Gel spinning of silk tubes for tissue engineering.

abstract：:The hypothesis that E-selectin on activated endothelial cells could be exploited to selectively target drug delivery systems to tumor vasculature was investigated. HPMA copolymer-doxorubicin (DOX) conjugates displaying the high affinity E-selectin binding peptide (Esbp, primary sequence DITWDQLWDLMK) as targeting liga...

journal_title：Biomaterials

authors： Shamay Y,Paulin D,Ashkenasy G,David A

更新日期：2009-11-01 00:00:00

abstract：:Degradable hydrogels to deliver bioactive proteins represent an emerging platform for promoting tissue repair and vascularization in various applications. However, implanting these biomaterials requires invasive surgery, which is associated with complications such as inflammation, scarring, and infection. To address t...

journal_title：Biomaterials

authors： Foster GA,Headen DM,González-García C,Salmerón-Sánchez M,Shirwan H,García AJ

更新日期：2017-01-01 00:00:00

abstract：:The ageing behaviour of ultra-high molecular weight polyethylene (UHMWPE) has been studied following gamma irradiation (25 or 40 kGy) in air. Accelerated ageing procedures used elevated temperature (70 degrees C) and/or pressurised oxygen (5bar). Shelf-aged UHMWPE was also studied. The variation in surface density and...

journal_title：Biomaterials

authors： Buchanan FJ,Shipway PH

更新日期：2002-01-01 00:00:00

abstract：:To prevent wear debris-induced osteolysis and aseptic loosening, cross-linked ultra-high molecular weight polyethylene's (UHMWPE) with improved wear resistance have been developed. Hip simulator studies have demonstrated very low wear rates with these new materials leading to their widespread clinical use. However, th...

journal_title：Biomaterials

authors： Sethi RK,Neavyn MJ,Rubash HE,Shanbhag AS

更新日期：2003-07-01 00:00:00

abstract：:Approximately 285 million people worldwide suffer from diabetes, with insulin supplementation as the most common treatment measure. Regenerative medicine approaches such as a bioengineered pancreas has been proposed as potential therapeutic alternatives. A bioengineered pancreas will benefit from the development of a ...

journal_title：Biomaterials

authors： Goh SK,Bertera S,Olsen P,Candiello JE,Halfter W,Uechi G,Balasubramani M,Johnson SA,Sicari BM,Kollar E,Badylak SF,Banerjee I

更新日期：2013-09-01 00:00:00

abstract：:Polypyrrole (PPy) is a conducting polymer and is obtained electrochemically on an electrode such as indium-tin oxide (ITO). In this study, in order to develop a novel cell-culture system which makes it possible to communicate with cultured mammalian cells, bovine adrenal chromaffin cells were cultured on PPy-coated IT...

journal_title：Biomaterials

authors： Aoki T,Tanino M,Sanui K,Ogata N,Kumakura K

更新日期：1996-10-01 00:00:00

abstract：:We report here the development of a chitosan/beta-glycerophosphate(Ch/beta-GP) thermo-sensitive gel to deliver ellagic acid (EA) for cancer treatment. The properties of the Ch/beta-GP gels were characterized regarding chemical structure, surface morphology, and viscoelasticity. In vitro EA release rate from the EA loa...

journal_title：Biomaterials

authors： Kim S,Nishimoto SK,Bumgardner JD,Haggard WO,Gaber MW,Yang Y

更新日期：2010-05-01 00:00:00

abstract：:We present a dual-drug delivery system (DDDS) of hydrogel/polypeptide micelle composites in this work. The DDDS was constructed from aspirin (Asp) dispersed poly(vinyl alcohol) (PVA) or Chitosan (CS)/PVA hydrogel and doxorubicin (DOX) loaded poly(L-glutamic acid)-b-poly(propylene oxide)-b-poly(L-glutamic acid) (GPG) m...

journal_title：Biomaterials

authors： Wei L,Cai C,Lin J,Chen T

更新日期：2009-05-01 00:00:00

abstract：:Hybrid drug delivery system containing both organic and inorganic nanocarriers is expected to achieve its complementary advantages for the aim of improving the performance of antineoplastic drugs in tumor therapy. Here we report the use of liposomes and gold nanoparticles to construct a liposome with a hybrid Cluster ...

journal_title：Biomaterials

authors： Zhang N,Chen H,Liu AY,Shen JJ,Shah V,Zhang C,Hong J,Ding Y

更新日期：2016-01-01 00:00:00

abstract：:Bone morphogenetic protein (BMP) 2-incorporated gelatin sponge is effective for in vivo osteoinduction. However, the modeling capacity of bone decreases with age. As atrial to stimulate effective bone formation for animals with decreased osteogenic potential, Wnt1 inducible signaling pathway protein (WISP) 1, an osteo...

journal_title：Biomaterials

authors： Kohara H,Tabata Y

更新日期：2011-08-01 00:00:00

abstract：:Understanding and controlling cell proliferation on biomaterial surfaces is critical for scaffold/artificial-niche design in tissue engineering. The mechanism by which underlying integrin ligates with functionalized biomaterials to induce cell proliferation is still not completely understood. In this study, poly-l-lac...

journal_title：Biomaterials

authors： Naganuma T,Traversa E

更新日期：2014-05-01 00:00:00

abstract：:Microspheres of a hydrophobic and a hydrophilic poly(ether-ester) copolymer were evaluated for their in vitro and in vivo biocompatibility and degradation. The microspheres prior to and after sterilization were tested for in vitro cytotoxicity. The in vivo biocompatibility of the poly(ethylene glycol) terephthalate an...

journal_title：Biomaterials

authors： van Dijkhuizen-Radersma R,Hesseling SC,Kaim PE,de Groot K,Bezemer JM

更新日期：2002-12-01 00:00:00

abstract：:The aminohexyl derivative of the copolymer of 2-hydroxyethyl methacrylate and ethylene dimethacrylate (p(HEMA)-Hex) in the form of regular spherical particles was used as a polymeric carrier for chemically sorbed methotrexate (MTX). The effect of the washed p(HEMA)-Hex-MTX carrier on the morphological structure of don...

journal_title：Biomaterials

authors： Horák D,Svec F,Adamyan A,Titova M,Skuba N,Voronkova O,Trostenyuk N,Vishnevskii V,Gumargalieva K

更新日期：1992-01-01 00:00:00

abstract：:The conventional biomimetic apatite coating process can be accelerated by immersing substrates into concentrated simulated body fluid (5 x SBF) at 37 degrees C to form an initial coating of apatite precursor spheres, and transform the precursors into plate-like apatite structures. Depending on processing parameters, d...

journal_title：Biomaterials

authors： Chou YF,Huang W,Dunn JC,Miller TA,Wu BM

更新日期：2005-01-01 00:00:00

abstract：:Suture materials may interact with immune competent cells and thereby affect localized immunity. Macrophages are central to the inflammatory response and coordinate wound healing. They are also involved in the clearance of foreign material, bacteria and malignant cells. We studied the influence of soluble factors asso...

journal_title：Biomaterials

authors： Uff CR,Scott AD,Pockley AG,Phillips RK

更新日期：1995-03-01 00:00:00

abstract：:A novel technique has been developed for microstructural studies of bone. The spatial organizations of the mineral and collagen fibres in bone have been a matter of discussion for some time, with numerous diverse observations arising from various preparative techniques. In this latest investigation details of the mine...

journal_title：Biomaterials

authors： Green M,Isaac DH,Jenkins GM

更新日期：1985-05-01 00:00:00

abstract：:The aim of this study was to characterize a nasally delivered bioadhesive liposome using an inactivated H5N3 virus as a model antigen. Bioadhesive liposomes were developed using tremella (T) or xanthan gum (XG) as the bioadhesive polysaccharide. Using chickens as the target animal, we evaluated whether delivery of a b...

journal_title：Biomaterials

authors： Chiou CJ,Tseng LP,Deng MC,Jiang PR,Tasi SL,Chung TW,Huang YY,Liu DZ

更新日期：2009-10-01 00:00:00

abstract：:This article reports a novel preparation method of poly(ethylene glycol) (PEG)-polystyrene (PST) amphiphilic block copolymers with well-defined block lengths by using photopolymerization of an iniferter, benzyl N,N-diethyldithiocarbamate. PEG macroiniferters, which were prepared by end-capping of PEG monomethyl ethers...

journal_title：Biomaterials

authors： Nakayama Y,Miyamura M,Hirano Y,Goto K,Matsuda T

更新日期：1999-05-01 00:00:00

abstract：:In order to overcome the problem of rapid clearance of the polysaccharide hyaluronic acid (Hyal) in the treatment of osteoarthritis (OA), a 50% cross-linked Hyal hydrogel (Hyal 50%) was synthesised. The 50% refers to the amount of COOH groups of the polysaccharide involved in the cross-linking reaction. i.e. 50% of th...

journal_title：Biomaterials

authors： Barbucci R,Lamponi S,Borzacchiello A,Ambrosio L,Fini M,Torricelli P,Giardino R

更新日期：2002-12-01 00:00:00

abstract：:The continuous release of nitric oxide (NO) by the native endothelium of blood vessels plays a substantial role in the cardiovascular physiology, as it influences important pathways of cardiovascular homeostasis, inhibits vascular smooth muscle cell (VSMC) proliferation, inhibits platelet activation and aggregation, a...

journal_title：Biomaterials

authors： Yang Z,Yang Y,Xiong K,Li X,Qi P,Tu Q,Jing F,Weng Y,Wang J,Huang N

更新日期：2015-09-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) are generally induced to differentiate by forming spherical structures termed embryoid bodies (EBs) in the presence of soluble growth factors. hEBs are generated by suspending small clumps of hESC colonies; however, the resulting hEBs are heterogeneous because this method lacks the a...

journal_title：Biomaterials

authors： Moon SH,Ju J,Park SJ,Bae D,Chung HM,Lee SH

更新日期：2014-07-01 00:00:00

abstract：:The removal of tenacious dental plaque is of paramount importance; however, early diagnosis can be a challenging task in dental clinics due to the limitations of current approaches, specifically X-ray-based techniques. We have approached this problem by integrating antibacterial properties and X-ray contrast enhanceme...

journal_title：Biomaterials

authors： Ostadhossein F,Misra SK,Tripathi I,Kravchuk V,Vulugundam G,LoBato D,Selmic LE,Pan D

更新日期：2018-10-01 00:00:00

abstract：:Decellularized adipose tissue (DAT) has shown promise as an adipogenic bioscaffold for soft tissue augmentation and reconstruction. The objective of the current study was to investigate the effects of allogeneic adipose-derived stem/stromal cells (ASCs) on in vivo fat regeneration in DAT bioscaffolds using an immunoco...

journal_title：Biomaterials

authors： Han TT,Toutounji S,Amsden BG,Flynn LE

更新日期：2015-12-01 00:00:00

abstract：:Angiogenesis plays a prominent role in cancer progression. Anti-angiogenic therapy therefore, either alone or in combination with conventional cytotoxic therapy, offers a promising therapeutic approach. Paclitaxel (PTX) is a widely-used potent cytotoxic drug that also exhibits anti-angiogenic effects at low doses. How...

journal_title：Biomaterials

authors： Eldar-Boock A,Miller K,Sanchis J,Lupu R,Vicent MJ,Satchi-Fainaro R

更新日期：2011-05-01 00:00:00

abstract：:This study examined the nature of the surface presented by a machinable feldspathic porcelain and by a machinable glass-ceramic for bonding to conventional composite luting agents and measured the bond strengths which may be achieved with various surface treatments. There was no significant difference between the bond...

journal_title：Biomaterials

authors： Jedynakiewicz NM,Martin N

更新日期：2001-04-01 00:00:00

abstract：:Three-dimensional constructs formed by cells embedded in an exogenous scaffold could not represent a faithful in vitro replica of native and functional tissues. In this work we produced an endogenous human skin equivalent by means of a tissue engineering process that induces the full morphogenesis of functional dermal...

journal_title：Biomaterials

authors： Casale C,Imparato G,Urciuolo F,Netti PA

更新日期：2016-09-01 00:00:00

abstract：:This article reviews the controlled release of biologically active agents by the erosion or chemical degradation of a polymer matrix into which the agent is incorporated. Chemically bound active agents and work on steroid release from cholesterol implants are not covered. The mechanisms of polymer erosion discussed ar...

journal_title：Biomaterials

authors： Heller J

更新日期：1980-01-01 00:00:00

abstract：:In human body ascorbic acid plays an essential role in the synthesis and function of skeletal tissues and immune system factors. Ascorbic acid is also a major physiological antioxidant, repairing oxidatively damaged biomolecules, preventing the formation of excessive reactive oxygen species or scavenging these species...

journal_title：Biomaterials

authors： Wang Y,Singh A,Xu P,Pindrus MA,Blasioli DJ,Kaplan DL

更新日期：2006-06-01 00:00:00

abstract：:Two commercially available amalgam alloy powders (one lathe-cut, the other spherical) were characterized in terms of density, surface area, particle size distribution and appearance under the scanning electron microscope. A third, experimental alloy powder, prepared by electrodeposition, was subjected to a similar ana...

journal_title：Biomaterials

authors： Davies EH,Kuhn AT

更新日期：1984-11-01 00:00:00

abstract：:The successful delivery of anti-cancer drugs relies on the simultaneous capability to actively target a specific location, a sufficient lifetime in the active form in the circulation, and traceability and quantification of drug distribution via in vivo medical imaging. Herein, a highly magnetic nanocarrier (HMNC) comp...

journal_title：Biomaterials

authors： Yang HW,Hua MY,Liu HL,Huang CY,Tsai RY,Lu YJ,Chen JY,Tang HJ,Hsien HY,Chang YS,Yen TC,Chen PY,Wei KC

更新日期：2011-09-01 00:00:00