当前位置： SCI文献检索 > BIOMATERIALS期刊下所有文献 > Physicochemical characterisation and biological evaluation of hydrogel-poly(epsilon-caprolactone) interpenetrating polymer networks as novel urinary biomaterials.

Physicochemical characterisation and biological evaluation of hydrogel-poly(epsilon-caprolactone) interpenetrating polymer networks as novel urinary biomaterials.

Abstract：

:Hydrogels are frequently employed as medical device biomaterials due to their advantageous biological properties, e.g. resistance to infection and encrustation, biocompatibility; however, their poor mechanical properties generally limit the scope of application to coatings of medical devices. To address this limitation, this study described the formulation of sequential interpenetrating polymer networks (IPN) of poly(-caprolactone) (PCL) and poly(hydroxyethylmethacrylate) (p(HEMA)). IPN containing 20% w/w PCL, p(HEMA), both in the presence or absence of ethyleneglycol dimethacrylate (EGDMA 1% w/w), were prepared by free radical polymerisation. Following preparation the degradation and the mechanical and surface properties of the biomaterials and, in addition, the resistances to microbial adherence and encrustation in vitro were examined. In comparison to p(HEMA) the various IPN exhibited substantially greater tensile properties (ultimate tensile strength, % elongation, Young's modulus) that were accredited to the discrete distribution of PCL within the hydrogel network. The IPN exhibited two glass transition temperatures that were statistically similar to those of the individual components, thereby providing evidence of the immiscible nature of the two polymers. The IPN possessed higher receding contact angles and lower equilibrium water contents in comparison to p(HEMA), whereas the limited degradation of the IPN at both pH 7 and 9 was deemed suitable for clinical usage for periods of at least 4 weeks. The resistances of the various IPN to bacterial adherence and urinary encrustation were examined using in vitro models. Importantly the resistance of the IPN to encrustation was, in general, similar to that of p(HEMA) but greater than that of PCL whereas, the resistance of the IPN to bacterial adherence was frequently greater than that of p(HEMA) and PCL. Therefore, this study has shown that the mechanical properties of p(HEMA) may be substantially increased by the formation of IPN with PCL whilst maintaining other appropriate physicochemical properties and resistances to urinary encrustation and bacterial adherence. It is suggested that these IPN may be suitable for device fabrication thereby expanding the manufacturing application of hydrogels without compromising their potential clinical efficacy.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Jones DS,McLaughlin DW,McCoy CP,Gorman SP

doi

10.1016/j.biomaterials.2004.06.002

keywords:

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

1761-70

issue

eissn

0142-9612

issn

1878-5905

pii

S014296120400540X

journal_volume

pub_type

杂志文章

在线工具

Physicochemical characterisation and biological evaluation of hydrogel-poly(epsilon-caprolactone) interpenetrating polymer networks as novel urinary biomaterials.