-acetamido-2-deoxy-beta-D-glucan] and its partially deacetylated derivatives, chitosans, on the proliferation of human dermal fibroblasts and keratinocytes were examined in vitro. Chitosans with relatively high degrees of deacetylation strongly stimulated fibroblast proliferation whil...

journal_title：Biomaterials

authors： Howling GI,Dettmar PW,Goddard PA,Hampson FC,Dornish M,Wood EJ

更新日期：2001-11-01 00:00:00

abstract：:A silicone-based prepolymer was used as the major component for the fabrication of novel ocular devices. Gentamicin sulphate was used as a probe drug, due to its high aqueous solubility and widespread application. Mechanical properties of films containing the drug before and after gamma sterilization and exposure to h...

journal_title：Biomaterials

authors： Bawa R,Nandu M

更新日期：1990-11-01 00:00:00

abstract：:We have created a porous bioresorbable nanocomposite bone scaffold that chemically, structurally and mechanically matched natural bone so that it could be recognized and remodeled by natural bone. Containing collagen fibers and synthetic apatite nanocrystals, our scaffold has high strength for supporting the surroundi...

journal_title：Biomaterials

authors： Pek YS,Gao S,Arshad MS,Leck KJ,Ying JY

更新日期：2008-11-01 00:00:00

abstract：:To broaden the clinical application of cartilage regenerative medicine, we should develop an implant-type tissue-engineered cartilage with firmness and 3-D structure. For that, we attempted to use a porous biodegradable polymer scaffold in the combination with atelocollagen hydrogel, and optimized the structure and co...

journal_title：Biomaterials

authors： Tanaka Y,Yamaoka H,Nishizawa S,Nagata S,Ogasawara T,Asawa Y,Fujihara Y,Takato T,Hoshi K

更新日期：2010-06-01 00:00:00

abstract：:Lower back pain is mainly caused by intervertebral disc degeneration, in which calcification is frequently involved. Here novel nanofibrous spongy microspheres (NF-SMS) are used to carry rabbit bone marrow mesenchymal stromal cells (MSCs) to regenerate nucleus pulposus tissues. NF-SMS are shown to significantly enhanc...

journal_title：Biomaterials

authors： Feng G,Zhang Z,Dang M,Rambhia KJ,Ma PX

更新日期：2020-10-01 00:00:00

abstract：:Articular cartilage injuries do not heal and large defects result in osteoarthritis with major personal and socioeconomic costs. Osteochondral transplantation is an effective treatment for large joint defects but its use is limited by the inability to store cartilage for long periods of time. Cryopreservation/vitrific...

journal_title：Biomaterials

authors： Jomha NM,Elliott JA,Law GK,Maghdoori B,Forbes JF,Abazari A,Adesida AB,Laouar L,Zhou X,McGann LE

更新日期：2012-09-01 00:00:00

abstract：:Remote microactuators are of great interest in biology and medicine as minimally-invasive tools for cellular stimulation. Remote actuation can be achieved by active magnetostrictive transducers which are capable of changing shape in response to external magnetic fields thereby creating controlled displacements. Among ...

journal_title：Biomaterials

authors： Vargas-Estevez C,Blanquer A,Dulal P,Pérez Del Real R,Duch M,Ibáñez E,Barrios L,Murillo G,Torras N,Nogués C,Stadler BJH,Plaza JA,Esteve J

更新日期：2017-09-01 00:00:00

abstract：:Unhealed chronic wounds often deteriorate into multiple infection with several kinds of bacteria and excessive proteolytic wound exudate and remains one of the common healthcare issues. Here, the functional and antimicrobial hydrogel and cryogel biomaterials were prepared from glycol chitosan and a novel biodegradable...

journal_title：Biomaterials

authors： Chen TY,Wen TK,Dai NT,Hsu SH

更新日期：2020-12-16 00:00:00

abstract：:During organogenesis groups of differentiating cells self-organize into a series of structural intermediates with defined architectural forms. Evidence is emerging that such architectural forms are important in guiding cell fate, yet in vitro methods to guide cell fate have focused primarily on un-patterned exposure o...

journal_title：Biomaterials

authors： Soleas JP,D'Arcangelo E,Huang L,Karoubi G,Nostro MC,McGuigan AP,Waddell TK

更新日期：2020-09-01 00:00:00

abstract：:The objective of this study is to develop a carrier for the controlled release of bone morphogenetic protein-2 (BMP-2) suitable for enhancement of the bone regeneration activity. Hydrogels with different water contents were prepared through glutaraldehyde crosslinking of gelatin with an isoelectric point of 9.0 under ...

journal_title：Biomaterials

authors： Yamamoto M,Takahashi Y,Tabata Y

更新日期：2003-11-01 00:00:00

abstract：:As synergistic photothermal immunotherapy has developed as one of the most attractive strategies for cancer therapy, it is crucial to design an effective photothermal immunotherapy system to enhance the synergistic anti-tumor effect and reveal the essential role of each treatment. In this study, we designed CpG self-c...

journal_title：Biomaterials

authors： Dong X,Liang J,Yang A,Qian Z,Kong D,Lv F

更新日期：2019-07-01 00:00:00