Abstract:
:Over the past two decades, in vitro autologous endothelial cell (EC) coverage of expanded polytetrafluoroethylene (ePTFE) graft has been developed and clinically applied with success in infrainguinal bypasses. Before endothelialization, the luminal surface of the graft has to be coated with a currently used fibrinolytically inhibited fibrin glue. The aim of this work is to validate the precoating of the ePTFE (4 mm ID) ringed graft with fibrin. Twenty cm-long grafts were precoated with fibrin glue (2 operators) then fixed for microscopy investigations. Grafts were sliced into 3 regions. Thickness analysis was evaluated by image processing. Three grafts have been tested for endothelialization and observed at days 3, 8. Cell-free coated ePTFE were imaged using high-frequency ultrasound modality. Whatever the examined segment an overall homogeneous covering protein is shown. Fibrin thickness after image processing is 8.5+/-0.25 and 4.1+/-0.4 microm for two operators (P < .001). We have evaluated reproducibility and inter- and intra-variability of the operator, assessed quality controls and quality assurance all along the prosthesis and finally endothelialization and subsequent behaviour under shear stress conditions.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Fernandez P,Deguette A,Pothuaud L,Belleannée G,Coste P,Bordenave Ldoi
10.1016/j.biomaterials.2005.01.011keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
5042-7issue
24eissn
0142-9612issn
1878-5905pii
S0142-9612(05)00036-0journal_volume
26pub_type
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