In vitro assessment of bacterial adhesion to Hydromer-coated cerebrospinal fluid shunts.

Abstract:

:The adherence of five strains of Staphylococcus epidermidis and one strain of S. aureus to both untreated and Hydromer-coated silicone rubber cerebrospinal fluid shunts was studied in vitro using epifluorescent image analysis. All five strains of S. epidermidis showed similar levels of adherence to untreated shunts, whilst S. aureus adhered slightly better. The Hydromer coating, a hydrogel material which creates a hydrophilic layer on the shunt surface, was found to reduce bacterial adhesion levels by approximately 90% in the six strains of bacteria tested. Unfortunately, uniform coverage of the shunt surfaces (particularly internally) with Hydromer coating was not achieved during sample preparation. Bacterial adhesion levels in such areas were identical to untreated controls. This may pose problems in the in vivo use of Hydromer-coated shunts.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Bridgett MJ,Davies MC,Denyer SP,Eldridge PR

doi

10.1016/0142-9612(93)90021-s

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

184-8

issue

3

eissn

0142-9612

issn

1878-5905

pii

0142-9612(93)90021-S

journal_volume

14

pub_type

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