Abstract：
:Leveraging the multifunctional nature of citrate in chemistry and inspired by its important role in biological tissues, a class of highly versatile and functional citrate-based materials (CBBs) has been developed via facile and cost-effective polycondensation. CBBs exhibiting tunable mechanical properties and degradation rates, together with excellent biocompatibility and processability, have been successfully applied in vitro and in vivo for applications ranging from soft to hard tissue regeneration, as well as for nanomedicine designs. We summarize in the review, chemistry considerations for CBBs design to tune polymer properties and to introduce functionality with a focus on the most recent advances, biological functions of citrate in native tissues with the new notion of degradation products as cell modulator highlighted, and the applications of CBBs in wound healing, nanomedicine, orthopedic, cardiovascular, nerve and bladder tissue engineering. Given the expansive evidence for citrate's potential in biology and biomaterial science outlined in this review, it is expected that citrate based materials will continue to play an important role in regenerative engineering.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Ma C,Gerhard E,Lu D,Yang Jdoi
10.1016/j.biomaterials.2018.05.003subject
Has Abstractpub_date
2018-09-01 00:00:00pages
383-400eissn
0142-9612issn
1878-5905pii
S0142-9612(18)30340-5journal_volume
178pub_type
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