Abstract：
:Intracellular reactive sulfur species and reactive oxygen species play vital roles in immunologic mechanism. As an emerging signal transmitter, SO2 can be generated as the anti-oxidant, while SO2 is also a potential oxidative stress-inducer in organism. Aiming to elucidate in-depth the dichotomous role of SO2 under oxidative stress, we designed a dual-response fluorescent probe that enabled the respective or successive detection of SO2 and ClO-. The probe itself emits the red fluorescence (625 nm) which can largely switch to blue (410 nm) and green fluorescence (500 nm) respectively in response to SO2 and ClO-, allowing the highly selective and accurate ratiometric quantification for both SO2 and ClO- in cells. Moreover the ultrafast (SO2: <60 s; ClO-: within sec) and highly sensitive (detection limits: SO2: 3.5 nM; ClO-: 12.5 nM) detection were achieved. With the robust applicability, the developed probe was successfully used to quantify SO2 and endogenous ClO- in respectively the HeLa cells and the RAW 264.7 cells, as well as to visualize the dynamic of SO2/ClO- in zebrafish. The fluorescent imaging studies and flow cytometry analysis confirmed the burst-and-depletion and meanwhile the oxidative-and-antioxidative effects of intracellular SO2 under the NaClO induced oxidative stress.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Dou K,Fu Q,Chen G,Yu F,Liu Y,Cao Z,Li G,Zhao X,Xia L,Chen L,Wang H,You Jdoi
10.1016/j.biomaterials.2017.04.024subject
Has Abstractpub_date
2017-07-01 00:00:00pages
82-93eissn
0142-9612issn
1878-5905pii
S0142-9612(17)30254-5journal_volume
133pub_type
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