Optical and electrochemical detection of DNA.

abstract：:This paper presents for the first time a mathematical model for a mechanism of controlled drug release involving both ion exchange and transient counter diffusion of a drug and counterions. Numerical analysis was conducted to study the effect of different factors on drug release kinetics including environmental condit...

journal_title：Biomaterials

authors： Abdekhodaie MJ,Wu XY

更新日期：2008-04-01 00:00:00

abstract：:Over the past two decades, in vitro autologous endothelial cell (EC) coverage of expanded polytetrafluoroethylene (ePTFE) graft has been developed and clinically applied with success in infrainguinal bypasses. Before endothelialization, the luminal surface of the graft has to be coated with a currently used fibrinolyt...

journal_title：Biomaterials

authors： Fernandez P,Deguette A,Pothuaud L,Belleannée G,Coste P,Bordenave L

更新日期：2005-08-01 00:00:00

abstract：:Type I collagen constitutes a major portion of the extracellular matrix (ECM) in arterial wall and it is the major substrate for cell growth and differentiation. The goal of this study was to evaluate the differentiation and proliferation of placenta-derived multipotent cells (PDMCs) on polymerized type I collagen fib...

journal_title：Biomaterials

authors： Chou MT,Chang SN,Ke C,Chang HI,Sung ML,Kuo HC,Chen CN

更新日期：2010-05-01 00:00:00

abstract：:We genetically introduced the Fc-binding peptide (FcBP) into the loop of a self-assembled protein cage, ferritin, constituting four-fold symmetry at the surface to use it as a modular delivery nanoplatform. FcBP-presenting ferritin (FcBP-ferritin) formed very stable non-covalent complexes with both human and rabbit Ig...

journal_title：Biomaterials

authors： Kang HJ,Kang YJ,Lee YM,Shin HH,Chung SJ,Kang S

更新日期：2012-07-01 00:00:00

abstract：:The sintering behavior of calcium pyrophosphate (CPP, Ca2P2O7)-doped beta-tricalcium phosphate [TCP, Ca3(PO4)2], prepared by solid state reaction, was investigated in-situ, using dilatometry. Pure beta-TCP undergoes phase transition to alpha-TCP at about 1200 degrees C; hence pure beta-TCP ceramics should be sintered ...

journal_title：Biomaterials

authors： Ryu HS,Youn HJ,Hong KS,Chang BS,Lee CK,Chung SS

更新日期：2002-02-01 00:00:00

abstract：:A graft copolymer having poly(L-lysine) (PLL) as the backbone and monomethoxy poly(ethylene glycol) (MPEG) as pendent chains was synthesized. This polycationic copolymer was used to form microcapsules with sodium alginate, a polyanion. Microcapsules and model surfaces formed with PLL-graft-MPEG demonstrated reduced pr...

journal_title：Biomaterials

authors： Sawhney AS,Hubbell JA

更新日期：1992-01-01 00:00:00

abstract：:Rational design and develop of targeted contrast agents binding to cancer-related proteins will achieve more accurate cancer diagnosis and prognosis by magnetic resonance (MR) imaging. CREKA is a tumor-homing pentapeptide (Cys-Arg-Glu-Lys-Ala) specifically homes to fibrin-fibronectin complexes abundantly expressed in ...

journal_title：Biomaterials

authors： Zhou Z,Wu X,Kresak A,Griswold M,Lu ZR

更新日期：2013-10-01 00:00:00

abstract：:Targeted therapy is needed for hepatitis B virus (HBV)-mediated hepatocellular carcinoma (HCC) which shows overexpression of HBV surface antigen (HBsAg). We previously developed scFv15, a human single-chain antibody against HBsAg. Here we tested the strategic feasibility of scFv15-mediated delivery of apoptotic effect...

journal_title：Biomaterials

authors： Yan B,Ouyang Q,Zhao Z,Cao F,Wang T,Jia X,Meng Y,Jiang S,Liu J,Chen R,Jia L,Zhang R,Wen W,Jin B,Chen S,Zhao J,Yang A

更新日期：2013-07-01 00:00:00

abstract：:Tissue engineering of clinical-relevant large tissue constructs remains a big challenge due to the mass transfer limit. A modular approach via the assembling of modular tissues thus eliminating the mass transfer limit holds great promise for fabricating centimeter-sized constructs. In the present study, we investigate...

journal_title：Biomaterials

authors： Chen M,Wang X,Ye Z,Zhang Y,Zhou Y,Tan WS

更新日期：2011-10-01 00:00:00

abstract：:Polyacrylamide hydrogels have been used extensively to study cell responses to the mechanical and biochemical properties of extracellular matrix substrates. A key step in fabricating these substrates is the conjugation of cell adhesion proteins to the polyacrylamide surfaces, which typically involves nonspecifically a...

journal_title：Biomaterials

authors： Lee JP,Kassianidou E,MacDonald JI,Francis MB,Kumar S

更新日期：2016-09-01 00:00:00

abstract：:Crystalline carbonate- and sodium-and-carbonate-substituted hydroxyapatite (CO3HAp and NaCO3HAp) powders were prepared at room temperature via a heterogeneous reaction between Ca(OH)2/CaCO3/Na2CO3 and (NH4)2HPO4 aqueous solution using the mechanochemical hydrothermal route. X-ray diffraction, infrared spectroscopy, th...

journal_title：Biomaterials

authors： Suchanek WL,Shuk P,Byrappa K,Riman RE,TenHuisen KS,Janas VF

更新日期：2002-02-01 00:00:00

abstract：:We describe here for the first time an efficient high yield production method for clinical grade recombinant human Oncofetal Antigen/immature laminin receptor protein (OFA/iLRP). We also demonstrate significant antitumor activity for this protein when administered in liposomal delivery form in a murine model of syngen...

journal_title：Biomaterials

authors： Barsoum AL,Liu B,Rohrer JW,Coggin JH Jr,Tucker JA,Pannell LK,Schwarzenberger PO

更新日期：2009-06-01 00:00:00

abstract：:The polymerization of N,N' carbonylbis (caprolactam) (CBC) and polyol in the presence of alcoholate as catalyst produced cross-linked poly(ester-urea)s via ring opening addition reaction. In contrast to conventional synthetic routes, the use of non-toxic CBC eliminates the need for toxic isocyanate-based monomers. The...

journal_title：Biomaterials

authors： Zimmermann J,Loontjens T,Scholtens BJ,Mülhaupt RR

更新日期：2004-06-01 00:00:00

abstract：:Specifically inhibiting the proliferation of activated macrophages and clearing the high levels of reactive oxygen species (ROS) secreted by macrophages is crucial for osteoarthritis (OA) treatment. Moreover, if the clearance of these high levels of ROS can be simultaneously used to induce oxidation-responsive release...

journal_title：Biomaterials

authors： Yang G,Fan M,Zhu J,Ling C,Wu L,Zhang X,Zhang M,Li J,Yao Q,Gu Z,Cai X

更新日期：2020-10-01 00:00:00

abstract：:Nanomaterials conjugated with biomacromolecules, including viruses, have great potential for in vivo applications. Therefore, it is important to evaluate the safety of nanoparticle-conjugated macromolecule biomaterials (Nano-mbio). Although a number of studies have assessed the risks of nanoparticles and macromolecule...

journal_title：Biomaterials

authors： Wang M,Zheng Z,Meng J,Wang H,He M,Zhang F,Liu Y,Hu B,He Z,Hu Q,Wang H

更新日期：2015-09-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment and have been shown to play an important role in the progression of cancer. To probe these tumour-stroma interactions, we incorporated CAFs derived from head and neck cancer patients and squamous carcinoma cells of the hypopharynx ...

journal_title：Biomaterials

authors： Young M,Rodenhizer D,Dean T,D'Arcangelo E,Xu B,Ailles L,McGuigan AP

更新日期：2018-05-01 00:00:00

abstract：:A biodegradable microvessel scaffold comprised of distinct parenchymal and vascular compartments separated by a permeable membrane interface was conceptualized, fabricated, cellularized, and implanted. The device was designed with perfusable microfluidic channels on the order of 100 μm to mimic small blood vessels, an...

journal_title：Biomaterials

authors： Ye X,Lu L,Kolewe ME,Park H,Larson BL,Kim ES,Freed LE

更新日期：2013-12-01 00:00:00

abstract：:High-molecular-weight polyethylenimine (25 kDa, PEI25k) is one of the most common cationic polymers utilized in non-viral gene therapy. However, its methylene backbone (-CH(2)CH(2)N(x)-) and high charge density can result in poor biodegradability and high toxicity to cells. We hypothesize that optimizing the polymer l...

journal_title：Biomaterials

authors： Xiong MP,Forrest ML,Ton G,Zhao A,Davies NM,Kwon GS

更新日期：2007-11-01 00:00:00

abstract：:The water-soluble, low toxic and less biodegradable chitosan derivative N-succinyl-chitosan (Suc-chitosan) was investigated for body distribution and urinary excretion on a long-time scale (24-72 h after i.v. injection) using a fluorescein-labeling technique. Fluorescein isothiocyanate (FITC)-labeled Suc-chitosan (Suc...

journal_title：Biomaterials

authors： Kato Y,Onishi H,Machida Y

更新日期：2000-08-01 00:00:00

abstract：:Tumor cells interact with the microenvironment that specifically supports and promotes tumor development. Key components in the tumor environment have been linked to various aggressive cancer features and can further influence the presence of subpopulations of cancer cells with specific functions, including cancer ste...

journal_title：Biomaterials

authors： Landberg G,Fitzpatrick P,Isakson P,Jonasson E,Karlsson J,Larsson E,Svanström A,Rafnsdottir S,Persson E,Gustafsson A,Andersson D,Rosendahl J,Petronis S,Ranji P,Gregersson P,Magnusson Y,Håkansson J,Ståhlberg A

更新日期：2020-03-01 00:00:00

abstract：:Collagen has been widely used for tissue engineering. Here, we applied bioactive laminin-derived peptides as an additive for collagen, laminin-111, and fibronectin matrices resulting in peptide/collagen, peptide/laminin-111, and peptide/fibronectin matrices. Several syndecan-binding peptides, including AG73 (RKRLQVQLS...

journal_title：Biomaterials

authors： Yamada Y,Katagiri F,Hozumi K,Kikkawa Y,Nomizu M

更新日期：2011-07-01 00:00:00

abstract：:Dense, reconstituted collagen membranes, using an optimized cross-linking protocol, were implanted subcutaneously into rats. After implantation, only a mild inflammatory response in the surrounding tissues was observed. The morphology of the fibroblasts around the membranes was seen to go through characteristic stages...

journal_title：Biomaterials

authors： Boon ME,Ruijgrok JM,Vardaxis MJ

更新日期：1995-09-01 00:00:00

abstract：:The calcination and natural sintering of calcium deficient hydroxyapatite powders Ca(10-x)(PO4)(6-x)(HPO4)x(OH)(2-x) (with 0 < or = x < or = 1) were studied. For temperature below 700 degrees C, particle coalescence occurs without densification. The particle coalescence is associated with a reduction of the specific s...

journal_title：Biomaterials

authors： Raynaud S,Champion E,Bernache-Assollant D

更新日期：2002-02-01 00:00:00

abstract：:Macropores in tissue engineering scaffolds provide space for vascularization, cell-proliferation and cellular interactions, and is crucial for successful tissue regeneration. Modulating the size and density of macropores may promote desirable cellular processes at different stages of tissue development. Most current t...

journal_title：Biomaterials

authors： Han LH,Lai JH,Yu S,Yang F

更新日期：2013-06-01 00:00:00

abstract：:For a temporomandibular joint prosthesis, an estimation of the wear rate was needed, prior to patient application. Therefore, we determined the in vitro wear rate of the ball-socket articulation of this prosthesis, consisting of a metal head and an ultra-high molecular weight polyethylene (UHMWPE) cup. The basic testi...

journal_title：Biomaterials

authors： Van Loon JP,Verkerke GJ,de Bont LG,Liem RS

更新日期：1999-08-01 00:00:00

abstract：:Ultrasoft biomaterials-polymers, gels, and human soft tissues with an elastic modulus less than ∼100 kPa-are increasingly used in medical devices. While bacterial interactions (adhesion and biofilm formation) have been extensively studied on stiffer materials, little is known about how bacteria colonize ultrasoft mate...

journal_title：Biomaterials

authors： Wang Y,Guan A,Isayeva I,Vorvolakos K,Das S,Li Z,Phillips KS

更新日期：2016-07-01 00:00:00

abstract：:To develop a polymer-anticancer drug conjugate, we employed gelatin nanoparticles (GPs) as carriers of cisplatin (CDDP) with anticipated improved therapeutic effect and reduced side effects. The anticancer activities of CDDP-incorporated in GPs (GP-Pt) with biotinylated-EGF (bEGF) modification (GP-Pt-bEGF) were studie...

journal_title：Biomaterials

authors： Tseng CL,Su WY,Yen KC,Yang KC,Lin FH

更新日期：2009-07-01 00:00:00

abstract：:The large surface area of highly porous titanium structures produced by additive manufacturing can be modified using biofunctionalizing surface treatments to improve the bone regeneration performance of these otherwise bioinert biomaterials. In this longitudinal study, we applied and compared three types of biofunctio...

journal_title：Biomaterials

authors： Amin Yavari S,van der Stok J,Chai YC,Wauthle R,Tahmasebi Birgani Z,Habibovic P,Mulier M,Schrooten J,Weinans H,Zadpoor AA

更新日期：2014-08-01 00:00:00

abstract：:Retinal degeneration impairs the vision of millions in all age groups worldwide. Increasing evidence suggests that the etiology of many retinal degenerative diseases is associated with impairment in biochemical reactions involved in the visual cycle, a metabolic pathway responsible for regeneration of the visual chrom...

journal_title：Biomaterials

authors： Puntel A,Maeda A,Golczak M,Gao SQ,Yu G,Palczewski K,Lu ZR

更新日期：2015-03-01 00:00:00

abstract：:Self-assembling peptides and peptide derivatives bearing cell-binding ligands are increasingly being investigated as defined cell culture matrices and as scaffolds for regenerative medicine. In order to systematically refine such scaffolds to elicit specific desired cell behaviors, ligand display should ideally be ach...

journal_title：Biomaterials

authors： Jung JP,Nagaraj AK,Fox EK,Rudra JS,Devgun JM,Collier JH

更新日期：2009-04-01 00:00:00