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Contractile behavior of smooth muscle actin-containing osteoblasts in collagen-GAG matrices in vitro: implant-related cell contraction.

Abstract：

:The contraction of connective tissue cells may facilitate their production and maintenance of extracellular matrix architecture and can benefit healing through wound closure. However, aberrant cell contraction can result in pathological contracture. Implants may stimulate this process leading to contracture of the surrounding fibrous capsule. In the case of compliant porous matrices used for tissue engineering the cell contraction may cause the constriction of pores and the distortion of the implant. The objective of this study was to determine if osteoblasts expressed a specific muscle actin, alpha-smooth muscle actin (SMA), that could provide for their contraction. Immunohistochemistry revealed the presence of SMA in some cells in all of three human and three canine trabecular bone specimens. The majority of the cells of an osteoblastic cell line, MC3T3-E 1, also expressed this actin isoform in two-dimensional culture and when seeded into a collagen-glycosaminoglycan (GAG) matrix. These SMA-containing cells were found to cause contraction of the collagen-GAG analog of extracellular matrix. These findings demonstrate that osteoblasts can display contractile behavior that might help to explain the mechanism by which they impart architecture to bone matrix, including that at implant interfaces. An understanding of this process could also guide the development of matrices for bone tissue engineering.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Menard C,Mitchell S,Spector M

doi

10.1016/s0142-9612(00)00062-4

keywords:

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

1867-77

issue

18

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(00)00062-4

journal_volume

21

pub_type

杂志文章

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